An Automatic Assessment System for Alzheimer's Disease Based on Speech Using Feature Sequence Generator and Recurrent Neural Network.

Abstract:

:Alzheimer disease and other dementias have become the 7th cause of death worldwide. Still lacking a cure, an early detection of the disease in order to provide the best intervention is crucial. To develop an assessment system for the general public, speech analysis is the optimal solution since it reflects the speaker's cognitive skills abundantly and data collection is relatively inexpensive compared with brain imaging, blood testing, etc. While most of the existing literature extracted statistics-based features and relied on a feature selection process, we have proposed a novel Feature Sequence representation and utilized a data-driven approach, namely, the recurrent neural network to perform classification in this study. The system is also shown to be fully-automated, which implies the system can be deployed widely to all places easily. To validate our study, a series of experiments have been conducted with 120 speech samples, and the score in terms of the area under the receiver operating characteristic curve is as high as 0.838.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Chien YW,Hong SY,Cheah WT,Yao LH,Chang YL,Fu LC

doi

10.1038/s41598-019-56020-x

subject

Has Abstract

pub_date

2019-12-20 00:00:00

pages

19597

issue

1

issn

2045-2322

pii

10.1038/s41598-019-56020-x

journal_volume

9

pub_type

杂志文章
  • Neutralization of Acidic Intracellular Vesicles by Niclosamide Inhibits Multiple Steps of the Dengue Virus Life Cycle In Vitro.

    abstract::Dengue fever is one of the most important mosquito-borne viral infections in large parts of tropical and subtropical countries and is a significant public health concern and socioeconomic burden. There is an urgent need to develop antivirals that can effectively reduce dengue virus (DENV) replication and decrease vira...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45095-1

    authors: Jung E,Nam S,Oh H,Jun S,Ro HJ,Kim B,Kim M,Go YY

    更新日期:2019-06-18 00:00:00

  • Comparison of three models fitting the soil water retention curves in a degraded alpine meadow region.

    abstract::Soil water retention curve (SWRC) plays an important role in simulating soil water movement and assessing soil water holding capacity and availability. Comparison of fitness between different models to determine the best SWRC model of specific regions is required. In this study, three popular models, van Genuchten, Br...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-54449-8

    authors: Pan T,Hou S,Liu Y,Tan Q

    更新日期:2019-12-05 00:00:00

  • Author Correction: Some coral diseases track climate oscillations in the Caribbean.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-018-23087-x

    authors: Randall CJ,van Woesik R

    更新日期:2018-03-19 00:00:00

  • Efficacy and safety of stereotactic radiosurgery for pulmonary metastases from osteosarcoma: Experience in 73 patients.

    abstract::Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary me...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-14521-7

    authors: Yu W,Liu Z,Tang L,Lin F,Yao Y,Shen Z

    更新日期:2017-12-12 00:00:00

  • High-affinity Cu(I) chelator PSP-2 as potential anti-angiogenic agent.

    abstract::Copper is an essential trace metal that has been implicated in angiogenesis, the formation of new blood vessels. As tumor growth relies on establishing a functional capillary network for blood supply, copper chelation therapy may hold promise as an anti-cancer strategy by suppressing angiogenesis. To test the anti-ang...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50494-5

    authors: Heuberger DM,Harankhedkar S,Morgan T,Wolint P,Calcagni M,Lai B,Fahrni CJ,Buschmann J

    更新日期:2019-10-01 00:00:00

  • A Machine-learning Approach to Forecast Aggravation Risk in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Clinical Indicators.

    abstract::Patients with chronic obstructive pulmonary disease (COPD) repeat acute exacerbations (AE). Global Initiative for Chronic Obstructive Lung Disease (GOLD) is only available for patients in stable phase. Currently, there is a lack of assessment and prediction methods for acute exacerbation of chronic obstructive pulmona...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-60042-1

    authors: Peng J,Chen C,Zhou M,Xie X,Zhou Y,Luo CH

    更新日期:2020-02-20 00:00:00

  • Elemental Zn and its Binding Protein Zinc-α2-Glycoprotein are Elevated in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.

    abstract::Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is biologically distinct from HPV-negative HNSCC. Outside of HPV-status, few tumor-intrinsic variables have been identified that correlate to improved survival. As part of exploratory analysis into the trace elemental composition of orop...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-53268-1

    authors: Poropatich K,Paunesku T,Zander A,Wray B,Schipma M,Dalal P,Agulnik M,Chen S,Lai B,Antipova O,Maxey E,Brown K,Wanzer MB,Gursel D,Fan H,Rademaker A,Woloschak GE,Mittal BB

    更新日期:2019-11-18 00:00:00

  • Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor.

    abstract::Endocytosis and postendocytic sorting of G-protein-coupled receptors (GPCRs) is important for the regulation of both their cell surface density and signaling profile. Unlike the mechanisms of clathrin-dependent endocytosis (CDE), the mechanisms underlying the control of GPCR signaling by clathrin-independent endocytos...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep11408

    authors: Wan M,Zhang W,Tian Y,Xu C,Xu T,Liu J,Zhang R

    更新日期:2015-06-22 00:00:00

  • Silibinin, A Natural Blend In Polytherapy Formulation For Targeting Cd44v6 Expressing Colon Cancer Stem Cells.

    abstract::Colon cancer stem cells have been attributed to poor prognosis, therapeutic resistance and aggressive nature of the malignancy. Recent reports associated CD44v6 expression with relapse, metastasis and reduced 5-year survival of colon cancer patients, thereby making it a potential therapeutic target. Thus, in this stud...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35069-0

    authors: Patel S,Waghela B,Shah K,Vaidya F,Mirza S,Patel S,Pathak C,Rawal R

    更新日期:2018-11-19 00:00:00

  • Polyploidy and introgression in invasive giant knotweed (Fallopia sachalinensis) during the colonization of remote volcanic islands.

    abstract::Invasive giant knotweed (Fallopia sachalinensis) is native to northeastern Asia. In Korea, F. sachalinensis is confined to two volcanic islands, Ullung and Dok islands, where it occurs as dodecaploids (2n = 132). We investigated the molecular variation in 104 accessions from 94 populations of F. sachalinensis and its ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-34025-2

    authors: Park CW,Bhandari GS,Won H,Park JH,Park DS

    更新日期:2018-10-30 00:00:00

  • Determination and correction of persistent biases in quantum annealers.

    abstract::Calibration of quantum computers is essential to the effective utilisation of their quantum resources. Specifically, the performance of quantum annealers is likely to be significantly impaired by noise in their programmable parameters, effectively misspecification of the computational problem to be solved, often resul...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep18628

    authors: Perdomo-Ortiz A,O'Gorman B,Fluegemann J,Biswas R,Smelyanskiy VN

    更新日期:2016-01-19 00:00:00

  • Phylogenomic analysis of MKKs and MAPKs from 16 legumes and detection of interacting pairs in chickpea divulge MAPK signalling modules.

    abstract::The mitogen-activated protein kinase (MAPK)-mediated phosphorylation cascade is a vital component of plant cellular signalling. Despite this, MAPK signalling cascade is less characterized in crop legumes. To fill this void, we present here a comprehensive phylogeny of MAPK kinases (MKKs) and MAPKs identified from 16 l...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04913-0

    authors: Purayannur S,Kumar K,Kaladhar VC,Verma PK

    更新日期:2017-07-10 00:00:00

  • Social and Physiological Context can Affect the Meaning of Physiological Synchrony.

    abstract::Survival of many species, from insects and birds to human and non-human mammals, requires synchronized activity. Among humans, synchrony occurs even at the level of autonomic functioning; people interacting often show mutual, simultaneous changes in activity of the sympathetic or parasympathetic branches of the autono...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44667-5

    authors: Danyluck C,Page-Gould E

    更新日期:2019-06-03 00:00:00

  • Y-box protein-associated acidic protein (YBAP1/C1QBP) affects the localization and cytoplasmic functions of YB-1.

    abstract::The Y-box proteins are multifunctional nucleic acid-binding proteins involved in various aspects of gene regulation. The founding member of the Y-box protein family, YB-1, functions as a transcription factor as well as a principal component of messenger ribonucleoprotein particles (mRNPs) in somatic cells. The nuclear...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-24401-3

    authors: Matsumoto K,Kose S,Kuwahara I,Yoshimura M,Imamoto N,Yoshida M

    更新日期:2018-04-18 00:00:00

  • Horseradish peroxidase inactivation: heme destruction and influence of polyethylene glycol.

    abstract::Horseradish peroxidase (HRP) mediates efficient conversion of many phenolic contaminants and thus has potential applications for pollution control. Such potentially important applications suffer however from the fact that the enzyme becomes quickly inactivated during phenol oxidation and polymerization. The work here ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03126

    authors: Mao L,Luo S,Huang Q,Lu J

    更新日期:2013-11-04 00:00:00

  • Impedance-based analysis of Natural Killer cell stimulation.

    abstract::The use of impedance-based label free cell analysis is increasingly popular and has many different applications. Here, we report that a real-time cell analyzer (RTCA) can be used to study the stimulation of Natural Killer (NK) cells. Engagement of NK cells via plate-bound antibodies directed against different activati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-23368-5

    authors: Fasbender F,Watzl C

    更新日期:2018-03-21 00:00:00

  • TMEM16F activation by Ca2+ triggers plasma membrane expansion and directs PD-1 trafficking.

    abstract::TMEM16F is a Ca2+ -gated ion channel that is required for Ca2+ -activated phosphatidylserine exposure on the surface of many eukaryotic cells. TMEM16F is widely expressed and has roles in platelet activation during blood clotting, bone formation and T cell activation. By combining microscopy and patch clamp recording ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-37056-x

    authors: Bricogne C,Fine M,Pereira PM,Sung J,Tijani M,Wang Y,Henriques R,Collins MK,Hilgemann DW

    更新日期:2019-01-24 00:00:00

  • Circadian rhythmicity persists through the Polar night and midnight sun in Svalbard reindeer.

    abstract::Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-32778-4

    authors: Arnold W,Ruf T,Loe LE,Irvine RJ,Ropstad E,Veiberg V,Albon SD

    更新日期:2018-09-27 00:00:00

  • Qualitative and quantitative differences in endometrial inflammatory gene expression precede the development of bovine uterine disease.

    abstract::The transcriptome of the endometrium early postpartum was profiled to determine if inflammatory gene expression was elevated in cows which subsequently developed uterine disease. Endometrial cytobrush samples were collected at 7 days postpartum (DPP) from 112 Holstein-Friesian dairy cows, from which 27 were retrospect...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-75104-7

    authors: Brewer A,Cormican P,Lim JJ,Chapwanya A,O'Farrelly C,Meade KG

    更新日期:2020-10-26 00:00:00

  • The adeno-associated virus rh10 vector is an effective gene transfer system for chronic spinal cord injury.

    abstract::Treatment options for chronic spinal cord injury (SCI) remain limited due to unfavourable changes in the microenvironment. Gene therapy can overcome these barriers through continuous delivery of therapeutic gene products to the target tissue. In particular, adeno-associated virus (AAV) vectors are potential candidates...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-46069-z

    authors: Hoshino Y,Nishide K,Nagoshi N,Shibata S,Moritoki N,Kojima K,Tsuji O,Matsumoto M,Kohyama J,Nakamura M,Okano H

    更新日期:2019-07-08 00:00:00

  • Enrichment of Eucalyptus oil nanoemulsion by micellar nanotechnology: transdermal analgesic activity using hot plate test in rats' assay.

    abstract::Eucalyptus globulus is an aromatic medicinal plant which known for its 1,8-cineole main pharmacological constituent exhibits as natural analgesic agent. Eucalyptus globulus-loaded micellar nanoparticle was developed via spontaneous emulsification technique and further evaluation for its analgesic efficacy study, in vi...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50134-y

    authors: Aziz ZAA,Nasir HM,Ahmad A,Setapar SHM,Ahmad H,Noor MHM,Rafatullah M,Khatoon A,Kausar MA,Ahmad I,Khan S,Al-Shaeri M,Ashraf GM

    更新日期:2019-09-23 00:00:00

  • TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells.

    abstract::The epithelial-mesenchymal plasticity, in tight association with stemness, contributes to the mammary gland homeostasis, evolution of early neoplastic lesions and cancer dissemination. Focused on cell surfaceome, we used mouse models of pre-neoplastic mammary epithelial and cancer stem cells to reveal the connection b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-67827-4

    authors: Remšík J,Pícková M,Vacek O,Fedr R,Binó L,Hampl A,Souček K

    更新日期:2020-07-09 00:00:00

  • In-situ fabrication of macroporous films for dye-sensitised solar cells: formation of the scattering layer and the gelation of electrolytes.

    abstract::Dye-sensitised solar cells (DSCs) are a promising substitute for conventional silicon solar cells. A scattering layer of submicrometer pores or particles has been widely introduced to achieve a high light-harvesting efficiency. However, many such fabrication processes require high temperatures and multiple steps to pr...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05375

    authors: Ha SJ,Moon JH

    更新日期:2014-07-09 00:00:00

  • Investigating the Life Expectancy and Proteolytic Degradation of Engineered Skeletal Muscle Biological Machines.

    abstract::A combination of techniques from 3D printing, tissue engineering and biomaterials has yielded a new class of engineered biological robots that could be reliably controlled via applied signals. These machines are powered by a muscle strip composed of differentiated skeletal myofibers in a matrix of natural proteins, in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03723-8

    authors: Cvetkovic C,Ferrall-Fairbanks MC,Ko E,Grant L,Kong H,Platt MO,Bashir R

    更新日期:2017-06-19 00:00:00

  • Quantum interference induced photon blockade in a coupled single quantum dot-cavity system.

    abstract::We propose an experimental scheme to implement a strong photon blockade with a single quantum dot coupled to a nanocavity. The photon blockade effect can be tremendously enhanced by driving the cavity and the quantum dot simultaneously with two classical laser fields. This enhancement of photon blockade is ascribed to...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep09252

    authors: Tang J,Geng W,Xu X

    更新日期:2015-03-18 00:00:00

  • Energetic mitochondrial failing in vitiligo and possible rescue by cardiolipin.

    abstract::Vitiligo is characterized by death or functional defects of epidermal melanocytes through still controversial pathogenic process. Previously, we showed that mitochondria-driven pre-senescent phenotype diminishes the capability of vitiligo melanocytes to cope with stressful stimuli. In the current study, we investigate...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13961-5

    authors: Dell'Anna ML,Ottaviani M,Kovacs D,Mirabilii S,Brown DA,Cota C,Migliano E,Bastonini E,Bellei B,Cardinali G,Ricciardi MR,Tafuri A,Picardo M

    更新日期:2017-10-20 00:00:00

  • Vegetation morphologic and aerodynamic characteristics reduce aeolian erosion.

    abstract:ABSRACT:Vegetation cover is crucial to controlling aeolian erosion but highly efficient vegetation is critical. How this efficiency is influenced by vegetation response to airflow is not clear. Here we evaluate the responses of Cosmos bipinnatus and Ligustrum lucidum Ait to a range of wind speeds in a wind tunnel. For ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13084-x

    authors: Miri A,Dragovich D,Dong Z

    更新日期:2017-10-09 00:00:00

  • Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.

    abstract::Antitumor drug development based on the concept of intervening in the antioxidant system of cancer cells has been gaining increased interest. In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxida...

    journal_title:Scientific reports

    pub_type: 杂志文章,收录出版

    doi:10.1038/s41598-019-51462-9

    authors: Fujitani N,Yoneda A,Takahashi M,Takasawa A,Aoyama T,Miyazaki T

    更新日期:2019-10-14 00:00:00

  • Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF.

    abstract::Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair. However, MSCs grafting present disadvantages, such as, a high number of cells required for transplantation and low survival rate when transplanted ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-03592-1

    authors: Martins LF,Costa RO,Pedro JR,Aguiar P,Serra SC,Teixeira FG,Sousa N,Salgado AJ,Almeida RD

    更新日期:2017-06-23 00:00:00

  • The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early- and late-onset asthma.

    abstract::Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43681

    authors: Lau MY,Dharmage SC,Burgess JA,Win AK,Lowe AJ,Lodge C,Perret J,Hui J,Thomas PS,Morrison S,Giles GG,Hopper J,Abramson MJ,Walters EH,Matheson MC

    更新日期:2017-03-06 00:00:00