Breast cancer cells exhibits specific dielectric signature in vitro using the open-ended coaxial probe technique from 200 MHz to 13.6 GHz.

Abstract:

:Here we investigated the feasibility of using microwave spectroscopy for characterization of normal and breast cancer cell lines cultured in vitro. Healthy non-tumorigenic, MCF-10A and breast cancer, MDA-MB-231, Hs578T, T47D and MCF-7 cell lines were electrically characterized using the open-ended coaxial probe technique from 200 MHz to 13.6 GHz. The dielectric constant, dielectric loss and conductivity between breast non-tumorigenic and breast cancer cells lines were analyzed and their differences determined. Our results showed that the four breast cancer cell lines analyzed exhibited higher dielectric properties when compared to healthy cells. Interestingly, we found that breast and colon cancer cells have different dielectric properties as well, thus suggesting that each type of cancer has a unique microwave signature. This study shows that microwave characterization of breast cancer cell lines is reliable with potential in biomedical applications such as designing electromagnetic models for detection of tumorous cells in healthy tissues.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Hussein M,Awwad F,Jithin D,El Hasasna H,Athamneh K,Iratni R

doi

10.1038/s41598-019-41124-1

subject

Has Abstract

pub_date

2019-03-18 00:00:00

pages

4681

issue

1

issn

2045-2322

pii

10.1038/s41598-019-41124-1

journal_volume

9

pub_type

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