Abstract:
:While Brassica oleracea vegetables have been linked to cancer prevention, the exact mechanism remains unknown. Regulation of gene expression by cross-species microRNAs has been previously reported; however, its link to cancer suppression remains unexplored. In this study we address both issues. We confirm plant microRNAs in human blood in a large nutrigenomics study cohort and in a randomized dose-controlled trial, finding a significant positive correlation between the daily amount of broccoli consumed and the amount of microRNA in the blood. We also demonstrate that Brassica microRNAs regulate expression of human genes and proteins in vitro, and that microRNAs cooperate with other Brassica-specific compounds in a possible cancer-preventive mechanism. Combined, we provide strong evidence and a possible multimodal mechanism for broccoli in cancer prevention.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Pastrello C,Tsay M,McQuaid R,Abovsky M,Pasini E,Shirdel E,Angeli M,Tokar T,Jamnik J,Kotlyar M,Jurisicova A,Kotsopoulos J,El-Sohemy A,Jurisica Idoi
10.1038/srep32773subject
Has Abstractpub_date
2016-09-08 00:00:00pages
32773issn
2045-2322pii
srep32773journal_volume
6pub_type
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