Brain APOE expression quantitative trait loci-based association study identified one susceptibility locus for Alzheimer's disease by interacting with APOE ε4.

abstract：:Axonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as ...

journal_title：Scientific reports

authors： Nadal-Nicolás FM,Galindo-Romero C,Valiente-Soriano FJ,Barberà-Cremades M,deTorre-Minguela C,Salinas-Navarro M,Pelegrín P,Agudo-Barriuso M

更新日期：2016-12-08 00:00:00

abstract：:Fracture of initially crack-free bodies often occurs due to plastic instabilities known as shear bands. Previous computer simulations advanced a myriad of mechanisms to rationalize shear banding. However, they were restricted to planar geometries. We investigate the relevance of anisotropic plasticity by picking an ax...

journal_title：Scientific reports

authors： Benzerga AA,Thomas N,Herrington JS

更新日期：2019-02-05 00:00:00

abstract：:Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diag...

journal_title：Scientific reports

authors： Chang J,Dumitrache A,Böhling N,Abu-Omar J,Meyer C,Strobel D,Luetkens J,Luu AM,Rockstroh J,Strassburg CP,Trebicka J,Gonzalez-Carmona MA,Marinova M,Praktiknjo M

更新日期：2020-11-26 00:00:00

abstract：:The complement system is the first line of defense against foreign intruders, and deregulation of this system has been described in multiple diseases. In age-related macular degeneration (AMD), patients have higher complement activation levels compared to controls. Recently, a combination of three single nucleotide po...

journal_title：Scientific reports

authors： Paun CC,Lechanteur YTE,Groenewoud JMM,Altay L,Schick T,Daha MR,Fauser S,Hoyng CB,den Hollander AI,de Jong EK

更新日期：2016-05-31 00:00:00

abstract：:Inhibition of the androgen receptor (AR) by second-generation anti-androgens is a standard treatment for metastatic castration resistant prostate cancer (mCRPC), but it inevitably leads to the development of resistance. Since the introduction of highly efficient AR signalling inhibitors, approximately 20% of mCRPC pat...

journal_title：Scientific reports

authors： Handle F,Prekovic S,Helsen C,Van den Broeck T,Smeets E,Moris L,Eerlings R,Kharraz SE,Urbanucci A,Mills IG,Joniau S,Attard G,Claessens F

更新日期：2019-09-24 00:00:00

abstract：:Graphene has shown enormous potential for innovation in various research fields. The current chemical approaches based on exfoliation of graphite via graphite oxide (GO) are potential for large-scale synthesis of graphene but suffer from high cost, great operation difficulties, and serious waste discharge. We report a...

journal_title：Scientific reports

authors： Hong Y,Wang Z,Jin X

更新日期：2013-12-06 00:00:00

abstract：:New clinical trials for diabetic macular oedema (DMO) are being designed to prove superiority over aflibercept when this agent is already very effective in improving visual acuity (VA) and DMO. The aim of this study was to determine the optimal inclusion-exclusion criteria for trials to aim for superiority in visual o...

journal_title：Scientific reports

authors： Halim S,Gurudas S,Chandra S,Greenwood J,Sivaprasad S

更新日期：2020-10-05 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by excessive production and deposition of amyloid-beta (Aβ) proteins as well as synapse dysfunction and loss. While soluble Aβ oligomers (AβOs) have deleterious effects on synapse function and reduce synapse number, the underlying molecular mechanisms are not well understood. ...

journal_title：Scientific reports

authors： Naito Y,Tanabe Y,Lee AK,Hamel E,Takahashi H

更新日期：2017-02-13 00:00:00

abstract：:RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REVec for in vivo gene delivery...

journal_title：Scientific reports

authors： Komatsu Y,Tanaka C,Komorizono R,Tomonaga K

更新日期：2020-04-03 00:00:00

abstract：:Two-dimensional (2D) porous carbon AC-SPN-3 possessing of amazing high micropore volume ratio of 83% and large surface area of about 1069 m(2) g(-1) is high-yield obtained by pyrolysis of natural waste Pistachio nutshells with KOH activation. The AC-SPN-3 has a curved 2D lamellar morphology with the thickness of each ...

journal_title：Scientific reports

authors： Xu J,Gao Q,Zhang Y,Tan Y,Tian W,Zhu L,Jiang L

更新日期：2014-07-02 00:00:00

abstract：:Mulching with organic materials is a management practice with long history for weed suppression, soil water conservation and erosion control. Its potential impact on crop pests is less well explored. Here we report its utility for reducing crop damage by the serious pest, sweetpotato weevil (Cylas formicarius). Labora...

journal_title：Scientific reports

authors： Rehman M,Liu J,Johnson AC,Dada TE,Gurr GM

更新日期：2019-10-16 00:00:00

abstract：:There is a huge request for the development of low dielectric constant polymeric materials for microelectronic applications. In thisstudy, polymer blends based on PVA:POZ with low dielectric constant has been fabricated. The results of XRD indicate that crystalline domain is enhanced at higher POZ concentration. Brill...

journal_title：Scientific reports

authors： Aziz SB,Kadir MFZ,Hamsan MH,Woo HJ,Brza MA

更新日期：2019-09-11 00:00:00

abstract：:Moonlighting proteins, including metabolic enzymes acting as transcription factors (TF), are present in a variety of organisms but have not been described in higher fungi so far. In a previous genome-wide analysis of the TF repertoire of the plant-symbiotic fungus Tuber melanosporum, we identified various enzymes, inc...

journal_title：Scientific reports

authors： Levati E,Sartini S,Bolchi A,Ottonello S,Montanini B

更新日期：2016-04-28 00:00:00

abstract：:A cell-type saturable absorber has been demonstrated by filling the single mode photonic crystal fiber (SMPCF) with tungsten disulfide (WS2) nanosheets. The modulation depth, saturable intensity, and non-saturable loss of this SA are measured to be 3.53%, 159 MW/cm(2) and 23.2%, respectively. Based on this SA, a passi...

journal_title：Scientific reports

authors： Yan P,Liu A,Chen Y,Wang J,Ruan S,Chen H,Ding J

更新日期：2015-07-27 00:00:00

abstract：:Urbanization-driven landscape changes are harmful to many species. Negative effects can be mitigated through habitat preservation and restoration, but it is often difficult to prioritize these conservation actions. This is due, in part, to the scarcity of species response data, which limit the predictive accuracy of m...

journal_title：Scientific reports

authors： Ettinger AK,Buhle ER,Feist BE,Howe E,Spromberg JA,Scholz NL,Levin PS

更新日期：2021-01-12 00:00:00

abstract：:According to amputees, sensory feedback is amongst the most important features lacking from commercial prostheses. Although restoration of touch by means of implantable neural interfaces has been achieved, these approaches require surgical interventions, and their long-term usability still needs to be fully investigat...

journal_title：Scientific reports

authors： D'Anna E,Petrini FM,Artoni F,Popovic I,Simanić I,Raspopovic S,Micera S

更新日期：2017-09-07 00:00:00

abstract：:Ocular graft-versus-host disease (GVHD) is a common complication after hematopoietic stem cell transplantation (HSCT). Here we compared the diagnostic rates of ocular GVHD, including its severity, prognosis and the agreement, obtained using three grading scales: the National Institutes of Health (NIH) eye score, Japan...

journal_title：Scientific reports

authors： Tatematsu Y,Ogawa Y,Abe T,Kamoi M,Uchino M,Saijo-Ban Y,Yaguchi S,Mukai S,Mori T,Okamoto S,Tsubota K

更新日期：2014-10-22 00:00:00

abstract：:The entire recrystallisation sequence and associated crystallographic texture evolution of Mg-0.8Zn-0.2Ca (wt.%) alloy was tracked using a quasi-in-situ electron backscatter diffraction (EBSD) method. Characteristic "Rare Earth" (RE) texture was formed, originating mainly from double twins and twinning-related shear b...

journal_title：Scientific reports

authors： Guan D,Liu X,Gao J,Ma L,Wynne BP,Rainforth WM

更新日期：2019-05-09 00:00:00

abstract：:Interactions between human cytomegalovirus (HCMV) infection and environmental factors can increase susceptibility to essential hypertension (EH). Although endothelial dysfunction is the initial factor of EH, the epigenetic mechanisms through which HCMV infection induces endothelial cell dysfunction are poorly understo...

journal_title：Scientific reports

authors： Zhang X,Tang N,Xi D,Feng Q,Liu Y,Wang L,Tang Y,Zhong H,He F

更新日期：2020-02-10 00:00:00

abstract：:Functional neuroimaging, using genetically-encoded Ca2+ sensors in larval zebrafish, offers a powerful combination of high spatiotemporal resolution and higher vertebrate relevance for quantitative neuropharmacological profiling. Here we use zebrafish larvae with pan-neuronal expression of GCaMP6s, combined with light...

journal_title：Scientific reports

authors： Winter MJ,Windell D,Metz J,Matthews P,Pinion J,Brown JT,Hetheridge MJ,Ball JS,Owen SF,Redfern WS,Moger J,Randall AD,Tyler CR

更新日期：2017-07-26 00:00:00

abstract：:The development is reported of an ultra-rapid, point-of-care diagnostic device which harnesses surface acoustic wave (SAW) biochips, to detect HIV in a finger prick of blood within 10 seconds (sample-in-result-out). The disposable quartz biochip, based on microelectronic components found in every consumer smartphone, ...

journal_title：Scientific reports

authors： Turbé V,Gray ER,Lawson VE,Nastouli E,Brookes JC,Weiss RA,Pillay D,Emery VC,Verrips CT,Yatsuda H,Athey D,McKendry RA

更新日期：2017-09-20 00:00:00

abstract：:The triple negative basal-like (TNBL) breast carcinoma is an aggressive and unfavorable prognosis disease. Inhibitors of poly(ADP-ribose) polymerase such as Olaparib could represent a promising targeted therapy but their sensitivity against Multidrug Resistance proteins (MDR), which causes resistance, is not well defi...

journal_title：Scientific reports

authors： Dufour R,Daumar P,Mounetou E,Aubel C,Kwiatkowski F,Abrial C,Vatoux C,Penault-Llorca F,Bamdad M

更新日期：2015-08-03 00:00:00

abstract：:The muscular dystrophy X-linked mouse (mdx) is the most commonly used preclinical model for Duchenne muscular dystrophy. Although disease progression in the mouse does not perfectly model the human disease, it shares many pathological features. Early characterizations of the model reported severe pathology through ear...

journal_title：Scientific reports

authors： Massopust RT,Lee YI,Pritchard AL,Nguyen VM,McCreedy DA,Thompson WJ

更新日期：2020-10-14 00:00:00

abstract：:Although an increasing interest in vision training for sport performance, whether it may have a transfer to sport-specific skills and whether such transfer could be mediated by cognition remain open issues. To enlighten this point, we tested the effect of 6-weeks sport vision training programmes (requiring generic or ...

journal_title：Scientific reports

authors： Formenti D,Duca M,Trecroci A,Ansaldi L,Bonfanti L,Alberti G,Iodice P

更新日期：2019-12-10 00:00:00

abstract：:Two series of Ge0.8Sn0.2 samples were grown on Ge buffered Si substrate by molecular beam epitaxy (MBE) to investigate the influence of growth temperature and film thickness towards the evolution of surface morphology. A novel phenomena was observed that the Ge0.8Sn0.2 film was segregated and relaxed by the formation ...

journal_title：Scientific reports

authors： Wang N,Xue C,Wan F,Zhao Y,Xu G,Liu Z,Zheng J,Zuo Y,Cheng B,Wang Q

更新日期：2020-04-09 00:00:00

abstract：:Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We p...

journal_title：Scientific reports

authors： Nair SK,Tomaras GD,Sales AP,Boczkowski D,Chan C,Plonk K,Cai Y,Dannull J,Kepler TB,Pruitt SK,Weinhold KJ

更新日期：2014-04-23 00:00:00

abstract：:Freshwater mussels are ecosystem engineers and keystone species in aquatic environments. Unfortunately, due to dramatic declines this fauna is among the most threatened globally. Here, we clarify the taxonomy and biogeography of Russian Unionidae species based on the most comprehensive multi-locus dataset sampled to d...

journal_title：Scientific reports

authors： Bolotov IN,Kondakov AV,Konopleva ES,Vikhrev IV,Aksenova OV,Aksenov AS,Bespalaya YV,Borovskoy AV,Danilov PP,Dvoryankin GA,Gofarov MY,Kabakov MB,Klishko OK,Kolosova YS,Lyubas AA,Novoselov AP,Palatov DM,Savvinov GN,Solom

更新日期：2020-02-20 00:00:00

abstract：:Inflammation plays central roles in the immune response. Inflammatory response normally requires higher energy and therefore is associated with glucose metabolism. Our recent study demonstrates that lncRNA HOTAIR plays key roles in NF-kB activation, cytokine expression, and inflammation. Here, we investigated if HOTAI...

journal_title：Scientific reports

authors： Obaid M,Udden SMN,Alluri P,Mandal SS

更新日期：2021-01-08 00:00:00

abstract：:Speaking involves coordination of multiple neuromotor systems, including respiration, phonation and articulation. Developing non-invasive imaging methods to study how the brain controls these systems is critical for understanding the neurobiology of speech production. Recent models and animal research suggest that reg...

journal_title：Scientific reports

authors： Correia JM,Caballero-Gaudes C,Guediche S,Carreiras M

更新日期：2020-03-11 00:00:00

abstract：:Povidone-iodine (PVI) is principally used as an antimicrobial agent. It has been found that 0.5% PVI can attenuate congestion, edema and pain induced by pressure sores. Thus this study aimed to assess the effects of 0.5% PVI on acute skin wounds. Four full-thickness excisional wounds were generated on the dorsal skin ...

journal_title：Scientific reports

authors： Wang L,Qin W,Zhou Y,Chen B,Zhao X,Zhao H,Mi E,Mi E,Wang Q,Ning J

更新日期：2017-04-20 00:00:00