Abstract：
:In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%). Notably, younger persons (≤30 years old) were 6.58 times more likely to be infected with a Beijing genotype compared to older persons (>70 years) (p < 0.05). Combining molecular typing methods and geographical information system (GIS) analysis, we uncovered a twofold higher incidence of Beijing strains in a hotspot area (33%) compared to non-hotspot areas (17%). By 24 MIRU-VNTR typing, persons in clustered groups were 1.96 times more likely to be infected with a Beijing strain compared with non-clustered persons, suggesting recent spread and emergence of MTB. Finally, we observed a trend in which TB incidence increased as the density/concentration of analyzed environmental factors increased, suggesting that environmental factors are associated with TB transmission; however, only population density was found to be significantly associated with increased risk of TB (p < 0.05). Molecular typing methods combined with spatial analysis suggest possible TB transmission. Early intervention to interrupt transmission may be most effective if targeted to hot zones of TB.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen YY,Chang JR,Wu CD,Yeh YP,Yang SJ,Hsu CH,Lin MC,Tsai CF,Lin MS,Su IJ,Dou HYdoi
10.1038/s41598-017-05674-6subject
Has Abstractpub_date
2017-07-14 00:00:00pages
5394issue
1issn
2045-2322pii
10.1038/s41598-017-05674-6journal_volume
7pub_type
杂志文章abstract：:Hox proteins are transcription factors and key regulators of segmental identity along the anterior posterior axis across all bilaterian animals. Despite decades of research, the mechanisms by which Hox proteins select and regulate their targets remain elusive. We have carried out whole-genome ChIP-chip experiments to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00205
更新日期：2011-01-01 00:00:00
abstract：:Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01495-9
更新日期：2017-05-03 00:00:00
abstract：:A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi fil...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37750-w
更新日期：2019-02-04 00:00:00
abstract：:In vivo, bone morphogenetic protein 2 (BMP-2) exists both in solution and bound to the extracellular matrix (ECM). While these two modes of presentation are known to influence cell behavior distinctly, their role in the niche microenvironment and their functional relevance in the genesis of a biological response has s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41479
更新日期：2017-01-30 00:00:00
abstract：:Bisphenol A (BPA) is widely used in the manufacture of plastics and epoxy resins and is prevalent in the aquatic environment. BPA disrupts endocrine pathways in fish, but the long-term developmental implications are unknown. We demonstrate that BPA deposition in the eggs of rainbow trout (Oncorhynchus mykiss), an ecol...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13301-7
更新日期：2017-10-26 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2019-12-27 00:00:00
abstract：:Synovial fibroblasts (SF) were reported to produce B cell activating factor (BAFF) in response to stimulation with interferon-γ (IFN-γ) or tumor necrosis factor (TNF). However, the influence of these pro-inflammatory cytokines on other receptors/ligands of the TNF superfamily or associated cytokine receptors in SF has...
journal_title：Scientific reports
pub_type： 杂志文章
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abstract：:This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differenti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43680
更新日期：2017-03-02 00:00:00
abstract：:Aggressive interactions between groups are frequent in human societies and can bear significant fitness costs and benefits (e.g. death or access to resources). During between-group competitive interactions, more cohesive groups (i.e. groups formed by individuals who cooperate in group defence) should out-perform less ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43277
更新日期：2017-02-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43959
更新日期：2017-03-17 00:00:00
abstract：:The Italian hare (Lepus corsicanus) is endemic to Central-Southern Italy and Sicily, classified as vulnerable due to habitat alterations, low density and fragmented populations and ecological competition with the sympatric European hare (Lepus europaeus). Despite this status, only few and local studies have explored i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70013-1
更新日期：2020-08-04 00:00:00
abstract：:Legionella pneumophila is a ubiquitous, pathogenic, Gram-negative bacterium responsible for legionellosis. Like many other amoeba-resistant microorganisms, L. pneumophila resists host clearance and multiplies inside the cell. Through its Dot/Icm type IV secretion system, the bacterium injects more than three hundred e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36448
更新日期：2016-11-02 00:00:00
abstract：:Male infertility due to spermatogenesis defects affects millions of men worldwide. However, the genetic etiology of the vast majority remains unclear. Here we describe three men with primary infertility due to multiple morphological abnormalities of the sperm flagella (MMAF) from two unrelated Han Chinese families. We...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-52436-7
更新日期：2019-11-01 00:00:00
abstract：:We report the synthesis of single-crystal iron germanium nanowires via chemical vapor deposition without the assistance of any catalysts. The assembly of single-crystal FeGe2 nanowires with tetragonal C16 crystal structure shows anisotropic magnetic behavior along the radial direction or the growth axial direction, wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05771-6
更新日期：2017-08-02 00:00:00
abstract：:The aim of this study is to develop an internal-external correlation model for internal motion estimation for lung cancer radiotherapy. Deformation vector fields that characterize the internal-external motion are obtained by respectively registering the internal organ meshes and external surface meshes from the 4DCT i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22023-3
更新日期：2018-02-27 00:00:00
abstract：:For the application of formic acid as a liquid organic hydrogen carrier, development of efficient catalysts for dehydrogenation of formic acid is a challenging topic, and most studies have so far focused on the composition of metals and supports, the size effect of metal nanoparticles, and surface chemistry of support...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33502
更新日期：2016-09-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06032-2
更新日期：2017-07-17 00:00:00
abstract：:The aim was to analyze the effect of fractional flow reserve (FFR), intravascular ultrasound (IVUS) and optical coherence tomography (OCT) on fluoroscopy time (FT), radiation dose (RD) and contrast volume (CV) in patients undergoing coronary angiography. This case-control study included consecutive patients above the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63791-1
更新日期：2020-04-24 00:00:00
abstract：:We summarized published data on the associations of apolipoprotein E (APOE) gene ε2/ε3/ε4 polymorphism with both cancer risk and circulating lipid profiles, aiming to examine the causal relevance between lipids and cancer risk. Article identification and data abstraction were conducted in duplicate and independently b...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep09495
更新日期：2015-03-30 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30599-z
更新日期：2018-08-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-03-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54833-4
更新日期：2019-12-05 00:00:00
abstract：:Manipulating the polarization states of electromagnetic (EM) waves, a fundamental issue in optics, attracted intensive attention recently. However, most of the devices realized so far are either too bulky in size, and/or are passive with only specific functionalities. Here we combine theory and experiment to demonstra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep27503
更新日期：2016-06-08 00:00:00
abstract：:Here we proposed a novel architectural design of a ternary MnO2-based electrode - a hierarchical Co3O4@Pt@MnO2 core-shell-shell structure, where the complemental features of the three key components (a well-defined Co3O4 nanowire array on the conductive Ti substrate, an ultrathin layer of small Pt nanoparticles, and a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02978
更新日期：2013-10-17 00:00:00
abstract：:In this paper we report a low complexity compression method that is suitable for compact optical scanning holography (OSH) systems with different optical settings. Our proposed method can be divided into 2 major parts. First, an automatic decision maker is applied to select the rows of holographic pixels to be scanned...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34724
更新日期：2016-10-06 00:00:00
abstract：:Thyroid nodules can be classified into benign and malignant tumors. However, distinguishing between these two types of tumors can be challenging in clinics. Since malignant nodules require surgical intervention whereas asymptomatic benign tumors do not, there is an urgent need for new techniques that enable accurate d...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-10-21 00:00:00
abstract：:The psychrophilic (cold-loving) fungus Pseudogymnoascus destructans was discovered more than a decade ago to be the pathogen responsible for white-nose syndrome, an emerging disease of North American bats causing unprecedented population declines. The same species of fungus is found in Europe but without associated mo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70375-6
更新日期：2020-08-17 00:00:00
abstract：:Epidemiological knowledge of pediatric diseases may improve professionals' understanding of the pathophysiology of and risk factors for diseases and is also crucial for decision making related to workforce and resource planning in pediatric departments. In this study, a pediatric disease epidemiology knowledgebase cal...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-11-28 00:00:00
abstract：:The present study reports a natural infection of emus, Dromaius novaehollandiae, by the nematode Procyrnea uncinipenis. Five adult emus from a scientific breeding farm at North Fluminense State University located in the city of Campos dos Goytacazes, Rio de Janeiro state, Brazil were necropsied, and their gastrointest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73754-1
更新日期：2020-10-06 00:00:00
