Heterozygous HbAC but not HbAS is associated with higher newborn birthweight among women with pregnancy-associated malaria.


:Pregnancy-associated malaria (PAM) is associated with poor pregnancy outcomes. Hemoglobin S (HbS) and hemoglobin C (HbC) mutations are frequently encountered in malaria-endemic areas of Africa, where they protect children from severe and uncomplicated Plasmodium falciparum malaria. However, scant epidemiological data exist on the impact of these Hb variants on PAM. A prospective cohort of 635 Beninese pregnant women was recruited before 24 weeks of gestational age and followed until the end of pregnancy. HbAA, HbAC, and HbAS genotypes were determined and tested for association with pregnancy outcomes and PAM indicators using linear and logistic multivariate models. Newborns from HbAC mothers had higher birthweights than those from HbAA mothers among women infected at any time during pregnancy (mean difference 182.9 g, p = 0.08), or during the first half of pregnancy (654.3 g, p = 0.0006). No such birthweight differences were observed between newborns from HbAS and HbAA mothers. HbAC and HbAS were not associated with other pregnancy outcomes or PAM indicators. In conclusion, HbAC but not HbAS is associated with an improved birth outcome in pregnant women with documented PAM. Higher-birthweight newborns from HbAC mothers may have a survival advantage that contributes to the natural selection of HbC in malaria-endemic areas.


Sci Rep


Scientific reports


Tétard M,Milet J,Dechavanne S,Fievet N,Dorin-Semblat D,Elion J,Fairhurst RM,Deloron P,Tuikue-Ndam N,Gamain B




Has Abstract


2017-05-03 00:00:00












  • Tumor resection ameliorates tumor-induced suppression of neuroinflammatory and behavioral responses to an immune challenge in a cancer survivor model.

    abstract::Breast cancer survivors display altered inflammatory responses to immune challenges relative to cancer-naive controls likely due to previous cancer treatments, stress associated with cancer, and/or tumor physiology. Proper inflammatory responses are necessary for adaptive sickness behaviors (e.g., fatigue, anorexia, a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Santos JC,Bever SR,Pereira-da-Silva G,Pyter LM

    更新日期:2019-01-24 00:00:00

  • Diagnostic accuracy of contrast enhanced ultrasound in patients with blunt abdominal trauma presenting to the emergency department: a systematic review and meta-analysis.

    abstract::We aimed to investigate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) in evaluating blunt abdominal trauma for patients presenting to the emergency department. Electronic search of Scopus and Pubmed was performed from inception to September 2016. Human studies investigating the diagnostic accuracy of ...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析


    authors: Zhang Z,Hong Y,Liu N,Chen Y

    更新日期:2017-06-30 00:00:00

  • Contact effects in thin 3D-topological insulators: how does the current flow?

    abstract::The effect of different contact configurations (semi-infinite extended-channel, normal metal and ferromagnetic metal) on quantum transport through thin Bi2Se3 three-dimensional (3D) topological insulator (TI) slab (channel) has been investigated through Non-Equilibrium Green Function. The issue of contact dependent cu...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Gupta G,Jalil MB,Liang G

    更新日期:2015-03-30 00:00:00

  • Environmental control of mammary carcinoma cell expansion by acidification and spheroid formation in vitro.

    abstract::Breast cancer is the leading cause of cancer death among women worldwide. Like other cancers, mammary carcinoma progression involves acidification of the tumor microenvironment, which is an important factor for cancer detection and treatment strategies. However, the effects of acidity on mammary carcinoma cell morphol...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ralph ACL,Valadão IC,Cardoso EC,Martins VR,Oliveira LMS,Bevilacqua EMAF,Geraldo MV,Jaeger RG,Goldberg GS,Freitas VM

    更新日期:2020-12-15 00:00:00

  • Onset of summer monsoon in Northeast India is preceded by enhanced transpiration.

    abstract::Variations in isotopic composition of water vapor in the atmosphere is an important indicator of the processes within the hydrological cycle. Isotopic signature of water vapor and precipitation can be helpful in partitioning evaporation and transpiration fluxes. It is well known that transpiration from forested region...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Pradhan R,Singh N,Singh RP

    更新日期:2019-12-09 00:00:00

  • Author Correction: Early‑life short‑term environmental enrichment counteracts the effects of stress on anxiety‑like behavior, brain‑derived neurotrophic factor and nuclear translocation of glucocorticoid receptors in the basolateral amygdala.

    abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Hegde A,Suresh S,Mitra R

    更新日期:2020-10-06 00:00:00

  • Satellite-based indicator of zooplankton distribution for global monitoring.

    abstract::This study investigates the association between an index of mesozooplankton biomass, derived from the Continuous Plankton Recorder survey and satellite-derived productivity fronts in the North Atlantic. While chlorophyll-a content (CHL) is commonly described as a proxy for phytoplankton biomass, the size of productivi...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Druon JN,Hélaouët P,Beaugrand G,Fromentin JM,Palialexis A,Hoepffner N

    更新日期:2019-03-18 00:00:00

  • Tuning methane decomposition on stepped Ni surface: The role of subsurface atoms in catalyst design.

    abstract::The decomposition of methane (CH4) is a catalytically important reaction in the production of syngas that is used to make a wide spectrum of hydrocarbons and alcohols, and a principal carbon deposition pathway in methane reforming. Literatures suggest that stepped Ni surface is uniquely selective toward methane decomp...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Arevalo RL,Aspera SM,Escaño MCS,Nakanishi H,Kasai H

    更新日期:2017-10-25 00:00:00

  • Lithia/(Ir, Li2IrO3) nanocomposites for new cathode materials based on pure anionic redox reaction.

    abstract::Anionic redox reactions attributed to oxygen have attracted much attention as a new approach to overcoming the energy-density limits of cathode materials. Several oxides have been suggested as new cathode materials with high capacities based on anionic (oxygen) redox reactions. Although most still have a large portion...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Lee SY,Park YJ

    更新日期:2019-09-12 00:00:00

  • The application of a biostimulant based on tannins affects root architecture and improves tolerance to salinity in tomato plants.

    abstract::Roots have important roles for plants to withstand adverse environmental conditions, including salt stress. Biostimulant application was shown to enhance plant resilience towards abiotic stresses. Here, we studied the effect of a tannin-based biostimulant on tomato (Solanum lycopersicum L.) grown under salt stress con...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Campobenedetto C,Mannino G,Beekwilder J,Contartese V,Karlova R,Bertea CM

    更新日期:2021-01-11 00:00:00

  • HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.

    abstract::Tumor progression, limited efficacy of current standard treatments, and the rise in patient mortality are associated with gene expression caused by the synergistic action of intratumoral hypoxia and HIF-1α activation. For this reason, recent investigations have focused on HIF-targeting therapeutic agents, with encoura...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mangraviti A,Raghavan T,Volpin F,Skuli N,Gullotti D,Zhou J,Asnaghi L,Sankey E,Liu A,Wang Y,Lee DH,Gorelick N,Serra R,Peters M,Schriefer D,Delaspre F,Rodriguez FJ,Eberhart CG,Brem H,Olivi A,Tyler B

    更新日期:2017-11-02 00:00:00

  • Towards Quantification of Inflammation in Atherosclerotic Plaque in the Clinic - Characterization and Optimization of Fluorine-19 MRI in Mice at 3 T.

    abstract::Fluorine-19 (19F) magnetic resonance imaging (MRI) of injected perfluorocarbons (PFCs) can be used for the quantification and monitoring of inflammation in diseases such as atherosclerosis. To advance the translation of this technique to the clinical setting, we aimed to 1) demonstrate the feasibility of quantitative ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Darçot E,Colotti R,Pellegrin M,Wilson A,Siegert S,Bouzourene K,Yerly J,Mazzolai L,Stuber M,van Heeswijk RB

    更新日期:2019-11-25 00:00:00

  • Excessive cholecalciferol supplementation increases kidney dysfunction associated with intrarenal artery calcification in obese insulin-resistant mice.

    abstract::Diabetes mellitus accelerates vascular calcification (VC) and increases the risk of end-stage renal disease (ESRD). Nevertheless, the impact of VC in renal disease progression in type 2 diabetes mellitus (T2DM) is poorly understood. We addressed the effect of VC and mechanisms involved in renal dysfunction in a murine...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Almeida YE,Fessel MR,do Carmo LS,Jorgetti V,Farias-Silva E,Pescatore LA,Gamarra LF,Andrade MC,Simplicio-Filho A,Mangueira CLP,Rangel ÉB,Liberman M

    更新日期:2020-01-09 00:00:00

  • Author Correction: The impact of the introduction of new recognition criteria for overwork-related cardiovascular and cerebrovascular diseases: a cross-country comparison.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误


    authors: Lin RT,Lin CK,Christiani DC,Kawachi I,Cheng Y,Verguet S,Jong S

    更新日期:2018-03-12 00:00:00

  • Understanding turbulent free-surface vortex flows using a Taylor-Couette flow analogy.

    abstract::Free-surface vortices have long been studied to develop an understanding of similar rotating flow phenomena observed in nature and technology. However, a complete description of its turbulent three-dimensional flow field still remains elusive. In contrast, the related Taylor-Couette flow system has been well explicate...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Mulligan S,De Cesare G,Casserly J,Sherlock R

    更新日期:2018-01-16 00:00:00

  • The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression.

    abstract::Expression of the mismatch repair gene MutL homolog 1 (MLH1) is silenced in a clinically important subgroup of sporadic colorectal cancers. These cancers exhibit hypermutability with microsatellite instability (MSI) and differ from microsatellite-stable (MSS) colorectal cancers in both prognosis and response to therap...

    journal_title:Scientific reports

    pub_type: 杂志文章,meta分析


    authors: Thomas R,Trapani D,Goodyer-Sait L,Tomkova M,Fernandez-Rozadilla C,Sahnane N,Woolley C,Davis H,Chegwidden L,Kriaucionis S,Maughan T,Leedham S,Palles C,Furlan D,Tomlinson I,Lewis A

    更新日期:2019-09-17 00:00:00

  • Ontogenesis of the HPI axis and molecular regulation of the cortisol stress response during early development in Dicentrarchus labrax.

    abstract::The cortisol stress response and the molecular programming of the corticoid axis were characterized for the first time during early ontogeny in a Mediterranean marine teleost, the European sea bass (Dicentrarchus labrax). Sea bass embryos, pre-larvae and larvae at specific points of development were exposed to acute s...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Tsalafouta A,Papandroulakis N,Gorissen M,Katharios P,Flik G,Pavlidis M

    更新日期:2014-07-02 00:00:00

  • Determination and correction of persistent biases in quantum annealers.

    abstract::Calibration of quantum computers is essential to the effective utilisation of their quantum resources. Specifically, the performance of quantum annealers is likely to be significantly impaired by noise in their programmable parameters, effectively misspecification of the computational problem to be solved, often resul...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Perdomo-Ortiz A,O'Gorman B,Fluegemann J,Biswas R,Smelyanskiy VN

    更新日期:2016-01-19 00:00:00

  • Predicting the response of olfactory sensory neurons to odor mixtures from single odor response.

    abstract::The response of olfactory receptor neurons to odor mixtures is not well understood. Here, using experimental constraints, we investigate the mathematical structure of the odor response space and its consequences. The analysis suggests that the odor response space is 3-dimensional, and predicts that the dose-response c...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Marasco A,De Paris A,Migliore M

    更新日期:2016-04-07 00:00:00

  • Modelling Dunes from Lençóis Maranhenses National Park (Brazil): Largest dune field in South America.

    abstract::This paper presents a digital elevation model (DEM) of the dunes found in the Lençóis Maranhenses National Park, an environmental protection area located in the Maranhão state (Brazil). The DEM supports the modeling studies of sand-dune evolution using multi-temporal satellite images and ground truth data, obtained th...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Dos Santos ALS,Borges HP,Silva Junior CHL,Piedade Junior RN,da Silva Bezerra D

    更新日期:2019-05-15 00:00:00

  • Ocean acidification increases the accumulation of titanium dioxide nanoparticles (nTiO2) in edible bivalve mollusks and poses a potential threat to seafood safety.

    abstract::Large amounts of anthropogenic CO2 in the atmosphere are taken up by the ocean, which leads to 'ocean acidification' (OA). In addition, the increasing application of nanoparticles inevitably leads to their increased release into the aquatic environment. However, the impact of OA on the bioaccumulation of nanoparticles...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Shi W,Han Y,Guo C,Su W,Zhao X,Zha S,Wang Y,Liu G

    更新日期:2019-03-05 00:00:00

  • Catalytic preparation of levulinic acid from cellobiose via Brønsted-Lewis acidic ionic liquids functional catalysts.

    abstract::Brønsted-Lewis acidic ionic liquids (ILs) were applied to catalyze cellobiose to prepare levulinic acid (LA) in one pot under hydrothermal conditions. Under the optimum conditions, the highest LA yield of 67.51% was obtained when low [HO3S-(CH2)3-mim]Cl-FeCl3 (molar fraction of FeCl3 x = 0.60) was used. This indicated...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Liu S,Wang K,Yu H,Li B,Yu S

    更新日期:2019-02-12 00:00:00

  • Assessing fuel properties effects of 2,5-dimethylfuran on microscopic and macroscopic characteristics of oxygenated fuel/diesel blends spray.

    abstract::2,5-Dimethylfuran (DMF) is a type of attractive sustainable green energy for diesel engines that is designed to reduce soot emission. This study investigated the effect of fuel properties on the macroscopic and microscopic spray characteristics of four test blends under injection pressures of 90, 120 and 150 MPa and a...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Zhang P,Su X,Chen H,Geng L,Zhao X

    更新日期:2020-01-29 00:00:00

  • The microbiomes of blowflies and houseflies as bacterial transmission reservoirs.

    abstract::Blowflies and houseflies are mechanical vectors inhabiting synanthropic environments around the world. They feed and breed in fecal and decaying organic matter, but the microbiome they harbour and transport is largely uncharacterized. We sampled 116 individual houseflies and blowflies from varying habitats on three co...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Junqueira ACM,Ratan A,Acerbi E,Drautz-Moses DI,Premkrishnan BNV,Costea PI,Linz B,Purbojati RW,Paulo DF,Gaultier NE,Subramanian P,Hasan NA,Colwell RR,Bork P,Azeredo-Espin AML,Bryant DA,Schuster SC

    更新日期:2017-11-24 00:00:00

  • Active Control of the Spoof Plasmon Propagation in Time Varying and Non-reciprocal Metamaterial.

    abstract::We present an efficient concept based on time varying and non reciprocal metamaterials to achieve an active control of the spoof plasmon (SP) propagation at sub-wavelength scale. An experimental demonstration of non-reciprocal guiding device based on split ring resonator is proposed as an application of this concept i...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Ourir A,Fink M

    更新日期:2019-02-20 00:00:00

  • CD61 promotes the differentiation of canine ADMSCs into PGC-like cells through modulation of TGF-β signaling.

    abstract::Previous studies have shown that CD61 (integrin-β3) promotes the differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) into germ-like cells. However, the mechanism remains unclear. In this study, we showed that overexpression of CD61 in canine adipose-derived mesenchymal stem cells (cADMSCs) promot...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Fang J,Wei Y,Lv C,Peng S,Zhao S,Hua J

    更新日期:2017-03-03 00:00:00

  • The association of medication-related osteonecrosis of the jaw with Actinomyces spp. infection.

    abstract::Medication-related osteonecrosis of the jaw (MRONJ) represents a complication of bisphosphonate treatment that responds poorly to standard treatment. In a retrospective cohort study we investigated a possible role of Actinomyces spp. in the pathogenesis of MRONJ. Deep biopsies of necrotic bone were collected during su...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Russmueller G,Seemann R,Weiss K,Stadler V,Speiss M,Perisanidis C,Fuereder T,Willinger B,Sulzbacher I,Steininger C

    更新日期:2016-08-17 00:00:00

  • Wave manipulation with magnetically tunable metasurfaces.

    abstract::Tunable metasurfaces have emerged as an efficient approach to manipulate the wave propagation. Different from previous work concentrating on electrically tunable mechanisms, here we demonstrate a magnetically tunable metasurface composed of ferrite rods and metallic foils. By tuning the thickness of ferrite rods, meta...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Yang H,Yu T,Wang Q,Lei M

    更新日期:2017-07-14 00:00:00

  • Wavelength and orientation dependent capture of light by diatom frustule nanostructures.

    abstract::The ecological success of diatoms is emphasized by regular blooms of many different species in all aquatic systems, but the reason behind their success is not fully understood. A special feature of the diatom cell is the frustule, a nano-patterned cell encasement made of amorphous biosilica. The optical properties of ...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Romann J,Valmalette JC,Chauton MS,Tranell G,Einarsrud MA,Vadstein O

    更新日期:2015-12-02 00:00:00

  • Disease-syndrome combination modeling: metabolomic strategy for the pathogenesis of chronic kidney disease.

    abstract::Conventional disease animal models have limitations on the conformity to the actual clinical situation. Disease-syndrome combination (DS) modeling may provide a more efficient strategy for biomedicine research. Disease model and DS model of renal fibrosis in chronic kidney disease were established by ligating the left...

    journal_title:Scientific reports

    pub_type: 杂志文章


    authors: Li S,Xu P,Han L,Mao W,Wang Y,Luo G,Yang N

    更新日期:2017-08-18 00:00:00