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DNA methylation of the INSR gene as a mediator of the association between prenatal exposure to famine and adulthood waist circumference.

Abstract：

:The aims of this study were to explore whether DNA methylation at INSR and IGF2 mediated the association of prenatal exposure to the Chinese great famine with adulthood waist circumference (WC) and BMI. A total of 235 subjects were selected into the present study from severely affected province and a neighbor province with less severely affected famine in China through multi-stage clustered random sampling. DNA methylation at the INSR and IGF2 gene promoter regions was detected by the Sequenom's MassARRAY system. The "mediation" package of R was used to evaluate the mediation effect of DNA methylation on the association between prenatal exposure to the famine and adult WC and BMI. The results showed that prenatal famine exposure was significantly associated with higher overall methylation level of the INSR gene (d = 3.6%; 95% CI 1.2-6.0; P = 0.027) and larger adulthood WC (d = 2.72 cm; 95% CI 0.20-5.24; P = 0.034). Furthermore, famine significantly increased methylation levels at four CpG sites. Methylation of the CpG7 site mediated 32.0% (95% CI 5.0-100.0%, P = 0.029) of the association between prenatal exposure to the Chinese great famine and adulthood WC. In conclusion, Epigenetic changes to the INSR might mediate the adverse effect of prenatal famine exposure on WC in adulthood.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Wang Z,Song J,Li C,Li Y,Shen L,Dong B,Zou Z,Ma J

doi

10.1038/s41598-020-69120-w

subject

Has Abstract

pub_date

2020-07-22 00:00:00

pages

12212

issue

1

issn

2045-2322

pii

10.1038/s41598-020-69120-w

journal_volume

10

pub_type

历史文章,杂志文章

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