miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met.

abstract：:Anti-mucin1 (MUC1) antibodies have long been used clinically in cancer diagnosis and therapy and specific bindings of some of them are known to be dependent on the differential glycosylation of MUC1. However, a systematic comparison of the binding specificities of anti-MUC1 antibodies was not previously conducted. Her...

journal_title：Scientific reports

authors： Yoshimura Y,Denda-Nagai K,Takahashi Y,Nagashima I,Shimizu H,Kishimoto T,Noji M,Shichino S,Chiba Y,Irimura T

更新日期：2019-11-12 00:00:00

abstract：:Stemborers (Busseola fusca, Sesamia calamistis and Chilo partellus), the fall armyworm (Spodoptera frugiperda) and associated parasitoids constitute an interacting system in maize fields in Kenya. This work aims at developing and evaluating models that represent the evolution of those interactions by applying system t...

journal_title：Scientific reports

authors： Sokame BM,Tonnang HEZ,Subramanian S,Bruce AY,Dubois T,Ekesi S,Calatayud PA

更新日期：2021-01-14 00:00:00

abstract：:Photonic qubits lie at the heart of quantum information technology, often encoding information in their polarization state. So far, only low-frequency optical and infrared photons have been employed as flying qubits, as the resources that are at present easiest to control. With their essentially different way of inter...

journal_title：Scientific reports

authors： Gunst J,Keitel CH,Pálffy A

更新日期：2016-04-27 00:00:00

abstract：:Constrained layer dampers (CLD) are in widespread use for passive vibration damping, in applications including aerospace structures. However, the introducing of the damping layer can reduce the stiffness of the sandwich structures. A viscoelastic material filling (VMF) is chosen to balance structural and vibrational p...

journal_title：Scientific reports

authors： Wang R,Shang J,Li X,Luo Z,Wu W

更新日期：2018-06-25 00:00:00

abstract：:This article presents a study whose purpose is to elucidate the damage effects in thin films on their magnetic response. Co40Fe40B20 and Ni80Fe20 films of different nanometric thicknesses were stretched by more than 10% and in situ probed by atomic force microscopy measurements to determine their irreversible mechanic...

journal_title：Scientific reports

authors： Merabtine S,Zighem F,Garcia-Sanchez A,Gunasekaran V,Belmeguenai M,Zhou X,Lupo P,Adeyeye AO,Faurie D

更新日期：2018-09-12 00:00:00

abstract：:Artificial tissues constructed from therapeutic cells offer a promising approach for improving the treatment of severe peripheral nerve injuries. In this study the effectiveness of using CTX0E03, a conditionally immortalised human neural stem cell line, as a source of allogeneic cells for constructing living artificia...

journal_title：Scientific reports

authors： O'Rourke C,Day AGE,Murray-Dunning C,Thanabalasundaram L,Cowan J,Stevanato L,Grace N,Cameron G,Drake RAL,Sinden J,Phillips JB

更新日期：2018-02-13 00:00:00

abstract：:Little is known about the effects of posterior tethers on the development of proximal junctional kyphosis (PJK). We evaluated the ability of posterior tethers to the proximal motion segment stiffness in long instrumented spinal instrumentation and fusion using a whole body human FE model. A series of finite element (F...

journal_title：Scientific reports

authors： Yagi M,Nakahira Y,Watanabe K,Nakamura M,Matsumoto M,Iwamoto M

更新日期：2020-02-26 00:00:00

abstract：:Reconstructed annual streamflows using tree-ring chronologies provide useful information on moisture availability during the pre-historic period, but they have limitations in estimating high flows due to the upper bound on soil water holding capacity and trees' metabolic growth limits. We propose a hybrid approach tha...

journal_title：Scientific reports

authors： Mukhopadhyay S,Patskoski JM,Sankarasubramanian A

更新日期：2018-03-21 00:00:00

abstract：:MicroRNAs are a class of small noncoding RNAs that regulate gene expression post-transcriptionally either by inhibiting protein translation or by causing the degradation of target mRNAs. Current evidence indicates that miR-33b is involved in the regulation of lipid metabolism, cholesterol homeostasis, glucose metaboli...

journal_title：Scientific reports

authors： Lin Y,Liu AY,Fan C,Zheng H,Li Y,Zhang C,Wu S,Yu D,Huang Z,Liu F,Luo Q,Yang CJ,Ouyang G

更新日期：2015-04-28 00:00:00

abstract：:We have performed a genome-wide association study (GWAS) including 473 Japanese HBV (hepatitis B virus)-positive HCC (hepatocellular carcinoma) patients and 516 HBV carriers including chronic hepatitis and asymptomatic carrier individuals to identify new host genetic factors associated with HBV-derived HCC in Japanese...

journal_title：Scientific reports

authors： Sawai H,Nishida N,Khor SS,Honda M,Sugiyama M,Baba N,Yamada K,Sawada N,Tsugane S,Koike K,Kondo Y,Yatsuhashi H,Nagaoka S,Taketomi A,Fukai M,Kurosaki M,Izumi N,Kang JH,Murata K,Hino K,Nishina S,Matsumoto A,Tanaka

更新日期：2018-05-21 00:00:00

abstract：:Ocean uptake of anthropogenic CO2 reduces pH and saturation state of calcium carbonate materials of seawater, which could reduce the calcification rate of some marine organisms, triggering a negative feedback on the growth of atmospheric CO2. We quantify the effect of this CO2-calcification feedback by conducting a se...

journal_title：Scientific reports

authors： Zhang H,Cao L

更新日期：2016-02-03 00:00:00

abstract：:The purpose of this study was the preparation, characterization and application of high-performance activated carbons (ACs) derived from oily sludge through chemical activation by KOH. The produced ACs were characterized using iodine number, N2 adsorption-desorption, Fourier-transform infrared spectroscopy (FTIR) and ...

journal_title：Scientific reports

authors： Mojoudi N,Mirghaffari N,Soleimani M,Shariatmadari H,Belver C,Bedia J

更新日期：2019-12-18 00:00:00

abstract：:The taxa of Astragalus section Hymenostegis are an important element of mountainous and steppe habitats in Southwest Asia. A phylogenetic hypothesis of sect. Hymenostegis has been obtained from nuclear ribosomal DNA internal transcribed spacer (ITS) and plastid ycf1 sequences of up to 303 individuals from 106 species,...

journal_title：Scientific reports

authors： Bagheri A,Maassoumi AA,Rahiminejad MR,Brassac J,Blattner FR

更新日期：2017-10-25 00:00:00

abstract：:It is essential to understand how the loss of biodiversity impacts both ecosystem function (EF) and multifunctionality (EMF). Previous studies have mostly focused on predicting how species richness (SR) impacts EMF, while the effect of functional diversity (FD) on EMF remains unclear. Specifically, we know little abou...

journal_title：Scientific reports

authors： Huang X,Su J,Li S,Liu W,Lang X

更新日期：2019-05-06 00:00:00

abstract：:TRPV1 is a polymodal nociceptor for diverse physical and chemical stimuli that interact with different parts of the channel protein. Recent cryo-EM studies revealed detailed channel structures, opening the door for mapping structural elements mediating activation by each stimulus. Towards this goal, here we have combi...

journal_title：Scientific reports

authors： Ma L,Yang F,Vu S,Zheng J

更新日期：2016-09-26 00:00:00

abstract：:This study aimed to investigate the dosimetric characteristics of an isocentrically shielded RapidArc (IS-RA) technique for treatment of locally recurrent nasopharyngeal cancer (lrNPC). In IS-RA, the isocenter was placed at the center of the pre-irradiated brainstem (BS)/spinal cord (SC) and the jaws were set to shiel...

journal_title：Scientific reports

authors： Lu JY,Huang BT,Xing L,Chang DT,Peng X,Xie LX,Lin ZX,Li M

更新日期：2016-05-13 00:00:00

abstract：:Since temperature is a key factor affecting photosynthetic and respiration rates, the rates of gross primary production (GPP) and ecosystem respiration (ER) are expected to be lower for rivers at higher latitudes, while the net ecosystem production (NEP) rate likely decrease in rivers at lower latitude due to higher s...

journal_title：Scientific reports

authors： Gurung A,Iwata T,Nakano D,Urabe J

更新日期：2019-03-20 00:00:00

abstract：:Behavioral alterations emerging after central or peripheral vision loss suggest that cerebral reorganization occurs for both the afferented and deafferented early visual cortex (EVC). We explored the functional reorganization of the central and peripheral EVC following visual field defects specifically affecting centr...

journal_title：Scientific reports

authors： Sabbah N,Sanda N,Authié CN,Mohand-Saïd S,Sahel JA,Habas C,Amedi A,Safran AB

更新日期：2017-02-24 00:00:00

abstract：:We demonstrate the capability of a novel Electron Backscatter Diffraction (EBSD) dictionary indexing (DI) approach by means of orientation mapping of a highly deformed graded microstructure in a shot peened Aluminium 7075-T651 alloy. A low microscope accelerating voltage was used to extract, for the first time from a ...

journal_title：Scientific reports

authors： Singh S,Guo Y,Winiarski B,Burnett TL,Withers PJ,De Graef M

更新日期：2018-07-20 00:00:00

abstract：:Selective amygdalohippocampectomy is an effective treatment for patients with therapy-refractory temporal lobe epilepsy but may cause visual field defect (VFD). Here, we aimed to describe tissue-specific pre- and postoperative imaging correlates of the VFD severity using whole-brain analyses from voxel- to network-lev...

journal_title：Scientific reports

authors： David B,Eberle J,Delev D,Gaubatz J,Prillwitz CC,Wagner J,Schoene-Bake JC,Luechters G,Radbruch A,Wabbels B,Schramm J,Weber B,Surges R,Elger CE,Rüber T

更新日期：2021-01-14 00:00:00

abstract：:Er(3+) doped oxyfluoride tellurite glasses have been prepared. Three Judd-Ofelt parameters Ωt (t=2, 4, 6) and radiative properties are calculated for prepared glasses. Emission characteristics are analyzed and it is found that prepared glasses possess larger calculated predicted spontaneous transition probability (39....

journal_title：Scientific reports

authors： Chen F,Wei T,Jing X,Tian Y,Zhang J,Xu S

更新日期：2015-06-02 00:00:00

abstract：:Continuous gas-phase synthesis of nanoparticles is associated with rapid agglomeration, which can be a limiting factor for numerous applications. In this report, we challenge this paradigm by providing experimental evidence to support that gas-phase methods can be used to produce ultrapure non-agglomerated "singlet" n...

journal_title：Scientific reports

authors： Feng J,Biskos G,Schmidt-Ott A

更新日期：2015-10-29 00:00:00

abstract：:Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present ...

journal_title：Scientific reports

authors： Kim A,Popovici J,Vantaux A,Samreth R,Bin S,Kim S,Roesch C,Liang L,Davies H,Felgner P,Herrera S,Arévalo-Herrera M,Ménard D,Serre D

更新日期：2017-08-10 00:00:00

abstract：:Locusts have excellent jumping and kicking abilities to survive in nature, which are achieved through the energy storage and release processes occurring in cuticles, especially in the semi-lunar processes (SLP) at the femorotibial joints. As yet, however, the strain energy-storage mechanisms of the SLP cuticles remain...

journal_title：Scientific reports

authors： Wan C,Hao Z,Feng X

更新日期：2016-10-17 00:00:00

abstract：:Cortical spreading depolarization (SD) involves activation of NMDA receptors and elicit neurovascular unit dysfunction. NMDA cannot trigger SD in newborns, thus its effect on neurovascular function is not confounded by other aspects of SD. The present study investigated if NMDA affected hypercapnia-induced microvascul...

journal_title：Scientific reports

authors： Remzső G,Németh J,Tóth-Szűki V,Varga V,Kovács V,Domoki F

更新日期：2019-12-11 00:00:00

abstract：:Quantum physics is undoubtedly the most successful theory of the microscopic world, yet the complexities which arise in applying it even to simple atomic and molecular systems render the description of basic collision probabilities a formidable task. For this reason, approximations are often employed, the validity of ...

journal_title：Scientific reports

authors： Laricchia G,Van Reeth P,Fayer SE,Brawley SJ,Kadokura R,Loreti A,Shipman M

更新日期：2018-10-10 00:00:00

abstract：:Patients hospitalised with COVID-19 have a high mortality. Identification of patients at increased risk of adverse outcome would be important, to allow closer observation and earlier medical intervention for those at risk, and to objectively guide prognosis for friends and family of affected individuals. We conducted ...

journal_title：Scientific reports

authors： Gue YX,Tennyson M,Gao J,Ren S,Kanji R,Gorog DA

更新日期：2020-12-07 00:00:00

abstract：:Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial communities. To test this scenar...

journal_title：Scientific reports

authors： Chamosa LS,Álvarez VE,Nardelli M,Quiroga MP,Cassini MH,Centrón D

更新日期：2017-03-31 00:00:00

abstract：:Hot days in summer (involving a few hours at particularly high temperatures) are expected to become more common under climate change. How such events at different life stages affect survival and reproduction remains unclear in most organisms. Here, we investigated how an exposure to 40 °C at different life stages in t...

journal_title：Scientific reports

authors： Zhang W,Chang XQ,Hoffmann A,Zhang S,Ma CS

更新日期：2015-05-22 00:00:00

abstract：:Chromatin remodeling has been newly established as an important cancer genome characterization and recent exome and whole-genome sequencing studies of hepatocellular carcinoma (HCC) showed that recurrent inactivating mutations in SWI/SNF subunits involved in the molecular basis of hepatocarcinogenesis. To test the hyp...

journal_title：Scientific reports

authors： Zhong R,Liu L,Tian Y,Wang Y,Tian J,Zhu BB,Chen W,Qian JM,Zou L,Xiao M,Shen N,Yang H,Lou J,Qiu Q,Ke JT,Lu XH,Wang ZL,Song W,Zhang T,Li H,Wang L,Miao XP

更新日期：2014-02-21 00:00:00