Abstract：
:Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial communities. To test this scenario, we studied native IntI1 functionality of 11 class 1 integron-positive environmental strains of distant genera collected in cold and subtropical forests of Argentina. We found natural competence and successful site-specific insertion with no significant fitness cost of both aadB and bla VIM-2 antimicrobial resistance gene cassettes, in a model system without antibiotic pressure. A bidirectional flow of antimicrobial resistance gene cassettes between natural and nosocomial habitats is proposed, which implies an active role of the open environment as a reservoir, recipient and source of antimicrobial resistance mechanisms, outlining an environmental threat where novel concepts of rational use of antibiotics are extremely urgent and mandatory.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chamosa LS,Álvarez VE,Nardelli M,Quiroga MP,Cassini MH,Centrón Ddoi
10.1038/s41598-017-00600-2subject
Has Abstractpub_date
2017-03-31 00:00:00pages
513issue
1issn
2045-2322pii
10.1038/s41598-017-00600-2journal_volume
7pub_type
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