Abstract：
:Photoacoustic tomography (PAT) offers three-dimensional (3D) structural and functional imaging of living biological tissue with label-free, optical absorption contrast. These attributes lend PAT imaging to a wide variety of applications in clinical medicine and preclinical research. Despite advances in live animal imaging with PAT, there is still a need for 3D imaging at centimeter depths in real-time. We report the development of four dimensional (4D) PAT, which integrates time resolutions with 3D spatial resolution, obtained using spherical arrays of ultrasonic detectors. The 4D PAT technique generates motion pictures of imaged tissue, enabling real time tracking of dynamic physiological and pathological processes at hundred micrometer-millisecond resolutions. The 4D PAT technique is used here to image needle-based drug delivery and pharmacokinetics. We also use this technique to monitor 1) fast hemodynamic changes during inter-ictal epileptic seizures and 2) temperature variations during tumor thermal therapy.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Xiang L,Wang B,Ji L,Jiang Hdoi
10.1038/srep01113subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1113issn
2045-2322journal_volume
3pub_type
杂志文章abstract：:The first instar larva of a species of the Australian endemic genus Aenigmetopia Malloch is described for the first time, along with the first instar larvae of three other Australian species representing the genera Amobia Robineau-Desvoidy and Protomiltogramma Townsend. Larval morphology was analysed using a combinati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80139-x
更新日期：2021-01-29 00:00:00
abstract：:Fundamental interest for 2D electron gas (2DEG) systems has been recently renewed with the advent of 2D materials and their potential high-impact applications in optoelectronics. Here, we investigate a 2DEG created by the electron transfer from a Ag adatom gas deposited on a Si(111) [Formula: see text]-Ag surface to a...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10300-6
更新日期：2017-09-06 00:00:00
abstract：:The application of nitrogen (N) fertilizer deep in soil at the same time as mechanical transplanting of rice seedlings is an effective alternative to conventional broadcasting of fertilizer, but its effects on yields and profitability have not been analysed in detail. Here, we analysed the effects of a side deep appli...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42039-7
更新日期：2019-04-04 00:00:00
abstract：:Nanocarrier systems for the encapsulation of agrochemicals can contribute to sustainable agriculture, but few nanosystems have been developed for plant growth regulators (PGRs). The present study evaluated the effects of seed priming using alginate/chitosan (nanoALG/CS) and chitosan/tripolyphosphate (nanoCS/TPP) conta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43494-y
更新日期：2019-05-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep02968
更新日期：2013-10-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-28448-0
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24993
更新日期：2016-04-26 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-35364-w
更新日期：2018-11-16 00:00:00
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pub_type： 已发布勘误
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更新日期：2020-02-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79578-3
更新日期：2021-01-13 00:00:00
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journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-017-12094-z
更新日期：2017-09-21 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41598-020-57414-y
更新日期：2020-01-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71066-y
更新日期：2020-09-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21865
更新日期：2016-02-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57057-8
更新日期：2020-01-13 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13750
更新日期：2015-09-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-14618-z
更新日期：2017-10-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep43532
更新日期：2017-03-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65607-8
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17759-3
更新日期：2017-12-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29720
更新日期：2016-07-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-09904-9
更新日期：2017-08-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10073
更新日期：2015-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-03418-0
更新日期：2017-06-07 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-77060-8
更新日期：2020-12-10 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10540-6
更新日期：2017-09-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39628-x
更新日期：2019-02-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08815
更新日期：2015-03-06 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-49306-7
更新日期：2019-09-03 00:00:00
