Abstract：
:The prognosis of pancreatic cancer remains dismal despite continuous and considerable efforts. Integrins (ITGs) are highly expressed in various malignant cancers. However, very few studies investigated the role of integrin α3 (ITGα3) in malignant cancers. Here, we determined the functional role of ITGα3 in pancreatic cancer. Analysis of public microarray databases and Western blot analysis indicated a unique expression of ITGα3 in human pancreatic cancer. Silencing ITGα3 expression significantly inhibited the viability and migration of human pancreatic cancer cells. Notably, ablation of ITGα3 expression resulted in a significant decrease of epidermal growth factor receptor (EGFR) expression compared with transfection of control-siRNA through an increased number of leucine-rich repeats and immunoglobulin-like domain protein 1 (LRIG1) expression. In addition, ablating ITGα3 inhibited tumour growth via blockade of EGFR signalling in vivo. Furthermore, the highly expressed ITGα3 led to a poor prognosis of pancreatic cancer patients. Our results provide novel insights into ITGα3-induced aggressive pancreatic cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Lee J,Lee J,Choi C,Kim JHdoi
10.1038/s41598-019-39628-xsubject
Has Abstractpub_date
2019-02-26 00:00:00pages
2793issue
1issn
2045-2322pii
10.1038/s41598-019-39628-xjournal_volume
9pub_type
杂志文章abstract：:Synthetic fungicides are pesticides widely used in agriculture to control phytopathogenic fungi. The systemicity, persistency and intense application of some of these fungicides, such as boscalid, leads to long periods of exposure for honeybees via contaminated water, pollen and nectar. We exposed adult honeybees in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24746-9
更新日期：2018-05-08 00:00:00
abstract：:Identifying the unintended effects of drugs (side effects) is a very important issue in pharmacological studies. The laboratory verification of associations between drugs and side effects requires costly, time-intensive research. Thus, an approach to predicting drug side effects based on known side effects, using a co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46939-6
更新日期：2019-07-18 00:00:00
abstract：:Soil erosion due to underground leakage is a major factor causing land degradation in karst regions. Rhizosphere effects (REs) on soil anti-erodibility (SAE) can alleviate this type of soil erosion by improving soil physical processes such as aggregate stability. However, the magnitudes and causes of interspecific var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58784-z
更新日期：2020-02-12 00:00:00
abstract：:We investigated retinal structure and function in eyes with optic nerve hypoplasia (ONH). Twenty-nine eyes of 18 patients with ONH and 21 eyes of 21 control patients were analyzed. Spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (FF-ERG), and focal macular ERG (FM-ERG) were perfor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42480
更新日期：2017-02-16 00:00:00
abstract：:Gestational diabetes mellitus (GDM) is conventionally confirmed with oral glucose tolerance test (OGTT) in 24 to 28 weeks of gestation, but it is still uncertain whether it can be predicted with secondary use of electronic health records (EHRs) in early pregnancy. To this purpose, the cost-sensitive hybrid model (CSHM...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16665-y
更新日期：2017-11-27 00:00:00
abstract：:The Coronavirus Disease 2019 (COVID-19) pandemic continues to have a devastating effect on the health and well-being of the global population. A critical step in the fight against COVID-19 is effective screening of infected patients, with one of the key screening approaches being radiology examination using chest radi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76550-z
更新日期：2020-11-11 00:00:00
abstract：:CHF5633 is a novel synthetic clinical pulmonary surfactant preparation composed by two phospholipid species, dipalmitoyl phosphatidylcholine (DPPC) and palmitoyloleoyl phosphatidylglycerol (POPG), and synthetic analogues of the hydrophobic surfactant proteins SP-B and SP-C. In this study, the interfacial properties of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58248-4
更新日期：2020-01-28 00:00:00
abstract：:In the research field of extracellular vesicles (EVs), the use of fetal bovine serum (FBS) depleted of EVs for in vitro studies is advocated to eliminate the confounding effects of media derived EVs. EV-depleted FBS may either be prepared by ultracentrifugation or purchased commercially. Nevertheless, these preparatio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41772-3
更新日期：2019-04-02 00:00:00
abstract：:Two cabbage (Brassica oleracea) cultivars 'Tekila' and 'Kilaherb' were identified as resistant to several pathotypes of Plasmodiophora brassicae. In this study, we identified a clubroot resistance gene (Rcr7) in 'Tekila' for resistance to pathotype 3 of P. brassicae from a segregating population derived from 'Tekila' ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36187-5
更新日期：2018-12-05 00:00:00
abstract：:3'-Sialyllactose (3'-SL), a natural prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. Although regulatory T cells (Tregs) prevent excessive inflammation and maintain immune tolerance, the effect of 3'-SL on Treg regulation is unclear. This study aimed to investigate the e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62527-5
更新日期：2020-03-27 00:00:00
abstract：:Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on trans...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10403-0
更新日期：2017-09-05 00:00:00
abstract：:Sub-gap density of states (DOS) is a key parameter to impact the electrical characteristics of semiconductor materials-based transistors in integrated circuits. Previously, spectroscopy methodologies for DOS extractions include the static methods, temperature dependent spectroscopy and photonic spectroscopy. However, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24096
更新日期：2016-06-14 00:00:00
abstract：:To realize power efficient solution-processed phosphorescent organic light-emitting diodes (s-PhOLEDs), the corresponding high driving voltage issue should be well solved. To solve it, efforts have been devoted to the exploitation of novel host or interfacial materials. However, the issues of charge trapping of phosph...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12487
更新日期：2015-07-24 00:00:00
abstract：:Protein kinases are enzymes whose abundance, protein-protein interactions, and posttranslational modifications together determine net signaling activity in cells. Large-scale data on cellular kinase activity are limited, because existing assays are cumbersome, poorly sensitive, low throughput, and restricted to measur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55998-8
更新日期：2019-12-19 00:00:00
abstract：:Several epidemiological studies have found a positive association between diabetic retinopathy (DR) and subclinical hypothyroidism (SCH), but the findings are varied or even contradictory. In the work, we performed a meta-analysis to ascertain the relationship between DR and SCH. We searched relevant studies on the re...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/srep12212
更新日期：2015-07-20 00:00:00
abstract：:The aim of this study was to compare the effects of an aerobic training program with a strength training program on body composition and energy expenditure in overweight or obese (29.06 ± 3.49 kg/m2) young adults (21.96 ± 1.90 years). Subjects (N = 109) were randomly assigned to one of three groups: a control group (C...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62249-8
更新日期：2020-03-24 00:00:00
abstract：:Environmental stimuli have the ability to generate specific representations of the rewards they predict and in so doing alter the selection and performance of reward-seeking actions. The basolateral amygdala participates in this process, but precisely how is unknown. To rectify this, we monitored, in near-real time, b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12511
更新日期：2015-07-27 00:00:00
abstract：:Immersive virtual reality has become increasingly popular to improve the assessment and treatment of health problems. This rising popularity is likely to be facilitated by the availability of affordable headsets that deliver high quality immersive experiences. As many health problems are more prevalent in older adults...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41200-6
更新日期：2019-03-14 00:00:00
abstract：:This study aims to investigate the relation between vaginal microbiota and exposition to intra-amniotic inflammation (IAI). We conducted a prospective cohort study in women with preterm labor <34 weeks who had undergone amniocentesis to rule out IAI. Vaginal samples were collected after amniocentesis. Women with IAI i...
journal_title：Scientific reports
pub_type： 临床试验,杂志文章
doi：10.1038/s41598-019-55611-y
更新日期：2019-12-12 00:00:00
abstract：:Rubber-filler composites are a key component in the manufacture of tyres. The filler provides mechanical reinforcement and additional wear resistance to the rubber, but it in turn introduces non-linear mechanical behaviour to the material which most likely arises from interactions between the filler particles, mediate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07389
更新日期：2014-12-09 00:00:00
abstract：:Seven new formyl phloroglucinol meroterpenoids (FPMs), namely eucalrobusones J-P (1-7), as well as three known ones (8-10) were isolated from the leaves of Eucalyptus robusta. Their structures were elucidated by spectroscopic data analysis, and their absolute configurations were determined by applications of the Snatz...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39815
更新日期：2016-12-22 00:00:00
abstract：:Analyzing drug-drug interactions may unravel previously unknown drug action patterns, leading to the development of new drug discovery tools. We present a new approach to analyzing drug-drug interaction networks, based on clustering and topological community detection techniques that are specific to complex network sc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32745
更新日期：2016-09-07 00:00:00
abstract：:Visual loss caused by retinopathy of prematurity (ROP) will be prevented if treatment-requiring ROP (TR-ROP) can be predicted. In this retrospective study including 418 infants with ≤32 weeks of gestational age (GA) and/or ≤1500 grams of birthweight, we attempted to identify useful predictors. We also examined the eff...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04269-5
更新日期：2017-06-20 00:00:00
abstract：:Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possib...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49923-2
更新日期：2019-09-19 00:00:00
abstract：:Embryonic Stem Cells (ESCs) are expected to show a stable euploid karyotype, but in the last decade (sub)chromosomal aberrations have been systematically described in these cell lines when maintained in vitro. Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05324
更新日期：2014-06-17 00:00:00
abstract：:Quantification of cellular antigens and their interactions via antibody-based detection methods are widely used in scientific research. Accurate high-throughput quantitation of these assays using general image analysis software can be time consuming and challenging, particularly when attempted by users with limited im...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-15885-6
更新日期：2017-11-16 00:00:00
abstract：:Nuclear proteins are primarily regulatory factors governing gene expression. Multiple factors determine the localization of a protein in the nucleus. An upright identification of nuclear proteins is way far from accuracy. We have attempted to combine information from subcellular prediction tools, experimental evidence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70713-8
更新日期：2020-09-15 00:00:00
abstract：:The antioxidant and multiple organ protection effects of acid- extracted mycelia polysaccharides (Ac-MPS) from Pleurotus eryngii var. tuoliensis on HFE-induced hypertriglyceridemic mice were investigated. The results showed that Ac-MPS have potential ability to relieve the hypertriglyceridemia and preventing oxidative...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35706-8
更新日期：2018-11-30 00:00:00
abstract：:Seed size/weight is a major agronomic trait which determine crop productivity in legumes. To understand the genetic basis of seed size determination, we sought to identify DNA polymorphisms between two small (Himchana 1 and Pusa 362) and two large-seeded (JGK 3 and PG 0515) chickpea cultivars via whole genome resequen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35140-w
更新日期：2018-11-14 00:00:00
abstract：:Visceral adiposity is a risk factor for cardiovascular disorders, type 2 diabetes mellitus (T2D) and associated metabolic diseases. Sub-cutaneous fat is believed to be intrinsically different from visceral fat. To understand molecular mechanisms involved in metabolic advantages of fat transplantation, we studied a rat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00081
更新日期：2011-01-01 00:00:00
