Abstract:
:Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that mucosal secretion of IgM can compensate for a lack of secretory IgA. We used 16S rRNA gene sequencing and bacterial cell sorting to evaluate gut microbiota composition and taxa-specific antibody coating of the gut microbiota in 15 sIgAd subjects and matched controls. Despite the secretion of compensatory IgM into the gut lumen, sIgAd subjects displayed an altered gut microbiota composition as compared to healthy controls. These alterations were characterized by a trend towards decreased overall microbial diversity as well as significant shifts in the relative abundances of specific microbial taxa. While secretory IgA in healthy controls targeted a defined subset of the microbiota via high-level coating, compensatory IgM in sIgAd subjects showed less specificity than IgA and bound a broader subset of the microbiota. We conclude that IgA plays a critical and non-redundant role in controlling gut microbiota composition in humans and that secretory IgA has evolved to maintain a diverse and stable gut microbial community.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Catanzaro JR,Strauss JD,Bielecka A,Porto AF,Lobo FM,Urban A,Schofield WB,Palm NWdoi
10.1038/s41598-019-49923-2subject
Has Abstractpub_date
2019-09-19 00:00:00pages
13574issue
1issn
2045-2322pii
10.1038/s41598-019-49923-2journal_volume
9pub_type
杂志文章abstract::Eph receptors have emerged as targets for therapy in both neoplastic and non-neoplastic disease, however, particularly in non-neoplastic diseases, redundancy of function limits the effectiveness of targeting individual Eph proteins. We have shown previously that a soluble fusion protein, where the EphA4 ectodomain was...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06685-z
更新日期:2017-07-26 00:00:00
abstract::To assess the prevalence of cataract and cataract surgery in a population from Russia, we conducted the population-based Ural Eye and Medical Study with 5899 participants (80.5% out of 7328 eligible individuals), with an age of 40 + years as the eligibility criterion. In the phakic population, the prevalence of nuclea...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75313-0
更新日期:2020-10-23 00:00:00
abstract::Bitter taste receptors (TAS2Rs) are present in extra-oral tissues, including gut endocrine cells. This study explored the presence and mechanism of action of TAS2R agonists on gut smooth muscle in vitro and investigated functional effects of intra-gastric administration of TAS2R agonists on gastric motility and satiat...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15985
更新日期:2015-11-06 00:00:00
abstract::Immunoaffinity enrichment of proteotypic peptides, coupled with selected reaction monitoring, enables indirect protein quantification. However the lack of suitable antibodies limits its widespread application. We developed a method in which multi-specific antibodies are used to enrich groups of peptides, thus facilita...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08759
更新日期:2015-03-04 00:00:00
abstract::Steering magnetism by electric fields upon interfacing ferromagnetic (FM) and ferroelectric (FE) materials to achieve an emergent multiferroic response bears a great potential for nano-scale devices with novel functionalities. FM/FE heterostructures allow, for instance, the electrical manipulation of magnetic anisotro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep11111
更新日期:2015-06-09 00:00:00
abstract::To determine the incidence of acute cardiac injury (ACI), the factors associated with ACI and the in-hospital mortality in patients with COVID-19, especially in severe patients. All consecutive in-patients with laboratory-confirmed COVID-19 from Tongji Hospital in Wuhan during February 1 and March 29, 2020 were includ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-77172-1
更新日期:2020-11-24 00:00:00
abstract::Protein ubiquitination, which is a major post-translational modifications that occurs in eukaryotic cells, is involved in diverse biological processes. To date, large-scale profiling of the ubiquitome in common wheat has not been reported, despite its status as the major cereal crop in the world. Here, we performed th...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13992-y
更新日期:2017-10-19 00:00:00
abstract::Due to the limitations of current imaging techniques, visualization of lymphatic capillaries within tissue in vivo has been challenging. Here, we present a label-free high resolution optical coherence tomography (OCT) based lymphangiography (OLAG) within human skin in vivo. OLAG enables rapid (~seconds) mapping of lym...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21122
更新日期:2016-02-19 00:00:00
abstract::Promoter CpG methylation is a fundamental regulatory process of gene expression. TET proteins are active CpG demethylases converting 5-methylcytosine to 5-hydroxymethylcytosine, with loss of 5 hmC as an epigenetic hallmark of cancers, indicating critical roles of TET proteins in epigenetic tumorigenesis. Through analy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26591
更新日期:2016-05-26 00:00:00
abstract::A synthetic monoketone analog of curcumin, termed 3, 5-bis (2-flurobenzylidene) piperidin-4-one (EF24), has been reported to inhibit the growth of a variety of cancer cells both in vitro and in vivo. However, whether EF24 has anticancer effects on cholangiocarcinoma (CCA) cells and the mechanisms remain to be investig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32167
更新日期:2016-08-30 00:00:00
abstract::For many applications heterogeneity is a direct indicator of material quality. Reliable determination of chemical heterogeneity is however not a trivial task. Spectral imaging can be used for determining the spatial distribution of an analyte in a sample, thus transforming each pixel of an image into a sampling cell. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28889-7
更新日期:2018-07-11 00:00:00
abstract::In this paper, the composition, structure, morphology and kinetics of evolution during isothermal oxidation of Fe48Cr15Mo14Y2C15B6 metallic glass powder in the supercooled region are investigated by an integrated ex-situ and in-situ characterization and modelling approach. Raman and X-ray diffraction spectra establish...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43317-0
更新日期:2019-05-02 00:00:00
abstract::Chemotherapy often induces oral ulcerative mucositis (OUM) in patients with cancer, characterized by severe painful inflammation. Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57192-2
更新日期:2020-01-17 00:00:00
abstract::Cell motility requires the precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation. LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellular leading edge of motile cells and suppresses FAK. We sought to understand how LKB1 coordinates these...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep40929
更新日期:2017-01-19 00:00:00
abstract::Depression is a severe and chronic mental disorder, affecting about 322 million individuals worldwide. A recent study showed that diterpene ginkgolides (DG) have antidepressant-like effects on baseline behaviours in mice. Here, we examined the effects of DG and venlafaxine (VLX) in a chronic social defeat stress model...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10391-1
更新日期:2017-08-29 00:00:00
abstract::The rat is an important model for liver regeneration. However, there is no in vitro culture system that can capture the massive proliferation that can be observed after partial hepatectomy in rats. We here describe the generation of rat liver stem cell lines. Rat liver stem cells, which grow as cystic organoids, were ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22154
更新日期:2016-02-26 00:00:00
abstract::Here we investigated whether endothelial colony forming cells (ECFC) and mesenchymal progenitor cells (MPC) form vascular networks and restore blood flow in ischemic skeletal muscle, and whether host myeloid cells play a role. ECFC + MPC, ECFC alone, MPC alone, or vehicle alone were injected into the hind limb ischemi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-00809-1
更新日期:2017-04-10 00:00:00
abstract::In order to limit the smoking tobacco sector crisis, a new non-GMO Nicotiana tabacum L. cv. Solaris was proposed as oil seed crop. Residues of oil extraction were successfully used in swine nutrition. The aim of this study was to explore the full potential of this innovative tobacco cultivar as multitasking feedstock ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53237-8
更新日期:2019-11-14 00:00:00
abstract::Lung adenocarcinoma (LUAD) is characterized by high infiltration and rapid growth. The function of the stem cell population is to control and maintain cell regeneration. Therefore, it is necessary to study the prognostic value of stem cell-related genes in LUAD. Signature genes were screened out from 166 stem cell-rel...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80453-4
更新日期:2021-01-18 00:00:00
abstract::The formation of snow-dirt sludge (SDS) via the mixing of snow and surface-deposited sediment by vehicles and pedestrians is one of the least studied sedimentation processes in urban areas. The aim of this study was to analyse the material, mineral, particle size, and chemical compositions of the SDS solid phase. The ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53793-z
更新日期:2019-11-21 00:00:00
abstract::Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug finasteride counteracts these pathological processes in preclinical ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46640-8
更新日期:2019-07-12 00:00:00
abstract::Metal-insulator transition is observed in the La0.8Sr0.2MnO3 thin films with thickness larger than 5 unit cells. Insulating phase at lower temperature appeared in the ultrathin films with thickness ranging from 6 unit cells to 10 unit cells and it is found that the Mott variable range hopping conduction dominates in t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep22382
更新日期:2016-03-01 00:00:00
abstract::Natural competence for genetic transformation refers to the natural ability of various bacteria to take up exogenous DNA from their surroundings and to incorporate internalized genetic information into their genomes. By promoting bacterial diversification and adaptability, this process represents a major driving force...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-47423-x
更新日期:2019-07-30 00:00:00
abstract::CSNK2B, which encodes the beta subunit of casein kinase II (CK2), plays an important role in neuron morphology and synaptic transmission. Variants in CSNK2B associated with epilepsy and/or intellectual disability (ID)/developmental delay (DD) have been reported in five cases only. Among the 816 probands suspected here...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53484-9
更新日期:2019-11-29 00:00:00
abstract::Interactions between microalgae and bacteria are often obligatory for harmful algal blooms (HABs). Here, we investigated the specific bacterial communities associated with Alexandrium tamarense and Cochlodinium polykrikoides, which cause ecological and economic damage during their blooms. To this end, the bacterial me...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-23634-6
更新日期:2018-03-28 00:00:00
abstract::Discs Large Homolog 5 (DLG5) plays an important role in the maintenance of epithelial cell polarity. Recent research showed that DLG5 is decreased in Yes-associated protein (YAP)-overexpressing cells. However, the exact relationship between DLG5 and YAP is not clear. In this study, we showed that loss of DLG5 promoted...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep42125
更新日期:2017-02-07 00:00:00
abstract::This study assessed cortical tracking of temporal information in incoming natural speech in seven-month-old infants. Cortical tracking refers to the process by which neural activity follows the dynamic patterns of the speech input. In adults, it has been shown to involve attentional mechanisms and to facilitate effect...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32150-6
更新日期:2018-09-13 00:00:00
abstract::Oscillatory media can exhibit the coexistence of synchronized and desynchronized regions, so-called chimera states, for uniform parameters and symmetrical coupling. In a phase-balanced chimera state, where the totals of synchronized and desynchronized regions, respectively, are of the same size, the symmetry of the sy...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09883
更新日期:2015-04-30 00:00:00
abstract::Recent advances in genetic analyses have significantly refined human type 1 diabetes (T1D) associated loci. The goal of such effort is to identify the causal genes and have a complete understanding of the molecular pathways that independently or interactively influence cellular processes leading to the destruction of ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68956-6
更新日期:2020-07-21 00:00:00
abstract::Improving the prevention efficacy of health screening campaigns by increasing their attendance rate represents a challenge that calls for new strategies. This paper analyzes the response to a Pap test screening campaign of 155,000 women over the last decade. Using a mathematical model of statistical physics origins we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09904
更新日期:2015-04-23 00:00:00