当前位置： SCI文献检索 > Scientific Reports期刊下所有文献 > Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.

Innate immune activating ligand SUMOylation affects tumor cell recognition by NK cells.

Abstract：

:Natural Killer cells are innate lymphocytes involved in tumor immunosurveillance. They express activating receptors able to recognize self-molecules poorly expressed on healthy cells but up-regulated upon stress conditions, including transformation. Regulation of ligand expression in tumor cells mainly relays on transcriptional mechanisms, while the involvement of ubiquitin or ubiquitin-like modifiers remains largely unexplored. Here, we focused on the SUMO pathway and demonstrated that the ligand of DNAM1 activating receptor, PVR, undergoes SUMOylation in multiple myeloma. Concurrently, we found that PVR is preferentially located in intracellular compartments in human multiple myeloma cell lines and malignant plasma cells and that inhibition of the SUMO pathway promotes its translocation to the cell surface, increasing tumor cell susceptibility to NK cell-mediated cytolysis. Our findings provide the first evidence of an innate immune activating ligand regulated by SUMOylation, and confer to this modification a novel role in impairing recognition and killing of tumor cells.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Zitti B,Molfetta R,Fionda C,Quatrini L,Stabile H,Lecce M,de Turris V,Ricciardi MR,Petrucci MT,Cippitelli M,Gismondi A,Santoni A,Paolini R

doi

10.1038/s41598-017-10403-0

subject

Has Abstract

pub_date

2017-09-05 00:00:00

pages

10445

issue

1

issn

2045-2322

pii

10.1038/s41598-017-10403-0

journal_volume

7

pub_type

杂志文章

相关文献

Scientific Reports文献大全
  • Life cycle assessment of polyphenols extraction processes from waste biomass.

    abstract：:Waste biomass from forestry and wood processing industries is a source to obtain fine chemicals, and its processing is a good example of circular economy, but it generates secondary environmental impacts. The main objective of this study was to analyse the environmental performances of laboratory scale processes for p...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-70587-w

    authors： Barjoveanu G,Pătrăuțanu OA,Teodosiu C,Volf I

    更新日期：2020-08-12 00:00:00

  • Metabolic networks for nitrogen utilization in Prevotella ruminicola 23.

    abstract：:Nitrogen metabolism in gut systems remains poorly studied in spite of its importance for microbial growth and its implications for the metabolism of the host. Prevotella spp. are the most predominant bacteria detected in the rumen, but their presence has also been related to health and disease states in the human gut ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-08463-3

    authors： Kim JN,Méndez-García C,Geier RR,Iakiviak M,Chang J,Cann I,Mackie RI

    更新日期：2017-08-10 00:00:00

  • Association of NF-E2 Related Factor 2 (Nrf2) and inflammatory cytokines in recent onset Type 2 Diabetes Mellitus.

    abstract：:We investigated the association of redox regulator Nuclear factor erythroid 2-related factor 2 (Nrf2) and inflammatory cytokines as well as clinical remission in patients with recent onset type 2 diabetes (DM). Blood was collected from 180 DM patients (105 males/75 females) and 150 control subjects (86 males/64 female...

    journal_title：Scientific reports

    pub_type： 临床试验,杂志文章

    doi：10.1038/s41598-018-22913-6

    authors： Sireesh D,Dhamodharan U,Ezhilarasi K,Vijay V,Ramkumar KM

    更新日期：2018-03-23 00:00:00

  • Synthesis and Characterization of Zirconium Nitride Nanopowders by Internal Gelation and Carbothermic Nitridation.

    abstract：:Zirconium compounds has been widely attention over the last decades due to its excellent physical and chemical properties. Zirconium nitride nanopowders were synthesized via a simple direct carbothermic nitridation process of internal gel derived zirconia in the presence of nano-sized carbon black. The effects of reac...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-55450-x

    authors： Zhao S,Ma J,Xu R,Lin X,Cheng X,Hao S,Zhao X,Deng C,Liu B

    更新日期：2019-12-16 00:00:00

  • Formation environments and mechanisms of multistage paleokarst of Ordovician carbonates in Southern North China Basin.

    abstract：:With the reduction of oil and gas reserves and the increase of mining difficulty in Northern China, the carbonate rocks in Southern North China Basin are becoming a significant exploration target for carbonate reservoirs. However, the development characteristics, formation stages, formation environments and mechanisms...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-80878-x

    authors： Zhang H,Xu G,Liu M,Wang M

    更新日期：2021-01-12 00:00:00

  • Migraine and possible etiologic heterogeneity for hormone-receptor-negative breast cancer.

    abstract：:Migraine headache is often timed with the menstrual cycle. Some studies have reported reduced risk of breast cancer in migraineurs but most of those did not distinguish menstrually-related from non-menstrually-related migraine. To examine the possible associations between breast cancer and migraine overall and between...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep14943

    authors： Shi M,DeRoo LA,Sandler DP,Weinberg CR

    更新日期：2015-10-12 00:00:00

  • Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary Features in Hepatocellular Carcinoma.

    abstract：:Histological molecular classification of hepatocellular carcinoma (HCC) is clinically important for predicting the prognosis. However, a reliable serum marker has not been established. The aim of this study was to evaluate the diagnostic value of serum Wisteria Floribunda agglutinin-positive sialylated mucin 1 (WFA-si...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00357-8

    authors： Tamaki N,Kuno A,Matsuda A,Tsujikawa H,Yamazaki K,Yasui Y,Tsuchiya K,Nakanishi H,Itakura J,Korenaga M,Mizokami M,Kurosaki M,Sakamoto M,Narimatsu H,Izumi N

    更新日期：2017-03-21 00:00:00

  • Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury.

    abstract：:Although intestinal trefoil factor (ITF) can alleviate the burn-induced intestinal mucosa injury, the underlying mechanisms remains elusive. In this study, we investigated if ITF alters glutamine transport on the brush border membrane vesicles (BBMVs) of the intestines in Sprague-Dawley rats inflicted with 30% TBSA an...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-21282-4

    authors： Hu J,Shi Y,Wang C,Wan H,Wu D,Wang H,Peng X

    更新日期：2018-02-16 00:00:00

  • Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish.

    abstract：:An unresolved mystery in the field of spinal muscular atrophy (SMA) is why a reduction of the ubiquitously expressed Smn protein causes defects mostly in motoneurons. We addressed the possibility that this restricted vulnerability stems from elevated Smn expression in motoneurons. To explore this, we established an ex...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep27470

    authors： Spiró Z,Koh A,Tay S,See K,Winkler C

    更新日期：2016-06-07 00:00:00

  • On the Relationship between MRI and Local Field Potential Measurements of Spatial and Temporal Variations in Functional Connectivity.

    abstract：:Correlations between fluctuations in resting state BOLD fMRI signals are interpreted as measures of functional connectivity (FC), but the neural basis of their origins and their relationships to specific features of underlying electrophysiologic activity, have not been fully established. In particular, the dependence ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-45404-8

    authors： Shi Z,Wilkes DM,Yang PF,Wang F,Wu R,Wu TL,Chen LM,Gore JC

    更新日期：2019-06-20 00:00:00

  • Functional and morphological changes of the retinal vessels in Alzheimer's disease and mild cognitive impairment.

    abstract：:Imaging and histopathological studies have demonstrated that structural changes of the retina affect subjects with Alzheimer's disease (AD) or mild cognitive impairment (MCI). The aim of this study was to quantitatively investigate the retinal vessels in these disorders, using dynamic vessel analyzer (DVA) and optical...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-37271-6

    authors： Querques G,Borrelli E,Sacconi R,De Vitis L,Leocani L,Santangelo R,Magnani G,Comi G,Bandello F

    更新日期：2019-01-11 00:00:00

  • Chromatin accessibility contributes to simultaneous mutations of cancer genes.

    abstract：:Somatic mutations of many cancer genes tend to co-occur (termed co-mutations) in certain patterns during tumor initiation and progression. However, the genetic and epigenetic mechanisms that contribute to the co-mutations of these cancer genes have yet to be explored. Here, we systematically investigated the associati...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep35270

    authors： Shi Y,Su XB,He KY,Wu BH,Zhang BY,Han ZG

    更新日期：2016-10-20 00:00:00

  • Velvet-mediated repression of β-glucan synthesis in Aspergillus nidulans spores.

    abstract：:Beta-glucans are a heterologous group of fibrous glucose polymers that are a major constituent of cell walls in Ascomycetes and Basidiomycetes fungi. Synthesis of β (1,3)- and (1,6)-glucans is coordinated with fungal cell growth and development, thus, is under tight genetic regulation. Here, we report that β-glucan sy...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep10199

    authors： Park HS,Man Yu Y,Lee MK,Jae Maeng P,Chang Kim S,Yu JH

    更新日期：2015-05-11 00:00:00

  • Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.

    abstract：:Although pneumococcal infection is a serious problem worldwide and has a high mortality rate, the molecular mechanisms underlying the lethality caused by pneumococcus remain elusive. Here, we show that BLT2, a G protein-coupled receptor for leukotriene B4 and 12(S)-hydroxyheptadecatrienoic acid (12-HHT), protects mice...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep34560

    authors： Shigematsu M,Koga T,Ishimori A,Saeki K,Ishii Y,Taketomi Y,Ohba M,Jo-Watanabe A,Okuno T,Harada N,Harayama T,Shindou H,Li JD,Murakami M,Hoka S,Yokomizo T

    更新日期：2016-10-05 00:00:00

  • Experimental design approach for deposition optimization of RF sputtered chalcogenide thin films devoted to environmental optical sensors.

    abstract：:The development of the optical bio-chemical sensing technology is an extremely important scientific and technological issue for diagnosis and monitoring of diseases, control of industrial processes, environmental detection of air and water pollutants. Owing to their distinctive features, chalcogenide amorphous thin fi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-03678-w

    authors： Baudet E,Sergent M,Němec P,Cardinaud C,Rinnert E,Michel K,Jouany L,Bureau B,Nazabal V

    更新日期：2017-06-14 00:00:00

  • Rare earth ion Tb3+ doped natural sodium feldspar (NaAlSi3O8) Luminescent properties and energy transfer.

    abstract：:In this study, Tb3+-doped natural sodium feldspar (NaAlSi3O8) phosphors have been successfully prepared using high-temperature solid-state method with natural sodium feldspar as a substrate. Energy-dispersive X-ray spectrometry analysis (EDX) of NaAlSi3O8 showed that 0.03 wt% of Eu element was present, and elemental d...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-51171-3

    authors： Halmurat D,Yusufu T,Wang QL,He J,Sidike A

    更新日期：2019-10-10 00:00:00

  • Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1.

    abstract：:Absolute numbers of lymphocytes are decreased in uninfected infants born to HIV-1-infected women (HIV-1-exposed). Although the exact mechanism is unknown, fetal exposure to maternal HIV-1-infection could prime the immune system and affect T cell trafficking. We compared the expression of chemokine receptors on cord bl...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep06690

    authors： Bunders MJ,van Hamme JL,Jansen MH,Boer K,Kootstra NA,Kuijpers TW

    更新日期：2014-10-24 00:00:00

  • Whole Mitogenomes Reveal the History of Swamp Buffalo: Initially Shaped by Glacial Periods and Eventually Modelled by Domestication.

    abstract：:The newly sequenced mitochondrial genomes of 107 Asian swamp buffalo (Bubalus bubalis carabensis) allowed the reconstruction of the matrilineal divergence since ~900 Kya. Phylogenetic trees and Bayesian skyline plots suggest a role of the glacial periods in the demographic history of swamp buffalo. The ancestral swamp...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-04830-2

    authors： Wang S,Chen N,Capodiferro MR,Zhang T,Lancioni H,Zhang H,Miao Y,Chanthakhoun V,Wanapat M,Yindee M,Zhang Y,Lu H,Caporali L,Dang R,Huang Y,Lan X,Plath M,Chen H,Lenstra JA,Achilli A,Lei C

    更新日期：2017-07-05 00:00:00

  • Vocal complexity influences female responses to gelada male calls.

    abstract：:Extensive research indicates that inter-sexual selection drives the evolution of complex vocal communication in birds, but parallel lines of evidence are almost entirely absent in mammals. This dearth of evidence, particularly among primates, limits our understanding of the link between sociality and vocal complexity....

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19680

    authors： Gustison ML,Bergman TJ

    更新日期：2016-01-21 00:00:00

  • An interneuron progenitor maintains neurogenic potential in vivo and differentiates into GABAergic interneurons after transplantation in the postnatal rat brain.

    abstract：:Dysfunction of cortical GABAergic interneurons are involved in numerous neurological disorders including epilepsy, schizophrenia and autism; and replenishment of these cells by transplantation strategy has proven to be a feasible and effective method to help revert the symptoms in several animal models. To develop met...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep19003

    authors： Wang Q,Hong P,Gao H,Chen Y,Yang Q,Jiang M,Li H

    更新日期：2016-01-11 00:00:00

  • Europium Silicide - a Prospective Material for Contacts with Silicon.

    abstract：:Metal-silicon junctions are crucial to the operation of semiconductor devices: aggressive scaling demands low-resistive metallic terminals to replace high-doped silicon in transistors. It suggests an efficient charge injection through a low Schottky barrier between a metal and Si. Tremendous efforts invested into engi...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep25980

    authors： Averyanov DV,Tokmachev AM,Karateeva CG,Karateev IA,Lobanovich EF,Prutskov GV,Parfenov OE,Taldenkov AN,Vasiliev AL,Storchak VG

    更新日期：2016-05-23 00:00:00

  • Selective Particle Filtering in a Large Acoustophoretic Serpentine Channel.

    abstract：:The objective of this study is to investigate the performance of a serpentine channel for acoustically driven selective particle filtering. The channel consists of sharp corners and straight sections, and the acoustic field is affecting the particles throughout the channel. A prototype of the separator channel is manu...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-019-43711-8

    authors： Kandemir MH,Wagterveld RM,Yntema DR,Keesman KJ

    更新日期：2019-05-09 00:00:00

  • Characteristics of the heme catabolic pathway in mild unconjugated hyperbilirubinemia and their associations with inflammation and disease prevention.

    abstract：:Heme catabolism exerts physiological functions that impact health through depressing inflammation. Upon reactive pathway progression, as in Gilbert's Syndrome (GS; UGT1A1*28 polymorphism), aggravated health effects have been determined. Based on lower inflammation and improved metabolic health reported for GS, inter-g...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-00933-y

    authors： Mölzer C,Wallner M,Kern C,Tosevska A,Zadnikar R,Doberer D,Marculescu R,Wagner KH

    更新日期：2017-04-07 00:00:00

  • HASE: Framework for efficient high-dimensional association analyses.

    abstract：:High-throughput technology can now provide rich information on a person's biological makeup and environmental surroundings. Important discoveries have been made by relating these data to various health outcomes in fields such as genomics, proteomics, and medical imaging. However, cross-investigations between several h...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36076

    authors： Roshchupkin GV,Adams HH,Vernooij MW,Hofman A,Van Duijn CM,Ikram MA,Niessen WJ

    更新日期：2016-10-26 00:00:00

  • Photobiomodulation of human dermal fibroblasts in vitro: decisive role of cell culture conditions and treatment protocols on experimental outcome.

    abstract：:Photobiomodulation-based (LLLT) therapies show tantalizing promise for treatment of skin diseases. Confidence in this approach is blighted however by lamentable inconsistency in published experimental designs, and so complicates interpretation. Here we interrogate the appropriateness of a range of previously-reported ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-02802-0

    authors： Mignon C,Uzunbajakava NE,Raafs B,Botchkareva NV,Tobin DJ

    更新日期：2017-06-05 00:00:00

  • Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations.

    abstract：:The synaptic protein SHANK3 encodes a multidomain scaffold protein expressed at the postsynaptic density of neuronal excitatory synapses. We previously identified de novo SHANK3 mutations in patients with autism spectrum disorders (ASD) and showed that SHANK3 represents one of the major genes for ASD. Here, we analyze...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-018-36993-x

    authors： Gouder L,Vitrac A,Goubran-Botros H,Danckaert A,Tinevez JY,André-Leroux G,Atanasova E,Lemière N,Biton A,Leblond CS,Poulet A,Boland A,Deleuze JF,Benchoua A,Delorme R,Bourgeron T,Cloëz-Tayarani I

    更新日期：2019-01-14 00:00:00

  • Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse.

    abstract：:Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fib...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/srep36579

    authors： Jackson IL,Zhang Y,Bentzen SM,Hu J,Zhang A,Vujaskovic Z

    更新日期：2016-11-15 00:00:00

  • Author Correction: Potential damaging mutation in LRP5 from genome sequencing of the first reported chimpanzee with the Chiari malformation.

    abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title：Scientific reports

    pub_type： 已发布勘误

    doi：10.1038/s41598-018-24993-w

    authors： Solis-Moruno M,de Manuel M,Hernandez-Rodriguez J,Fontsere C,Gomara-Castaño A,Valsera-Naranjo C,Crailsheim D,Navarro A,Llorente M,Riera L,Feliu-Olleta O,Marques-Bonet T

    更新日期：2018-05-04 00:00:00

  • Pedobacter schmidteae sp. nov., a new bacterium isolated from the microbiota of the planarian Schmidtea mediterranea.

    abstract：:Pedobacter schmidteae sp. nov. strain EGT (Collection de Souches de l'Unité des Rickettsie CSUR P6417 = Colección Española de Cultivos Tipo CECT 9771) is a new Pedobacter species isolated from the planarian Schmidtea mediterranea. Schmidtea mediterranea are flatworms living in freshwater and exhibiting an unusual abil...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-020-62985-x

    authors： Kangale LJ,Raoult D,Ghigo E,Fournier PE

    更新日期：2020-04-09 00:00:00

  • AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease.

    abstract：:Pompe disease (PD) is a metabolic myopathy due to acid alpha-glucosidase deficiency and characterized by extensive glycogen storage and impaired autophagy. We previously showed that modulation of autophagy and lysosomal exocytosis by overexpression of the transcription factor EB (TFEB) gene was effective in improving ...

    journal_title：Scientific reports

    pub_type： 杂志文章

    doi：10.1038/s41598-017-15352-2

    authors： Gatto F,Rossi B,Tarallo A,Polishchuk E,Polishchuk R,Carrella A,Nusco E,Alvino FG,Iacobellis F,De Leonibus E,Auricchio A,Diez-Roux G,Ballabio A,Parenti G

    更新日期：2017-11-08 00:00:00