Abstract：
:Hox proteins are transcription factors and key regulators of segmental identity along the anterior posterior axis across all bilaterian animals. Despite decades of research, the mechanisms by which Hox proteins select and regulate their targets remain elusive. We have carried out whole-genome ChIP-chip experiments to identify direct targets of Hox protein Ultrabithorax (Ubx) during haltere development in Drosophila. Direct targets identified include upstream regulators or cofactors of Ubx. Homothorax, a cofactor of Ubx during embryonic development, is one such target and is required for normal specification of haltere. Although Ubx bound sequences are conserved amongst various insect genomes, no consensus Ubx-specific motif was detected. Surprisingly, binding motifs for certain transcription factors that function either upstream or downstream to Ubx are enriched in these sequences suggesting complex regulatory loops governing Ubx function. Our data supports the hypothesis that specificity during Hox target selection is achieved by associating with other transcription factors.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Agrawal P,Habib F,Yelagandula R,Shashidhara LSdoi
10.1038/srep00205subject
Has Abstractpub_date
2011-01-01 00:00:00pages
205issn
2045-2322journal_volume
1pub_type
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-06-03 00:00:00
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pub_type： 杂志文章
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更新日期：2015-06-02 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-08-11 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-11-28 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-10 00:00:00
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pub_type： 杂志文章
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更新日期：2016-07-28 00:00:00
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pub_type： 杂志文章,meta分析
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journal_title：Scientific reports
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更新日期：2016-03-11 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2017-09-05 00:00:00
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pub_type： 已发布勘误
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-05 00:00:00
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pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
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