Whole genome sequencing, analyses of drug resistance-conferring mutations, and correlation with transmission of Mycobacterium tuberculosis carrying katG-S315T in Hanoi, Vietnam.

abstract：:Using a non-targeted metabolomics platform, we recently identified C-mannosyltryptophan and pseudouridine as non-traditional kidney function markers. The aims of this study were to obtain absolute concentrations of both metabolites in blood and urine from individuals with and without CKD to provide reference ranges an...

journal_title：Scientific reports

authors： Sekula P,Dettmer K,Vogl FC,Gronwald W,Ellmann L,Mohney RP,Eckardt KU,Suhre K,Kastenmüller G,Oefner PJ,Köttgen A

更新日期：2017-12-12 00:00:00

abstract：:Resistance of cancer cells to chemotherapy is a significant problem in oncology, and the development of sensitising agents or small-molecules with new mechanisms of action to kill these cells is needed. Autophagy is a cellular process responsible for the turnover of misfolded proteins or damaged organelles, and it als...

journal_title：Scientific reports

authors： Law BY,Chan WK,Xu SW,Wang JR,Bai LP,Liu L,Wong VK

更新日期：2014-07-01 00:00:00

abstract：:α-Ketoglutarate (αKG) is a metabolite of the tricarboxylic acid cycle, important for biomass synthesis and a precursor for biotechnological products like 1,4-butanediol. In the eukaryote Saccharomyces cerevisiae αKG is present in different compartments. Compartmentation and (intra-)cellular transport could interfere w...

journal_title：Scientific reports

authors： Zhang J,van den Herik BM,Wahl SA

更新日期：2020-07-30 00:00:00

abstract：:The association of cabbage white butterflies (Pieris spec., Lepidoptera: Pieridae) with their glucosinolate-containing host plants represents a well-investigated example of the sequential evolution of plant defenses and insect herbivore counteradaptations. The defensive potential of glucosinolates, a group of amino ac...

journal_title：Scientific reports

authors： Steiner AM,Busching C,Vogel H,Wittstock U

更新日期：2018-07-17 00:00:00

abstract：:Previously we reported that LIM1863 colorectal cancer (CRC) cells secrete three distinct extracellular vesicle subtypes - two subpopulations of exosomes (apical EpCAM-Exos and basolateral A33-Exos) and shed microvesicles (sMVs) - with distinct protein and miRNA signatures. Here, we extend our omics approach to underst...

journal_title：Scientific reports

authors： Chen M,Xu R,Ji H,Greening DW,Rai A,Izumikawa K,Ishikawa H,Takahashi N,Simpson RJ

更新日期：2016-12-05 00:00:00

abstract：:With the surge of GPS-technology, many studies uncovered space use of mobile animals and shed light on the underlying behavioral mechanisms of habitat selection. Habitat selection and variation in either occurrence or strength of functional responses (i.e. how selection changes with availability) have given new insigh...

journal_title：Scientific reports

authors： William G,Jean-Michel G,Sonia S,Christophe B,Atle M,Nicolas M,Maryline P,Clément C

更新日期：2018-03-23 00:00:00

abstract：:Mucus is responsible for controlling transport and barrier function in biological systems, and its properties can be significantly affected by compositional and environmental changes. In this study, the impacts of pH and CaCl2 were examined on the solution-to-gel transition of mucin, the primary structural component o...

journal_title：Scientific reports

authors： Curnutt A,Smith K,Darrow E,Walters KB

更新日期：2020-05-29 00:00:00

abstract：:Electrochemical biosensors have been studied intensively for several decades. Numerous sensing concepts and related interface architectures have been developed. However, all such architectures suffer a trade-off: simple architectures favour usability, whereas complex architectures favour better performance. To overcom...

journal_title：Scientific reports

authors： Zhu X,Feng C,Ye Z,Chen Y,Li G

更新日期：2014-02-25 00:00:00

abstract：:Climate change-induced extinctions are estimated to eliminate one in six known species by the end of the century. One major factor that will contribute to these extinctions is extreme climatic events. Here, we show the ecological impacts of recent record warm air temperatures and simultaneous peak drought conditions i...

journal_title：Scientific reports

authors： Bucciarelli GM,Clark MA,Delaney KS,Riley SPD,Shaffer HB,Fisher RN,Honeycutt RL,Kats LB

更新日期：2020-02-25 00:00:00

abstract：:Detecting communities or clusters in a real-world, networked system is of considerable interest in various fields such as sociology, biology, physics, engineering science, and interdisciplinary subjects, with significant efforts devoted in recent years. Many existing algorithms are only designed to identify the compos...

journal_title：Scientific reports

authors： Chen Y,Zhao P,Li P,Zhang K,Zhang J

更新日期：2016-04-07 00:00:00

abstract：:We use satellite gravity measurements in the Gravity Recovery and Climate Experiment (GRACE) to estimate terrestrial water storage (TWS) change in the continental United States (US) from 2003 to 2012, and establish a GRACE-based Hydrological Drought Index (GHDI) for drought monitoring. GRACE-inferred TWS exhibits oppo...

journal_title：Scientific reports

authors： Yi H,Wen L

更新日期：2016-01-27 00:00:00

abstract：:Glycoprotein nonmetastatic melanoma protein B (GPNMB) plays important roles in various types of cancer and amyotrophic lateral sclerosis (ALS). The details of GPNMB function and its interacting protein have not been clarified. Therefore, to identify GPNMB binding partners on the cell membrane, we used membrane protein...

journal_title：Scientific reports

authors： Ono Y,Tsuruma K,Takata M,Shimazawa M,Hara H

更新日期：2016-03-18 00:00:00

abstract：:The role of extractable pool of biochar in crop productivity and soil greenhouse gas (GHGs) emission is not yet clear. In this study, two biochars with and without extraction was added to a paddy before rice transplantation at 20 t·ha-1. Crop yield, plant traits and greenhouse gas emission monitored throughout a rice-...

journal_title：Scientific reports

authors： Korai PK,Xia X,Liu X,Bian R,Omondi MO,Nahayo A,Pan G

更新日期：2018-01-16 00:00:00

abstract：:Primordial germ cells (PGCs), the embryonic precursors of the sperm and egg, are used for the introduction of genetic modifications into avian genome. Introduction of small defined sequences using genome editing has not been demonstrated in bird species. Here, we compared oligonucleotide-mediated HDR using wild type S...

journal_title：Scientific reports

authors： Idoko-Akoh A,Taylor L,Sang HM,McGrew MJ

更新日期：2018-10-11 00:00:00

abstract：:The goal of the current study was to develop an asymmetric guided bone regeneration (GBR) membrane benefiting from curcumin and aspirin. The membrane was prepared using electrospinning technique and then was physic-chemically characterized by the conventional methods. The release profile of aspirin from the prepared m...

journal_title：Scientific reports

authors： Ghavimi MA,Bani Shahabadi A,Jarolmasjed S,Memar MY,Maleki Dizaj S,Sharifi S

更新日期：2020-10-23 00:00:00

abstract：:Halophilic proteins subjected to below about 15% salt in vitro denature through misfolding, aggregation and/or precipitation. Halobacteria, however, have been detected in environments of fluctuating salinity such as coastal salterns and even around fresh water springs in the depths of the Dead Sea. In order to identif...

journal_title：Scientific reports

authors： Vauclare P,Natali F,Kleman JP,Zaccai G,Franzetti B

更新日期：2020-02-24 00:00:00

abstract：:Erythropoietin (EPO) has been identified as being crucial for obesity modulation; however, its erythropoietic activity may limit its clinical application. EPO-derived Helix B-surface peptide (pHBSP) is nonerythrogenic but has been reported to retain other functions of EPO. The current study aimed to evaluate the effec...

journal_title：Scientific reports

authors： Liu Y,Luo B,Shi R,Wang J,Liu Z,Liu W,Wang S,Zhang Z

更新日期：2015-10-13 00:00:00

abstract：:The Frasnian-Famennian boundary records one of the most catastrophic mass extinctions of the Phanerozoic Eon. Several possible causes for this extinction have been suggested, including extra-terrestrial impacts and large-scale volcanism. However, linking the extinction with these potential causes is hindered by the la...

journal_title：Scientific reports

authors： Percival LME,Davies JHFL,Schaltegger U,De Vleeschouwer D,Da Silva AC,Föllmi KB

更新日期：2018-06-22 00:00:00

abstract：:Heterostructures based on two-dimensional (2D) materials have sparked wide interests in both fundamental physics and applied devices. Recently, Dirac/Weyl semimetals are emerging as capable functional materials for optoelectronic devices. However, thus far the interfacial coupling of an all-semimetal 2D heterostructur...

journal_title：Scientific reports

authors： Liu Y,Liu C,Wang X,He L,Wan X,Xu Y,Shi Y,Zhang R,Wang F

更新日期：2018-08-27 00:00:00

abstract：:Agriculture, forestry and other land uses are currently the second highest source of anthropogenic greenhouse gases (GHGs) emissions. In soil, these gases derive from microbial activity, during carbon (C) and nitrogen (N) cycling. To investigate how Eucalyptus land use and growth period impact the microbial community,...

journal_title：Scientific reports

authors： Monteiro DA,Fonseca EDS,Rodrigues RAR,da Silva JJN,da Silva EP,Balieiro FC,Alves BJR,Rachid CTCDC

更新日期：2020-06-03 00:00:00

abstract：:Hearing impairment is one of the most common sensory deficits in humans. Hearing aids are helpful to patients but can have poor sound quality or transmission due to insufficient output or acoustic feedback, such as for high frequencies. Implantable devices partially overcome these issues but require surgery with limit...

journal_title：Scientific reports

authors： Stahn P,Lim HH,Hinsberger MP,Sorg K,Pillong L,Kannengießer M,Schreiter C,Foth HJ,Langenbucher A,Schick B,Wenzel GI

更新日期：2019-03-12 00:00:00

abstract：:Reduced near-infrared reflectance observed in September 1973 in Skylab images of the western flank of Mt. Etna has been interpreted as an eruption precursor of the January 1974 eruption. Until now, it has been unclear when this signal started, whether it was sustained and which process(es) could have caused it. By ana...

journal_title：Scientific reports

authors： Seiler R,Houlié N,Cherubini P

更新日期：2017-03-07 00:00:00

abstract：:Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant...

journal_title：Scientific reports

authors： Sakano D,Inoue A,Enomoto T,Imasaka M,Okada S,Yokota M,Koike M,Araki K,Kume S

更新日期：2020-07-22 00:00:00

abstract：:Although various function of chemerin have been suggested, its physiological role remains to be elucidated. Here we show that chemerin-deficient mice are glucose intolerant irrespective of exhibiting reduced macrophage accumulation in adipose tissue. The glucose intolerance was mainly due to increased hepatic glucose ...

journal_title：Scientific reports

authors： Takahashi M,Okimura Y,Iguchi G,Nishizawa H,Yamamoto M,Suda K,Kitazawa R,Fujimoto W,Takahashi K,Zolotaryov FN,Hong KS,Kiyonari H,Abe T,Kaji H,Kitazawa S,Kasuga M,Chihara K,Takahashi Y

更新日期：2011-01-01 00:00:00

abstract：:The high manufacturing cost for metallic glasses hampers actual commercial applications of this class of fascinating materials. In this letter, the effect of oxygen impurity on the glass forming ability and tensile properties of Zr-BMG composites were studied. Our results have demonstrated that oxygen was absorbed and...

journal_title：Scientific reports

authors： Cheng JL,Chen G,Liu CT,Li Y

更新日期：2013-01-01 00:00:00

abstract：:Mycobacterium tuberculosis, the etiological agent of the infectious disease tuberculosis, kills approximately 1.5 million people annually, while the spread of multidrug-resistant strains is of great global concern. Thus, continuous efforts to identify new antitubercular drugs as well as novel targets are crucial. Rece...

journal_title：Scientific reports

authors： Chiarelli LR,Mori G,Orena BS,Esposito M,Lane T,de Jesus Lopes Ribeiro AL,Degiacomi G,Zemanová J,Szádocka S,Huszár S,Palčeková Z,Manfredi M,Gosetti F,Lelièvre J,Ballell L,Kazakova E,Makarov V,Marengo E,Mikusova K,Col

更新日期：2018-02-16 00:00:00

abstract：:Atmospheric new particle formation (NPF) and growth significantly influences climate by supplying new seeds for cloud condensation and brightness. Currently, there is a lack of understanding of whether and how marine biota emissions affect aerosol-cloud-climate interactions in the Arctic. Here, the aerosol population ...

journal_title：Scientific reports

authors： Dall Osto M,Beddows DCS,Tunved P,Krejci R,Ström J,Hansson HC,Yoon YJ,Park KT,Becagli S,Udisti R,Onasch T,O Dowd CD,Simó R,Harrison RM

更新日期：2017-06-12 00:00:00

abstract：:Few neuroimaigng studies on reading comprehension have been conducted under natural reading settings. In this study, we showed texts presented in a natural way during functional MRI (fMRI) measurements to reveal brain areas sensitive to reading comprehension. Specifically, this paradigm independently manipulated two h...

journal_title：Scientific reports

authors： Lin FH,Liu YF,Lee HJ,Chang CHC,Jaaskelainen IP,Yeh JN,Kuo WJ

更新日期：2019-09-13 00:00:00

abstract：:Radionuclide molecular imaging of cancer-specific targets is a promising method to identify patients for targeted antibody therapy. Radiolabeled full-length antibodies however suffer from slow clearance, resulting in high background radiation. To overcome this problem, a pretargeting system based on complementary pept...

journal_title：Scientific reports

authors： Myrhammar A,Vorobyeva A,Westerlund K,Yoneoka S,Orlova A,Tsukahara T,Tolmachev V,Karlström AE,Altai M

更新日期：2020-11-27 00:00:00

abstract：:Protein kinases are frequently mutated in human cancers, which leads to altered signaling pathways and contributes to tumor growth and progression. ERK3 is an atypical mitogen-activated protein kinase (MAPK) containing an S-E-G activation motif rather than the conserved T-X-Y motif in conventional MAPKs such as ERK1/2...

journal_title：Scientific reports

authors： Alsaran H,Elkhadragy L,Shakya A,Long W

更新日期：2017-11-03 00:00:00