Abstract：
:For lung and many other cancers, prognosis is essentially important, and extensive modeling has been carried out. Cancer is a genetic disease. In the past 2 decades, diverse molecular data (such as gene expressions and DNA mutations) have been analyzed in prognosis modeling. More recently, histopathological imaging data, which is a "byproduct" of biopsy, has been suggested as informative for prognosis. In this article, with the TCGA LUAD and LUSC data, we examine and directly compare modeling lung cancer overall survival using gene expressions versus histopathological imaging features. High-dimensional penalization methods are adopted for estimation and variable selection. Our findings include that gene expressions have slightly better prognostic performance, and that most of the gene expressions are weakly correlated imaging features. This study may provide additional insight into utilizing the two types of important data in cancer prognosis modeling and into lung cancer overall survival.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhang S,Fan Y,Zhong T,Ma Sdoi
10.1038/s41598-020-72201-5subject
Has Abstractpub_date
2020-09-14 00:00:00pages
15030issue
1issn
2045-2322pii
10.1038/s41598-020-72201-5journal_volume
10pub_type
杂志文章abstract：:This study was to evaluate the effectiveness of oral hygiene care in improving oral health- and health-related quality of life (OHRQoL and HRQoL) among patients receiving outpatient stroke rehabilitation. Subjects were randomized to: (1) a conventional oral hygiene care programme (COHCP) comprising a manual toothbrush...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-017-07666-y
更新日期：2017-08-09 00:00:00
abstract：:Jagged1 activates Notch signaling and subsequently promotes osteogenic differentiation in human periodontal ligament cells (hPDLs). The present study investigated the participation of the Notch receptor, NOTCH2, in the Jagged1-induced osteogenic differentiation in hPDLs. NOTCH2 and NOTCH4 mRNA expression levels increa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70277-7
更新日期：2020-08-07 00:00:00
abstract：:Phosphopantetheinyl transferases (PPTases) play essential roles in both primary metabolisms and secondary metabolisms via post-translational modification of acyl carrier proteins (ACPs) and peptidyl carrier proteins (PCPs). In this study, an industrial FK506 producing strain Streptomyces tsukubaensis L19, together wit...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24255
更新日期：2016-04-07 00:00:00
abstract：:Recent studies suggest that mRNAs may be differentially expressed between males and females. This study aimed to perform expression analysis of mRNA and its main regulatory molecule, microRNA (miRNA), to discuss the potential sex-specific expression patterns using abnormal expression profiles from The Cancer Genome At...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39812
更新日期：2017-01-03 00:00:00
abstract：:The restoration of dentine lost in deep caries lesions in teeth is a routine and common treatment that involves the use of inorganic cements based on calcium or silicon-based mineral aggregates. Such cements remain in the tooth and fail to degrade and thus normal mineral volume is never completely restored. Here we de...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39654
更新日期：2017-01-09 00:00:00
abstract：:Spatially resolved analysis of uranium (U) isotopes in small volumes of actinide-bearing materials is critical for a variety of technical disciplines, including earth and planetary sciences, environmental monitoring, bioremediation, and the nuclear fuel cycle. However, achieving subnanometer-scale spatial resolution f...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48479-5
更新日期：2019-08-23 00:00:00
abstract：:This work explores simulations of polarized discussions from a general and theoretical premise. Specifically the question of whether a plausible avenue exists for a subgroup in an online social network to find a disagreement beneficial and what that benefit could be. A methodological framework is proposed which repres...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-12-09 00:00:00
abstract：:Osteolineage cells represent one of the critical bone marrow niche components that support maintenance of hematopoietic stem and progenitor cells (HSPCs). Recent studies demonstrate that extracellular vesicles (EVs) regulate stem cell development via horizontal transfer of bioactive cargo, including microRNAs (miRNAs)...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32034
更新日期：2016-09-02 00:00:00
abstract：:Analysing the link between terrestrial ecosystem productivity (i.e., Net Primary Productivity: NPP) and extreme climate conditions is vital in the context of increasing threats due to climate change. To reveal the impact of changing extreme conditions on NPP, a copula-based probabilistic model was developed, and the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55067-0
更新日期：2019-12-12 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01770
更新日期：2013-01-01 00:00:00
abstract：:The photoactive Orange Carotenoid Protein (OCP) plays a key role in cyanobacterial photoprotection. In OCP, a single non-covalently bound keto-carotenoid molecule acts as a light intensity sensor, while the protein is responsible for forming molecular contacts with the light-harvesting antenna, the fluorescence of whi...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-07-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-12-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10073
更新日期：2015-05-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30327
更新日期：2016-07-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22025
更新日期：2016-02-25 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17843-8
更新日期：2018-01-15 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-06-26 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-02-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-10-07 00:00:00
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pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-08-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-12-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-07-13 00:00:00
abstract：:Combining spectral imaging with compressive sensing (CS) enables efficient data acquisition by fully utilizing the intrinsic redundancies in natural images. Current compressive multispectral imagers, which are mostly based on array sensors (e.g, CCD or CMOS), suffer from limited spectral range and relatively low photo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41435
更新日期：2017-01-27 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00092
更新日期：2011-01-01 00:00:00
abstract：:Latent class modeling can be used to combine the results of multiple tests to compare the sensitivity and specificity of those tests in the absence of a gold standard. Seroepidemiology for chlamydia infection may be useful for determining the cumulative risk of infection within a population. Initial studies using the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22708-9
更新日期：2018-03-09 00:00:00
abstract：:Decidualization is characterized by the differentiation of endometrial stromal cells (eSCs), which is critical for embryo implantation and maintenance of pregnancy. In the present study, we investigated the possible effect of simulated microgravity (SM) on the process of proliferation and in vitro decidualization usin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48580-9
更新日期：2019-08-20 00:00:00
abstract：:C. canimorsus and C. cynodegmi are dog and cat commensals which can be transmitted to humans via bites or scratches and can cause sepsis, meningitis, endocarditis, and eye- or wound infections. Recently an additional Capnocytophaga species was identified as part of the oral flora of healthy dogs and was given the name...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22919
更新日期：2016-03-07 00:00:00
abstract：:Although poaching (illegal killing) is an important cause of death for large carnivores globally, the effect of lethal management policies on poaching is unknown for many populations. Two opposing hypotheses have been proposed: liberalizing killing may decrease poaching incidence ('tolerance hunting') or increase it (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70837-x
更新日期：2020-08-17 00:00:00
abstract：:Inhibitory/repressor-receptors are upregulated significantly on activated T cells, and have been the molecules of attention as targets for inducing immune tolerance. Induction of effective antigen specific tolerance depends on concurrent engagement of the TCR and one or more of these inhibitory receptors. Here, we sho...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-48464-y
更新日期：2019-08-19 00:00:00
