Abstract：
:Pre-mRNA splicing deposits multi-protein complexes, termed exon junction complexes (EJCs), on mRNAs near exon-exon junctions. The core of EJC consists of four proteins, eIF4AIII, MLN51, Y14 and Magoh. Y14 is a nuclear protein that can shuttle between the nucleus and the cytoplasm, and binds specifically to Magoh. Here we delineate a Y14 nuclear localization signal that also confers its nuclear export, which we name YNS. We further identified a 12-amino-acid peptide near Y14's carboxyl terminus that is required for its association with spliced mRNAs, as well as for Magoh binding. Furthermore, the Y14 mutants, which are deficient in binding to Magoh, could still be localized to the nucleus, suggesting the existence of both the nuclear import pathway and function for Y14 unaccompanied by Magoh.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kataoka N,Diem MD,Yoshida M,Hatai C,Dobashi I,Dreyfuss G,Hagiwara M,Ohno Mdoi
10.1038/srep00092subject
Has Abstractpub_date
2011-01-01 00:00:00pages
92issn
2045-2322journal_volume
1pub_type
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