Abstract：
:Computed tomography (CT) and magnetic resonance imaging (MRI) can quantify muscle mass and quality. However, it is still unclear if CT and MRI derived measurements can be used interchangeable. In this prospective study, fifty consecutive participants of a cancer screening program underwent same day low-dose chest CT and MRI. Cross-sectional areas (CSA) of the paraspinal skeletal muscles were obtained. CT and MRI muscle fat infiltration (MFI) were assessed by mean radiodensity in Hounsfield units (HU) and proton density fat fraction (MRIPDFF), respectively. CSA and MFI were highly correlated between CT and MRI (CSA: r = 0.93, P < 0.001; MFI: r = - 0.90, P < 0.001). Mean CSA was higher in CT compared to MRI (46.6cm2 versus 43.0cm2; P = 0.05) without significance. Based on MRIPDFF, a linear regression model was established to directly estimate skeletal muscle fat content from CT. Bland-Altman plots showed a difference between measurements of - 0.5 cm2 to 7.6 cm2 and - 4.2% to 2.4% regarding measurements of CSA and MFI, respectively. In conclusion, the provided results indicate interchangeability of CT and MRI derived imaging biomarkers of skeletal muscle quantity and quality. Comparable to MRIPDFF, skeletal muscle fat content can be quantified from CT, which might have an impact of analyses in larger cohort studies, particularly in sarcopenia patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Faron A,Sprinkart AM,Kuetting DLR,Feisst A,Isaak A,Endler C,Chang J,Nowak S,Block W,Thomas D,Attenberger U,Luetkens JAdoi
10.1038/s41598-020-68797-3subject
Has Abstractpub_date
2020-07-16 00:00:00pages
11765issue
1issn
2045-2322pii
10.1038/s41598-020-68797-3journal_volume
10pub_type
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