Abstract：
:Ocular involvement in leukemia is considered rare. Ocular symptoms can be the presenting signs of leukemia, they can appear after diagnosis has been established, or they can be the first manifestation of a relapse after remission. We report, to the best of our knowledge for the first time, the ocular manifestation of a series of patients with ocular leukemia and the result of their treatment with intravitreal methotrexate (MTX) injections. This is a retrospective cohort study. The medical records of 12 consecutive patients with ocular leukemia (24 eyes, 11 eyes treated with MTX) treated at the Sheba Medical Center from January 2010 to December 2017 were retrospectively reviewed. Details on ocular inflammatory reaction and tumor cell infiltration at presentation and the end of follow-up were recorded as main outcome measures. The 12 patients included 7 women and 5 men (mean age ± standard deviation at diagnosis 25.92 ± 23.91 years, range 2-82 years). Eleven eyes of 6 patients were treated with intravitreal MTX injections. The indication for treatment was biopsy proven, tumor cell infiltration. The mean number of MTX injections was 3.37 ± 5.35 (range 1-18). The mean follow-up was 27.08 ± 36.79 months (range 1-93). All treated eyes showed improvement in the inflammatory reaction and tumor cell infiltration. In conclusion we found that Intravitreal MTX injections may be an effective therapeutic approach for eyes with intraocular leukemic tumor cell infiltration.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Vishnevskia-Dai V,Sella King S,Lekach R,Fabian ID,Zloto Odoi
10.1038/s41598-020-58654-8subject
Has Abstractpub_date
2020-02-06 00:00:00pages
1994issue
1issn
2045-2322pii
10.1038/s41598-020-58654-8journal_volume
10pub_type
杂志文章abstract：:As a typical organic solid waste, sludge plays an important role in contributing to greenhouse gas (GHG) emissions resulted by its treatment and disposal. As a temporary and emergent treatment measurement, sludge lime stabilization is regionally adopted in most sludge generated units in China. In present case, sludge ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35052-9
更新日期：2018-11-08 00:00:00
abstract：:Micronutrient deficiency is common in patients with HIV/AIDS, usually caused by mal-absorption and/or drug interactions. 25-hydroxyvitamin D is of fundamental importance for the homeostasis of musculoskeletal health. The current study aimed to evaluate the nutritional status of HIV-infected subjects in order to make t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep12990
更新日期：2015-08-10 00:00:00
abstract：:We report the temperature dependence of the dielectric function ε = ε1 + iε2 and critical point (CP) energies of biaxial α-SnS in the spectral energy region from 0.74 to 6.42 eV and temperatures from 27 to 350 K using spectroscopic ellipsometry. Bulk SnS was grown by temperature gradient method. Dielectric response fu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75383-0
更新日期：2020-10-27 00:00:00
abstract：:Macroevolutionary studies of insects at diverse taxonomic scales often reveal dynamic evolutionary patterns, with multiple inferred diversification rate shifts. Responses to major past environmental changes, such as the Cretaceous Terrestrial Revolution, or the development of major key innovations, such as wings or co...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19208
更新日期：2016-01-18 00:00:00
abstract：:Selective removal of lignin and other recalcitrant compounds, collectively registered as acid-unhyrolyzable residue (AUR), results in bleaching of leaf litter, but the importance of bleaching in decomposition processes on forest soil has not been fully evaluated. The aims of this study were to elucidate the occurrence...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81206-7
更新日期：2021-01-19 00:00:00
abstract：:Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40921
更新日期：2017-01-18 00:00:00
abstract：:In recent years, texture analysis of medical images has become increasingly popular in studies investigating diagnosis, classification and treatment response assessment of cancerous disease. Despite numerous applications in oncology and medical imaging in general, there is no consensus regarding texture analysis workf...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04151-4
更新日期：2017-06-22 00:00:00
abstract：:Accurate detection of accelerometer non-wear time is crucial for calculating physical activity summary statistics. In this study, we evaluated three epoch-based non-wear algorithms (Hecht, Troiano, and Choi) and one raw-based algorithm (Hees). In addition, we performed a sensitivity analysis to provide insight into th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62821-2
更新日期：2020-04-03 00:00:00
abstract：:Beneficial and deleterious mutations change an organism's fitness but the distribution of these mutational effects on fitness are unknown. Several experimental, theoretical, and computational studies have explored this question but are limited because of experimental restrictions, or disconnect with physiology. Here w...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46401-7
更新日期：2019-07-08 00:00:00
abstract：:The discovery of Weyl semimetals (WSM) has brought forth the condensed matter realization of Weyl fermions, which were previously theorized as low energy excitations in high energy particle physics. Recently, transition metal mono-pnictides are under intense investigation for understanding properties of inversion-symm...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46062
更新日期：2017-04-10 00:00:00
abstract：:Medulloblastoma (MB), the most common malignant paediatric brain tumour occurs in the cerebellum. Advances in molecular genomics have led to the identification of defined subgroups which are associated with distinct clinical prognoses. Despite this classification, standard therapies for all subgroups often leave child...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44950-5
更新日期：2019-06-13 00:00:00
abstract：:Crystal and electronic structures of ~380 nm BiFeO3 film grown on LaAlO3 substrate are comprehensively studied using advanced transmission electron microscopy (TEM) technique combined with first-principles theory. Cross-sectional TEM images reveal the BiFeO3 film consists of two zones with different crystal structures...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep46498
更新日期：2017-04-19 00:00:00
abstract：:In a developing nervous system, endogenous electric field (EF) influence embryonic growth. We reported the EF-directed migration of both rat Schwann cells (SCs) and oligodendrocyte precursor cells (OPCs) and explored the molecular mechanism using RNA-sequencing assay. However, previous studies revealed the differentia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74085-x
更新日期：2020-10-08 00:00:00
abstract：:This study utilized a Förster resonance energy transfer (FRET)-based molecular tension sensor and live cell imaging to evaluate the effect of osteocytes, a mechanosensitive bone cell, on the migratory behavior of tumor cells. Two cell lines derived from MDA-MB-231 breast cancer cells were transfected with the vinculin...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42132-x
更新日期：2019-04-04 00:00:00
abstract：:Abnormal dopaminergic transmission has been implicated as a risk determinant of HIV-1-associated neurocognitive disorders. HIV-1 Tat protein increases synaptic dopamine (DA) levels by directly inhibiting DA transporter (DAT) activity, ultimately leading to dopaminergic neuron damage. Through integrated computational m...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep39048
更新日期：2016-12-14 00:00:00
abstract：:Plasmonics offer an exciting way to mediate the interaction between light and matter, allowing strong field enhancement and confinement, large absorption and scattering at resonance. However, simultaneous realization of ultra-narrow band perfect absorption and electromagnetic field enhancement is challenging due to th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24063
更新日期：2016-04-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-40320-3
更新日期：2019-03-12 00:00:00
abstract：:The new π-extended redox-active ligand with both TTF and triazole units, 6-(4,5-bis(propylthio)-1,3-dithiol-2-ylidene)-1H-[1,3]dithiolo[4',5':4,5]benzo [1,2-d] [1-3]triazole, has been successfully prepared. Based on the versatile ligand and Cu(tta)2 precursors (tta(-) = 4,4,4-trifluoro-1-(thiophen-2-yl)butane-1,3-dion...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25544
更新日期：2016-05-06 00:00:00
abstract：:Noise-induced hearing loss (NIHL) is a common health concern with significant social, psychological, and cognitive implications. Moderate levels of acoustic overstimulation associated with tinnitus and impaired speech perception cause cochlear synaptopathy, characterized physiologically by reduction in wave I of the s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75058-w
更新日期：2020-10-22 00:00:00
abstract：:During rescue operations related to the elimination of the effects of industrial accidents or natural disasters, extinguishing agents are used that affect the migration and transformation of contamination in the environment. Firefighting foam sprayed onto an oil spill slowly drains to an aqueous solution and penetrate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65660-3
更新日期：2020-06-01 00:00:00
abstract：:Studies on the phenomenon of magnetoresistance (MR) have produced intriguing and application-oriented outcomes for decades-colossal MR, giant MR and recently discovered extremely large MR of millions of percents in semimetals can be taken as examples. We report here the discovery of novel multiple sign changes versus ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep42789
更新日期：2017-02-17 00:00:00
abstract：:Accumulating evidences suggest that p53 is a key coordinator of cellular events triggered by oxidative stress often associated with the impairment in thiamine metabolism and its functions. However, there are limited data regarding the pursuant feedback between p53 transactivation and thiamine homeostasis. Impairment i...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10878-x
更新日期：2017-09-06 00:00:00
abstract：:The population of hepatitis B combined with a number of metabolic disorders is increasing significantly. Resveratrol (RSV) has been used as a preclinical drug for the treatment of the metabolic disorders. However, the impact of RSV on HBV replication remains unknown. In this study, the HBV-expressing hepatocelluar car...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep24744
更新日期：2016-04-21 00:00:00
abstract：:Combination anti-retroviral therapy (cART) has drastically improved the clinical outcome of HIV-1 infection. Nonetheless, despite effective cART, HIV-1 persists indefinitely in infected individuals. Clonal expansion of HIV-1-infected cells in peripheral blood has been reported recently. cART is effective in stopping t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07307-4
更新日期：2017-07-31 00:00:00
abstract：:The precision and accuracy of quantifying semi-volatile organic compounds (SVOCs) in solution by GC/MS, particularly when volume errors are unpredictable or difficult to control, are improved by utilizing internal standards (IS). Not obvious though is the extent to which timing IS addition affects measurement. To illu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74688-4
更新日期：2020-10-19 00:00:00
abstract：:Locusts have excellent jumping and kicking abilities to survive in nature, which are achieved through the energy storage and release processes occurring in cuticles, especially in the semi-lunar processes (SLP) at the femorotibial joints. As yet, however, the strain energy-storage mechanisms of the SLP cuticles remain...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep35219
更新日期：2016-10-17 00:00:00
abstract：:We investigate the timescales of the horizontal mass flux decay of wind remobilised volcanic particles in Argentina, associated with the tephra-fallout deposit produced by the 2011-2012 Cordón Caulle (Chile) eruption. Particle removal processes are controlled by complex interactions of meteorological conditions, surfa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71022-w
更新日期：2020-09-02 00:00:00
abstract：:Helicobacter pullorum is an avian bacterium that causes gastroenteritis, intestinal bowel and hepatobiliary diseases in humans. Although H. pullorum has been shown to activate the mammalian innate immunity with release of nitric oxide (NO), the proteins that afford protection against NO and reactive nitrogen species (...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10375-1
更新日期：2017-08-30 00:00:00
abstract：:AMPA subtype ionotropic glutamate receptors (iGluRs) mediate the majority of fast neurotransmission across excitatory synapses in the central nervous system. Each AMPA receptor is composed of four multi-domain subunits that are organized into layers of two amino-terminal domain (ATD) dimers, two ligand-binding domain ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep19082
更新日期：2016-01-07 00:00:00
abstract：:Melanoma is the most lethal cutaneous cancer. New drugs have recently appeared; however, not all patients obtain a benefit of these new drugs. For this reason, it is still necessary to characterize melanoma at molecular level. The aim of this study was to explore the molecular differences between melanoma tumor subtyp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43512-z
更新日期：2019-05-10 00:00:00
