Abstract:
:This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hysteroscopic resection. Multivariable logistic regression analysis was performed to develop the predictive model, which incorporated preoperative menstrual characteristics and magnetic resonance imaging (MRI) findings. Surgical efficacy was defined as a decrease in postmenstrual spotting duration of at least 3 days at the 3-month follow-up compared with baseline. The predictive model was presented with a nomogram, and the performance was assessed with respect to its calibration, discrimination, and clinical use. Internal validation was performed using tenfold cross-validation. The predictive factors in the final model were as follows: preoperative menstrual duration, thickness of the residual myometrium (TRM), length, TRM/thickness of the adjacent myometrium ratio, angle γ, area, and presence of a lateral branch of the niche. The model showed good performance in predicting the effectiveness of hysteroscopic niche resection. Incorporating the preoperative duration of the menstrual period and MRI findings of the niche into an easy-to-use nomogram facilitates the individualized prediction of the effectiveness of a hysteroscopic niche resection by 26 Fr resectoscope, but multicenter prospective studies are needed to validate it.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Zhu Q,He X,Jiang L,Liang G,Zhu C,Pan H,Zhang J,Huirne JAdoi
10.1038/s41598-020-74622-8subject
Has Abstractpub_date
2020-10-15 00:00:00pages
17424issue
1issn
2045-2322pii
10.1038/s41598-020-74622-8journal_volume
10pub_type
杂志文章abstract::Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia in DENV infections we described a direct correlation between activation and depletion of platelets in patients. Our data showed a sharp decrease in platelet counts at day...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41697
更新日期:2017-01-31 00:00:00
abstract::Bio-functionalized nanoparticles with semiconducting/metallic core encapsulated in a bio- or bio-derived materials are promising for applications in biology and especially in cancer diagnostic and healing. In this report, we report a facile, single-step, first-time synthesis and in-situ functionalization strategy for ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep18629
更新日期:2015-12-21 00:00:00
abstract::Soil microbial responses to fire are likely to change over the course of forest recovery. Investigations on long-term changes in bacterial dynamics following fire are rare. We characterized the soil bacterial communities across three different times post fire in a 2 to 152-year fire chronosequence by Illumina MiSeq se...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep32411
更新日期:2016-08-30 00:00:00
abstract::Virus production in the deep-sea environment has been found to be high, and viruses have been suggested to play significant roles in the overall functioning of this ecosystem. Nevertheless, little is known about these viruses, including the mechanisms that control their production, which makes them one of the least un...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21908
更新日期:2016-02-22 00:00:00
abstract::Studies of locomotor activity in Svalbard reindeer reported the temporary absence of diel rhythms under Arctic photic conditions. However, using Lomb-Scargle periodogram analyses with high statistical power we found diel or circadian rhythmicity throughout the entire year in measures of behaviour, temperature in the r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32778-4
更新日期:2018-09-27 00:00:00
abstract::Measurement techniques that allow the global analysis of cellular responses while retaining single-cell sensitivity are increasingly needed in order to understand complex and dynamic biological processes. In this context, compromises between sensitivity, degree of multiplexing, throughput, and invasiveness are often u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53428-3
更新日期:2019-11-19 00:00:00
abstract::Herein, the formation and electrochemical performance of a novel binder-free turbostratic stacked/ well-ordered stacked δ-MnO2-carbon fiber composite cathodes in deep eutectic solvent (DES) based zinc-ion battery (ZIB) is reported. Results of morphological, elemental, and structural analyses revealed directly grown an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51692-x
更新日期:2019-10-22 00:00:00
abstract::While impressive improvements have been achieved in T-ALL therapy, current treatment approaches fail in approximately 25% of patients and these patients have limited treatment options. Another significant group of patients is being overtreated, which causes long-lasting side effects. Identification of molecules contro...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-15200-3
更新日期:2017-11-07 00:00:00
abstract::Platelets of α-zirconium phosphate (α-ZrP) obtained from the reflux method in H3PO4 are successfully exfoliated into water via the intercalation of alkanol amines. With volume fractions greater than 0.02 they are stacked into tactoids of few layers with a repeat distance in the order of 10 nm. The tactoids align into ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51934-y
更新日期:2019-11-08 00:00:00
abstract::Salts containing radical cations of 1,2,4,5-tetrakis(isopropylthio)benzene (TPB) and 1,2,4,5-tetrakis(ethylthio) benzene (TEB) have been successfully synthesized with . These newly synthesized salts have been characterized by UV-Vis absorption, EPR spectroscopy, conductivity measurement, single crystal X-ray diffracti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29314
更新日期:2016-07-11 00:00:00
abstract::ADP-ribosyltransferases (ARTs) modify proteins with single units or polymers of ADP-ribose to regulate DNA repair. However, the substrates for these enzymes are ill-defined. For example, although histones are modified by ARTs, the sites on these proteins ADP-ribosylated following DNA damage and the ARTs that catalyse ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43750
更新日期:2017-03-02 00:00:00
abstract::Tau is a Microtubule-associated protein that induces and stabilizes the formation of the Microtubule cytoskeleton and plays an important role in neurodegenerative diseases. The Microtubules binding region of Tau has been determined for a long time but where and how Tau binds to its partner still remain a topic of deba...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32096-9
更新日期:2018-09-14 00:00:00
abstract::Currently, blueberry bruising is evaluated by either human visual/tactile inspection or firmness measurement instruments. These methods are destructive, time-consuming, and subjective. The goal of this paper was to develop a non-destructive approach for blueberry bruising detection and quantification. Experiments were...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep35679
更新日期:2016-10-21 00:00:00
abstract::Tumor tissue mutational burden (TMB) has emerged as a promising predictive biomarker for immune checkpoint therapy. Measuring TMB from circulating tumor DNA (ctDNA) found in plasma is attractive in tissue-constrained indications. We compared the performance of two plasma-based commercial TMB assays including the effec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37128-y
更新日期:2019-01-14 00:00:00
abstract::Microbial survival in dynamic environments requires the ability to successfully respond to abrupt changes in osmolarity. The mechanosensitive channel of large conductance (MscL) is a ubiquitous channel that facilitates the survival of bacteria and archaea under severe osmotic downshock conditions by relieving excess t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32536-6
更新日期:2018-10-01 00:00:00
abstract::The N-methyl-D-aspartate subfamily of ionotropic glutamate receptors (NMDARs) is well known for its important roles in the central nervous system (CNS), e.g. learning and memory formation. Besides the CNS, NMDARs are also expressed in numerous peripheral tissues including the pancreas, kidney, stomach, and blood cells...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-46496-y
更新日期:2019-07-11 00:00:00
abstract::To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide associatio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20844-w
更新日期:2018-02-05 00:00:00
abstract::Despite non-structural carbohydrate (NSC) importance for tree productivity and resilience, little is known about their seasonal regulations and trade-off with growth and reproduction. We characterize the seasonal dynamics of NSC in relation to the aboveground phenology and temporal growth patterns of three deciduous M...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-57016-3
更新日期:2020-01-15 00:00:00
abstract::Pericytes are believed to originate from either mesenchymal or neural crest cells. It has recently been reported that pericytes play important roles in the central nervous system (CNS) by regulating blood-brain barrier homeostasis and blood flow at the capillary level. However, the origin of CNS microvascular pericyte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-03994-1
更新日期:2017-06-20 00:00:00
abstract::Using classical molecular dynamics with a more reliable reactive LCBOPII potential, we have performed a detailed study on the direct graphite-to-diamond phase transition. Our results reveal a new so-called "wave-like buckling and slipping" mechanism, which controls the transformation from hexagonal graphite to cubic d...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep05930
更新日期:2014-08-04 00:00:00
abstract::Ferroelectric-relaxor behavior of Ba(Zr0.3Ti0.7)O3 nanofibers (BZT NF) with a large aspect ratio were prepared via electrospinning and surface modified by PVP as dielectric fillers. The nanocomposite flexible films based on surface modified BZT NF and polyvinylidene fluoride (PVDF) were fabricated via a solution casti...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26198
更新日期:2016-05-17 00:00:00
abstract::Known γ-secretase inhibitors or modulators display an undesirable pharmacokinetic profile and toxicity and have therefore not been successful in clinical trials for Alzheimer's disease (AD). So far, no compounds from natural products have been identified as direct inhibitors of γ-secretase. To search for bioactive mol...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16541
更新日期:2015-11-16 00:00:00
abstract::Reef coral assemblages are highly dynamic and subject to repeated disturbances, which are predicted to increase in response to climate change. Consequently there is an urgent need to improve our understanding of the mechanisms underlying different recovery scenarios. Recent work has demonstrated that reef structural c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02402-y
更新日期:2017-05-22 00:00:00
abstract::Glaucoma is a leading cause of irreversible vision loss predicted to affect more than 100 million people by 2040. Intraocular pressure (IOP) reduction prevents development of glaucoma and vision loss from glaucoma. Glaucoma surgeries reduce IOP by facilitating aqueous humor outflow through a vent fashioned from the wa...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69687-4
更新日期:2020-07-31 00:00:00
abstract::Increased prostaglandin E2 (PGE2) levels were detected in mitochondrial disease patient cells harboring nuclear gene mutations in structural subunits of complex I, using a metabolomics screening approach. The increased levels of this principal inflammation mediator normalized following exposure of KH176m, an active re...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-79466-w
更新日期:2021-01-13 00:00:00
abstract::To investigate changes in the size of the population of patients who are receiving long-term, active treatment for neovascular age-related macular degeneration (AMD). This retrospective, observational study included 18,165 patients who received anti-vascular endothelial growth factor injections (3,974 eyes). The injec...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49749-y
更新日期:2019-09-13 00:00:00
abstract::Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...
journal_title:Scientific reports
pub_type: 杂志文章,多中心研究
doi:10.1038/s41598-019-51522-0
更新日期:2019-10-18 00:00:00
abstract::Speckle, amplitude fluctuations in optical coherence tomography (OCT) images, contains information on sub-resolution structural properties of the imaged sample. Speckle statistics could therefore be utilized in the characterization of biological tissues. However, a rigorous theoretical framework relating OCT speckle s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-14115-3
更新日期:2017-11-01 00:00:00
abstract::Dinosaurs thrived and reproduced in various regions worldwide, including the Arctic. In order to understand their nesting in diverse or extreme environments, the relationships between nests, nesting environments, and incubation methods in extant archosaurs were investigated. Statistical analyses reveal that species of...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-018-21386-x
更新日期:2018-03-15 00:00:00
abstract::Network structure has often proven to be important in understanding the decision behavior of individuals or agents in different interdependent situations. Computational studies predict that network structure has a crucial influence on behavior in iterated 2 by 2 asymmetric 'battle of the sexes' games. We test such beh...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43260-0
更新日期:2019-05-02 00:00:00