Controllable design of super-oscillatory lenses with multiple sub-diffraction-limit foci.

abstract：:Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the unavoidable exposure to external radiation sources, our knowledge regarding the radiosensitivity of human blood cell populations is limited and published data, obtained under different experimental conditions, are heterogeneous. To ...

journal_title：Scientific reports

authors： Heylmann D,Ponath V,Kindler T,Kaina B

更新日期：2021-01-28 00:00:00

abstract：:Euphausia pacifica is a good candidate for a resource of marine n-3 PUFA. However, few reports exist of the lipid and fatty acid composition of E. pacifica. To examine the potential of E. pacifica as a resource of marine n-3 PUFA, we analyzed E. pacifica oil. We extracted lipids from E. pacifica harvested from the Pac...

journal_title：Scientific reports

authors： Yamada H,Yamazaki Y,Koike S,Hakozaki M,Nagahora N,Yuki S,Yano A,Tsurumi K,Okumura T

更新日期：2017-08-30 00:00:00

abstract：:Immune-evasion and immune checkpoints are promising new therapeutic targets for several cancer entities. In ovarian cancer, the clinical role of programmed cell death receptor ligand 1 (PD-L1) expression as mechanism to escape immune recognition has not been clarified yet. We analyzed PD-L1 expression of primary ovari...

journal_title：Scientific reports

authors： Aust S,Felix S,Auer K,Bachmayr-Heyda A,Kenner L,Dekan S,Meier SM,Gerner C,Grimm C,Pils D

更新日期：2017-03-07 00:00:00

abstract：:Advances in Big Data make it possible to make short-term forecasts for market trends from previously unexplored sources. Trading strategies were recently developed by exploiting a link between the online search activity of certain terms semantically related to finance and market movements. Here we build on these earli...

journal_title：Scientific reports

authors： Zhong X,Raghib M

更新日期：2019-09-18 00:00:00

abstract：:The stria vascularis (SV) in the cochlea generates and maintains the endocochlear potential, thereby playing a pivotal role in normal hearing. Knowing transcriptional profiles and gene regulatory networks of SV cell types establishes a basis for studying the mechanism underlying SV-related hearing loss. While we have ...

journal_title：Scientific reports

authors： Gu S,Olszewski R,Taukulis I,Wei Z,Martin D,Morell RJ,Hoa M

更新日期：2020-10-22 00:00:00

abstract：:Increasingly researchers are looking to bring together perspectives across multiple scales, or to combine insights from different techniques, for the same region of interest. To this end, correlative microscopy has already yielded substantial new insights in two dimensions (2D). Here we develop correlative tomography ...

journal_title：Scientific reports

authors： Burnett TL,McDonald SA,Gholinia A,Geurts R,Janus M,Slater T,Haigh SJ,Ornek C,Almuaili F,Engelberg DL,Thompson GE,Withers PJ

更新日期：2014-04-16 00:00:00

abstract：:A new, efficient method based on a series of matrices is introduced to completely describe the detailed topology of individual domains and their topology evolution in three-dimensional cellular structures. With this approach, we found a lot of new topological grain forms which are never reported before, i.e., there ar...

journal_title：Scientific reports

authors： Xue W,Wang H,Liu G,Meng L,Xiang S,Ma G,Li W

更新日期：2016-05-10 00:00:00

abstract：:Optical measurement of membrane potentials enables fast, direct and simultaneous detection of membrane potentials from a population of neurons, providing a desirable approach for functional analysis of neuronal circuits. Here, we applied recently developed genetically encoded voltage indicators, ASAP1 (Accelerated Sen...

journal_title：Scientific reports

authors： Miyazawa H,Okumura K,Hiyoshi K,Maruyama K,Kakinuma H,Amo R,Okamoto H,Yamasu K,Tsuda S

更新日期：2018-04-16 00:00:00

abstract：:Better risk prediction and new molecular targets are key priorities in type 2 diabetes (T2D) research. Little is known about the role of the urine metabolome in predicting the risk of T2D. We aimed to use non-targeted urine metabolomics to discover biomarkers and improve risk prediction for T2D. Urine samples from two...

journal_title：Scientific reports

authors： Salihovic S,Broeckling CD,Ganna A,Prenni JE,Sundström J,Berne C,Lind L,Ingelsson E,Fall T,Ärnlöv J,Nowak C

更新日期：2020-10-05 00:00:00

abstract：:It is now well established that invasive plants may induce drifts in the quantity and/or quality of floral resources. They are then often pointed out as a potential driver of bee decline. However, their impact on bee population remains quite unclear and still controversial, as bee responses are highly variable among s...

journal_title：Scientific reports

authors： Drossart M,Michez D,Vanderplanck M

更新日期：2017-11-24 00:00:00

abstract：:Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the fermentation of non-digestible fibre can communicate from the microbiome to host tissues and modulate homeostasis in mammals. The microbiome has circadian rhythmicity and helps the host circadian clock function. We investigated the ef...

journal_title：Scientific reports

authors： Tahara Y,Yamazaki M,Sukigara H,Motohashi H,Sasaki H,Miyakawa H,Haraguchi A,Ikeda Y,Fukuda S,Shibata S

更新日期：2018-01-23 00:00:00

abstract：:Spatial organization of G-protein coupled receptors (GPCRs) into dimers and higher order oligomers has been demonstrated in vitro and in vivo. The pharmacological readout was shown to depend on the specific interfaces, but why particular regions of the GPCR structure are involved, and how ligand-determined states chan...

journal_title：Scientific reports

authors： Mondal S,Johnston JM,Wang H,Khelashvili G,Filizola M,Weinstein H

更新日期：2013-10-09 00:00:00

abstract：:Gut dysbiosis contributes to the development of a dysfunctional gut barrier, facilitating the translocation of bacteria and inflammagens, and is implicated in colorectal cancer (CRC) pathogenesis. Such 'leaky gut' conditions result in systemic inflammation, of which a hallmark is increased hypercoagulability. Fluoresc...

journal_title：Scientific reports

authors： de Waal GM,de Villiers WJS,Forgan T,Roberts T,Pretorius E

更新日期：2020-05-29 00:00:00

abstract：:The nuclear disaster at the Fukushima Daiichi Nuclear Power Plant (FDNPP) in March 2011 caused partial meltdowns of three reactors. During the meltdowns, a type of condensed particle, a caesium-rich micro-particle (CsMP), formed inside the reactors via unknown processes. Here we report the chemical and physical proces...

journal_title：Scientific reports

authors： Furuki G,Imoto J,Ochiai A,Yamasaki S,Nanba K,Ohnuki T,Grambow B,Ewing RC,Utsunomiya S

更新日期：2017-02-15 00:00:00

abstract：:Ovarian cancer (OC) is the most lethal gynecological carcinoma due to the lack of diagnostic markers and effective drug targets. Discovery of new therapeutic targets in OC to improve the treatment outcome is urgently needed. We performed proteomic analysis of OC specimens and the paired normal tissues and revealed tha...

journal_title：Scientific reports

authors： Guo J,Li X,Zhang W,Chen Y,Zhu S,Chen L,Xu R,Lv Y,Wu D,Guo M,Liu X,Lu W,Deng H

更新日期：2019-09-02 00:00:00

abstract：:Two polar vessels, Akademik Shokalskiy and Xuelong, were trapped by thick sea ice in the Antarctic coastal region just to the west of 144°E and between 66.5°S and 67°S in late December 2013. This event demonstrated the rapid establishment of extreme Antarctic sea ice conditions on synoptic time scales. The event was a...

journal_title：Scientific reports

authors： Wang Z,Turner J,Sun B,Li B,Liu C

更新日期：2014-06-17 00:00:00

abstract：:Bacterial outer membrane lipopolysaccharide (LPS) potently stimulates the mammalian innate immune system, and can lead to sepsis, the primary cause of death from infections. LPS is sensed by Toll-like receptor 4 (TLR4) in complex with its lipid-binding coreceptor MD-2, but subtle structural variations in LPS can profo...

journal_title：Scientific reports

authors： Paramo T,Tomasio SM,Irvine KL,Bryant CE,Bond PJ

更新日期：2015-12-09 00:00:00

abstract：:The Sansha Yongle Blue Hole (SYBH) is the deepest blue hole found anywhere to date. Study of the SYBH can provide insight into the interactions between hole wall morphology and many geological/hydrological mechanisms. A comprehensive investigation of the SYBH was carried out for the first time in 2017 using a professi...

journal_title：Scientific reports

authors： Li T,Feng A,Liu Y,Li Z,Guo K,Jiang W,Du J,Tian Z,Xu W,Liu Y,Wang Y

更新日期：2018-11-20 00:00:00

abstract：:Photoreceptor cell death is the ultimate process underlying many retinal diseases, including retinal detachment (RD). Both autophagy and inflammatory factors, such as tumor necrosis factor-alpha (TNF-α), participate in photoreceptor cell death after RD. In this study, we examined whether TNF-α inhibition would impact ...

journal_title：Scientific reports

authors： Xie J,Zhu R,Peng Y,Gao W,Du J,Zhao L,Chi Y,Yang L

更新日期：2017-12-07 00:00:00

abstract：:The role of orbital differentiation on the emergence of superconductivity in the Fe-based superconductors remains an open question to the scientific community. In this investigation, we employ a suitable microscopic spin probe technique, namely Electron Spin Resonance (ESR), to investigate this issue on selected chemi...

journal_title：Scientific reports

authors： Rosa PF,Adriano C,Garitezi TM,Grant T,Fisk Z,Urbano RR,Pagliuso PG

更新日期：2014-10-08 00:00:00

abstract：:Leaf nutrient resorption is an important mechanism in adapting to adverse environments. However, few studies examine how nutrient resorption responds to phosphorus (P) and potassium (K) fertilization or to a shift in nutrient limitation due to water supply and fertilization. On the Loess Plateau of China, we treated l...

journal_title：Scientific reports

authors： Yang M,Lu J,Liu M,Lu Y,Yang H

更新日期：2020-06-29 00:00:00

abstract：:Soil moisture is an important variable for land-climate and hydrological interactions. To investigate emergent large-scale, long-term interactions between soil moisture and other key hydro-climatic variables (precipitation, actual evapotranspiration, runoff, temperature), we analyze monthly values and anomalies of the...

journal_title：Scientific reports

authors： Ghajarnia N,Kalantari Z,Orth R,Destouni G

更新日期：2020-03-16 00:00:00

abstract：:The graft-versus-leukemia effect reminds us to observe the allogeneic cell elicited anti-tumor immune responses. Here we immunized recipient B6 mice with different types of allogenic leukocytes and found that vaccination with allogenic dendritic cells (alloDC) elicited the most efficient protection against broad-spect...

journal_title：Scientific reports

authors： Wang C,Li Z,Zhu Z,Chai Y,Wu Y,Yuan Z,Chang Z,Wang Z,Zhang M

更新日期：2019-10-29 00:00:00

abstract：:The role of the smoothelin-like 1 (SMTNL1) protein in mediating vascular smooth muscle contractile responses to intraluminal pressure was examined in resistance vessels. Mesenteric arterioles from wild type (WT) and SMTNL1 global knock-out (KO) mice were examined with pressure myography. SMTNL1 deletion was associated...

journal_title：Scientific reports

authors： Turner SR,Chappellaz M,Popowich B,Wooldridge AA,Haystead TAJ,Cole WC,MacDonald JA

更新日期：2019-01-24 00:00:00

abstract：:Elastic waves are guided along finite structures such as cylinders, plates, or rods through reflection, refraction, and mode conversion at the interfaces. Such wave propagation is ubiquitous in the world around us, and studies of elastic waveguides first emerged in the later part of the 19(th) century. Early work on e...

journal_title：Scientific reports

authors： Philippe FD,Murray TW,Prada C

更新日期：2015-06-08 00:00:00

abstract：:Angiogenin (hANG), a member of the Ribonuclease A superfamily has angiogenic, neurotrophic and neuroprotective activities. Mutations in hANG have been found in patients with Amyotrophic lateral sclerosis (ALS). The zebrafish (Danio rerio) rnasel-1, 2 and 3 are orthologues of hANG and of these only Rnasel-1 and Rnasel-...

journal_title：Scientific reports

authors： Ferguson R,Holloway DE,Chandrasekhar A,Acharya KR,Subramanian V

更新日期：2019-02-01 00:00:00

abstract：:The incidence of ovarian cancer dramatically increases in early menopause but the factors contributing to cancer onset are unclear. Most ovarian cancers originate in the fallopian tube with subsequent implantation of malignant cells into the ovary. However, the events and conditions that lead to cancer cell implantati...

journal_title：Scientific reports

authors： Jia D,Nagaoka Y,Katsumata M,Orsulic S

更新日期：2018-08-17 00:00:00

abstract：:A variety of animals use Earth's magnetic field as a reference for their orientation behaviour. Although distinctive magnetoreception mechanisms have been postulated for many migrating or homing animals, the molecular mechanisms are still undefined. In this study, we found that zebrafish, a model organism suitable for...

journal_title：Scientific reports

authors： Takebe A,Furutani T,Wada T,Koinuma M,Kubo Y,Okano K,Okano T

更新日期：2012-01-01 00:00:00

abstract：:Resistance of cancer cells to radiotherapy is a major clinical problem in cancer treatment. Therefore, understanding the molecular basis of cellular resistance to radiotherapy and identification of novel targets are essential for improving treatment efficacy for cancer patients. Our previous studies have demonstrated ...

journal_title：Scientific reports

authors： Chen S,Zhang Y,Zhang D

更新日期：2015-09-30 00:00:00

abstract：:Metformin is one of the treatments used for PCOS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin's effects on lipid metabolism, a crucial process in PCOS pathology. We have employed a lipidomic approach to explore alterations in the plasma...

journal_title：Scientific reports

authors： Pradas I,Rovira-Llopis S,Naudí A,Bañuls C,Rocha M,Hernandez-Mijares A,Pamplona R,Victor VM,Jové M

更新日期：2019-11-05 00:00:00