Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens.

abstract：:WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H d...

journal_title：Scientific reports

authors： Zhu J,Vasilopoulou M,Davazoglou D,Kennou S,Chroneos A,Schwingenschlögl U

更新日期：2017-01-18 00:00:00

abstract：:Mitochondrial activity is central to tissue homeostasis. Mitochondria dysfunction constitutes a hallmark of many genetic diseases and plays a key role in tumor progression. The essential role of mitochondria, added to their recently documented capacity to transfer from cell to cell, obviously contributes to their curr...

journal_title：Scientific reports

authors： Caicedo A,Fritz V,Brondello JM,Ayala M,Dennemont I,Abdellaoui N,de Fraipont F,Moisan A,Prouteau CA,Boukhaddaoui H,Jorgensen C,Vignais ML

更新日期：2015-03-13 00:00:00

abstract：:The macroscopically ordered structure of rod-like nanoapatites within the collagen matrix is of great significance for the mechanical performance of bones and teeth. However, the synthesis of macroscopically ordered nanoapatite remains a challenge. Inspired by the effect of citrate molecules on apatite crystals in nat...

journal_title：Scientific reports

authors： Tan J,Jin X,Chen M

更新日期：2019-01-24 00:00:00

abstract：:Temperature-modulated space-charge-limited-current spectroscopy (TMSCLC) is applied to quantitatively evaluate the density of trap states in the band-gap with high energy resolution of semiconducting hybrid lead halide perovskite single crystals. Interestingly multicomponent deep trap states were observed in the pure ...

journal_title：Scientific reports

authors： Pospisil J,Zmeskal O,Nespurek S,Krajcovic J,Weiter M,Kovalenko A

更新日期：2019-03-04 00:00:00

abstract：:To assess the response of lichen elemental compositions to road traffic and species difference in the context of high dust input and anthropogenic emissions, two foliose epiphytic lichens (Phaeophyscia hirtuosa, PHh; Candelaria fibrosa, CAf) were sampled near a road adjacent to Dolon Nor Town (Duolun County, Inner Mon...

journal_title：Scientific reports

authors： Liu HJ,Wang JG,Xia Y,Yang MJ,Liu SW,Zhao LC,Guo XP,Jiang YJ,Li X,Wu QF,Fang SB

更新日期：2017-07-17 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Seki H,Ogihara N,Kokubo T,Suda Y,Ishii K,Nagura T

更新日期：2020-02-19 00:00:00

abstract：:In many human cancers, including hepatocellular carcinoma (HCC), high density of infiltrating tumor-associated macrophages (TAM) is associated with poor prognosis. Most TAMs express a M2 phenotype subsequently supporting tumor growth. How tumor cells polarize these TAMs to a pro-tumor M2 phenotype is still poorly unde...

journal_title：Scientific reports

authors： Shiau DJ,Kuo WT,Davuluri GVN,Shieh CC,Tsai PJ,Chen CC,Lin YS,Wu YZ,Hsiao YP,Chang CP

更新日期：2020-08-12 00:00:00

abstract：:Clarifying the fundamental adsorption and diffusion process of CO2 on single crystal ZnO surfaces is critical in understanding CO2 activation and transformation over ZnO-based catalysts. By using ultrahigh vacuum-Fourier transform infrared spectroscopy (UHV-FTIRS), we observed the fine structures of CO2 vibrational ba...

journal_title：Scientific reports

authors： Cao Y,Yu M,Qi S,Wang T,Huang S,Hu S,Xu M,Yan S

更新日期：2017-03-06 00:00:00

abstract：:Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine...

journal_title：Scientific reports

authors： Guo X,Li D,Chen M,Chen L,Zhang B,Wu T,Guo R

更新日期：2016-10-12 00:00:00

abstract：:Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are desirable for diabetes, especially in patients with overweight/obesity. We aimed to determine whether GLP-1RAs exhibit different glucose-lowering efficacies between Asian type 2 diabetes (T2D) patients with and without overweight/obesity. Randomized controlled t...

journal_title：Scientific reports

authors： Zhang F,Tang L,Zhang Y,Lü Q,Tong N

更新日期：2017-11-22 00:00:00

abstract：:Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most conventional alginate microencapsulation systems are associated with low mechanical stability and protrusion of cells which is associated with...

journal_title：Scientific reports

authors： Bhujbal SV,de Haan B,Niclou SP,de Vos P

更新日期：2014-10-31 00:00:00

abstract：:Telomere length (TL) is linked to various age-related diseases, but little is known about telomeres in gestational diabetes mellitus (GDM). We surveyed 509 subjects (113 GDM patients and 396 frequency matched controls) in Nanjing Drum Tower Hospital, Jiangsu province of eastern China. Relative telomere length (RTL) of...

journal_title：Scientific reports

authors： Weng Q,Deng K,Wu F,Gan M,Li J,Dai Y,Jiang Y,Chen J,Dai J,Ma H,Hu Z,Shen H,Du J,Hu Y,Jin G

更新日期：2019-06-11 00:00:00

abstract：:This work presents a new method for assisting in the identification process of missing persons in several contexts, such as enforced disappearances. We apply a Bayesian technique to incorporate non-genetic variables in the construction of prior information. In that way, we can learn from the already-solved cases of a ...

journal_title：Scientific reports

authors： Caridi I,Alvarez EE,Somigliana C,Puerto MS

更新日期：2020-03-19 00:00:00

abstract：:Are you walking at me? Biological movement and the encoding of its motion and orientation. A person's motion conveys a wealth of information that ranges from the complex, such as intention or emotional state, to the simple, such as direction of locomotion. How we recognise and recover people's motion is addressed by m...

journal_title：Scientific reports

authors： Benton CP,Thirkettle M,Scott-Samuel NE

更新日期：2016-02-29 00:00:00

abstract：:Increased connectivity with the mainland has led to the arrival of many invasive species to the Galápagos Islands, including novel pathogens, threatening the archipelago's unique fauna. Here we consider the potential role of the mosquito Aedes taeniorhynchus in maintaining the flavivirus West Nile virus [WNV] should i...

journal_title：Scientific reports

authors： Eastwood G,Goodman SJ,Cunningham AA,Kramer LD

更新日期：2013-01-01 00:00:00

abstract：:Gapmer antisense oligonucleotides cleave target RNA effectively in vivo, and is considered as promising therapeutics. Especially, gapmers modified with locked nucleic acid (LNA) shows potent knockdown activity; however, they also cause hepatotoxic side effects. For developing safe and effective gapmer drugs, a deeper ...

journal_title：Scientific reports

authors： Kasuya T,Hori S,Watanabe A,Nakajima M,Gahara Y,Rokushima M,Yanagimoto T,Kugimiya A

更新日期：2016-07-27 00:00:00

abstract：:Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investiga...

journal_title：Scientific reports

authors： Won E,Kang J,Choi S,Kim A,Han KM,Yoon HK,Cho SH,Tae WS,Lee MS,Joe SH,Kim YK,Ham BJ

更新日期：2017-08-29 00:00:00

abstract：:The Japanese murrelet (Synthliboramphus wumizusume) is an endangered small seabird species in Japan. Molecular sexing using PCR targeting of the gene encoding chromodomain helicase DNA-binding protein 1(CHD1) has been used for sex identification. Specifically, PCR using any of three commonly used primer sets (CHD1F/1R...

journal_title：Scientific reports

authors： Hatakeyama H,Nakamura Y,Konaka T,Nishida S,Kriangwanich W,Uematsu K,Tsuchida S

更新日期：2020-05-22 00:00:00

abstract：:The anterior chamber of the eye (ACE) has emerged as a promising clinical islet transplantation site because of its multiple advantages over the conventional intra-hepatic portal site. This includes reduced surgical invasiveness and increased islet graft survival rate. It also allows for enhanced accessibility and mon...

journal_title：Scientific reports

authors： Fan Y,Zheng X,Ali Y,Berggren PO,Loo SCJ

更新日期：2019-03-08 00:00:00

abstract：:2D transition metal dichalcogenides (TMDs) have attracted a lot of attention recently for energy-efficient tunneling-field-effect transistor (TFET) applications due to their excellent gate control resulting from their atomically thin dimensions. However, most TMDs have bandgaps (Eg) and effective masses (m(*)) outside...

journal_title：Scientific reports

authors： Ameen TA,Ilatikhameneh H,Klimeck G,Rahman R

更新日期：2016-06-27 00:00:00

abstract：:The lack of bone morphological markers associated with the human control of wild animals has prevented the documentation of incipient animal domestication in archaeology. Here, we assess whether direct environmental changes (i.e. mobility reduction) could immediately affect ontogenetic changes in long bone structure, ...

journal_title：Scientific reports

authors： Harbers H,Zanolli C,Cazenave M,Theil JC,Ortiz K,Blanc B,Locatelli Y,Schafberg R,Lecompte F,Baly I,Laurens F,Callou C,Herrel A,Puymerail L,Cucchi T

更新日期：2020-11-04 00:00:00

abstract：:Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell contractility, and focal adhesion formation. Alteration in energy metabolism is a known characteristic of cancer cells (i.e., Warburg effect) and modulates cell invasion. There is little evidence to show if collagen density can alter can...

journal_title：Scientific reports

authors： Mah EJ,Lefebvre AEYT,McGahey GE,Yee AF,Digman MA

更新日期：2018-11-20 00:00:00

abstract：:One key ability of human brain is invariant object recognition, which refers to rapid and accurate recognition of objects in the presence of variations such as size, rotation and position. Despite decades of research into the topic, it remains unknown how the brain constructs invariant representations of objects. Prov...

journal_title：Scientific reports

authors： Karimi-Rouzbahani H,Bagheri N,Ebrahimpour R

更新日期：2017-10-31 00:00:00

abstract：:Studies of tumor models using syngeneic transplantation have advanced our understanding of tumor immunity, including both immune surveillance and evasion. Murine mammary carcinoma 4T1 cells secrete immunosuppressive soluble factors as demonstrated in splenocyte culture. Cultured primary splenocytes secrete IFN-γ, whic...

journal_title：Scientific reports

authors： Kano A

更新日期：2015-03-09 00:00:00

abstract：:Hfq is a pleiotropic regulator that mediates several aspects of bacterial RNA metabolism. The protein notably regulates translation efficiency and RNA decay in Gram-negative bacteria, usually via its interaction with small regulatory RNA. Besides these RNA-related functions, Hfq has also been described as one of the n...

journal_title：Scientific reports

authors： Malabirade A,Partouche D,El Hamoui O,Turbant F,Geinguenaud F,Recouvreux P,Bizien T,Busi F,Wien F,Arluison V

更新日期：2018-11-14 00:00:00

abstract：:The human genome is persistently exposed to damage caused by xenobiotics, therefore the assessment of genotoxicity of substances having a direct contact with humans is of importance. Phthalates are commonly used in industrial applications. Widespread exposure to phthalates has been evidenced by their presence in human...

journal_title：Scientific reports

authors： Sicińska P,Mokra K,Wozniak K,Michałowicz J,Bukowska B

更新日期：2021-01-18 00:00:00

abstract：:Poorer liver function is positively associated with diabetes in Mendelian randomization (MR) studies. Observationally, adiposity is associated with poorer liver function. To clarify the etiology, we assessed the association of liver enzymes with adiposity observationally and using two-sample MR for validation. In the ...

journal_title：Scientific reports

authors： Liu J,Au Yeung SL,Kwok MK,Leung JYY,Lin SL,Hui LL,Leung GM,Schooling CM

更新日期：2019-11-14 00:00:00

abstract：:Drug interaction analysis, which reports the extent to which the presence of one drug affects the efficacy of another, is a powerful tool to select potent combinatorial therapies and predict connectivity between cellular components. Combinatorial effects of drug pairs often vary even for drugs with similar mechanism o...

journal_title：Scientific reports

authors： Weinstein ZB,Zaman MH

更新日期：2017-02-16 00:00:00

abstract：:Bovine TB (bTB) is endemic in Irish cattle and has eluded eradication despite considerable expenditure, amid debate over the relative roles of badgers and cattle in disease transmission. Using a comprehensive dataset from Northern Ireland (>10,000 km(2); 29,513 cattle herds), we investigated interactions between host ...

journal_title：Scientific reports

authors： Wright DM,Reid N,Ian Montgomery W,Allen AR,Skuce RA,Kao RR

更新日期：2015-08-17 00:00:00

abstract：:Systemic lupus erythematosus (SLE) features a decreased pool of CD4+CD25+Foxp3+ T regulatory (Treg) cells. We had previously observed NKG2D+CD4+ T cell expansion in contrast to a decreased pool of Treg cells in SLE patients, but whether NKG2D+CD4+ T cells contribute to the decreased Treg cells remains unclear. In the ...

journal_title：Scientific reports

authors： Yang D,Tian Z,Zhang M,Yang W,Tang J,Wu Y,Ni B

更新日期：2017-04-28 00:00:00