Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene.

abstract：:Resistance of cancer cells to radiotherapy is a major clinical problem in cancer treatment. Therefore, understanding the molecular basis of cellular resistance to radiotherapy and identification of novel targets are essential for improving treatment efficacy for cancer patients. Our previous studies have demonstrated ...

journal_title：Scientific reports

authors： Chen S,Zhang Y,Zhang D

更新日期：2015-09-30 00:00:00

abstract：:Many neurological disorders of gluten-related diseases (GRD), not directly referable to the gastrointestinal tract, have been reported in association with celiac disease (CD), including ataxia, neuropathy and epilepsy. In particular, people with epilepsy diagnosed with CD seems to be characterized by intractable seizu...

journal_title：Scientific reports

authors： Gerace E,Resta F,Landucci E,Renzi D,Masi A,Pellegrini-Giampietro DE,Calabrò A,Mannaioni G

更新日期：2017-11-09 00:00:00

abstract：:We investigated clinical associations of ficolins and mannose-binding lectin (MBL) in 157 patients suffering from acute myeloid leukaemia (AML). Concentrations of ficolin-1, ficolin-2, ficolin-3 and MBL (before chemotherapy) in serum were determined as were selected polymorphisms of the corresponding genes (FCN1, FCN2...

journal_title：Scientific reports

authors： Sokołowska A,Świerzko AS,Gajek G,Gołos A,Michalski M,Nowicki M,Szala-Poździej A,Wolska-Washer A,Brzezińska O,Wierzbowska A,Jamroziak K,Kowalski ML,Thiel S,Matsushita M,Jensenius JC,Cedzyński M

更新日期：2020-06-29 00:00:00

abstract：:Axonal injury is a common feature of central nervous system insults that culminates with the death of the affected neurons, and an irreversible loss of function. Inflammation is an important component of the neurodegenerative process, where the microglia plays an important role by releasing proinflammatory factors as ...

journal_title：Scientific reports

authors： Nadal-Nicolás FM,Galindo-Romero C,Valiente-Soriano FJ,Barberà-Cremades M,deTorre-Minguela C,Salinas-Navarro M,Pelegrín P,Agudo-Barriuso M

更新日期：2016-12-08 00:00:00

abstract：:Gene expression regulation is a complex and highly organized process involving a variety of genomic factors. It is widely accepted that differences in gene expression can contribute to the phenotypic variability between species, and that their interpretation can aid in the understanding of the physiologic variability....

journal_title：Scientific reports

authors： Dweep H,Kubikova N,Gretz N,Voskarides K,Felekkis K

更新日期：2015-07-16 00:00:00

abstract：:FMS-like Tyrosine Kinase 3 (FLT3) is a clinically validated target for acute myeloid leukemia (AML). Inhibitors targeting FLT3 have been evaluated in clinical studies and have exhibited potential to treat FLT3-driven AML. A frequent, clinical limitation is FLT3 selectivity, as concomitant inhibition of FLT3 and c-KIT ...

journal_title：Scientific reports

authors： Bharate JB,McConnell N,Naresh G,Zhang L,Lakkaniga NR,Ding L,Shah NP,Frett B,Li HY

更新日期：2018-02-27 00:00:00

abstract：:Carbon-based nanomaterials such as single-walled carbon nanotubes and reduced graphene oxide are currently being evaluated for biomedical applications including in vivo drug delivery and tumor imaging. Several reports have studied the toxicity of carbon nanomaterials, but their effects on human male reproduction have ...

journal_title：Scientific reports

authors： Asghar W,Shafiee H,Velasco V,Sah VR,Guo S,El Assal R,Inci F,Rajagopalan A,Jahangir M,Anchan RM,Mutter GL,Ozkan M,Ozkan CS,Demirci U

更新日期：2016-08-19 00:00:00

abstract：:Mitigating climate change effects involves strategic decisions by individuals that may choose to limit their emissions at a cost. Everyone shares the ensuing benefits and thereby individuals can free ride on the effort of others, which may lead to the tragedy of the commons. For this reason, climate action can be conv...

journal_title：Scientific reports

authors： Góis AR,Santos FP,Pacheco JM,Santos FC

更新日期：2019-11-07 00:00:00

abstract：:This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according...

journal_title：Scientific reports

authors： Liang B,Xie L,Yang F,Makamure J,Zhang L,Pang R,Du P,Fan W,Zheng C

更新日期：2020-12-14 00:00:00

abstract：:Canalization is a result of intrinsic developmental buffering that ensures phenotypic robustness under genetic variation and environmental perturbation. As a consequence, animal phenotypes are remarkably consistent within a species under a wide range of conditions, a property that seems contradictory to evolutionary c...

journal_title：Scientific reports

authors： Sato A,Kawashima T,Fujie M,Hughes S,Satoh N,Shimeld SM

更新日期：2015-11-18 00:00:00

abstract：:The combination of genome-edited human embryonic stem cells (hESCs) and subsequent neural differentiation is a powerful tool to study neurodevelopmental disorders. Since the naïve state of pluripotency has favourable characteristics for efficient genome-editing, we optimized a workflow for the CRISPR/Cas9 system in th...

journal_title：Scientific reports

authors： Jacobs EZ,Warrier S,Volders PJ,D'haene E,Van Lombergen E,Vantomme L,Van der Jeught M,Heindryckx B,Menten B,Vergult S

更新日期：2017-11-30 00:00:00

abstract：:Although there are many reports on the effect of glucose metabolism on oocyte nuclear maturation, there are few studies on its effect on ooplasmic maturation. By manipulating glucose metabolism pathways using a maturation medium that could support oocyte nuclear maturation but only a limited blastocyst formation witho...

journal_title：Scientific reports

authors： Xie HL,Wang YB,Jiao GZ,Kong DL,Li Q,Li H,Zheng LL,Tan JH

更新日期：2016-02-09 00:00:00

abstract：:The wheat avenin-like proteins (ALP) are considered atypical gluten constituents and have shown positive effects on dough properties revealed using a transgenic approach. However, to date the genetic architecture of ALP genes is unclear, making it impossible to be utilized in wheat breeding. In the current study, thre...

journal_title：Scientific reports

authors： Chen XY,Cao XY,Zhang YJ,Islam S,Zhang JJ,Yang RC,Liu JJ,Li GY,Appels R,Keeble-Gagnere G,Ji WQ,He ZH,Ma WJ

更新日期：2016-08-09 00:00:00

abstract：:A key challenge of central nervous system tumor surgery is to discriminate between brain regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of autofluorescence could potentially be an efficient way to provide reliable information for these regions, we found little information on thi...

journal_title：Scientific reports

authors： Poulon F,Mehidine H,Juchaux M,Varlet P,Devaux B,Pallud J,Abi Haidar D

更新日期：2017-10-25 00:00:00

abstract：:Glucocorticoids (GC) display pleiotropic effects on the immune system. Macrophages are a major target for GC action. Here we show that dexamethasone (DEX), a synthetic GC, decreased viability of naïve bone marrow-derived macrophages (BMDM), involving an apoptotic mechanism. Administration of DEX together with lipopoly...

journal_title：Scientific reports

authors： Haim YO,Unger ND,Souroujon MC,Mittelman M,Neumann D

更新日期：2014-03-10 00:00:00

abstract：:Oryza coarctata (KKLL; 2n = 4x = 48, 665 Mb) also known as Porteresia coarctata is an extreme halophyte species of genus Oryza. Using Illumina and Nanopore reads, we achieved the assembled genome size of 569.9 Mb, accounting 85.69% of the estimated genome size with N50 of 1.85 Mb and 19.89% repetitive region. We also ...

journal_title：Scientific reports

authors： Mondal TK,Rawal HC,Chowrasia S,Varshney D,Panda AK,Mazumdar A,Kaur H,Gaikwad K,Sharma TR,Singh NK

更新日期：2018-09-12 00:00:00

abstract：:Fowl cholera is a serious, highly contagious disease caused by the bacterium Pasteurella multocida (P. multocida) in a range of avian species and is characterized by an acute form of septicaemia. The pathogenic mechanism of chicken lung injury caused by the bacterium is unclear. Therefore, P. multocida Q (a reference ...

journal_title：Scientific reports

authors： Li W,Tang Q,Dai N,Feng W,Xie C,Cheng G,Liu X,Zhang W,Hu X,Gu C

更新日期：2020-04-14 00:00:00

abstract：:Increasingly researchers are looking to bring together perspectives across multiple scales, or to combine insights from different techniques, for the same region of interest. To this end, correlative microscopy has already yielded substantial new insights in two dimensions (2D). Here we develop correlative tomography ...

journal_title：Scientific reports

authors： Burnett TL,McDonald SA,Gholinia A,Geurts R,Janus M,Slater T,Haigh SJ,Ornek C,Almuaili F,Engelberg DL,Thompson GE,Withers PJ

更新日期：2014-04-16 00:00:00

abstract：:As an important method for building blocks synthesis, whole cell biocatalysis is hindered by some shortcomings such as unpredictability of reactions, utilization of opportunistic pathogen, and side reactions. Due to its biological and extensively studied genetic background, Pseudomonas putida KT2440 is viewed as a pro...

journal_title：Scientific reports

authors： Wang Y,Lv M,Zhang Y,Xiao X,Jiang T,Zhang W,Hu C,Gao C,Ma C,Xu P

更新日期：2014-11-06 00:00:00

abstract：:While researches have focused on drag reduction of various coated surfaces such as superhydrophobic structures and polymer brushes, the insights tso understand the fundamental physics of the laminar skin friction coefficient and the related drag reduction due to the formation of finite velocity at porous surfaces is s...

journal_title：Scientific reports

authors： Mirbod P,Wu Z,Ahmadi G

更新日期：2017-12-08 00:00:00

abstract：:Recent technological advances in remote sensing sensors and platforms, such as high-resolution satellite imagers or unmanned aerial vehicles (UAV), facilitate the availability of fine-grained earth observation data. Such data reveal vegetation canopies in high spatial detail. Efficient methods are needed to fully harn...

journal_title：Scientific reports

authors： Kattenborn T,Eichel J,Fassnacht FE

更新日期：2019-11-27 00:00:00

abstract：:In this paper, phosphorene nanoribbons (PNRs) are theoretically studied using a multiscale simulation flow from the ab initio level to the tight binding (TB) level. The scaling effects of both armchair PNRs (aPNRs) and zigzag PNRs (zPNRs) from material properties to device properties are explored. The much larger effe...

journal_title：Scientific reports

authors： Lv Y,Chang S,Huang Q,Wang H,He J

更新日期：2016-11-29 00:00:00

abstract：:We developed a novel, erythropoietin-derived, non-erythropoiesis, cyclic helix B peptide (CHBP) that displays potent renoprotection against acute kidney injury (AKI). To determine the mechanism of CHBP-mediated protection, we investigated the proteomic profile of mice treated with CHBP in a kidney ischemia-reperfusion...

journal_title：Scientific reports

authors： Yang C,Liu J,Li L,Hu M,Long Y,Liu X,Zhu T,Huang X,Zhao S,Liu S,Rong R

更新日期：2015-12-10 00:00:00

abstract：:There is considerable interest in how early life experiences shape behavioural development. For example, the socialisation of unfamiliar pigs pre-weaning has been suggested to decrease aggression during later life. However, the behavioural mechanisms behind this socialisation effect remain unexplored. We allowed 12 li...

journal_title：Scientific reports

authors： Weller JE,Camerlink I,Turner SP,Farish M,Arnott G

更新日期：2019-03-12 00:00:00

abstract：:Early detection of breast cancer and its correct stage determination are important for prognosis and rendering appropriate personalized clinical treatment to breast cancer patients. However, despite considerable efforts and progress, there is a need to identify the specific genomic factors responsible for, or accompan...

journal_title：Scientific reports

authors： Roy S,Kumar R,Mittal V,Gupta D

更新日期：2020-03-05 00:00:00

abstract：:Defects of vitamin B6 metabolism are responsible for severe neurological disorders, such as pyridoxamine 5'-phosphate oxidase deficiency (PNPOD; OMIM: 610090), an autosomal recessive inborn error of metabolism that usually manifests with neonatal-onset severe seizures and subsequent encephalopathy. At present, 27 path...

journal_title：Scientific reports

authors： Barile A,Nogués I,di Salvo ML,Bunik V,Contestabile R,Tramonti A

更新日期：2020-08-12 00:00:00

abstract：:The Vavilov Institute of Plant Genetic Resources (VIR), in St. Petersburg, Russia, houses a unique genebank, with historical collections of landraces. When they were collected, the geographical distribution and genetic diversity of most crops closely reflected their historical patterns of cultivation established over ...

journal_title：Scientific reports

authors： Plekhanova E,Vishnyakova MA,Bulyntsev S,Chang PL,Carrasquilla-Garcia N,Negash K,Wettberg EV,Noujdina N,Cook DR,Samsonova MG,Nuzhdin SV

更新日期：2017-07-06 00:00:00

abstract：:Perceptual decisions are biased by recent perceptual history-a phenomenon termed 'serial dependence.' Here, we investigated what aspects of perceptual decisions lead to serial dependence, and disambiguated the influences of low-level sensory information, prior choices and motor actions. Participants discriminated whet...

journal_title：Scientific reports

authors： Feigin H,Baror S,Bar M,Zaidel A

更新日期：2021-01-12 00:00:00

abstract：:Alternate bearing (AB) refers to the tendency of trees to have an irregular crop load from 1 year (ON) to the next year (OFF). Despite its economic importance, it is not fully understood how gene networks and their related metabolic pathways may influence the irregular bearing in olive trees. To unravel molecular mech...

journal_title：Scientific reports

authors： Dastkar E,Soleimani A,Jafary H,de Dios Alche J,Bahari A,Zeinalabedini M,Salami SA

更新日期：2020-09-25 00:00:00

abstract：:Invasive non-native species have pervasive impacts on native biodiversity, including population extirpations and species extinctions. Identifying reasons why a population of a native species is extirpated following an invasion often relies on literature-based results of anecdotal observations. The well-established sch...

journal_title：Scientific reports

authors： Haubrock PJ,Balzani P,Britton JR,Haase P

更新日期：2020-12-10 00:00:00