Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury.

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Cazanave S,Podtelezhnikov A,Jensen K,Seneshaw M,Kumar DP,Min HK,Santhekadur PK,Banini B,Mauro AG,Oseini AM,Vincent R,Tanis KQ,Webber AL,Wang L,Bedossa P,Mirshahi F,Sanyal AJ

更新日期：2020-05-15 00:00:00

abstract：:To explore the association between methylation of antisense non-coding RNA in the INK4 locus (ANRIL) and coronary artery disease (CAD) development. Methylation levels of ANRIL in 100 subjects with CAD and 100 controls were quantitatively analyzed using Sequenom MassARRAY. Kyoto Encyclopedia of Genes and Genomes (KEGG)...

journal_title：Scientific reports

authors： Zhao CH,Cao HT,Zhang J,Jia QW,An FH,Chen ZH,Li LH,Wang LS,Ma WZ,Yang ZJ,Jia EZ

更新日期：2019-10-25 00:00:00

abstract：:The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na(+))-chloride (Cl(-)) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on expression of NCC in mouse...

journal_title：Scientific reports

authors： Fang YW,Yang SS,Cheng CJ,Tseng MH,Hsu HM,Lin SH

更新日期：2016-01-05 00:00:00

abstract：:Dietary niche width and trophic position are key functional traits describing a consumer's trophic ecology and the role it plays in a community. However, our understanding of the environmental and biological drivers of both traits is predominantly derived from theory or geographically restricted studies and lacks a br...

journal_title：Scientific reports

authors： Hayden B,Palomares MLD,Smith BE,Poelen JH

更新日期：2019-08-06 00:00:00

abstract：:Postmortem diagnosis of cantharidin-induced myocardial injury and postmortem interval estimation (PMI) are the challenges in forensic science. Cardiac biomarkers play an important role in the prediction and diagnosis of myocardial injury and can be used to determine the PMI. Based on the evidence, we aimed to explore ...

journal_title：Scientific reports

authors： Zhang Y,Yu Y,Zhang J,Guan C,Liu L,Ren L

更新日期：2020-07-21 00:00:00

abstract：:Modulation of initial burst and long term release from electrospun fibrous mats can be achieved by sandwiching the drug loaded mats between hydrophobic layers of fibrous polycaprolactone (PCL). Ibuprofen (IBU) loaded PCL fibrous mats (12% PCL-IBU) were sandwiched between fibrous polycaprolactone layers during the proc...

journal_title：Scientific reports

authors： Kamath SM,Sridhar K,Jaison D,Gopinath V,Ibrahim BKM,Gupta N,Sundaram A,Sivaperumal P,Padmapriya S,Patil SS

更新日期：2020-10-23 00:00:00

abstract：:Acquisition of the lower jaw (mandible) was evolutionarily important for jawed vertebrates. In humans, syndromic craniofacial malformations often accompany jaw anomalies. The basic helix-loop-helix transcription factor Hand2, which is conserved among jawed vertebrates, is expressed in the neural crest in the mandibula...

journal_title：Scientific reports

authors： Funato N,Kokubo H,Nakamura M,Yanagisawa H,Saga Y

更新日期：2016-06-22 00:00:00

abstract：:In external radiotherapy (RT), the use of flattening filter-free (FFF) radiation beams obtained by removing the flattening filter (FF) in standard linear accelerators is rapidly increasing, and the benefits of clinical use are the issue of research. Advanced treatment techniques have increased the interest in the oper...

journal_title：Scientific reports

authors： Arslan A,Sengul B

更新日期：2020-06-02 00:00:00

abstract：:The aim of this study was to investigate the characteristics of insulin producing cells (IPCs) differentiated from adipose-tissue derived stem cells (ADSCs) isolated from human subcutaneous and visceral adipose tissues and identify ADSCs suitable for differentiation into efficient and functional IPCs. Subcutaneous and...

journal_title：Scientific reports

authors： Wada Y,Ikemoto T,Morine Y,Imura S,Saito Y,Yamada S,Shimada M

更新日期：2019-09-13 00:00:00

abstract：:Fire-induced permafrost degradation is well documented in boreal forests, but the role of fires in initiating thermokarst development in Arctic tundra is less well understood. Here we show that Arctic tundra fires may induce widespread thaw subsidence of permafrost terrain in the first seven years following the distur...

journal_title：Scientific reports

authors： Jones BM,Grosse G,Arp CD,Miller E,Liu L,Hayes DJ,Larsen CF

更新日期：2015-10-29 00:00:00

abstract：:The yield of pepper plants (Capsicum spp.) is their most important trait and is affected by the flower number and flowering time. Capsicum annuum produces a single flower per node and has an early flowering habit. By contrast, Capsicum chinense yields multiple flowers per node and has a late flowering character. Howev...

journal_title：Scientific reports

authors： Zhu Z,Sun B,Wei J,Cai W,Huang Z,Chen C,Cao B,Chen G,Lei J

更新日期：2019-01-31 00:00:00

abstract：:Pesticides, including neonicotinoids, typically target pest insects by being neurotoxic. Inadvertent exposure to foraging insect pollinators is usually sub-lethal, but may affect cognition. One cognitive trait, spatial working memory, may be important in avoiding previously-visited flowers and other spatial tasks such...

journal_title：Scientific reports

authors： Samuelson EE,Chen-Wishart ZP,Gill RJ,Leadbeater E

更新日期：2016-12-13 00:00:00

abstract：:For the first time, soil core samples from the Jiuquan region have been analyzed for Pu isotopes for radioactive source identification and radiological assessment. The Jiuquan region is in downwind from the Lop Nor Chinese nuclear test (CNT) site. The high Pu inventories (13 to 546 Bq/m(2)) in most of the sampling loc...

journal_title：Scientific reports

authors： Bu W,Ni Y,Guo Q,Zheng J,Uchida S

更新日期：2015-07-17 00:00:00

abstract：:Microinjection is commonly performed to achieve fish transgenesis; however, due to difficulties associated with this technique, new strategies are being developed. Here we evaluate the potential of lentiviral particles to genetically modify Nile tilapia cells to achieve transgenesis using three different approaches: s...

journal_title：Scientific reports

authors： Tonelli FM,Lacerda SM,Procópio MS,Lemos BL,de França LR,Resende RR

更新日期：2017-03-20 00:00:00

abstract：:Colorectal cancer (CRC) is the leading cause of cancer-related mortality worldwide. Although the role of tumor programmed cell death 1 ligand 1 (PD-L1) in suppressing antitumor immunity has been validated in various malignances, the impact of PD-L2 (PD-L2/PDCD1LG2) within tumors remains elusive. Here, we examined tumo...

journal_title：Scientific reports

authors： Huang KC,Chiang SF,Chen TW,Chen WT,Yang PC,Ke TW,Chao KSC

更新日期：2020-12-18 00:00:00

abstract：:Alzheimer's disease (AD), an irreversible progressive neurodegenerative disease, causes characteristic cognitive impairment, and no curative treatments are currently available. Stem cell transplantation offers a powerful tool for the treatment of AD. We conducted a systematic review and meta-analysis of data from cont...

journal_title：Scientific reports

authors： Wang Z,Peng W,Zhang C,Sheng C,Huang W,Wang Y,Fan R

更新日期：2015-07-10 00:00:00

abstract：:Driven diffusive systems have been a paradigm for modelling many physical, chemical, and biological transport processes. In the systems, spatial correlation plays an important role in the emergence of a variety of nonequilibrium phenomena and exhibits rich features such as pronounced oscillations. However, the lack of...

journal_title：Scientific reports

authors： Hao QY,Jiang R,Hu MB,Jia B,Wang WX

更新日期：2016-01-25 00:00:00

abstract：:Tupistra chinensis is widely distributed in southwestern China and its rhizome is a famous folk medicine for the treatment of carbuncles and pharyngitis. Its chemical identity of potent antiproliferative and anti-inflammatory constituents has been carried out in this study. Twenty-three polyhydroxylated spirostanol sa...

journal_title：Scientific reports

authors： Xiang L,Yi X,Wang Y,He X

更新日期：2016-08-17 00:00:00

abstract：:The D40 gene encodes a kinetochore protein that plays an essential role in kinetochore formation during mitosis. Short inhibitory RNA against D40, D40 siRNA, has been shown to deplete the D40 protein in the human cancer cell line HeLa, which harbors wild-type p53, and this activity was followed by the significant inhi...

journal_title：Scientific reports

authors： Urata YN,Takeshita F,Tanaka H,Ochiya T,Takimoto M

更新日期：2015-09-08 00:00:00

abstract：:Dissection of the neural circuits of the cerebral cortex is essential for studying mechanisms underlying brain function. Herein, combining a retrograde rabies tracing system with fluorescent micro-optical sectional tomography, we investigated long-range input neurons of corticotropin-releasing hormone containing neuro...

journal_title：Scientific reports

authors： Zhao P,Zhao M,Wang H,Jiang T,Jia X,Tian J,Li A,Gong H,Li X

更新日期：2020-07-22 00:00:00

abstract：:In order to understand the physical properties of materials it is necessary to determine the 3D positions of all atoms. There has been significant progress towards this goal using electron tomography. However, this method requires a relatively high electron dose and often extended acquisition times which precludes the...

journal_title：Scientific reports

authors： Chen LG,Warner J,Kirkland AI,Chen FR,Van Dyck D

更新日期：2017-09-07 00:00:00

abstract：:A record 500,000 hectares burned in Portugal during the extreme wildfire season of 2017, with more than 120 human lives lost. Here we analyse the climatic factors responsible for the burned area (BA) from June to October series in Portugal for the period 1980-2017. Superposed onto a substantially stationary trend on B...

journal_title：Scientific reports

authors： Turco M,Jerez S,Augusto S,Tarín-Carrasco P,Ratola N,Jiménez-Guerrero P,Trigo RM

更新日期：2019-10-10 00:00:00

abstract：:Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase's solution ensemble. However, this remains challenging due to the immense c...

journal_title：Scientific reports

authors： Sultan MM,Denny RA,Unwalla R,Lovering F,Pande VS

更新日期：2017-11-15 00:00:00

abstract：:We theoretically investigate the problem of finding optimal characteristics of photon pairs, produced in the spontaneous parametric down-conversion (SPDC) process, for fiber-based quantum communication protocols. By using the accessible setup parameters, the pump pulse duration and the extended phase-matching function...

journal_title：Scientific reports

authors： Lasota M,Kolenderski P

更新日期：2020-11-30 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is an X-linked genetic disorder resulting from mutations in the dystrophin gene. The mdx/utrn -/- mouse, lacking in both dystrophin and its autosomal homologue utrophin, is commonly used to model the clinical symptoms of DMD. Interestingly, these mice are infertile but the mechanisms ...

journal_title：Scientific reports

authors： Chen HC,Chin YF,Lundy DJ,Liang CT,Chi YH,Kuo P,Hsieh PCH

更新日期：2017-08-07 00:00:00

abstract：:Echovirus 11 (E-11) is one of the most frequently isolated enteroviruses causing meningitis and other diseases such as hand, foot, and mouth disease (HFMD) and acute flaccid paralysis (AFP). Fifty-nine newly determined E-11 VP1 sequences from the China AFP and HFMD surveillance network and 500 E-11 VP1 sequences obtai...

journal_title：Scientific reports

authors： Li J,Yan D,Chen L,Zhang Y,Song Y,Zhu S,Ji T,Zhou W,Gan F,Wang X,Hong M,Guan L,Shi Y,Wu G,Xu W

更新日期：2019-07-22 00:00:00

abstract：:The aim of this study was to identify novel genetic markers related to coronary artery disease (CAD) using a whole-exome sequencing (WES) approach and determine any associations between the selected gene polymorphisms and CAD prevalence. CUBN, HNF1A and LIPC gene polymorphisms related to CAD susceptibility were identi...

journal_title：Scientific reports

authors： Park HS,Kim IJ,Kim EG,Ryu CS,Lee JY,Ko EJ,Park HW,Sung JH,Kim NK

更新日期：2020-10-01 00:00:00

abstract：:We report an experimental demonstration of positive-negative sub-wavelength interference without correlation. Typically, people can achieve sub-wavelength effects with correlation measurement no matter by using bi-photon or thermal light sources. In this paper, we adopt a thermal light source, and we count the realiza...

journal_title：Scientific reports

authors： Dou LY,Cao DZ,Xu DQ,Zhang AN,Song XB

更新日期：2021-01-28 00:00:00

abstract：:Biological networks play a key role in determining biological function and therefore, an understanding of their structure and dynamics is of central interest in systems biology. In Boolean models of such networks, the status of each molecule is either "on" or "off" and along with the molecules interact with each other...

journal_title：Scientific reports

authors： Chen H,Wang G,Simha R,Du C,Zeng C

更新日期：2016-01-29 00:00:00

abstract：:Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods' effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has ...

journal_title：Scientific reports

authors： Pérez-Pérez A,Lozano M,Romero A,Martínez LM,Galbany J,Pinilla B,Estebaranz-Sánchez F,Bermúdez de Castro JM,Carbonell E,Arsuaga JL

更新日期：2017-02-27 00:00:00