Abstract:
:Resistance of cancer cells to radiotherapy is a major clinical problem in cancer treatment. Therefore, understanding the molecular basis of cellular resistance to radiotherapy and identification of novel targets are essential for improving treatment efficacy for cancer patients. Our previous studies have demonstrated a significant role of ERp29 in breast cancer cell survival against doxorubicin-induced genotoxic stress. We here reported that ERp29 expression in the triple negative MDA-MB-231 breast cancer cells significantly increased cell survival against ionizing radiation. Methylation PCR array analysis identified that ERp29 expression increased promoter hypomethylation of the DNA repair gene, O(6)-methylguanine DNA-methyltransferase (MGMT), by downregulating DNA methyltransferase 1. Knockdown of MGMT in the ERp29-transfected cancer cells increased radiosensitivity, leading to a decreased post-irradiation survival. In addition, radiation treatment in the MGMT-knockdown cells elevated phosphorylation of γ-H2AX and cleavage of caspase 3, indicating that depletion of MGMT facilitates DNA double strands breaks and increases cell apoptosis. Hence, our studies prove a novel function of ERp29\MGMT in cancer cell survival against radiation. Targeting ERp29\MGMT axis may be useful for providing better treatment efficacy in combination with radiotherapy in breast cancer.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen S,Zhang Y,Zhang Ddoi
10.1038/srep14723subject
Has Abstractpub_date
2015-09-30 00:00:00pages
14723issn
2045-2322pii
srep14723journal_volume
5pub_type
杂志文章abstract::The overlap between pain and reward processing pathways leds researchers to hypothesize that there are interactions between them in the human brain. Two hypotheses have been proposed. The "competition hypothesis" posits that reward can reduce pain-related neural activity and vice versa. The "salience hypothesis" sugge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26426
更新日期:2016-05-19 00:00:00
abstract::Metastasis suppressor genes (MS genes) are genes that play important roles in inhibiting the process of cancer metastasis without preventing growth of the primary tumor. Identification of these genes and understanding their functions are critical for investigation of cancer metastasis. Recent studies on cancer metasta...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15478
更新日期:2015-10-21 00:00:00
abstract::Rhodopseudomonas palustris CGA009 is a purple non-sulfur bacterium that can fix carbon dioxide (CO2) and nitrogen or break down organic compounds for its carbon and nitrogen requirements. Light, inorganic, and organic compounds can all be used for its source of energy. Excess electrons produced during its metabolic pr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-49079-z
更新日期:2019-09-02 00:00:00
abstract::In this work, CoMoO4@NiMoO4·xH2O core-shell heterostructure electrode is directly grown on carbon fabric (CF) via a feasible hydrothermal procedure with CoMoO4 nanowires (NWs) as the core and NiMoO4 nanosheets (NSs) as the shell. This core-shell heterostructure could provide fast ion and electron transfer, a large num...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41088
更新日期:2017-01-20 00:00:00
abstract::The mammalian Major Histocompatibility Complex (MHC) region contains several gene families characterized by highly polymorphic loci with extensive nucleotide diversity, copy number variation of paralogous genes, and long repetitive sequences. This structural complexity has made it difficult to construct a reliable ref...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45518
更新日期:2017-03-31 00:00:00
abstract::The L-iduronic acid (IdoA) residue is a critically important structural component in heparan sulphate polysaccharide for the biological functions. The pyranose ring of IdoA is present in (1)C4-chair, (2)SO-skew boat, and less frequently, in (4)C1-chair conformations. Here, we analyzed the conformation of IdoA residue ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29602
更新日期:2016-07-14 00:00:00
abstract::Application of alginate-microencapsulated therapeutic cells is a promising approach for diseases that require a local and constant supply of therapeutic molecules. However most conventional alginate microencapsulation systems are associated with low mechanical stability and protrusion of cells which is associated with...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06856
更新日期:2014-10-31 00:00:00
abstract::Fracture of initially crack-free bodies often occurs due to plastic instabilities known as shear bands. Previous computer simulations advanced a myriad of mechanisms to rationalize shear banding. However, they were restricted to planar geometries. We investigate the relevance of anisotropic plasticity by picking an ax...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-38437-y
更新日期:2019-02-05 00:00:00
abstract::A method is proposed to drive an ultrafast non-adiabatic dynamics of an ultracold gas trapped in a time-dependent box potential. The resulting state is free from spurious excitations associated with the breakdown of adiabaticity, and preserves the quantum correlations of the initial state up to a scaling factor. The p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00648
更新日期:2012-01-01 00:00:00
abstract::Although N-acyl-L-homoserine lactone (AHL) based quorum sensing (QS) phenomenon has been observed in mature anaerobic granules, the biological role of AHL-based QS system in anaerobic granulation process remains unexplored. For the first time, a long-term anaerobic bioreactor was operated for 168 days to investigate t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34183-3
更新日期:2018-10-25 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-75176-5
更新日期:2020-10-28 00:00:00
abstract::Both CC and CXC-class chemokines drive inflammatory disease. Tick salivary chemokine-binding proteins (CKBPs), or evasins, specifically bind subsets of CC- or CXC-chemokines, and could precisely target disease-relevant chemokines. Here we have used yeast surface display to identify two tick evasins: a CC-CKBP, P1243 f...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24568-9
更新日期:2018-04-20 00:00:00
abstract::Male specific DNA sequences were selected from a Diversity Arrays Technology (DArT) mapping study to evaluate their suitability for determination of the sex phenotype among young seedlings in a hop (Humulus lupulus L.) breeding program. Ten male specific DArT markers showed complete linkage with male sex phenotype in ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50400-z
更新日期:2019-10-02 00:00:00
abstract::We report two brothers from a non-consanguineous Irish family presenting with a novel syndrome characterised by intellectual disability, facial dysmorphism, scoliosis and long QT. Their mother has a milder phenotype including long QT. X-linked inheritance was suspected. Whole exome sequencing identified a novel missen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16022
更新日期:2015-11-02 00:00:00
abstract::The Acoustic Complexity Index (ACI) is increasingly applied to the study of biodiversity in aquatic habitats. However, it remains unknown which types of acoustic information are highlighted by this index in underwater environments. This study explored the robustness of the ACI to fine variations in fish sound abundanc...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28771-6
更新日期:2018-07-12 00:00:00
abstract::Adapters bind motor proteins to cargoes and therefore play essential roles in Kinesin-1 mediated intracellular transport. The regulatory mechanisms governing adapter functions and the spectrum of cargoes recognized by individual adapters remain poorly defined. Here, we show that cargoes transported by the Kinesin-1 ad...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep26965
更新日期:2016-06-01 00:00:00
abstract::Omono River virus (OmRV) is a double-stranded RNA virus isolated from Culex mosquitos, and it belongs to a group of unassigned insect viruses that appear to be related to Totiviridae. This paper describes electron cryo-microscopy (cryoEM) structures for the intact OmRV virion to 8.9 Å resolution and the structure of t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep33170
更新日期:2016-09-12 00:00:00
abstract::Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69960-6
更新日期:2020-08-04 00:00:00
abstract::The frontal lobes are essential for human volition and goal-directed behavior, yet their function remains unclear. While various models have highlighted working memory, reinforcement learning, and cognitive control as key functions, a single framework for interpreting the range of effects observed in prefrontal cortex...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21407-9
更新日期:2018-03-01 00:00:00
abstract::Although plants are essentially sessile in nature, these organisms are very much in tune with their environment and are capable of a variety of movements. This may come as a surprise to many non-botanists, but not to Charles Darwin, who reported that plants do produce movements. Following Darwin's specific interest on...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53118-0
更新日期:2019-11-12 00:00:00
abstract::Injection of pure spin current using a nonlocal geometry is a promising method for controlling magnetization in spintronic devices from the viewpoints of increasing freedom in device structure and avoiding problems related to charge current. Here, we report an experimental demonstration of magnetization switching of a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56082-x
更新日期:2019-12-20 00:00:00
abstract::While cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included in the diagnostic criteria, no blood biomarkers are available. Here, we assessed the utility of serum neurofilament light chain (NF-L) and tau protein in comparison to CSF markers (NF-L and phosphorylated...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep38737
更新日期:2016-12-08 00:00:00
abstract::Extracellular vesicles derived from mesenchymal stem cells (MSCs) represent a novel approach for regenerative and immunosuppressive therapy. Recently, cytochalasin B-induced microvesicles (CIMVs) were shown to be effective drug delivery mediators. However, little is known about their immunological properties. We propo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67563-9
更新日期:2020-07-01 00:00:00
abstract::The sex ratio at birth (SRB) may be patterned by maternal condition and/or environmental stressors. However, despite decades of research, empirical results from across the social and biological sciences are equivocal on this topic. Using longitudinal individual-level data from a US population during the interwar perio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45316-7
更新日期:2019-06-21 00:00:00
abstract::To better understand the effects of transient thermal stress in an aquatic insect, we first identified static temperatures associated with fitness deficits, and then reared larvae from egg hatch to adulthood under diurnally variable regimens including daily forays into deleterious temperatures. We sampled mature larva...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-75064-y
更新日期:2020-11-05 00:00:00
abstract::Silver nanowires have attracted much attention for use in flexible transparent conductive films (TCFs) due to their low sheet resistance and flexibility. However, the haze was too high for replacing indium-tin-oxide in high-quality display devices. Herein, we report flexible TCFs, which were prepared using a scalable ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16371
更新日期:2015-11-17 00:00:00
abstract::Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is required to automatically identify regions of fluorescent signal in tw...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08786-1
更新日期:2017-08-21 00:00:00
abstract::An intact cell wall is critical for cellular interactions with the environment and protecting the cell from environmental challenges. Signaling mechanisms are necessary to monitor cell wall integrity and to regulate cell wall production and remodeling during growth and division cycles. The green alga, Chlamydomonas, h...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48523-4
更新日期:2019-08-21 00:00:00
abstract::Lnc2Catlas ( http://lnc2catlas.bioinfotech.org/ ) is an atlas of long noncoding RNAs (lncRNAs) associated with cancer risk. LncRNAs are a class of functional noncoding RNAs with lengths over 200 nt and play a vital role in diverse biological processes. Increasing evidence shows that lncRNA dysfunction is associated wi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20232-4
更新日期:2018-01-30 00:00:00
abstract::Hypoxia-inducible factor (HIF)-1α and HIF-2α play an important role in liver fibrosis. von Hippel-Lindau protein (VHL), a key mediator of HIF-α, regulates fibrosis in an organ- and cell-specific way. In this study, human liver samples were collected from hepatitis C-, alcoholic-, and cholestatic-associated fibrotic an...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep41038
更新日期:2017-01-23 00:00:00