Abstract：
:A key challenge of central nervous system tumor surgery is to discriminate between brain regions infiltrated by tumor cells and surrounding healthy tissue. Although monitoring of autofluorescence could potentially be an efficient way to provide reliable information for these regions, we found little information on this subject, and thus we conducted studies of brain tissue optical properties. This particular study focuses on the different optical quantitative responses of human central nervous system tumors and their corresponding controls. Measurements were performed on different fixed human tumoral and healthy brain samples. Four groups of central nervous system tumors (glioblastoma, diffuse glioma, meningioma and metastasis) were discriminated from healthy brain and meninx control tissues. A threshold value was found for the scattering and absorption coefficient between tumoral and healthy groups. Emission Spectra of healthy tissue had a significant higher intensity than tumoral groups. The redox and optical index ratio were thenn calculated and these also showed significant discrimination. Two fluorescent molecules, NADH and porphyrins, showed distinct lifetim values among the different groups of samples. This study defines several optical indexes that can act as combinated indicators to discriminate healthy from tumoral tissues.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Poulon F,Mehidine H,Juchaux M,Varlet P,Devaux B,Pallud J,Abi Haidar Ddoi
10.1038/s41598-017-14381-1subject
Has Abstractpub_date
2017-10-25 00:00:00pages
13995issue
1issn
2045-2322pii
10.1038/s41598-017-14381-1journal_volume
7pub_type
杂志文章abstract：:Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions. We hypothesized that early nutritional insult would first affect the dynamic responsiveness to nutritional chal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10380-4
更新日期：2017-08-29 00:00:00
abstract：:Functional DNA sub-sequences and genome elements are spatially clustered through the genome just as keywords in literary texts. Therefore, some of the methods for ranking words in texts can also be used to compare different DNA sub-sequences. In analogy with the literary texts, here we claim that the distribution of d...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41543
更新日期：2017-01-27 00:00:00
abstract：:We demonstrate that the propagation path of a surface acoustic wave (SAW), excited with an interdigitated transducer (IDT), can be visualized using a thin liquid film dispensed onto a lithium niobate (LiNbO3) substrate. The practical advantages of this visualization method are its rapid and simple implementation, with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21980
更新日期：2016-02-26 00:00:00
abstract：:The future Internet is very likely the mixture of all-optical Internet with low power consumption and quantum Internet with absolute security guaranteed by the laws of quantum mechanics. Photons would be used for processing, routing and com-munication of data, and photonic transistor using a weak light to control a st...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45582
更新日期：2017-03-28 00:00:00
abstract：:The CRISPR/Cas9 system is widely used to generate gene-edited animals. Here, we developed an efficient system for generating genetically modified mice using maternal Cas9 from Cas9 transgenic mice. Using this system, we achieved lower mosaicism and higher rates of knock-in success, gene-editing, and birth compared to ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57996-7
更新日期：2020-01-23 00:00:00
abstract：:Endovascular methods have been increasingly applied in treating cervicocranial artery dissection (CCAD). Anti-thrombotic therapy, which is used in non-interventional care of CCAD patients, has differential effects in East Asian patients. Therefore, we aimed to compare the clinical outcomes of endovascular versus non-i...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep10474
更新日期：2015-05-20 00:00:00
abstract：:Asymmetric cell division is a ubiquitous feature during the development of higher organisms. Asymmetry is achieved by differential localization or activities of biological molecules such as proteins, and coding and non-coding RNAs. Here, we present subcellular transcriptomic and proteomic analyses along the animal-veg...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-26592-1
更新日期：2018-05-29 00:00:00
abstract：:Metal sulfide (MS, nickel sulfide/copper sulfide) hollow spheres with hierarchical, ultrathin shell structures have been constructed by a facile method. The as-formed MS hollow structures are shown to be uniform in sizes with hierarchical ultrathin shells, which could facilitate the transport of electrolyte ions. Elec...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-18504-6
更新日期：2018-01-08 00:00:00
abstract：:Prognostic biomarkers serve a variety of purposes in cancer treatment and research, such as prediction of cancer progression, and treatment eligibility. Despite growing interest in multi-omic data integration for defining prognostic biomarkers, validated methods have been slow to emerge. Given that breast cancer has b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23494-0
更新日期：2018-03-26 00:00:00
abstract：:Massive gully land consolidation projects, launched in China's Loess Plateau, aim to restore 2667 [Formula: see text] agricultural lands in total by consolidating 2026 highly eroded gullies. This effort represents a social engineering project where the economic development and livelihood of the farming families are cl...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73910-7
更新日期：2020-10-09 00:00:00
abstract：:Since the spring 2018, a large part of Europe has been in the midst of a record-setting drought. Using long-term observations, we demonstrate that the occurrence of the 2018-2019 (consecutive) summer drought is unprecedented in the last 250 years, and its combined impact on the growing season vegetation activities is ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68872-9
更新日期：2020-08-06 00:00:00
abstract：:Third-generation sequencing technologies allow to sequence long reads of tens of kbp, that are expected to solve various problems. However, they display high error rates, currently capped around 10%. Self-correction is thus regularly used in long reads analysis projects. We introduce CONSENT, a new self-correction met...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80757-5
更新日期：2021-01-12 00:00:00
abstract：:Bemisia tabaci is a cryptic whitefly-species complex that includes some of the most damaging pests and plant-virus vectors of a diverse range of food and fibre crops worldwide. We combine experimental evidence of: (i) differences in reproductive compatibility, (ii) hybrid verification using a specific nuclear DNA mark...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29305-w
更新日期：2018-07-18 00:00:00
abstract：:We report on an angle resolved photoemission (ARPES) study of bulk electron-doped perovskite iridate, (Sr(1-x)La(x))3Ir2O7. Fermi surface pockets are observed with a total electron count in keeping with that expected from La substitution. Depending on the energy and polarization of the incident photons, these pockets ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08533
更新日期：2015-02-23 00:00:00
abstract：:Osteogenesis imperfecta (OI), a congenital bone disorder, is caused by mutations in COL1A1 and COL1A2 genes, leading to deficiency of type I collagen. The high resolution melting (HRM) analysis has been used for detecting mutations, polymorphisms and epigenetic alteration in double-stranded DNAs. This study was to eva...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13468
更新日期：2015-08-26 00:00:00
abstract：:Injured adult tendons do not exhibit optimal healing through a regenerative process, whereas fetal tendons can heal in a regenerative fashion without scar formation. Hence, we compared FFs (mouse fetal fibroblasts) and AFs (mouse adult fibroblasts) as seed cells for the fabrication of scaffold-free engineered tendons....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05515
更新日期：2014-07-03 00:00:00
abstract：:Porcine epidemic diarrhea virus (PEDV) is a devastating cause of diarrhea in pigs worldwide. Most of studies have focused on molecular and pathogenic characterization of PEDV, whereas there were limited studies in understanding the role of gut microbiota (GM) in viral-associated diarrhea. Here, using the Illumina MiSe...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17830-z
更新日期：2017-12-12 00:00:00
abstract：:Sporadic outbreaks caused by coxsackievirus A4 (CV-A4) have been reported worldwide. To further elucidate the detailed genetic characteristics and evolutionary recombination events of CV-A4, virus samples from nationwide hand, foot and mouth disease (HFMD) surveillance, encompassing 27 out of the 31 provinces in China...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49859-7
更新日期：2019-09-20 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-68522-0
更新日期：2020-07-10 00:00:00
abstract：:The muscular dystrophy X-linked mouse (mdx) is the most commonly used preclinical model for Duchenne muscular dystrophy. Although disease progression in the mouse does not perfectly model the human disease, it shares many pathological features. Early characterizations of the model reported severe pathology through ear...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74192-9
更新日期：2020-10-14 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease for which the pathophysiological mechanisms of motor neuron loss are not precisely clarified. Environmental and epigenetic mechanisms such as microRNAs (miRNAs) could have a role in disease progression. We studied the expression pattern of miRNAs in AL...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61246-1
更新日期：2020-03-09 00:00:00
abstract：:Coxsackievirus B3 (CVB3) is an important human pathogen associated with the development of acute pancreatitis, myocarditis, and type 1 diabetes. Currently, no vaccines or antiviral therapeutics are approved for the prevention and treatment of CVB3 infection. We found that Saururus chinensis Baill extract showed critic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-45868-8
更新日期：2019-06-28 00:00:00
abstract：:Human travel impacts the spread of infectious diseases across spatial and temporal scales, with broad implications for the biological and social sciences. Individual data on travel patterns have been difficult to obtain, particularly in low-income countries. Travel survey data provide detailed demographic information,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05678
更新日期：2014-07-14 00:00:00
abstract：:A spontaneous exchange bias (SEB) discovered by Wang et al. [Phys. Rev. Lett. 106 (2011) 077203.] after zero-field cooling (ZFC) has attracted recent attention due to its interesting physics. In this letter, we report a giant SEB tuned by Sb-doping in Ni50Mn38Ga12-xSbx Heusler alloys. Such an SEB was switched on below...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30801
更新日期：2016-08-01 00:00:00
abstract：:The prevalence of patients on automated peritoneal dialysis (APD) is increasing worldwide and may be guided by clinical characteristics, financial issues and patient option. Whether socioeconomic factors at the patient level may influence the decision for the initial peritoneal dialysis (PD) modality is unknown. This ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05544-1
更新日期：2017-07-12 00:00:00
abstract：:Space radiation brings uneven damages to cells. The detection of the distribution of cell damage plays a very important role in radiation medicine and the related research. In this paper, a new hand-held microfluidic flow cytometer was developed to evaluate the degree of radiation damage of cells. The device we propos...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23165
更新日期：2016-03-17 00:00:00
abstract：:Stylosanthes guianensis (Aubl.) Sw. is an economically important pasture and forage legume in tropical regions of the world. Genetic improvement of the crop can be enhanced through marker-assisted breeding. However, neither single nucleotide polymorphism (SNP) markers nor SNP-based genetic linkage map has been previou...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40489-7
更新日期：2019-03-07 00:00:00
abstract：:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is currently a global pandemic, and there are limited laboratory studies targeting pathogen resistance. This study aimed to investigate the effect of selected disinfection products and methods on the inactivation of SARS-CoV-2 in the laboratory. We...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-82148-w
更新日期：2021-01-28 00:00:00
abstract：:Nonperturbing and simple transfection methods are important for modern techniques used in biotechnology. Recently, we reported that electrospraying can be applied to DNA transfection in cell lines, bacteria, and chicken embryos. However, the transfection efficiency was only about 2%. To improve the transfection rate, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00289
更新日期：2012-01-01 00:00:00
abstract：:Alternative oxidase (AOX) is a mitochondrial inner-membrane oxidase that accepts electrons directly from ubiquinol and reduces oxygen to water without involving cytochrome-linked electron transport chain. It is highly conserved in many non-vertebrate taxa and may protect cells against hypoxia and oxidative stress. We ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10976-w
更新日期：2017-09-07 00:00:00
