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In vitro inactivation of SARS-CoV-2 by commonly used disinfection products and methods.

Abstract：

:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is currently a global pandemic, and there are limited laboratory studies targeting pathogen resistance. This study aimed to investigate the effect of selected disinfection products and methods on the inactivation of SARS-CoV-2 in the laboratory. We used quantitative suspension testing to evaluate the effectiveness of the disinfectant/method. Available chlorine of 250 mg/L, 500 mg/L, and 1000 mg/L required 20 min, 5 min, and 0.5 min to inactivate SARS-CoV-2, respectively. A 600-fold dilution of 17% concentration of di-N-decyl dimethyl ammonium bromide (283 mg/L) and the same concentration of di-N-decyl dimethyl ammonium chloride required only 0.5 min to inactivate the virus efficiently. At 30% concentration for 1 min and 40% and above for 0.5 min, ethanol could efficiently inactivate SARS-CoV-2. Heat takes approximately 30 min at 56 °C, 10 min above 70 °C, or 5 min above 90 °C to inactivate the virus. The chlorinated disinfectants, Di-N-decyl dimethyl ammonium bromide/chloride, ethanol, and heat could effectively inactivate SARS-CoV-2 in the laboratory test. The response of SARS-CoV-2 to disinfectants is very similar to that of SARS-CoV.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Xiling G,Yin C,Ling W,Xiaosong W,Jingjing F,Fang L,Xiaoyan Z,Yiyue G,Ying C,Lunbiao C,Liubo Z,Hong S,Yan X

doi

10.1038/s41598-021-82148-w

subject

Has Abstract

pub_date

2021-01-28 00:00:00

pages

2418

issue

1

issn

2045-2322

pii

10.1038/s41598-021-82148-w

journal_volume

11

pub_type

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