Dual targeting of ANGPT1 and TGFBR2 genes by miR-204 controls angiogenesis in breast cancer.

abstract：:The Pax3/7 transcription factor family is integral to developmental gene networks contributing to important innovations in vertebrate evolution, including the neural crest. The basal chordate lineage of amphioxus is ideally placed to understand the dynamics of the gene regulatory network evolution that produced these ...

journal_title：Scientific reports

authors： Barton-Owen TB,Ferrier DEK,Somorjai IML

更新日期：2018-06-20 00:00:00

abstract：:The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prosp...

journal_title：Scientific reports

authors： Menzel J,di Giuseppe R,Biemann R,Wittenbecher C,Aleksandrova K,Eichelmann F,Fritsche A,Schulze MB,Boeing H,Isermann B,Weikert C

更新日期：2017-10-26 00:00:00

abstract：:The ability to shape the index profile of optical fibers holds the key to fully flexible engineering of their optical properties and future applications. We present a new approach for the development of a graded index fused silica fiber based on core nanostructurization. A graded index core is obtained by means of dis...

journal_title：Scientific reports

authors： Anuszkiewicz A,Kasztelanic R,Filipkowski A,Stepniewski G,Stefaniuk T,Siwicki B,Pysz D,Klimczak M,Buczynski R

更新日期：2018-08-17 00:00:00

abstract：:The biodosimetric information is critical for evaluating the human health hazards caused by radon and its progeny. Here, we demonstrated that the formation of phosphorylated histone variant H2AX (γ-H2AX), p53-binding protein 1 (53BP1) and phosphorylated KRAB-associated protein 1 (pKAP-1) foci and their linear tracks i...

journal_title：Scientific reports

authors： Ding D,Zhang Y,Wang J,Wang X,Fan D,He L,Zhang X,Gao Y,Li Q,Chen H

更新日期：2016-12-06 00:00:00

abstract：:Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a mem...

journal_title：Scientific reports

authors： Tian L,Li L,Xing W,Li R,Pei C,Dong X,Fu Y,Gu C,Guo X,Jia Y,Wang G,Wang J,Li B,Ren H,Xu H

更新日期：2015-07-23 00:00:00

abstract：:HSV-2 is one of the most common sexually transmitted pathogens worldwide and HSV-2 infection triggers cytokine and chemokine production. However, little is known about which HSV-2 genes engage in the regulation of NF-κB signaling and what mechanisms are involved. In a screen of the unique short (Us) regions of HSV-2, ...

journal_title：Scientific reports

authors： Lu X,Huang C,Zhang Y,Lin Y,Wang X,Li Q,Liu S,Tang J,Zhou L

更新日期：2017-08-21 00:00:00

abstract：:Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

journal_title：Scientific reports

authors： Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

更新日期：2019-02-22 00:00:00

abstract：:In this paper we report a low complexity compression method that is suitable for compact optical scanning holography (OSH) systems with different optical settings. Our proposed method can be divided into 2 major parts. First, an automatic decision maker is applied to select the rows of holographic pixels to be scanned...

journal_title：Scientific reports

authors： Tsang PW,Poon TC,Liu JP,Kim T,Kim YS

更新日期：2016-10-06 00:00:00

abstract：:Excess Phosphorus (P) in agriculture is causing serious environmental problems like eutrophication of lakes and rivers. Unlike the enormous information available for phosphate starvation response (P0), very few information is available for the effect of excess phosphate Pi on plants. Characterization of Excess Phospha...

journal_title：Scientific reports

authors： Shukla D,Rinehart CA,Sahi SV

更新日期：2017-06-08 00:00:00

abstract：:Recruitment is one of the dominant processes regulating fish population productivity. It is, however, notoriously difficult to predict, as it is the result of a complex multi-step process. Various fine-scale drivers might act on the pathway from adult population characteristics to spawning behaviour and egg production...

journal_title：Scientific reports

authors： Brosset P,Smith AD,Plourde S,Castonguay M,Lehoux C,Van Beveren E

更新日期：2020-09-30 00:00:00

abstract：:The fine-tuning of gene expression contributes to both basic science and applications. Here, we develop a novel gene expression technology termed CRITGI (CRISPR/Transposon gene integration). CRITGI uses CRISPR/Cas9 to integrate multiple copies of the plasmid pTy1 into Ty1 loci, budding yeast retrotransposons. The pTy1...

journal_title：Scientific reports

authors： Hanasaki M,Masumoto H

更新日期：2019-10-25 00:00:00

abstract：:The Wall Gecko shows heterogeneous colour pattern, which may vary among individuals, depending on the time of day and on the habitat segregation. Nocturnal pale geckos live exclusively on walls. Diurnal dark geckos preferentially live on olive tree trunks, demonstrating an ability to change skin colour that is superio...

journal_title：Scientific reports

authors： Fulgione D,Buglione M,Rippa D,Trapanese M,Petrelli S,Monti DM,Aria M,Del Giudice R,Maselli V

更新日期：2019-02-04 00:00:00

abstract：:Alzheimer's disease (AD) is a severe neurodegenerative disorder for which identification of differentially expressed genes is one way to find new therapeutic targets. Here, we conducted analysis to identify age-independent, AD-specific genes. We found that the MET, WIF1, and NPTX2 genes are downregulated in AD. WIF1 a...

journal_title：Scientific reports

authors： Liu H,Luo K,Luo D

更新日期：2018-02-09 00:00:00

abstract：:Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis in a Chinese Han population. We recruited 1601 pulmonary tuberculosis patients matched with 1526 healthy con...

journal_title：Scientific reports

authors： Wang M,Xu G,Lü L,Xu K,Chen Y,Pan H,Burstrom B,Burstrom K,Wang J

更新日期：2016-06-24 00:00:00

abstract：:Wild and domesticated bee species are exposed to a variety of pesticides which may drive pollinator decline. Due to wild bee sensitivity data shortage, it is unclear if the honey bee Apis mellifera is a suitable surrogate species in the current EU risk assessment scheme. Furthermore, the underlying causes for sensitiv...

journal_title：Scientific reports

authors： Uhl P,Franke LA,Rehberg C,Wollmann C,Stahlschmidt P,Jeker L,Brühl CA

更新日期：2016-09-30 00:00:00

abstract：:Ursolic acid (UA) has proved to have broad-spectrum anti-tumor effects, but its poor water solubility and incompetent targeting property largely limit its clinical application and efficiency. Here, we synthesized a nanoparticle-based drug carrier composed of chitosan, UA and folate (FA-CS-UA-NPs) and demonstrated that...

journal_title：Scientific reports

authors： Jin H,Pi J,Yang F,Jiang J,Wang X,Bai H,Shao M,Huang L,Zhu H,Yang P,Li L,Li T,Cai J,Chen ZW

更新日期：2016-07-29 00:00:00

abstract：:The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sam...

journal_title：Scientific reports

authors： Frühbeck G,Catalán V,Rodríguez A,Ramírez B,Becerril S,Salvador J,Portincasa P,Colina I,Gómez-Ambrosi J

更新日期：2017-07-26 00:00:00

abstract：:A polarized macrophage response into inflammatory (M1) or regenerative/anti-inflammatory (M2) phenotypes is critical in host response to multiple intracellular bacterial infections. Ehrlichia is an obligate Gram-negative intracellular bacterium that causes human monocytic ehrlichiosis (HME): a febrile illness that may...

journal_title：Scientific reports

authors： Haloul M,Oliveira ERA,Kader M,Wells JZ,Tominello TR,El Andaloussi A,Yates CC,Ismail N

更新日期：2019-10-01 00:00:00

abstract：:Symbiodinium is a dinoflagellate that plays an important role in the physiology of the symbiotic relationships of Cnidarians such as corals and sea anemones. However, it is very difficult to cultivate free-living dinoflagellates after being isolated from the host, as they are very sensitive to environmental changes. H...

journal_title：Scientific reports

authors： Pasaribu B,Weng LC,Lin IP,Camargo E,Tzen JT,Tsai CH,Ho SL,Lin MR,Wang LH,Chen CS,Jiang PL

更新日期：2015-10-20 00:00:00

abstract：:The use of smart colloidal microgels for advanced applications critically depends on their response kinetics. We use pressure jump small angle neutron scattering with supreme time resolution to study the rapid volume phase transition kinetics of such microgels. Utilizing the pressure induced microphase separation insi...

journal_title：Scientific reports

authors： Wrede O,Reimann Y,Lülsdorf S,Emmrich D,Schneider K,Schmid AJ,Zauser D,Hannappel Y,Beyer A,Schweins R,Gölzhäuser A,Hellweg T,Sottmann T

更新日期：2018-09-13 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Xu S,Fan S,Fang S,Lang X,Wang Y,Chen J

更新日期：2020-05-26 00:00:00

abstract：:Sufficient tissue oxygenation is required for regular brain function; thus oxygen supply must be tightly regulated to avoid hypoxia and irreversible cell damage. If hypoxia occurs the transcription factor complex hypoxia-inducible factor (HIF) will accumulate and coordinate adaptation of cells to hypoxia. However, eve...

journal_title：Scientific reports

authors： Kleszka K,Leu T,Quinting T,Jastrow H,Pechlivanis S,Fandrey J,Schreiber T

更新日期：2020-11-05 00:00:00

abstract：:Biological networks play a key role in determining biological function and therefore, an understanding of their structure and dynamics is of central interest in systems biology. In Boolean models of such networks, the status of each molecule is either "on" or "off" and along with the molecules interact with each other...

journal_title：Scientific reports

authors： Chen H,Wang G,Simha R,Du C,Zeng C

更新日期：2016-01-29 00:00:00

abstract：:Insulin resistance is a major risk factor for metabolic diseases such as Type 2 diabetes. Although the underlying mechanisms of insulin resistance remain elusive, oxidative stress is a unifying driver by which numerous extrinsic signals and cellular stresses trigger insulin resistance. Consequently, we sought to under...

journal_title：Scientific reports

authors： Chaudhuri R,Krycer JR,Fazakerley DJ,Fisher-Wellman KH,Su Z,Hoehn KL,Yang JYH,Kuncic Z,Vafaee F,James DE

更新日期：2018-01-29 00:00:00

abstract：:Inspired by adhesive mussel proteins, nanospherical self-assemblies were prepared from bolaamphiphiles containing 3,4-dihydroxyphenylalanine (DOPA) moieties, and a suspension of the bolaamphiphile assemblies was used for the preparation of a patterned surface that enhanced cell adhesion and viability. The abundant sur...

journal_title：Scientific reports

authors： Lee C,Kim SH,Jang JH,Lee SY

更新日期：2017-10-23 00:00:00

abstract：:The concept of milk as a healthy food has opened the way for studies on milk components, from nutrients to microRNAs, molecules with broad regulatory properties present in large quantities in milk. Characterization of these components has been performed in several species, such as humans and bovine, depending on the s...

journal_title：Scientific reports

authors： Le Guillou S,Leduc A,Laubier J,Barbey S,Rossignol MN,Lefebvre R,Marthey S,Laloë D,Le Provost F

更新日期：2019-12-30 00:00:00

abstract：:Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication o...

journal_title：Scientific reports

authors： Naranda J,Sušec M,Maver U,Gradišnik L,Gorenjak M,Vukasović A,Ivković A,Rupnik MS,Vogrin M,Krajnc P

更新日期：2016-06-24 00:00:00

abstract：:Spin fluctuations are widely believed to play an important role in the superconducting mechanisms of unconventional high temperature superconductors. Spin fluctuations have been observed in iron-based superconductors as well. However, in some iron-based superconductors such as LaFePO0.9, they have not been observed by...

journal_title：Scientific reports

authors： Ishikado M,Shamoto SI,Kodama K,Kajimoto R,Nakamura M,Hong T,Mutka H

更新日期：2018-11-05 00:00:00

abstract：:The parasitic nematode Trichuris trichiura is a significant burden on public health in developing countries, and currently available drugs exhibit a poor cure rate. Worms live within a specialised tunnel of host intestinal epithelial cells and have anterior-ventral projections of the cuticle termed "cuticular inflatio...

journal_title：Scientific reports

authors： O'Sullivan JDB,Cruickshank SM,Starborg T,Withers PJ,Else KJ

更新日期：2020-04-03 00:00:00

abstract：:Heparin is a widely used anticoagulant which inhibits factor Xa and thrombin through potentiation of antithrombin. We recently identified that the nucleic acid stain SYTOX reacts with platelet polyphosphate due to molecular similarities, some of which are shared by heparin. We attempted to study heparin in flowing blo...

journal_title：Scientific reports

authors： de Vries JC,Barendrecht AD,Clark CC,Urbanus RT,Boross P,de Maat S,Maas C

更新日期：2019-12-04 00:00:00