Abstract：
:Melanoma is one of the most aggressive skin cancers and is well known for its high metastatic rate. Studies have shown that epithelial mesenchymal transition (EMT) is essential for melanoma cell metastasis. However, the molecular mechanisms underlying EMT are still not fully understood. We have shown that IRGM1, a member of immunity-related GTPase family that regulates immune cell motility, is highly expressed by melanoma cells. The current study aimed to explore whether and how IRGM1 may regulate melanoma cell metastasis. To test this, we modified IRGM1 expression in B16 melanoma cells. We found that over-expression of IRGM1 substantially enhanced pulmonary metastasis in vivo. In keeping with that, knocking-in IRGM1 strongly enhanced while knocking-down IRGM1 impaired B16 cell migration and invasion ability in vitro. Interestingly, we observed that IRGM1 enhanced F-actin polymerization and triggers epithelial mesenchymal transition (EMT) through a mechanism involved in PIK3CA mediated Rac1 activation. Together, these data reveals a novel molecular mechanism that involved in melanoma metastasis.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Tian L,Li L,Xing W,Li R,Pei C,Dong X,Fu Y,Gu C,Guo X,Jia Y,Wang G,Wang J,Li B,Ren H,Xu Hdoi
10.1038/srep12357subject
Has Abstractpub_date
2015-07-23 00:00:00pages
12357issn
2045-2322pii
srep12357journal_volume
5pub_type
杂志文章abstract：:Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Zebrafish were overfed a commercially available fish food using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-01432-w
更新日期：2017-05-03 00:00:00
abstract：:The study was aimed at assessing the diagnostic performance of 68Ga-PSMA-617 PET/CT in the detection of prostate cancer (PCa) in patients with a prostate-specific antigen (PSA) level of 4-20 ng/ml and to compare its efficacy with that of multiparametric MRI (mpMRI). We analyzed the data of 67 consecutive patients with...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67385-9
更新日期：2020-07-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03765
更新日期：2014-01-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32196
更新日期：2016-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-31229-4
更新日期：2018-08-24 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-03-09 00:00:00
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pub_type： 杂志文章
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更新日期：2020-02-14 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-018-23089-9
更新日期：2018-03-14 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18363
更新日期：2015-12-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2020-10-20 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-04-28 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep30871
更新日期：2016-08-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35319-1
更新日期：2018-11-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-05-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41752
更新日期：2017-02-02 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-02-04 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23526
更新日期：2016-03-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep17576
更新日期：2015-12-01 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29902
更新日期：2016-07-19 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-08-03 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-12-19 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2018-07-05 00:00:00
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pub_type： 杂志文章
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更新日期：2020-01-16 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-03-29 00:00:00
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pub_type： 杂志文章
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更新日期：2018-03-15 00:00:00
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pub_type： 杂志文章
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更新日期：2017-08-08 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2016-02-29 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08976-x
更新日期：2017-08-18 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
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更新日期：2018-07-20 00:00:00
abstract：:In order to study the molecular differences between type 2 diabetes mellitus (T2DM) and T2DM with depression (DD), we aimed to screen the differential expression of lncRNA, mRNA, and circRNA in the blood of patients with T2DM and DD. Based on the self-rating depression scale (SDS), patient health questionnaire 9 (PHQ9...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-07-24 00:00:00
