Abstract:
:This study aimed to explore the development of mental rotation ability throughout life by comparing different kinds of stimuli. Thirty-six children (6-9 years-old), 30 young (20-28 years-old) and 30 elderly people (60-82 years-old) performed mental rotation tasks with abstract (i.e. two-dimensional lines) and concrete stimuli (i.e. hands, human/animal faces). The results showed that overall young people outperformed children and elderly people, while children were less accurate than the elderly. However, the effect of age was shaped by the kinds of stimuli: (a) young people were more accurate than children and elderly people particularly with abstract stimuli; (b) elderly people improved their performance with images depicting faces; (c) children performed better with body-related stimuli than animal faces. Finally, performance was more difficult when stimuli were rotated by 180°, especially for younger and older females. We may conclude that the effects of age are modulated by the characteristics of the stimuli with a specific difficulty for abstract stimuli and a facilitation for concrete stimuli. As an innovative aspect, during childhood there appeared a specific facilitation for body-related stimuli, not just for concrete ones. These findings are interpreted according to embodied models of cognitive development and the effects of ageing on the brain.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Iachini T,Ruggiero G,Bartolo A,Rapuano M,Ruotolo Fdoi
10.1038/s41598-018-37729-7subject
Has Abstractpub_date
2019-02-04 00:00:00pages
1169issue
1issn
2045-2322pii
10.1038/s41598-018-37729-7journal_volume
9pub_type
杂志文章abstract::HIV-exposed uninfected (HEU) infants are disproportionately at a higher risk of morbidity and mortality, as compared to HIV-unexposed uninfected (HUU) infants. Here, we used transcriptional profiling of peripheral blood mononuclear cells to determine immunological signatures of in utero HIV exposure. We identified 262...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54083-4
更新日期:2019-12-02 00:00:00
abstract::Through a geomorphological study relying on statistically assessed classes of hilltop elevations, we reconstruct a suite of paleo-surfaces along the Tiber River Valley north of Rome that we identify as fluvial terraces formed by interplay between global sea-level fluctuations and regional upift. Using biostratigraphic...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02437-1
更新日期:2017-05-31 00:00:00
abstract::We study a simple realistic model for describing the diffusion of an infectious disease on a population of individuals. The dynamics is governed by a single functional delay differential equation, which, in the case of a large population, can be solved exactly, even in the presence of a time-dependent infection rate. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-72529-y
更新日期:2020-09-25 00:00:00
abstract::The spatial distributions of diverse facilities are often understood in terms of the optimization of the commute distance or the economic profit. Incorporating more general objective functions into such optimization framework may be useful, helping the policy decisions to meet various social and economic demands. As a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-65337-x
更新日期:2020-05-25 00:00:00
abstract::There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45780
更新日期:2017-04-07 00:00:00
abstract::Membrane potential (Vmem) is a key bioelectric property of non-excitable cells that plays important roles in regulating cell proliferation. However, the regulation of Vmem itself remains largely unexplored. We found that, under nutrient starvation, during which cell division is inhibited, MKN45 gastric cancer cells we...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24460-6
更新日期:2018-04-16 00:00:00
abstract::Host-generalist pathogens sporadically infect naive hosts, potentially triggering epizootics. The waterborne fungus Batrachochytrium dendrobatidis (Bd) is linked to declines of hundreds of amphibian species with aquatic larvae. Although several population declines and extinctions attributed to Bd have been reported am...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-16425-y
更新日期:2017-11-30 00:00:00
abstract::The antibiosis effect of gallic acid on Spodoptera litura F. (Lepidoptera: Noctuidae) and its parasitoid evaluated by feeding six days old larvae on artificial diet incorporated with different concentrations (5 ppm, 25 ppm, 125 ppm, 625 ppm, 3125 ppm) of the phenolic compound revealed higher concentration (LC50) of ga...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-80232-1
更新日期:2021-01-12 00:00:00
abstract::Although Heme Oxygenase-1 (HO-1) induction in various forms of kidney injury is protective, its role in age-related renal pathology is unknown. In the ageing kidney there is nephron loss and lesions of focal glomerulosclerosis, interstitial fibrosis, tubular atrophy and arteriolosclerosis. Underlying mechanisms includ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62016-9
更新日期:2020-03-31 00:00:00
abstract::Sesamin is a furofuran-type lignan that is found abundantly in seeds of Sesamum indicum (sesame) and has been widely accepted as a dietary supplement with positive effects on human health. The biological activity of sesamin in human cells and organs has been analysed extensively, although comparatively few studies sho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-45003-7
更新日期:2019-06-14 00:00:00
abstract::The extended Hückel (eH) tight-binding method has historically been prized for its computational ease and intuitive chemical clarity. However, its lack of quantitative predictiveness has prevented the eH method from being used as a tool for rapidly screening materials for desired electronic properties. In this work, w...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28864-2
更新日期:2018-07-12 00:00:00
abstract::The high-speed liquid-jet velocity achieved using an injector strongly depends on the piston motion, physical property of the liquid, and container shape of the injector. Herein, we investigate the liquid ejection mechanism and a technique for estimating the ejection velocity of a high-speed liquid jet using a pyro je...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56511-x
更新日期:2019-12-27 00:00:00
abstract::A novel and simple method to fabricate microchannels is reported based on an inkjet printing of a volatile solid mold. A liquid ink -1,6 hexanediol- ejected from a piezoelectric nozzle is instantaneously frozen when touching a cooled substrate. The created mold is then poured with PDMS. Once the PDMS is crosslinked, t...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53729-7
更新日期:2019-11-25 00:00:00
abstract::A sensitive and selective chemiluminescence (CL) sensor based on the peroxidase-like activity of copper nanoclusters was established for the detection of cholesterol. Copper nanoclusters catalyse the CL reaction between luminol and H2O2. Because H2O2 is the oxidative product of cholesterol in the presence of cholester...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39157
更新日期:2016-12-14 00:00:00
abstract::Building porosity in monolithic materials is highly desired to design 3D electrodes, however ex-situ introduction or in-situ generation of nano-scale sacrificial template is still a great challenge. Here Al-Si eutectic droplet templates are uniformly injected into bulk Si through Al-induced solid-solid convection to c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep10381
更新日期:2015-05-19 00:00:00
abstract::Danggui Buxue Tang (DBT) is a classic Chinese herbal formula which consists of Astragali mongholici Radix and Angelica sinensis Radix (ASR). For chemical ingredients, HPLC were performed. Results showed compared with single herbs, DBT decoction could promote the dissolution of ingredients such as ferulic acid and caly...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep45111
更新日期:2017-03-22 00:00:00
abstract::Species generalization in the profound, modality-specific effects of Hedgehog pathway inhibition (HPI) in taste organ homeostasis and sensation is shown. With the HPI, cancer drug sonidegib, we demonstrate that the rat taste system, in addition to mouse, is regulated by Hedgehog signaling. After sonidegib treatment fo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-34399-3
更新日期:2018-11-01 00:00:00
abstract::COX-2 inhibition may be of benefit in the treatment of tuberculosis (TB) through a number of pathways including efflux pump inhibition (increasing intracellular TB drug levels) and diverse effects on inflammation and the immune response. We investigated celecoxib (a COX-2 inhibitor) alone and with standard anti-tuberc...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-018-31590-4
更新日期:2018-09-10 00:00:00
abstract::The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association bet...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02408
更新日期:2013-01-01 00:00:00
abstract::Objectives were to evaluate the role of canonical WNT signaling in development of the preimplantation embryo. Signaling was activated with 2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine (AMBMP) and inhibited with Dickkopf-related protein 1 (DKK1). Treatment of bovine embryos with AMBMP at da...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep01266
更新日期:2013-01-01 00:00:00
abstract::The topical application of lactic acid bacteria (LAB) is recognized as a useful approach to improve skin health. This work aims to characterize by a multidisciplinary approach, the wound healing, anti-inflammatory, anti-pathogens and proteomic effects of six LAB lysates, belonging to the genus Lactobacillus. Our resul...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68483-4
更新日期:2020-07-14 00:00:00
abstract::PCR inhibitors in clinical specimens negatively affect the sensitivity of diagnostic PCR and RT-PCR or may even cause false-negative results. To overcome PCR inhibition, increase the sensitivity of the assays and simplify the detection protocols, simple methods based on quantitative nested real-time PCR and RT-PCR wer...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-21224-0
更新日期:2018-02-21 00:00:00
abstract::In the Ultimatum Game, two players are offered a chance to win a pie. The proposer suggests how to split the pie. The responder can either accept or reject the deal. If an agreement is not reached, neither player gets anything. Both game theory and evolutionary game theory predict the rational solution that the propos...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04534
更新日期:2014-04-01 00:00:00
abstract::We developed a solvothermal-induced self-assembly approach to construct three dimensional (3D) macroscopic Fe2O3 nanocubes/nitrogen-doped graphene (Fe2O3-NC/GN) aerogel as anode materials for lithium-ion batteries (LIBs). The Fe2O3 nanocubes with length of ~50 nm are homogeneously anchored on 3D GN frameworks and as s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep07171
更新日期:2014-11-25 00:00:00
abstract::Adult hippocampal neurogenesis is associated with learning and affective behavioural regulation. Its diverse functionality is segregated along the septotemporal axis from the dorsal to ventral hippocampus. However, features distinguishing immature neurons in these regions have yet to be characterized. Additionally, al...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep30467
更新日期:2016-07-29 00:00:00
abstract::Olfactory dysfunction is a robust and early sign for Parkinson's disease (PD). Previous studies have revealed its association with dementia and related neural changes in PD. Yet, how olfactory dysfunction affects white matter (WM) microstructure in newly diagnosed and untreated PD remains unclear. Here we comprehensiv...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-12947-7
更新日期:2017-10-02 00:00:00
abstract::In this article, we experimentally and numerically investigate a planar terahertz metamaterial (MM) geometry capable of exhibiting independently tunable multi-band electromagnetically induced transparency effect (EIT). The MM structure exhibits multi-band EIT effect due to the strong near field coupling between the br...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-54414-5
更新日期:2019-12-02 00:00:00
abstract::Ras mutations (e.g., occur in K-Ras, N-Ras, and H-Ras) are one of the most desirable and promising drug targets in chemotherapy treatments for cancer. However, there are still no approved drugs directly targeting mutated Ras. In 2017, an artificial cyclic peptide, KRpep-2d, was discovered as the first selective inhibi...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78712-5
更新日期:2020-12-10 00:00:00
abstract::We report command electro-optical switching on photolithographically-patterned graphene into a high-density electrode pattern for a high-transmission in-plane-switching (IPS) liquid crystal device. A highly-effective liquid crystal photoalignment method is used to maximize the field-driven optical contrast of a protot...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-11903-9
更新日期:2017-09-18 00:00:00
abstract::After active lengthening contractions, a given amount of force can be maintained with less muscle activation compared to pure isometric contractions at the same muscle length and intensity. This increase in neuromuscular efficiency is associated with mechanisms of stretch-induced residual force enhancement. We hypothe...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep39052
更新日期:2016-12-14 00:00:00