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Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

Abstract：

:Biological validation of new radiotherapy modalities is essential to understand their therapeutic potential. Antiprotons have been proposed for cancer therapy due to enhanced dose deposition provided by antiproton-nucleon annihilation. We assessed cellular DNA damage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam. Despite a modest LET (~19 keV/μm), antiproton spread out Bragg peak (SOBP) irradiation caused significant residual γ-H2AX foci compared to X-ray, proton and antiproton plateau irradiation. RBE of ~1.48 in the SOBP and ~1 in the plateau were measured and used for a qualitative effective dose curve comparison with proton and carbon-ions. Foci in the antiproton SOBP were larger and more structured compared to X-rays, protons and carbon-ions. This is likely due to overlapping particle tracks near the annihilation vertex, creating spatially correlated DNA lesions. No biological effects were observed at 28-42 mm away from the primary beam suggesting minimal risk from long-range secondary particles.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kavanagh JN,Currell FJ,Timson DJ,Savage KI,Richard DJ,McMahon SJ,Hartley O,Cirrone GA,Romano F,Prise KM,Bassler N,Holzscheiter MH,Schettino G

doi

10.1038/srep01770

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1770

issn

2045-2322

pii

srep01770

journal_volume

3

pub_type

杂志文章

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