Abstract:
:Heat stress threatens agriculture worldwide. Plants acquire heat stress tolerance through priming, which establishes stress memory during mild or severe transient heat stress. Such induced thermotolerance restructures metabolic networks and helps maintain metabolic homeostasis under heat stress. Here, we used an electrospray ionization mass spectrometry-based platform to explore the composition and dynamics of the metabolome of Arabidopsis thaliana under heat stress and identify metabolites involved in thermopriming. Primed plants performed better than non-primed plants under severe heat stress due to altered energy pathways and increased production of branched-chain amino acids, raffinose family oligosaccharides (RFOs), lipolysis products, and tocopherols. These metabolites serve as osmolytes, antioxidants and growth precursors to help plants recover from heat stress, while lipid metabolites help protect membranes against heat stress. The carbohydrate (e.g., sucrose and RFOs) and lipid superpathway metabolites showed the most significant increases. Under heat stress, there appears to be crosstalk between carbohydrate metabolism (i.e., the thermomemory metabolites stachyose, galactinol, and raffinose) and tyrosine metabolism towards the production of the thermomemory metabolite salidroside, a phenylethanoid glycoside. Crosstalk occurs between two glycerophospholipid pathways (the biosynthetic pathways of the thermomemory metabolite S-adenosyl-L-homocysteine and the terpenoid backbone) and the δ-tocopherol (chloroplast lipid) pathway, which favors the production of glycine betaine and other essential tocopherols, respectively, compounds which are essential for abiotic stress tolerance in plants. Therefore, metabolomic analysis can provide comprehensive insights into the metabolites involved in stress responses, which could facilitate plant breeding to maximize crop yields under adverse conditions.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Serrano N,Ling Y,Bahieldin A,Mahfouz MMdoi
10.1038/s41598-018-36484-zsubject
Has Abstractpub_date
2019-01-17 00:00:00pages
181issue
1issn
2045-2322pii
10.1038/s41598-018-36484-zjournal_volume
9pub_type
杂志文章abstract::We compared markers of glucose homeostasis and their association with diabetes and impaired fasting glucose (IFG) in Fukuoka, Japanese subjects (n = 1108) and age-, gender- and menopausal status-matched participants in the Framingham Offspring Study (n = 1096). The markers examined included fasting glucose, insulin, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36725
更新日期:2016-11-10 00:00:00
abstract::We report a theoretical and experimental study of the aggregation kinetics of oppositely charged nanoparticles. Kinetic Monte Carlo simulations are performed for symmetric, charge-asymmetric and size-asymmetric systems of oppositely charged nanoparticles. Simulation results show that both the weight and number average...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40379-y
更新日期:2019-03-06 00:00:00
abstract::Reactive Intermediate Deaminase (Rid) protein superfamily includes eight families among which the RidA is conserved in all domains of life. RidA proteins accelerate the deamination of the reactive 2-aminoacrylate (2AA), an enamine produced by some pyridoxal phosphate (PLP)-dependent enzymes. 2AA accumulation inhibits ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-66663-w
更新日期:2020-06-23 00:00:00
abstract::Tradional antireflection coatings composed of dielectric layers usually require the thickness to be larger than quarter wavelength. Here, we demonstrate that materials with permittivity or permeability dominated by imaginary parts, i.e. lossy or gain media, can realize non-resonant antireflection coatings in deep sub-...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28681
更新日期:2016-06-28 00:00:00
abstract::Baited remote underwater video cameras were deployed in the Eastern Canadian Arctic, for the purpose of estimating local densities of the long-lived Greenland shark within five deep-water, data-poor regions of interest for fisheries development and marine conservation in Nunavut, Canada. A total of 31 camera deploymen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-19115-x
更新日期:2018-01-17 00:00:00
abstract::Glioblastoma (grade IV glioma) is the most common and aggressive adult brain tumor. A better understanding of the biology of glioblastoma cells is crucial to identify molecular targets stimulating cell death. NPM1 (nucleophosmin) is a multifunctional chaperone that plays an important role in cancer development. Herein...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16495
更新日期:2015-11-12 00:00:00
abstract::PARP inhibitors have shown remarkable efficacy in the clinical management of several BRCA-mutated tumors. This approach is based on the long-standing hypothesis that PARP inhibition will impair the repair of single stranded breaks, causing synthetic lethality in tumors with loss of high-fidelity double-strand break ho...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-76975-6
更新日期:2020-11-19 00:00:00
abstract::CD47 is overexpressed in many human cancers, its level positively correlates with tumor invasion and metastasis. However, it is largely unknown whether CD47 overexpression drives metastasis and how CD47 lead to tumor metastasis in non-small cell lung cancer (NSCLC). In this study, we analyzed NSCLC specimens and cell ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29719
更新日期:2016-07-14 00:00:00
abstract::17β-estradiol (E2) regulates diverse physiological effects, including cell proliferation, by binding to estrogen receptor α (ERα). ERα is both a transcription factor that drives E2-sensitive gene expression and an extra-nuclear localized receptor that triggers the activation of diverse kinase cascades. While E2 trigge...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23727
更新日期:2016-03-24 00:00:00
abstract::In the cricket Gryllus bimaculatus, flying occurs soon after the last imaginal molt and precedes the mating behavior in natural conditions. Here, we tested the hypothesis that flying may improve subsequent behavioral performance in a novel environment in female crickets. We developed a behavioral set-up to test female...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-78969-w
更新日期:2020-12-18 00:00:00
abstract::In patients with type 1 diabetes mellitus (T1DM), glucose dynamics are influenced by insulin reactions, diet, lifestyle, etc., and characterized by instability and nonlinearity. With the objective of a dependable decision support system for T1DM self-management, we aim to model glucose dynamics using their nonlinear c...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-06478-4
更新日期:2017-07-24 00:00:00
abstract::Which factors are related to false negative results of the interferon-γ release assay (IGRA) is unclear. This systematic review described the risk factors associated with false negative IGRA results. Two authors independently identified studies designed to evaluate risk factors for false negative IGRA results from Pub...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-020-58459-9
更新日期:2020-01-31 00:00:00
abstract::Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3 (HDAC3) appears to be important in HD pathology by negatively regula...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05125-2
更新日期:2017-07-20 00:00:00
abstract::Medical folk wisdom (MFW) refers to widely held, but factually inaccurate, beliefs about disease, immunity, pregnancy, and other medically-relevant topics. Examples include the idea that fasting when feverish ("starving a fever") can increase the pace of recovery, or that showering after sex can prevent pregnancy. The...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-67744-6
更新日期:2020-07-01 00:00:00
abstract::Based on the polarization-sensitive absorption of graphene under conditions of total internal reflection, a novel optical sensor combining graphene and a microfluidic structure was constructed to achieve the sensitive real-time monitoring of refractive indexes. The atomic thickness and strong broadband absorption of g...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep00908
更新日期:2012-01-01 00:00:00
abstract::A cross-correlative precession electron diffraction - atom probe tomography investigation of Cr segregation in a Fe(Cr) nanocrystalline alloy was undertaken. Solute segregation was found to be dependent on grain boundary type. The results of which were compared to a hybrid Molecular Dynamics and Monte Carlo simulation...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep34642
更新日期:2016-10-06 00:00:00
abstract::MicroRNAs are potent regulators of gene expression that have been widely implicated in reproduction and embryo development. Recent studies have demonstrated that miR-21, a microRNA extensively studied in the context of disease, is important in multiple facets of reproductive biology including folliculogenesis, ovulati...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-29874-w
更新日期:2018-08-01 00:00:00
abstract::Strong pinning depends on the pinning force strength and number density of effective defects. Using the hydrostatic pressure method, we demonstrate here that hydrostatic pressure of 1.2 GPa can significantly enhance flux pinning or the critical current density (Jc) of optimally doped Ba0.6K0.4Fe2As2 crystals by a fact...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23044
更新日期:2016-03-17 00:00:00
abstract::Patients with advanced ovarian cancer develop recurrence despite initial treatment response to standard treatment of surgery and intravenous/intraperitoneal (IP) chemotherapy, partly due to a limited peritoneal exposure time of chemotherapeutics. Paclitaxel-loaded genipin-crosslinked gelatin microspheres (PTX-GP-MS) a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51419-y
更新日期:2019-10-16 00:00:00
abstract::Solid-state femtosecond lasers have stimulated the broad adoption of multiphoton microscopy in the modern laboratory. However, these devices remain costly. Fiber lasers offer promise as a means to inexpensively produce ultrashort pulses of light suitable for nonlinear microscopy in compact, robust and portable devices...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40871-5
更新日期:2019-03-12 00:00:00
abstract::Two of the most common nonhuman animals that interact with humans are domestic dogs (Canis familiaris) and cats (Felis catus). In contrast to dogs, the ability of domestic cats to communicate with humans has not been explored thoroughly. We used a habituation-dishabituation method to investigate whether domestic cats ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40616-4
更新日期:2019-04-04 00:00:00
abstract::To determine levels of change in risk factors for cardiovascular disease among people with and without a previous diagnosis of diabetes from 2007 to 2016 in Iran. Data were obtained from five rounds of the World Health Organization STEPwise approach to Surveillance (STEPS) cross-sectional surveys. Participants were 76...
journal_title:Scientific reports
pub_type: 历史文章,杂志文章
doi:10.1038/s41598-020-68640-9
更新日期:2020-07-16 00:00:00
abstract::Auxetic mechanical metamaterials are engineered systems that exhibit the unusual macroscopic property of a negative Poisson's ratio due to sub-unit structure rather than chemical composition. Although their unique behaviour makes them superior to conventional materials in many practical applications, they are limited ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep08395
更新日期:2015-02-11 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60470-z
更新日期:2020-03-10 00:00:00
abstract::Adenocarcinoma, large cell carcinoma and squamous cell carcinoma are the most commonly diagnosed subtypes of non-small cell lung cancers (NSCLC). Numerous lung cancer cell types have exhibited electrotaxis under direct current electric fields (dcEF). Physiological electric fields (EF) play key roles in cancer cell mig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-44505-8
更新日期:2019-05-30 00:00:00
abstract::A culture system that can recapitulate myelination in vitro will not only help us better understand the mechanism of myelination and demyelination, but also find out possible therapeutic interventions for treating demyelinating diseases. Here, we introduce a simple and reproducible myelination culture system using mou...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep15122
更新日期:2015-10-12 00:00:00
abstract::Bacterial vaginosis (BV) causes genital inflammation and increased HIV acquisition risk. The standard-of-care for BV, antibiotic therapy, is associated with high recurrence rates. Probiotics may improve treatment outcomes, although substantial heterogeneity in efficacy has been observed during clinical trials. To eval...
journal_title:Scientific reports
pub_type: 临床试验,杂志文章
doi:10.1038/s41598-018-38253-4
更新日期:2019-02-13 00:00:00
abstract::Defect engineering is a promising route for controlling the electronic properties of monolayer transition-metal dichalcogenide (TMD) materials. Here, we demonstrate that the electronic structure of MoS2 depends sensitively on the defect charge, both its sign and magnitude. In particular, we study shallow bound states ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-31941-1
更新日期:2018-09-11 00:00:00
abstract::Soluble starch synthase I (SSI) is a key enzyme in the biosynthesis of plant amylopectin. In this study, the gene named IbSSI, was cloned from sweet potato, an important starch crop. A high expression level of IbSSI was detected in the leaves and storage roots of the sweet potato. Its overexpression significantly incr...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02481-x
更新日期:2017-05-24 00:00:00
abstract::Fuel substrate supply and oxidative phosphorylation are key determinants of muscle performance. Numerous studies of mammalian mitochondria are carried out (i) with substrate supply that limits electron flow, and (ii) far below physiological temperature. To analyze potentially implicated biases, we studied mitochondria...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02789-8
更新日期:2017-06-06 00:00:00