Abstract：
:Adenocarcinoma, large cell carcinoma and squamous cell carcinoma are the most commonly diagnosed subtypes of non-small cell lung cancers (NSCLC). Numerous lung cancer cell types have exhibited electrotaxis under direct current electric fields (dcEF). Physiological electric fields (EF) play key roles in cancer cell migration. In this study, we investigated electrotaxis of NSCLC cells, including human large cell lung carcinoma NCI-H460 and human lung squamous cell carcinoma NCI-H520 cells. Non-cancerous MRC-5 lung fibroblasts were included as a control. After dcEF stimulation, NCI-H460 and NCI-H520 cells, which both exhibit epithelial-like morphology, migrated towards the cathode, while MRC-5 cells, which have fibroblast-like morphology, migrated towards the anode. The effect of doxycycline, a common antibiotic, on electrotaxis of MRC-5, NCI-H460 and NCI-H520 cells was examined. Doxycycline enhanced the tested cells' motility but inhibited electrotaxis in the NSCLC cells without inhibiting non-cancerous MRC-5 cells. Based on our finding, further in-vivo studies could be devised to investigate the metastasis inhibition effect of doxycycline in an organism level.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chang HF,Cheng HT,Chen HY,Yeung WK,Cheng JYdoi
10.1038/s41598-019-44505-8subject
Has Abstractpub_date
2019-05-30 00:00:00pages
8094issue
1issn
2045-2322pii
10.1038/s41598-019-44505-8journal_volume
9pub_type
杂志文章abstract：:Imaging the fields of magnetic materials provides crucial insight into the physical and chemical processes surrounding magnetism, and has been a key ingredient in the spectacular development of magnetic data storage. Existing approaches using the magneto-optic Kerr effect, x-ray and electron microscopy have limitation...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep22797
更新日期：2016-03-14 00:00:00
abstract：:Hepatic encephalopathy is a neuropsychiatric syndrome evolving from cerebral osmotic disturbances and oxidative/nitrosative stress. Ammonia, the main toxin of hepatic encephalopathy, triggers astrocyte senescence in an oxidative stress-dependent way. As miRNAs are critically involved in cell cycle regulation and their...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18493
更新日期：2016-01-12 00:00:00
abstract：:Mercury pollution in soil poses serious risks to human health through consumption of contaminated vegetables. We used a meta-analysis to examine the mercury enrichment ability of different vegetables and the main factors affecting mercury uptake. We drew the following conclusions. (1) Plants with a lower bioconcentrat...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-018-19519-3
更新日期：2018-01-19 00:00:00
abstract：:Vlasouliolides A-D (1-4), four rare sesquiterpene lactone dimers, were isolated from Vladimiria souliei. The common structural characteristic of 1-4 is the C32 skeleton comprising two sesquiterpene lactone units linked by a C11-C13' single bond with one acetyl connected to the C-13 position of one of the two sesquiter...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep43837
更新日期：2017-03-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-60509-1
更新日期：2020-02-20 00:00:00
abstract：:Nanodidamonds containing colour centres open up many applications in quantum information processing, metrology, and quantum sensing. However, controlling the synthesis of nanodiamonds containing silicon vacancy (SiV) centres is still not well understood. Here we study nanodiamonds produced by a high-pressure high-temp...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21953-2
更新日期：2018-02-28 00:00:00
abstract：:Phylogenetic clustering approaches can elucidate HIV transmission dynamics. Comparisons across countries are essential for evaluating public health policies. Here, we used a standardised approach to compare the UK HIV Drug Resistance Database and the Swiss HIV Cohort Study while maintaining data-protection requirement...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/srep32251
更新日期：2016-09-19 00:00:00
abstract：:Agriculture provides livelihood for 65% of Nepal's population contributing for 27% of its GDP. Smallholder farms constitute 60% of farming segment. Distress farming, with inadequate minimum support price, subsidies and inadequate revenue generation force 29% of the general population to be malnourished. Farming system...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67657-4
更新日期：2020-06-29 00:00:00
abstract：:YPEL3 that induces cellular senescence in both normal and tumour cells of humans may show altered expression under the influence of incidental mutations. In this study, we proposed the first structure of Native YPEL3 protein and its five possible deleterious mutants-V40M, C61Y, G98R, G108S, and A131T and predicted the...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72333-8
更新日期：2020-09-17 00:00:00
abstract：:Milk oligosaccharides (MOs) are complex carbohydrates with multifunctional health benefits for the neonate. Poor reproductive performance in primiparous gilts limits their productivity. Changes in the structure and abundance of porcine MO (PMOs) through lactation with parity remains unknown and may explain superior ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23025-x
更新日期：2018-03-16 00:00:00
abstract：:Clostridium ljungdahlii derives energy by lithotrophic and organotrophic acetogenesis. C. ljungdahlii was grown organotrophically with fructose and also lithotrophically, either with syngas - a gas mixture containing hydrogen (H2), carbon dioxide (CO2), and carbon monoxide (CO), or with H2 and CO2. Gene expression was...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12712-w
更新日期：2017-10-13 00:00:00
abstract：:Climatic changes can induce geographic expansion and altitudinal shifts in the distribution of invasive species by offering more thermally suitable habitats. At the remote sub-Antarctic Kerguelen Islands, the predatory insect Merizodus soledadinus (Coleoptera: Carabidae), introduced in 1913, rapidly invaded coastal ha...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57868-0
更新日期：2020-01-27 00:00:00
abstract：:Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have roles in cell-to-cell signaling, biofilm formation, and stress responses. Here, the effects of abiotic stressors on OMV contents and composition from biofilm cells of the plant health-promoting bacterium Pseudomonas chlororaphis O6 (PcO6) are exami...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78357-4
更新日期：2020-12-04 00:00:00
abstract：:Image classification uses computers to simulate human understanding and cognition of images by automatically categorizing images. This study proposes a faster image classification approach that parallelizes the traditional Adaboost-Backpropagation (BP) neural network using the MapReduce parallel programming model. Fir...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38201
更新日期：2016-12-01 00:00:00
abstract：:This study aims to assess the utility of internet search query analysis in pertussis surveillance. This study uses an empirical time series model based on internet search metrics to detect the pertussis incidence in Australia. Our research demonstrates a clear seasonal pattern of both pertussis infections and Google T...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11195-z
更新日期：2017-09-05 00:00:00
abstract：:Metamaterial full-sized absorber structures are numerically and experimentally investigated in GHz region and then examined in THz frequency. By manipulating monitoring the number and the position of the defect elements in conventional unit cells, the optimal integrative absorber structures are generated. The proposed...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27920-1
更新日期：2018-06-22 00:00:00
abstract：:Stabilization exercise (SE) is evident for the management of chronic non-specific low back pain (LBP). The optimal dose-response-relationship for the utmost treatment success is, thus, still unknown. The purpose is to systematically review the dose-response-relationship of stabilisation exercises on pain and disabilit...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-020-73954-9
更新日期：2020-10-09 00:00:00
abstract：:We address the impact of the spin-orbit (SO) coupling on the localization-delocalization-transition (LDT) in a spin-orbit coupled Bose-Einstein condensate in a bichromatic potential. We find that SO coupling significantly alters the threshold depth of the one of sublattices above which the lowest eigenstates transform...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep31700
更新日期：2016-08-17 00:00:00
abstract：:The present study evaluates the potential of Sar gassum muticum (Sar) and Jan ia rubens (Jan) seaweeds for enhancing growth and mitigating soil-salinity in chickpea (Cicer arietinum L.). Under control conditions, Sar and Jan extracts improved chickpea growth which was attributed to their potential for increasing photo...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07692-w
更新日期：2017-09-05 00:00:00
abstract：:The spine flexibility creates one of the most significant challenges to proper positioning in radiation therapy of head and neck cancers. Even though existing immobilization techniques can reduce the positioning uncertainty, residual errors (2-3 mm along the cervical spine) cannot be mitigated by single translation-ba...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-50797-7
更新日期：2019-10-07 00:00:00
abstract：:One of the famous results of network science states that networks with heterogeneous connectivity are more susceptible to epidemic spreading than their more homogeneous counterparts. In particular, in networks of identical nodes it has been shown that network heterogeneity, i.e. a broad degree distribution, can lower ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13122
更新日期：2015-08-21 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-63941-5
更新日期：2020-05-18 00:00:00
abstract：:Chromosomal polymorphism is widespread in the Drosophila genus, with extensive evidence supporting its adaptive character in diverse species. Moreover, inversions are the major contributors to the genus chromosomal evolution. The molecular characterization of a reduced number of polymorphic inversion breakpoints in Dr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36248
更新日期：2016-10-26 00:00:00
abstract：:Invasive fungal infections are a potentially life-threatening complication in immunocompromised patients. The aim of this study was to assess the efficacy and safety of posaconazole as compared with other antifungal agents for preventing invasive fungal infections in immunocompromised patients. Embase, CENTRAL, and ME...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71571-0
更新日期：2020-09-03 00:00:00
abstract：:Hybrid carbon films composed of graphene film and porous carbon film may give full play to the advantages of both carbon materials, and have great potential for application in energy storage and conversion devices. Unfortunately, there are very few reports on fabrication of hybrid carbon films. Here we demonstrate a s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07050
更新日期：2014-11-14 00:00:00
abstract：:The immune system is constantly challenged, being required to protect the organism against a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders. One of the most important molecules involved in these events is the Major Histocompatibility Complex class I (MHC-I), responsible for b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18413
更新日期：2015-12-17 00:00:00
abstract：:Verteporfin (VP), a light-activated drug used in photodynamic therapy for the treatment of choroidal neovascular membranes, has also been shown to be an effective inhibitor of malignant cells. Recently, studies have demonstrated that, even without photo-activation, VP may still inhibit certain tumor cell lines, includ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07632-8
更新日期：2017-08-08 00:00:00
abstract：:Organic photodetectors are interesting for low cost, large area optical sensing applications. Combining organic semiconductors with discrete absorption bands outside the visible wavelength range with transparent and conductive electrodes allows for the fabrication of visibly transparent photodetectors. Visibly transpa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09439
更新日期：2015-03-24 00:00:00
abstract：:Cover cropping is proposed to enhance soil microbial diversity and activity, with cover crop type affecting microbial groups in different ways. We compared fungal community compositions of bulk soils differing by cover crop treatment, season, and edaphic properties in the third year of an organic, conventionally tille...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63173-7
更新日期：2020-04-10 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-62994-w
更新日期：2020-04-24 00:00:00
