Abstract：
:Vlasouliolides A-D (1-4), four rare sesquiterpene lactone dimers, were isolated from Vladimiria souliei. The common structural characteristic of 1-4 is the C32 skeleton comprising two sesquiterpene lactone units linked by a C11-C13' single bond with one acetyl connected to the C-13 position of one of the two sesquiterpene lactone units. The stereochemistries of 1-4 were assigned by a combination of NOESY correlations and Cu-Κα X-ray crystallographic analyses. Compounds 1-4 strongly inhibited the production of NO in LPS-stimulated RAW 264.7 cells. Furthermore, 1 and 2 inhibited the activation of NF-κB in LPS-induced 293T cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Chen LP,Wu GZ,Zhang JP,Ye J,Liu QX,Shen YH,Li HL,Zhang WDdoi
10.1038/srep43837subject
Has Abstractpub_date
2017-03-03 00:00:00pages
43837issn
2045-2322pii
srep43837journal_volume
7pub_type
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