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Attenuation of Na/K-ATPase Mediated Oxidant Amplification with pNaKtide Ameliorates Experimental Uremic Cardiomyopathy.

Abstract：

:We have previously reported that the sodium potassium adenosine triphosphatase (Na/K-ATPase) can effect the amplification of reactive oxygen species. In this study, we examined whether attenuation of oxidant stress by antagonism of Na/K-ATPase oxidant amplification might ameliorate experimental uremic cardiomyopathy induced by partial nephrectomy (PNx). PNx induced the development of cardiac morphological and biochemical changes consistent with human uremic cardiomyopathy. Both inhibition of Na/K-ATPase oxidant amplification with pNaKtide and induction of heme oxygenase-1 (HO-1) with cobalt protoporphyrin (CoPP) markedly attenuated the development of phenotypical features of uremic cardiomyopathy. In a reversal study, administration of pNaKtide after the induction of uremic cardiomyopathy reversed many of the phenotypical features. Attenuation of Na/K-ATPase oxidant amplification may be a potential strategy for clinical therapy of this disorder.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Liu J,Tian J,Chaudhry M,Maxwell K,Yan Y,Wang X,Shah PT,Khawaja AA,Martin R,Robinette TJ,El-Hamdani A,Dodrill MW,Sodhi K,Drummond CA,Haller ST,Kennedy DJ,Abraham NG,Xie Z,Shapiro JI

doi

10.1038/srep34592

subject

Has Abstract

pub_date

2016-10-04 00:00:00

pages

34592

issn

2045-2322

pii

srep34592

journal_volume

6

pub_type

杂志文章

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