Genomic Analyses of Breast Cancer Progression Reveal Distinct Routes of Metastasis Emergence.

Abstract:

:A main controversy in cancer research is whether metastatic abilities are present in the most advanced clone of the primary tumor or result from independently acquired aberrations in early disseminated cancer cells as suggested by the linear and the parallel progression models, respectively. The genetic concordance between different steps of malignant progression is mostly unexplored as very few studies have included cancer samples separated by both space and time. We applied whole exome sequencing and targeted deep sequencing to 26 successive samples from six patients with metastatic estrogen receptor (ER)-positive breast cancer. Our data provide support for both linear and parallel progression towards metastasis. We report for the first time evidence of metastasis-to-metastasis seeding in breast cancer. Our results point to three distinct routes of metastasis emergence. This may have profound clinical implications and provides substantial novel molecular insights into the timing and mutational evolution of breast cancer metastasis.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Krøigård AB,Larsen MJ,Brasch-Andersen C,Lænkholm AV,Knoop AS,Jensen JD,Bak M,Mollenhauer J,Thomassen M,Kruse TA

doi

10.1038/srep43813

subject

Has Abstract

pub_date

2017-03-09 00:00:00

pages

43813

issn

2045-2322

pii

srep43813

journal_volume

7

pub_type

杂志文章
  • Egocentrically-stable discriminative stimulus-based spatial navigation in mice: implementation and comparison with allocentric cues.

    abstract::Animals are capable of using visual cues to find the correct route during navigation. These visual cues, which contain spatial information on the direction towards the goal point, are perceived either allocentrically or egocentrically. In this study, we examined how navigating with these two types of visual cues affec...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-42852-0

    authors: Chun J,Kim Y,Choi JW,Kim D,Jo S

    更新日期:2019-04-23 00:00:00

  • Robust light-dark patterns and reduced amyloid load in an Alzheimer's disease transgenic mouse model.

    abstract::Circadian disruption resulting from exposure to irregular light-dark patterns and sleep deprivation has been associated with beta amyloid peptide (Aβ) aggregation, which is a major event in Alzheimer's disease (AD) pathology. We exposed 5XFAD mice and littermate controls to dim-light vs. bright-light photophases to in...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-68199-5

    authors: Nagare R,Possidente B,Lagalwar S,Figueiro MG

    更新日期:2020-07-10 00:00:00

  • Circulating vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D and risk of colorectal cancer.

    abstract::Epidemiological investigation have suggested that there is a significantly inverse association between circulating 25-hydroxyvitamin D (25(OH)D) and the risk for developing colorectal cancer (CRC) in humans. However, little is known about the role of vitamin D binding protein (VDBP) in colorectal carcinogenesis. Blood...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep07956

    authors: Ying HQ,Sun HL,He BS,Pan YQ,Wang F,Deng QW,Chen J,Liu X,Wang SK

    更新日期:2015-01-22 00:00:00

  • The role of city size and urban form in the surface urban heat island.

    abstract::Urban climate is determined by a variety of factors, whose knowledge can help to attenuate heat stress in the context of ongoing urbanization and climate change. We study the influence of city size and urban form on the Urban Heat Island (UHI) phenomenon in Europe and find a complex interplay between UHI intensity and...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04242-2

    authors: Zhou B,Rybski D,Kropp JP

    更新日期:2017-07-06 00:00:00

  • Evolutionary food web model based on body masses gives realistic networks with permanent species turnover.

    abstract::The networks of predator-prey interactions in ecological systems are remarkably complex, but nevertheless surprisingly stable in terms of long term persistence of the system as a whole. In order to understand the mechanism driving the complexity and stability of such food webs, we developed an eco-evolutionary model i...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10955

    authors: Allhoff KT,Ritterskamp D,Rall BC,Drossel B,Guill C

    更新日期:2015-06-04 00:00:00

  • Variations in oral microbiome profiles in rheumatoid arthritis and osteoarthritis with potential biomarkers for arthritis screening.

    abstract::The key to arthritis management is early diagnosis and treatment to prevent further joint destruction and maximize functional ability. Osteoarthritis (OA) and rheumatoid arthritis (RA) are two common types of arthritis that the primary care provider must differentiate, in terms of diagnosis and treatment. Effective an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-35473-6

    authors: Chen B,Zhao Y,Li S,Yang L,Wang H,Wang T,Bin Shi,Gai Z,Heng X,Zhang C,Yang J,Zhang L

    更新日期:2018-11-20 00:00:00

  • Light Emission from Plasmonic Nanostructures Enhanced with Fluorescent Nanodiamonds.

    abstract::In the surface-enhanced fluorescence (SEF) process, it is well known that the plasmonic nanostructure can enhance the light emission of fluorescent emitters. With the help of atomic force microscopy, a hybrid system consisting of a fluorescent nanodiamond and a gold nanoparticle was assembled step-by-step for in situ ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-22019-z

    authors: Zhao J,Cheng Y,Shen H,Hui YY,Wen T,Chang HC,Gong Q,Lu G

    更新日期:2018-02-26 00:00:00

  • Efficient Alpha Radiation Detector using Low Temperature Hydrothermally Grown ZnO:Ga Nanorod Scintillator.

    abstract::We report efficient detection of alpha radiation on highly textured and vertically aligned along (002) Gallium-doped Zinc Oxide (ZnO:Ga) nanorods on a glass substrate with an average diameter ~150 ± 10 nm. Photoluminescence measurement showed near band emission 393 nm, in agreement with the bandgap value ~3.22 eV, mea...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47732-1

    authors: Sahani RM,Kumari C,Pandya A,Dixit A

    更新日期:2019-08-06 00:00:00

  • Unusual terahertz waveforms from a resonant medium controlled by diffractive optical elements.

    abstract::Up to now, full tunability of waveforms was possible only in electronics, up to radio-frequencies. Here we propose a new concept of producing few-cycle terahertz (THz) pulses with widely tunable waveforms. It is based on control of the phase delay between different parts of the THz wavefront using linear diffractive o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43852-w

    authors: Pakhomov AV,Arkhipov RM,Arkhipov MV,Demircan A,Morgner U,Rosanov NN,Babushkin I

    更新日期:2019-05-15 00:00:00

  • A preliminary analysis on the effect of copper on Anopheles coluzzii insecticide resistance in vegetable farms in Benin.

    abstract::The use of agrochemicals in vegetable production could influence the selection for insecticide resistance in malaria vectors. Unfortunately, there is a dearth of information on the potential contribution of agrochemicals to insecticide resistance in Anopheles mosquitoes breeding on vegetable farms in southern Benin. A...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-63086-5

    authors: Talom AD,Essoung MA,Gbankoto A,Tchigossou G,Akoton R,Sahabi BBA,Atoyebi SM,Fotso Kuate A,Verspoor RL,Tamò M,Tchuinkam T,Lehman GL,Lines J,Wondji CS,Djouaka R

    更新日期:2020-04-14 00:00:00

  • Genetic diversity and novel lineages in the cosmopolitan copepod Pleuromamma abdominalis in the Southeast Pacific.

    abstract::Across boundary currents, zooplankton are subject to strong oceanographic gradients and hence strong selective pressures. How such gradients interact with the speciation process of pelagic organisms is still poorly understood in the open ocean realm. Here we report on genetic diversity within the pelagic copepod Pleur...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56935-5

    authors: González CE,Goetze E,Escribano R,Ulloa O,Victoriano P

    更新日期:2020-01-24 00:00:00

  • Hypocretin in median raphe nucleus modulates footshock stimuli-induced REM sleep alteration.

    abstract::Stress is one of major factors that cause sleep problems. Hypocretin represents a stress-related neuropeptide and is well known in maintaining physiological wakefulness. The hypocretinergic neurons originate in the lateral hypothalamic area (LHA) and transmit to several brain regions, including the median raphe nuclei...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-44731-0

    authors: Hsiao YT,Lo Y,Yi PL,Chang FC

    更新日期:2019-06-03 00:00:00

  • Impairment of microbial and meiofaunal ecosystem functions linked to algal forest loss.

    abstract::Habitat loss is jeopardizing marine biodiversity. In the Mediterranean Sea, the algal forests of Cystoseira spp. form one of the most complex, productive and vulnerable shallow-water habitats. These forests are rapidly regressing with negative impact on the associated biodiversity, and potential consequences in terms ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76817-5

    authors: Bianchelli S,Danovaro R

    更新日期:2020-11-17 00:00:00

  • Social Environment Shapes the Speed of Cooperation.

    abstract::Are cooperative decisions typically made more quickly or slowly than non-cooperative decisions? While this question has attracted considerable attention in recent years, most research has focused on one-shot interactions. Yet it is repeated interactions that characterize most important real-world social interactions. ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29622

    authors: Nishi A,Christakis NA,Evans AM,O'Malley AJ,Rand DG

    更新日期:2016-07-20 00:00:00

  • SLC10A4 regulates IgE-mediated mast cell degranulation in vitro and mast cell-mediated reactions in vivo.

    abstract::Mast cells act as sensors in innate immunity and as effector cells in adaptive immune reactions. Here we demonstrate that SLC10A4, also referred to as the vesicular aminergic-associated transporter, VAAT, modifies mast cell degranulation. Strikingly, Slc10a4 -/- bone marrow-derived mast cells (BMMCs) had a significant...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01121-8

    authors: Pettersson H,Zarnegar B,Westin A,Persson V,Peuckert C,Jonsson J,Hallgren J,Kullander K

    更新日期:2017-04-24 00:00:00

  • c-axis preferential orientation of hydroxyapatite accounts for the high wear resistance of the teeth of black carp (Mylopharyngodon piceus).

    abstract::Biological armors such as mollusk shells have long been recognized and studied for their values in inspiring novel designs of engineering materials with higher toughness and strength. However, no material is invincible and biological armors also have their rivals. In this paper, our attention is focused on the teeth o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23509

    authors: Fu J,He C,Xia B,Li Y,Feng Q,Yin Q,Shi X,Feng X,Wang H,Yao H

    更新日期:2016-03-22 00:00:00

  • Vitamin D deficiency, cardiothoracic ratio, and long-term mortality in hemodialysis patients.

    abstract::Hemodialysis patients are a special group of patients with higher mortality rates. Hemodialysis patients with vitamin D deficiency {plasma levels of 25-hydroxyvitamin D [25(OH)D] below 20 ng/mL} are associated with even higher mortality rates. The prognostic importance of vitamin D deficiency in hemodialysis patients ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64359-9

    authors: Hsu HJ,Wu IW,Hsu KH,Sun CY,Chen CY,Lee CC

    更新日期:2020-05-05 00:00:00

  • Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers.

    abstract::Strategic delivery of IRDye 700DX (photosensitizer) is a key for improving its effect in photodynamic therapy. In this study, we have synthesized IRDye 700DX-conjugated polymers containing multiple cyclic RGD peptides to deliver IRDye 700DX selectively to tumor cells and tumor-associated blood vessels overexpressing α...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26593-0

    authors: Dou X,Nomoto T,Takemoto H,Matsui M,Tomoda K,Nishiyama N

    更新日期:2018-05-25 00:00:00

  • Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity.

    abstract::The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the endothelial cells of visceral adipose tissue have recently been reported to play a role in lipid metabolism and inflammation, we investigated the e...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-10240-1

    authors: Bae CR,Hino J,Hosoda H,Arai Y,Son C,Makino H,Tokudome T,Tomita T,Kimura T,Nojiri T,Hosoda K,Miyazato M,Kangawa K

    更新日期:2017-08-29 00:00:00

  • Identification of Tp0751 (Pallilysin) as a Treponema pallidum Vascular Adhesin by Heterologous Expression in the Lyme disease Spirochete.

    abstract::Treponema pallidum subsp. pallidum, the causative agent of syphilis, is a highly invasive spirochete pathogen that uses the vasculature to disseminate throughout the body. Identification of bacterial factors promoting dissemination is crucial for syphilis vaccine development. An important step in dissemination is bact...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-01589-4

    authors: Kao WA,Pětrošová H,Ebady R,Lithgow KV,Rojas P,Zhang Y,Kim YE,Kim YR,Odisho T,Gupta N,Moter A,Cameron CE,Moriarty TJ

    更新日期:2017-05-08 00:00:00

  • An improved overlap extension PCR for simultaneous multiple sites large fragments insertion, deletion and substitution.

    abstract::The existing molecular cloning methods are often limited by the availability of suitable restriction sites. It is still a challenge for simultaneous cloning of multiple fragments into different sites of a single vector. Here we developed a novel method named improved overlap extension PCR (IOEP) for restriction enzyme...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-52122-8

    authors: Guo W,Xie B,Jiang M,Zhu XJ,Qiu M,Dai ZM

    更新日期:2019-10-30 00:00:00

  • An fMRI-compatible force measurement system for the evaluation of the neural correlates of step initiation.

    abstract::Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition o...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep43088

    authors: de Lima-Pardini AC,de Azevedo Neto RM,Coelho DB,Boffino CC,Shergill SS,de Oliveira Souza C,Brant R,Barbosa ER,Cardoso EF,Teixeira LA,Cohen RG,Horak FB,Amaro E Jr

    更新日期:2017-02-23 00:00:00

  • Increase in predation risk and trophic level induced by nocturnal visits of piscivorous fishes in a temperate seagrass bed.

    abstract::The majority of surveys on food webs of aquatic ecosystems have been conducted during the day owning to difficulties in sampling animals at night. In this study, to examine diurnal changes in predator-prey interactions in a temperate seagrass Zostera marina bed, a quantitative day/night survey of fish, the dominant an...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-04217-3

    authors: Shoji J,Mitamura H,Ichikawa K,Kinoshita H,Arai N

    更新日期:2017-06-20 00:00:00

  • Selective suppression of rapid eye movement sleep increases next-day negative affect and amygdala responses to social exclusion.

    abstract::Healthy sleep, positive general affect, and the ability to regulate emotional experiences are fundamental for well-being. In contrast, various mental disorders are associated with altered rapid eye movement (REM) sleep, negative affect, and diminished emotion regulation abilities. However, the neural processes mediati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-74169-8

    authors: Glosemeyer RW,Diekelmann S,Cassel W,Kesper K,Koehler U,Westermann S,Steffen A,Borgwardt S,Wilhelm I,Müller-Pinzler L,Paulus FM,Krach S,Stolz DS

    更新日期:2020-10-14 00:00:00

  • Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer.

    abstract::Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagn...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55952-8

    authors: Martín-Blázquez A,Díaz C,González-Flores E,Franco-Rivas D,Jiménez-Luna C,Melguizo C,Prados J,Genilloud O,Vicente F,Caba O,Pérez Del Palacio J

    更新日期:2019-12-27 00:00:00

  • A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval.

    abstract::Nucleotide excision repair (NER) excises bulky DNA lesions induced by mutagens and carcinogens. The repair process includes recognition of DNA damage, excision of a short patch of nucleotides containing the damaged base, re-synthesis of a new DNA strand and ligation of the nicks to restore the sequence integrity. Muta...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04894

    authors: Shen JC,Fox EJ,Ahn EH,Loeb LA

    更新日期:2014-05-08 00:00:00

  • Failure dynamics of the global risk network.

    abstract::Risks threatening modern societies form an intricately interconnected network that often underlies crisis situations. Yet, little is known about how risk materializations in distinct domains influence each other. Here we present an approach in which expert assessments of likelihoods and influence of risks underlie a q...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep10998

    authors: Szymanski BK,Lin X,Asztalos A,Sreenivasan S

    更新日期:2015-06-18 00:00:00

  • Melatonin enhances the developmental competence of porcine somatic cell nuclear transfer embryos by preventing DNA damage induced by oxidative stress.

    abstract::Melatonin has antioxidant and scavenger effects in the cellular antioxidant system. This research investigated the protective effects and underlying mechanisms of melatonin action in porcine somatic cell nuclear transfer (SCNT) embryos. The results suggested that the developmental competence of porcine SCNT embryos wa...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11161-9

    authors: Liang S,Jin YX,Yuan B,Zhang JB,Kim NH

    更新日期:2017-09-11 00:00:00

  • Tracking actomyosin at fluorescence check points.

    abstract::Emerging concepts for on-chip biotechnologies aim to replace microfluidic flow by active, molecular-motor driven transport of cytoskeletal filaments, including applications in bio-simulation, biocomputation, diagnostics, and drug screening. Many of these applications require reliable detection, with minimal data acqui...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep01092

    authors: Lard M,ten Siethoff L,Månsson A,Linke H

    更新日期:2013-01-01 00:00:00

  • Wound healing profiles of hyperopic-small incision lenticule extraction (SMILE).

    abstract::Refractive surgical treatment of hyperopia still remains a challenge for refractive surgeons. A new nomogram of small incision lenticule extraction (SMILE) procedure has recently been developed for the treatment of hyperopia. In the present study, we aimed to evaluate the wound healing and inflammatory responses of th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep29802

    authors: Liu YC,Ang HP,Teo EP,Lwin NC,Yam GH,Mehta JS

    更新日期:2016-07-15 00:00:00