Abstract：
:Particle transport phenomena in the deep alveolated airways of the lungs (i.e. pulmonary acinus) govern deposition outcomes following inhalation of hazardous or pharmaceutical aerosols. Yet, there is still a dearth of experimental tools for resolving acinar particle dynamics and validating numerical simulations. Here, we present a true-scale experimental model of acinar structures consisting of bifurcating alveolated ducts that capture breathing-like wall motion and ensuing respiratory acinar flows. We study experimentally captured trajectories of inhaled polydispersed smoke particles (0.2 to 1 μm in diameter), demonstrating how intrinsic particle motion, i.e. gravity and diffusion, is crucial in determining dispersion and deposition of aerosols through a streamline crossing mechanism, a phenomenon paramount during flow reversal and locally within alveolar cavities. A simple conceptual framework is constructed for predicting the fate of inhaled particles near an alveolus by identifying capture and escape zones and considering how streamline crossing may shift particles between them. In addition, we examine the effect of particle size on detailed deposition patterns of monodispersed microspheres between 0.1-2 μm. Our experiments underline local modifications in the deposition patterns due to gravity for particles ≥0.5 μm compared to smaller particles, and show good agreement with corresponding numerical simulations.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Fishler R,Hofemeier P,Etzion Y,Dubowski Y,Sznitman Jdoi
10.1038/srep14071subject
Has Abstractpub_date
2015-09-11 00:00:00pages
14071issn
2045-2322pii
srep14071journal_volume
5pub_type
杂志文章abstract：:Alp14 is a TOG-family microtubule polymerase from S. pombe that tracks plus ends and accelerates their growth. To interrogate its mechanism, we reconstituted dynamically unstable single isoform S. pombe microtubules with full length Alp14/TOG and Alp7, the TACC-family binding partner of Alp14. We find that Alp14 can d...
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pub_type： 杂志文章
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更新日期：2016-02-11 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2016-05-20 00:00:00
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pub_type： 杂志文章
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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更新日期：2015-03-10 00:00:00
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更新日期：2017-03-08 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 已发布勘误
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更新日期：2016-11-18 00:00:00
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