Abstract：
:Spinal cord injury (SCI) is frequently accompanied by a degree of spontaneous functional recovery. The underlying mechanisms through which such recovery is generated remain elusive. In this study, we observed a significant spontaneous motor function recovery 14 to 28 days after spinal cord transection (SCT) in rats. Using a comparative proteomics approach, caudal to the injury, we detected difference in 20 proteins. Two of these proteins, are eukaryotic translation initiation factor 5A1 (eIF5A1) that is involved in cell survival and proliferation, and Rho GDP dissociation inhibitor alpha (RhoGDIα), a member of Rho GDI family that is involved in cytoskeletal reorganization. After confirming the changes in expression levels of these two proteins following SCT, we showed that in vivo eIF5A1 up-regulation and down-regulation significantly increased and decreased, respectively, motor function recovery. In vitro, eIF5A1 overexpression in primary neurons increased cell survival and elongated neurite length while eIF5A1 knockdown reversed these results. We found that RhoGDIα up-regulation and down-regulation rescues the effect of eIF5A1 down-regulation and up-regulation both in vivo and in vitro. Therefore, we have identified eIF5A1/RhoGDIα pathway as a new therapeutic target for treatment of spinal cord injured patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Liu W,Shang FF,Xu Y,Belegu V,Xia L,Zhao W,Liu R,Wang W,Liu J,Li CY,Wang THdoi
10.1038/srep16911subject
Has Abstractpub_date
2015-11-23 00:00:00pages
16911issn
2045-2322pii
srep16911journal_volume
5pub_type
杂志文章abstract：:The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period. The underlying mechanism for p53 variability is not fully understood. Here, we construct a core regulato...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41904-9
更新日期：2019-04-10 00:00:00
abstract：:Persistent human papillomavirus (HPV) infection is the vital factor driving cervical carcinogenesis; however, other features of the local cervicovaginal microenvironment (CVM) may play a critical role in development of precancerous cervical dysplasia and progression to invasive cervical carcinoma (ICC). Here we invest...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-43849-5
更新日期：2019-05-14 00:00:00
abstract：:A practical quantum computer must be capable of performing high fidelity quantum gates on a set of quantum bits (qubits). In the presence of noise, the realization of such gates poses daunting challenges. Geometric phases, which possess intrinsic noise-tolerant features, hold the promise for performing robust quantum ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18414
更新日期：2015-12-21 00:00:00
abstract：:Spin-polarized triangular graphene nanoflakes (t-GNFs) serve as ideal building blocks for the long-desired ferromagnetic graphene superlattices, but they are always assembled to planar structures which reduce its mechanical properties. Here, by joining t-GNFs in a spiral way, we propose one-dimensional graphene spiral...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05699
更新日期：2014-07-16 00:00:00
abstract：:Global warming is projected to continue, leading to intense fluctuations in precipitation and heat waves and thereby affecting the productivity and the relevant biological processes of grassland ecosystems. Here, we determined the functional responses to warming and altered precipitation in both typical and desert ste...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34801
更新日期：2016-10-10 00:00:00
abstract：:Various neurophysiological and cognitive functions are based on transferring information between spiking neurons via a complex system of synaptic connections. In particular, the capacity of presynaptic inputs to influence the postsynaptic outputs-the efficacy of the synapses-plays a principal role in all aspects of hi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-36807-0
更新日期：2019-01-24 00:00:00
abstract：:Soils are an important source of nitrogen in many of the world's cropping systems. Especially in low-input production systems, nitrogen release from soil organic matter turn-over is the major part of the crop's nitrogen supply and research suggests that this process is significantly affected by changes in climate. The...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-42274-y
更新日期：2019-04-10 00:00:00
abstract：:Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited efficacy. Present bisphosphonates stimulate γδ T cells but were designed to inhibit bone ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05553-0
更新日期：2017-07-20 00:00:00
abstract：:Marine biofouling can cause a biocorrosion, resulting in degradation and failure of materials and structures. In order to prevent sea creatures from attaching to the surface, in this work, a new environmentally friendly antifouling coating by incorporating antibacterial polymers and natural antifouling agents has been...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-67073-8
更新日期：2020-06-25 00:00:00
abstract：:Transmembrane flux of Cs+ (a K+ congener) was measured in human red blood cells (RBCs; erythrocytes) on the 10-s time scale. This is the first report on dissolution dynamic nuclear polarization (dDNP) nuclear magnetic resonance (NMR) spectroscopy with this nuclide in mammalian cells. Four technical developments regula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-56250-z
更新日期：2019-12-23 00:00:00
abstract：:Extranodal NK/T-cell lymphoma, nasal type (NKTL) is an aggressive type of non-Hodgkin lymphoma closely associated with Epstein-Barr virus and characterized by varying degrees of systemic inflammation. We aim to examine the prognostic significance of peripheral blood neutrophil-lymphocyte ratio (NLR) in patients with N...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/s41598-019-51522-0
更新日期：2019-10-18 00:00:00
abstract：:N-methyl-D-aspartate (NMDA) receptors are glutamate- and glycine-gated channels composed of two GluN1 and two GluN2 or/and GluN3 subunits. GluN3A expression is developmentally regulated, and changes in this normal pattern of expression, which occur in several brain disorders, alter synaptic maturation and function by ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep23344
更新日期：2016-03-22 00:00:00
abstract：:Aneuploidy has been reported to occur at remarkably high levels in normal somatic tissues using Fluorescence In Situ Hybridization (FISH). Recently, these reports were contradicted by single-cell low-coverage whole genome sequencing (scL-WGS) analyses, which showed aneuploidy frequencies at least an order of magnitude...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46606-w
更新日期：2019-07-19 00:00:00
abstract：:We used Mendelian randomization to estimate the causal effects of the liver enzymes, alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma glutamyltransferase (GGT), on diabetes and cardiovascular disease, using genetic variants predicting these liver enzymes at genome wide significance applied to exten...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38813
更新日期：2016-12-20 00:00:00
abstract：:Rheumatoid Arthritis (RA) causes chronic inflammation of joints. The cytokines TNFα and IFNγ are central players in RA, however their source has not been fully elucidated. Natural Killer (NK) cells are best known for their role in elimination of viral-infected and transformed cells, and they secrete pro-inflammatory c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37448-z
更新日期：2019-02-04 00:00:00
abstract：:Multishelled NiO hollow microspheres for high-performance supercapacitors have been prepared and the formation mechanism has been investigated. By using resin microspheres to absorb Ni(2+) and subsequent proper calcinations, the shell numbers, shell spacing and exterior shell structure were facilely controlled via var...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep33241
更新日期：2016-09-12 00:00:00
abstract：:Countries in the Asia Pacific region aim to eliminate malaria by 2030. A cornerstone of malaria elimination is the effective management of Anopheles mosquito vectors. Current control tools such as insecticide treated nets or indoor residual sprays target mosquitoes in human dwellings. We find in a high transmission re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40551
更新日期：2017-01-16 00:00:00
abstract：:Amino acid biosynthesis pathways observed in nature typically require enzymes that are made with the amino acids they produce. For example, Escherichia coli produces cysteine from serine via two enzymes that contain cysteine: serine acetyltransferase (CysE) and O-acetylserine sulfhydrylase (CysK/CysM). To solve this c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19920-y
更新日期：2018-01-29 00:00:00
abstract：:A soil remediation method based on magnetic beneficiation is reported. A new magnetic solid chelator powder, FS@IDA (core-shell Fe3O4@SiO2 nanoparticles coated with iminodiacetic acid chelators), was used as a reactive magnetic carrier to selectively capture non-magnetic heavy metals in soil by chelation and removal b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep21027
更新日期：2016-02-16 00:00:00
abstract：:This research investigated the association between prolonged disposable diaper (DD) wearing in infancy and primary enuresis (PNE). As a case-control study, we collected data from 376 children with enuresis and 379 healthy children who were sex- and age-matched at three tertiary care institutions in mainland China from...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70195-8
更新日期：2020-09-01 00:00:00
abstract：:Induction of premature senescence represents a novel functional strategy to curb the uncontrolled proliferation of malignant cancer cells. This study unveils the regiospecific synthesis of novel isoxazoline derivatives condensed to ring A of medicinal plant product Withaferin-A. Intriguingly, the cis fused products wi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13664-x
更新日期：2017-10-23 00:00:00
abstract：:Water-saving and drought-resistantce rice (WDR) breeding practices have greatly increased grain yield and drought resistance. To study the genetic basis of adaptation to drought, transcriptome sequences from the WDR maintainer line HuHan2B and the recurrent parent HanFengB were analyzed for alternative splicing (AS) c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12020-3
更新日期：2017-09-15 00:00:00
abstract：:Knowledge about a tool's dynamics can be acquired from the visual configuration of the tool and through physical interaction. Here, we examine how visual information affects the generalization of dynamic learning during tool use. Subjects rotated a virtual hammer-like object while we varied the object dynamics separat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39507-5
更新日期：2019-02-25 00:00:00
abstract：:This paper reports a facile and green method for conversion of graphene oxide (GO) into graphene by low-temperature heating (80 °C) in the presence of a glass wafer. Compared to conventional GO chemical reduction methods, the presented approach is easy-scalable, operationally simple, and based on the use of a non-toxi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32488-x
更新日期：2018-09-20 00:00:00
abstract：:The number of osteoarthritis patients is increasing with the rise in the number of elderly people in developed countries. Osteoarthritis, which causes joint pain and deformity leading to loss of activities of daily living, is often treated surgically. Here we show that mechanical stress promotes accumulation of reacti...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55297-2
更新日期：2019-12-10 00:00:00
abstract：:In this paper, a multi-band metal-insulator-metal (MIM) perfect absorber with refractive index sensing capability has been investigated in near-infrared region. The proposed structure has been studied for biomedical applications such as detection of solution of glucose in water, diagnosis of different stages of malari...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63459-w
更新日期：2020-04-14 00:00:00
abstract：:Natural Bacillus isolates generate limited amounts of surfactin (<10% of their biomass), which functions as an antibiotic or signalling molecule in inter-/intra-specific interactions. However, overproduction of surfactin in Bacillus amyloliquefaciens MT45 was observed at a titre of 2.93 g/l, which is equivalent to hal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40976
更新日期：2017-01-23 00:00:00
abstract：:Selenium and selenium nanoparticles (SeNPs) are extensively used in biomedicine, electronics and some other industrial applications. The bioproduction of SeNPs is gaining interest as a green method to manufacture these biotechnologically relevant products. Several microorganisms have been used for the production of Se...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-16252-1
更新日期：2017-11-22 00:00:00
abstract：:Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracellular domain. Here, we report that in both immature (before synaptogen...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75047-z
更新日期：2020-10-22 00:00:00
abstract：:Layered-structure materials are currently relevant given their quasi-2D nature. Knowledge of their physical properties is currently of major interest. Niobium ditelluride possesses a monoclinic layered-structure with a distortion in the tellurium planes. This structural complexity has hindered the determination of its...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35308-4
更新日期：2018-11-19 00:00:00
