Abstract:
:Collateral perfusion is important for sustaining tissue viability in acute ischemic stroke. Conventional techniques for its visualization are invasive, require contrast agents and demonstrate collateral vessels, rather than measuring perfusion directly. In this study we utilize a non-invasive, non-contrast magnetic resonance imaging (MRI)-based method to directly quantify collateral perfusion in acute stroke patients. Vessel-encoded multi-postlabeling delay arterial spin labeling (ASL) was used to separately quantify the blood flow and blood arrival time from four arteries supplying the brain in patients presenting within 18 hours of stroke onset. Twenty-nine acute ischemic stroke patients were scanned with a median time of onset to first MRI of 3 hours. Collateral perfusion at presentation was associated with tissue fate at 1-week. It sustained tissue prior to reperfusion, but was less effective than direct blood flow at maintaining tissue viability in patients who did not reperfuse. Delay in the blood arrival around the ischemic region was found at presentation and reduced over time but was not consistently associated with collateral perfusion. Vessel-encoded multi-postlabeling delay ASL provides a non-invasive tool for direct measurement of collateral perfusion and delayed blood arrival in acute stroke patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Okell TW,Harston GWJ,Chappell MA,Sheerin F,Kennedy J,Jezzard Pdoi
10.1038/s41598-019-44417-7subject
Has Abstractpub_date
2019-06-03 00:00:00pages
8181issue
1issn
2045-2322pii
10.1038/s41598-019-44417-7journal_volume
9pub_type
杂志文章abstract::Clinical observations suggest neuronal control of bone remodeling. Sensory nerve fibers innervating bone, bone marrow and periosteum signal via neurotransmitters including substance P (SP). In previous studies we observed impaired biomechanical and structural bone parameters in tachykinin (Tac) 1-deficient mice lackin...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27432-y
更新日期:2018-06-15 00:00:00
abstract::Magnetic carboxyl functional nanoporous polymer (MCFNP) was chemically fabricated by incorporation of magnetic Fe3O4 precursor into the carboxyl functional nanoporous polymer (CFNP). The as-synthesized MCFNP was characterized and used as an adsorbent for rapid adsorption removal of methylene blue (MB) from wastewater....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24873-3
更新日期:2018-04-25 00:00:00
abstract::Ectoine synthase (EctC) is the signature enzyme for the production of ectoine, a compatible solute and chemical chaperone widely synthesized by bacteria as a cellular defense against the detrimental effects of osmotic stress. EctC catalyzes the last step in ectoine synthesis through cyclo-condensation of the EctA-form...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-36247-w
更新日期:2019-01-23 00:00:00
abstract::Grain boundaries (GBs) in graphene prepared by chemical vapor deposition (CVD) greatly degrade the electrical and mechanical properties of graphene and thus hinder the applications of graphene in electronic devices. The seamless stitching of graphene flakes can avoid GBs, wherein the identical orientation of graphene ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep06541
更新日期:2014-10-07 00:00:00
abstract::Measurement techniques that allow the global analysis of cellular responses while retaining single-cell sensitivity are increasingly needed in order to understand complex and dynamic biological processes. In this context, compromises between sensitivity, degree of multiplexing, throughput, and invasiveness are often u...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53428-3
更新日期:2019-11-19 00:00:00
abstract::Tumor cells tend to behave differently in response to immune selective conditions. Contrary to those in therapeutic antitumor conditions, tumor cells in prophylactic antitumor conditions lose antigen expression for antitumor immune escape. Here, using a CT26/HER2 tumor model, we investigate the underlying mechanism(s)...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-39557-9
更新日期:2019-02-27 00:00:00
abstract::With the advent of nanotechnology, a variety of nanoarchitectures with varied physicochemical properties have been designed. Owing to the unique characteristics, DNAs have been used as a functional building block for novel nanoarchitecture. In particular, a self-assembly of long DNA molecules via a piece DNA staple ha...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17722
更新日期:2015-12-04 00:00:00
abstract::A visible light active Bi0.9Ho0.1FeO3 nanoparticles/TiO2 composite thin films with different mol.% of Bi0.9Ho0.1FeO3 were successfully prepared via non-aqueous sol-gel method. The incorporation of 5, 10 and 20 mol.% Bi0.9Ho0.1FeO3 nanoparticles in the precursor solution of TiO2 brings modifications in the functional p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41570-x
更新日期:2019-03-26 00:00:00
abstract::Several microbes, including Staphylococcus epidermidis (S. epidermidis), a Gram-positive bacterium, live inside the human nasal cavity as commensals. The role of these nasal commensals in host innate immunity is largely unknown, although bacterial interference in the nasal microbiome may promote ecological competition...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep27870
更新日期:2016-06-16 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60956-w
更新日期:2020-02-26 00:00:00
abstract::Cell-free enzymatic reaction cascades combine the advantages of well-established in vitro biocatalysis with the power of multi-step in vivo pathways. The absence of a regulatory cell environment enables direct process control including methods for facile bottleneck identification and process optimization. Within this ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48151-y
更新日期:2019-08-13 00:00:00
abstract::Lipidomic analyses address the problem of characterizing the lipid components of given cells, tissues and organisms by means of chromatographic separations coupled to high-resolution, tandem mass spectrometry analyses. A number of software tools have been developed to help in the daunting task of mass spectrometry sig...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-70259-9
更新日期:2020-08-07 00:00:00
abstract::Insects' exoskeleton, gut, hemocoel, and cells are colonized by various microorganisms that often play important roles in their host life. Moreover, insects are frequently infected by vertically transmitted symbionts that can manipulate their reproduction. The aims of this study were the characterization of bacterial ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-32747-x
更新日期:2018-09-26 00:00:00
abstract::Invasive species populations periodically collapse from high to low abundance, sometimes even to extinction. Pathogens and the burden they place on invader immune systems have been hypothesised as a mechanism for these collapses. We examined the association of the bacterial pathogen (Pseudomonas spp.) and the viral co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-41843-5
更新日期:2019-04-08 00:00:00
abstract::Earlier studies showed that endogenous estrogens have neuroprotective effect against oxidative damage. The present study seeks to investigate the protective effect of various endogenous estrogen metabolites against oxidative neurotoxicity in vitro and in vivo. Using immortalized mouse hippocampal neuronal cells as an ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-62984-y
更新日期:2020-04-29 00:00:00
abstract::Three carbapenem-resistant Escherichia coli were recovered from rectal swabs of different patients in a tertiary hospital and were found carrying bla NDM-4, an uncommon bla NDM variant. Genome sequences of the isolates were obtained using Illumina technology and the long-read MinION sequencer. The isolates belonged to...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-18910-w
更新日期:2018-01-10 00:00:00
abstract::In order to screen out an effective bone loss protectant from natural plant polyphenol and to elucidate the mechanism of the plant polyphenols that alleviate bone loss under simulated microgravity, the proliferation activities of 9 total polyphenol extracts from natural product (TPENP) on osteoblasts were measured. Po...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-30992-8
更新日期:2018-08-24 00:00:00
abstract::Recently, the discovery of room temperature magnetoelectricity in organic charge transfer complexes has reignited interest in the multiferroic field. The solution processed, large-area and low cost organic semiconductor materials offer new possibilities for the functional all organic multiferroic devices. Here we repo...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep28656
更新日期:2016-06-23 00:00:00
abstract::Environmental pollutants as non-heritable factors are now recognized as triggers for multiple human inflammatory diseases involving T cells. We postulated that lipid antigen presentation mediated by cluster of differentiation 1 (CD1) proteins for T cell activation is susceptible to lipophilic environmental pollutants....
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-02229-7
更新日期:2017-05-18 00:00:00
abstract::A simple and scalable approach has been reported for V2O5 encapsulation over interconnected multi-walled carbon nanotubes (MWCNTs) network using chemical bath deposition method. Chemically synthesized V2O5/MWCNTs electrode exhibited excellent charge-discharge capability with extraordinary cycling retention of 93% over...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep43430
更新日期:2017-03-03 00:00:00
abstract::When multiple information are spread on social networks, there may be Cooperation and Competition among these information. Based on a new spreading model of multiple information, we studied Cooperation and Competition in information spreading, and analyzed the influence of different factors on Cooperation and Competit...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-69098-5
更新日期:2020-07-22 00:00:00
abstract::Yeast Cdc48 is a well-conserved, essential chaperone of ATPases associated with diverse cellular activity (AAA) proteins, which recognizes substrate proteins and modulates their conformations to carry out many cellular processes. However, the fundamental mechanisms underlying the diverse pivotal roles of Cdc48 remain ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05806-y
更新日期:2017-07-14 00:00:00
abstract::All models of evolution of human behaviour depend on the correct identification and interpretation of bone surface modifications (BSM) on archaeofaunal assemblages. Crucial evolutionary features, such as the origin of stone tool use, meat-eating, food-sharing, cooperation and sociality can only be addressed through co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24071-1
更新日期:2018-04-10 00:00:00
abstract::Accurately representing the Indian Ocean Dipole (IOD) is crucial for reliable climate predictions and future projections. However, El Niño-Southern Oscillation (ENSO) and IOD interact, making it necessary to evaluate ENSO and IOD simultaneously. Using the historical simulation from 32 fifth phase of Coupled Model Inte...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-68268-9
更新日期:2020-07-13 00:00:00
abstract::CD31hiEmcnhi vessels were a subtype of vessels in the murine skeletal system, with high levels of platelet and endothelial cell adhesion molecule-1 (PECAM-1/CD31) and endomucin (Emcn). They were reported coupling angiogenesis and osteogenesis during bone development. We investigated the distribution of these vessels i...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04150-5
更新日期:2017-07-10 00:00:00
abstract::Neutrophils play an important role in the occurrence and development of acute lung injury (ALI). Leukotriene B4 (LTB4), a hydrolysis product of epoxide leukotriene A4 (LTA4) catalyzed by LTA4 hydrolase (LTA4H), is one of the most potent chemoattractants for neutrophil. Bufexamac is a drug widely used as an anti-inflam...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep25298
更新日期:2016-04-29 00:00:00
abstract::Ammonia can be utilised as an alternative nitrogen source to glutamine to support cell proliferation. However, the underlying molecular mechanisms and whether all cells have this ability is not fully understood. We find that eleven cancer and non-cancerous cell lines have opposite abilities to tolerate and utilise amm...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-37509-3
更新日期:2019-02-06 00:00:00
abstract::Nitrogen-doped graphene (N-graphene) has attractive properties that has been widely studied over the years. However, its possible formation process still remains unclear. Here, we propose a highly feasible formation mechanism of the graphitic-N doing in thermally treated graphene with ammonia by performing ab initio m...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep23495
更新日期:2016-03-22 00:00:00
abstract::Accumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be one important factor contributing to developmental failure in somatic cell cloned embryos. In the present study, we found microRNA-449b (miR-449b) was highly expressed in sperm. Target gene predictions and experimen...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-13899-8
更新日期:2017-10-17 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-62904-0
更新日期:2020-04-10 00:00:00