Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers.

abstract：:Understanding drought-tolerance mechanisms and identifying genetic dominance are important for crop improvement. Setaria italica, which is extremely drought-tolerant, has been regarded as a model plant for studying stress biology. Moreover, different genotypes of S. italica have evolved various drought-tolerance/avoid...

journal_title：Scientific reports

authors： Tang S,Li L,Wang Y,Chen Q,Zhang W,Jia G,Zhi H,Zhao B,Diao X

更新日期：2017-08-30 00:00:00

abstract：:Stromal capillary sheath cells in human spleens strongly express CD271, the low affinity nerve growth factor receptor p75. Serial sections of a representative adult human spleen were double-stained for CD271 versus smooth muscle alpha actin (SMA) plus CD34 to visualise capillary sheaths, the arterial tree and endothel...

journal_title：Scientific reports

authors： Steiniger BS,Wilhelmi V,Berthold M,Guthe M,Lobachev O

更新日期：2018-10-24 00:00:00

abstract：:Ghrelin is the only orexigenic peptide currently known and a potent prokinetic by promoting gastric motility but novel insights suggest that its role extends beyond satiety regulation. Whereas ghrelin was shown to provide somatic and colonic antinociception, its impact on gastric sensitivity is unknown even though sto...

journal_title：Scientific reports

authors： Meleine M,Mounien L,Atmani K,Ouelaa W,Bôle-Feysot C,Guérin C,Depoortere I,Gourcerol G

更新日期：2020-06-19 00:00:00

abstract：:This article presents the homodyne detection in a self-oscillation system, which represented by a short-range radar (SRR) circuit, that is analysed using a multi-time forced oscillator (MTFO) model. The MTFO model is based on a forced oscillation perspective with the signal and system theory, a second-order differenti...

journal_title：Scientific reports

authors： Kittipute K,Saratayon P,Srisook S,Wardkein P

更新日期：2017-03-02 00:00:00

abstract：:Fluorine-19 (19F) magnetic resonance imaging (MRI) of injected perfluorocarbons (PFCs) can be used for the quantification and monitoring of inflammation in diseases such as atherosclerosis. To advance the translation of this technique to the clinical setting, we aimed to 1) demonstrate the feasibility of quantitative ...

journal_title：Scientific reports

authors： Darçot E,Colotti R,Pellegrin M,Wilson A,Siegert S,Bouzourene K,Yerly J,Mazzolai L,Stuber M,van Heeswijk RB

更新日期：2019-11-25 00:00:00

abstract：:The clinical significance of STIM proteins and Orai Ca2+ channels in tumor progression has been demonstrated in different types of cancers. Podosomes are dynamic actin-rich cellular protrusions that facilitate cancer cell invasiveness by degrading extracellular matrix. Whether STIM1-dependent Ca2+ signaling facilitate...

journal_title：Scientific reports

authors： Chen YW,Lai CS,Chen YF,Chiu WT,Chen HC,Shen MR

更新日期：2017-09-14 00:00:00

abstract：:Ergothioneine (ERG), a unique thiol compound, is suggested to function as an antioxidant and cytoprotectant. Despite several recent attempts to produce ERG using various organisms, its yield was still very low and the costs remained high. Since the level of ERG produced depends strictly on the availability of three di...

journal_title：Scientific reports

authors： Tanaka N,Kawano Y,Satoh Y,Dairi T,Ohtsu I

更新日期：2019-02-13 00:00:00

abstract：:In a large German community sample of adults, we investigated the association of chronic anxiousness with cardiovascular disease and mortality. Self-reported anxiousness from 11,643 German adults between 40 and 80 years of age from the Gutenberg Health Study (GHS) was analyzed over 5 years. Multivariable regression mo...

journal_title：Scientific reports

authors： Reiner IC,Tibubos AN,Werner AM,Ernst M,Brähler E,Wiltink J,Michal M,Schulz A,Wild PS,Münzel T,Arnold N,Mahmoudpour SH,Lackner KJ,Pfeiffer N,Beutel ME

更新日期：2020-07-24 00:00:00

abstract：:The use of smart colloidal microgels for advanced applications critically depends on their response kinetics. We use pressure jump small angle neutron scattering with supreme time resolution to study the rapid volume phase transition kinetics of such microgels. Utilizing the pressure induced microphase separation insi...

journal_title：Scientific reports

authors： Wrede O,Reimann Y,Lülsdorf S,Emmrich D,Schneider K,Schmid AJ,Zauser D,Hannappel Y,Beyer A,Schweins R,Gölzhäuser A,Hellweg T,Sottmann T

更新日期：2018-09-13 00:00:00

abstract：:Aortic stenosis (AS) is the most common form of valve disease. Once symptoms develop, there is an inexorable deterioration with a poor prognosis; currently there are no therapies capable of modifying disease progression, and aortic valve replacement is the only available treatment. Our goal is to study the progression...

journal_title：Scientific reports

authors： Mourino-Alvarez L,Iloro I,de la Cuesta F,Azkargorta M,Sastre-Oliva T,Escobes I,Lopez-Almodovar LF,Sanchez PL,Urreta H,Fernandez-Aviles F,Pinto A,Padial LR,Akerström F,Elortza F,Barderas MG

更新日期：2016-06-03 00:00:00

abstract：:Organ transplantation remains the most effective treatment for patients with late stage organ failure. Transgenic pigs provide an alternative organ donor source to the limited availability of human organs. However, cellular rejection still remains to be the obstacle for xenotransplantation. Superior to other methods, ...

journal_title：Scientific reports

authors： Li M,Eckl J,Geiger C,Schendel DJ,Pohla H

更新日期：2017-06-21 00:00:00

abstract：:Taking advantage of the magnetoelectric and its inverse effect, this article demonstrates strain-mediated magnetoelectric write and read operations simultaneously in Co60Fe20B20/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 heterostructures based on a pseudo-magnetization µ ≡ mx2 - my2. By applying an external DC-voltage across a (011)-cu...

journal_title：Scientific reports

authors： Shen T,Ostwal V,Camsari KY,Appenzeller J

更新日期：2020-07-01 00:00:00

abstract：:As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to form biofilms on medical devices resulting in high mortality. Biofilms formed by C. albicans are a c...

journal_title：Scientific reports

authors： Kakade P,Sadhale P,Sanyal K,Nagaraja V

更新日期：2016-08-08 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Girardeau-Hubert S,Deneuville C,Pageon H,Abed K,Tacheau C,Cavusoglu N,Donovan M,Bernard D,Asselineau D

更新日期：2020-10-21 00:00:00

abstract：:In this study, a simple technique was developed for the electrochemical detection of anionic analytes in weakly supported media. This was conducted by the use of electrochemical paper-based analytical devices (ePADs). A sensing platform was modified with nereistoxin and used to determine nitrite as a case study. The e...

journal_title：Scientific reports

authors： Khoshroo A,Fattahi A

更新日期：2020-09-03 00:00:00

abstract：:Crotoxin (CTX) is the primary toxin of South American rattlesnake Crotalus durissus terrificus venom. CTX reduces tumour mass, and tumour cell proliferation and these effects seem to involve the formation of new vessels. Angiogenesis has a key role in tumour growth and progression and is regulated by macrophage secret...

journal_title：Scientific reports

authors： de Araújo Pimenta L,de Almeida MES,Bretones ML,Cirillo MC,Curi R,Sampaio SC

更新日期：2019-03-12 00:00:00

abstract：:We developed a novel integrated technology for diver-operated surveying of shallow marine ecosystems. The HyperDiver system captures rich multifaceted data in each transect: hyperspectral and color imagery, topographic profiles, incident irradiance and water chemistry at a rate of 15-30 m2 per minute. From surveys in ...

journal_title：Scientific reports

authors： Chennu A,Färber P,De'ath G,de Beer D,Fabricius KE

更新日期：2017-08-02 00:00:00

abstract：:Caveolins are essential structural proteins driving the formation of caveolae, specialized invaginations of the plasma membrane. Loss of Caveolin-1 (Cav1) function in mice causes distinct neurological phenotypes leading to impaired motor control, however, the underlying developmental mechanisms are largely unknown. In...

journal_title：Scientific reports

authors： Breuer M,Berger H,Borchers A

更新日期：2020-10-05 00:00:00

abstract：:Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the marginal sinuses could improve c...

journal_title：Scientific reports

authors： Kato S,Shirai Y,Sakamoto M,Mori S,Kodama T

更新日期：2019-09-13 00:00:00

abstract：:The patterns of evolution and expression of tissue-specific genes are poorly understood beyond sex-specific genes. Accordingly, we identified 3,191 tissue-specific genes and 38,745 common genes using 22 RNA-seq datasets from cultivated peanut. The expression levels of tissue-specific genes were significantly lower tha...

journal_title：Scientific reports

authors： Song H,Zhang Q,Tian P,Nan Z

更新日期：2017-08-21 00:00:00

abstract：:The interaction of osseous tissue with electric fields is an important subject. The electrical stimulation of bone promotes osteogenesis, while bone impedance has been proposed as a measure of osteoporosis, to follow fracture healing, or as a method to improve safety of surgical procedures. However, a deeper understan...

journal_title：Scientific reports

authors： Balmer TW,Vesztergom S,Broekmann P,Stahel A,Büchler P

更新日期：2018-06-05 00:00:00

abstract：:The human sweet taste receptor (T1R2) monomer-a member of the G-protein coupled receptor family that detects a wide variety of chemically and structurally diverse sweet tasting molecules, is known to pose a significant threat to human health. Protein that lack crystal structure is a challenge in structure-based protei...

journal_title：Scientific reports

authors： Arodola OA,Kanchi S,Hloma P,Bisetty K,Asiri AM,Inamuddin

更新日期：2020-10-27 00:00:00

abstract：:Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We therefore characterized the skeletal muscle proteome following exercise traini...

journal_title：Scientific reports

authors： Kleinert M,Parker BL,Jensen TE,Raun SH,Pham P,Han X,James DE,Richter EA,Sylow L

更新日期：2018-07-16 00:00:00

abstract：:We present a new general facile strategy for the preparation of protein-functionalized QDs in a single step at ambient conditions. We demonstrated that highly luminescent red to near-infrared (NIR) protein-functionalized QDs could be synthesized at room temperature in one second through a one-pot reaction that proceed...

journal_title：Scientific reports

authors： He X,Gao L,Ma N

更新日期：2013-10-02 00:00:00

abstract：:Viral capsids are metastable structures that perform many essential processes; they also act as robust cages during the extracellular phase. Viruses can use multifunctional proteins to optimize resources (e.g., VP3 in avian infectious bursal disease virus, IBDV). The IBDV genome is organized as ribonucleoproteins (RNP...

journal_title：Scientific reports

authors： Mertens J,Casado S,Mata CP,Hernando-Pérez M,de Pablo PJ,Carrascosa JL,Castón JR

更新日期：2015-09-04 00:00:00

abstract：:Proteasome inhibition represents an important anticancer strategy. Here, we studied the mechanisms at the basis of the pro-apoptotic activity of the standardized decoction of Hemidesmus indicus, a plant evoking a complex anticancer activity, and explored its inhibition of proteasome activity in human leukemia cells. A...

journal_title：Scientific reports

authors： Turrini E,Catanzaro E,Ferruzzi L,Guerrini A,Tacchini M,Sacchetti G,Paganetto G,Maffei F,Pellicioni V,Poli F,Hrelia P,Mandrone M,Sestili P,Brigotti M,Fimognari C

更新日期：2019-05-10 00:00:00

abstract：:Do scientists follow hot topics in their scientific investigations? In this paper, by performing analysis to papers published in the American Physical Society (APS) Physical Review journals, it is found that papers are more likely to be attracted by hot fields, where the hotness of a field is measured by the number of...

journal_title：Scientific reports

authors： Wei T,Li M,Wu C,Yan XY,Fan Y,Di Z,Wu J

更新日期：2013-01-01 00:00:00

abstract：:Musical performance requires extremely fast and dexterous limb movements. The underlying biological mechanisms have been an object of interest among scientists and non-scientists for centuries. Numerous studies of musicians and non-musicians have demonstrated that neuroplastic adaptations through early and deliberate ...

journal_title：Scientific reports

authors： Furuya S,Oku T,Miyazaki F,Kinoshita H

更新日期：2015-10-27 00:00:00

abstract：:Most enzymes that act on carbohydrates include non-catalytic carbohydrate-binding modules (CBMs) that recognize and target carbohydrates. CBMs bring their appended catalytic modules into close proximity with the target substrate and increase the hydrolytic rate of enzymes acting on insoluble substrates. We previously ...

journal_title：Scientific reports

authors： Duan CJ,Feng YL,Cao QL,Huang MY,Feng JX

更新日期：2016-01-14 00:00:00

abstract：:While a large body of research has focused on the study of functional brain "connectivity", few investigators have focused on directionality of brain-brain interactions which, in spite of the mostly bidirectional anatomical substrates, cannot be assumed to be symmetrical. We employ a multivariate Granger Causality-bas...

journal_title：Scientific reports

authors： Duggento A,Passamonti L,Valenza G,Barbieri R,Guerrisi M,Toschi N

更新日期：2018-04-03 00:00:00