Abstract：
:We present a new general facile strategy for the preparation of protein-functionalized QDs in a single step at ambient conditions. We demonstrated that highly luminescent red to near-infrared (NIR) protein-functionalized QDs could be synthesized at room temperature in one second through a one-pot reaction that proceeds in aqueous solution. Herein protein-functionalized QDs were successfully constructed for a variety of proteins with a wide range of molecular weights and isoelectric points. The as-prepared protein-conjugated QDs exhibited high quantum yield, high photostabiliy and colloidal stability, and high functionalization efficiency. Importantly, the proteins attached to the QDs maintain their biological activities and are capable of catalyzing reactions and biotargeting. In particular, the as-prepared transferrin-QDs could be used to label cancer cells with high specificity. Moreover, we demonstrated that this synthetic strategy could be extended to prepare QDs functionalized with folic acids and peptides, which were also successfully applied to cancer cell imaging.
journal_name
Sci Repjournal_title
Scientific reportsauthors
He X,Gao L,Ma Ndoi
10.1038/srep02825subject
Has Abstractpub_date
2013-10-02 00:00:00pages
2825issn
2045-2322pii
srep02825journal_volume
3pub_type
杂志文章abstract：:We have sequenced the genome of the largest freshwater fish species of the world, the arapaima. Analysis of gene family dynamics and signatures of positive selection identified genes involved in the specific adaptations and unique features of this iconic species, in particular it's large size and fast growth. Genome s...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41457-x
更新日期：2019-03-28 00:00:00
abstract：:Charge noise is critical in the performance of gate-controlled quantum dots (QDs). Such information is not yet available for QDs made out of the new material graphene, where both substrate and edge states are known to have important effects. Here we show the 1/f noise for a microscopic graphene QD is substantially lar...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08142
更新日期：2015-01-30 00:00:00
abstract：:Ca2+ release-activated Ca2+ (CRAC) channels elevate cytoplasmic Ca2+ concentration, which is essential for T cell activation, differentiation and effector functions. T cell receptor stimulation induces depletion of the endoplasmic reticulum (ER) Ca2+ stores, which is sensed by stromal interaction molecule 1 (STIM1). S...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-71489-7
更新日期：2020-09-02 00:00:00
abstract：:We have engineered the electronic structure at the interface between Cu2O and ZnO nanorods (NRs) array, through adjusting the carrier concentration of Cu2O. The electrodeposition of Cu2O at pH 11 acquired the highest carrier concentration, resulting in the largest interfacial electric field between Cu2O and ZnO, which...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep07882
更新日期：2015-01-20 00:00:00
abstract：:Prenatal skeletal muscle development genetically determines postnatal muscle characteristics such as growth and meat quality in pigs. However, the molecular mechanisms underlying prenatal skeletal muscle development remain unclear. Here, we performed the first genome-wide analysis of chimeric RNAs, single nuclear poly...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep29039
更新日期：2016-06-29 00:00:00
abstract：:Systemic lipopolysaccharide (LPS) is implicated in increasing mortality in patients with alcoholic hepatitis but the underlying mechanisms are not well characterised. The objective of this study was to characterise neutrophil function, LPS and cytokine concentrations within the splanchnic circulation of alcoholic cirr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep40157
更新日期：2017-01-04 00:00:00
abstract：:The discovery of novel ligand chemotypes allows to explore uncharted regions in chemical space, thereby potentially improving synthetic accessibility, potency, and the drug-likeness of molecules. Here, we demonstrate the scaffold-hopping ability of the new Weighted Holistic Atom Localization and Entity Shape (WHALES) ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-34677-0
更新日期：2018-11-07 00:00:00
abstract：:Many tissues exhibit subatmospheric interstitial pressures under normal physiologic conditions. The mechanisms by which the lymphatic system extracts fluid from these tissues against the overall pressure gradient are unknown. We address this important physiologic issue by combining experimental measurements of contrac...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-11599-x
更新日期：2017-09-21 00:00:00
abstract：:Results on the relationships between vitamin D receptor (VDR) gene polymorphisms and postmenopausal osteoporosis (PMOP) susceptibility and bone mineral density (BMD) are conflicting. The aim of the study is to identify more eligible studies that calculated pooled OR and WMD with 95% CI to assess their associations. Ov...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/s41598-017-18670-7
更新日期：2018-01-17 00:00:00
abstract：:Magnetic refrigeration is of great interest due to its high energy efficiency, environmental friendliness and low cost. However, undesired hysteresis losses, concentrated working temperature interval (WTI) and poor mechanical stability are vital drawbacks that hinder its practical application. Off-stoichiometric Ni-Mn...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35028-9
更新日期：2018-11-08 00:00:00
abstract：:Airports can affect birds by hindering acoustic communication. Here, we investigated the impacts of aircraft events on vocal behavior in wood thrush (Hylocichla mustelina) breeding one mile from an airport in Ithaca, NY, USA. We identified the number of wood thrush songs between 0500 and 0800 h at various distances fr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80380-4
更新日期：2021-01-13 00:00:00
abstract：:Glycan-protein lateral interactions have gained increased attention as important modulators of receptor function, by regulating surface residence time and endocytosis of membrane glycoproteins. The pathogen-recognition receptor DC-SIGN is highly expressed at the membrane of antigen-presenting dendritic cells, where it...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07220-w
更新日期：2017-07-27 00:00:00
abstract：:Birds play unique functional roles in the maintenance of ecosystems, such as pollination and seed dispersal, and thus monitoring bird species diversity is a first step towards avoiding undesirable consequences of anthropogenic impacts on bird communities. In the present study, we hypothesized that birds, regardless of...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22817-5
更新日期：2018-03-14 00:00:00
abstract：:Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage dysplasia, but the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-05033-5
更新日期：2017-07-07 00:00:00
abstract：:The association between active musical engagement (as leisure activity or professionally) and mental health is still unclear, with earlier studies reporting contrasting findings. Here we tested whether musical engagement predicts (1) a diagnosis of depression, anxiety, schizophrenia, bipolar or stress-related disorder...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49099-9
更新日期：2019-08-30 00:00:00
abstract：:Phase estimation represents a crucial challenge in many fields of Physics, ranging from Quantum Metrology to Quantum Information Processing. This task is usually pursued by means of interferometric schemes, in which the choice of the input states and of the detection apparatus is aimed at minimizing the uncertainty in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26025
更新日期：2016-05-18 00:00:00
abstract：:To investigate the particle size distribution of particulate matter and the concentration of specific perfluorinated compounds in indoor dust samples from several locations. Then, we used cell-based assays to investigate the effect of perfluorinated compounds on human corneal epithelial (HCEpiC), endothelial cells (HC...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72600-8
更新日期：2020-09-24 00:00:00
abstract：:The Spike protein of the novel coronavirus SARS-CoV2 contains an insertion 680SPRRAR↓SV687 forming a cleavage motif RxxR for furin-like enzymes at the boundary of S1/S2 subunits. Cleavage at S1/S2 is important for efficient viral entry into target cells. The insertion is absent in other CoV-s of the same clade, includ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74101-0
更新日期：2020-10-09 00:00:00
abstract：:Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative brain biomarkers that can predict postoperative neurological recovery in CM patients by using...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46859-5
更新日期：2019-07-18 00:00:00
abstract：:The ejection of internal organs, i.e., evisceration, is a well-known phenomenon in sea-cucumbers. We report the ability of a member of the Chordate phyla, the tropical ascidian Polycarpa mytiligera, to eviscerate and regenerate its gut within 12 days, and to rebuild its branchial sac within 19 days. Evisceration occur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09614
更新日期：2015-04-16 00:00:00
abstract：:The presence of hepatic steatosis (HS) is an important histological feature in a variety of liver disease. It is critical to assess HS accurately, particularly where it plays an integral part in defining the disease. Conventional methods of quantifying HS remain semi-quantitative, with potential limitations in precisi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39783-1
更新日期：2019-02-27 00:00:00
abstract：:Glaucoma is a group of progressive optic neuropathies that share common biological and clinical characteristics including irreversible changes to the optic nerve and visual field loss caused by the death of retinal ganglion cells (RGCs). The loss of RGCs manifests as characteristic cupping or optic nerve degeneration,...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68811-8
更新日期：2020-07-16 00:00:00
abstract：:Collateral perfusion is important for sustaining tissue viability in acute ischemic stroke. Conventional techniques for its visualization are invasive, require contrast agents and demonstrate collateral vessels, rather than measuring perfusion directly. In this study we utilize a non-invasive, non-contrast magnetic re...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-44417-7
更新日期：2019-06-03 00:00:00
abstract：:Accurate alignment of an intraocular lens (IOL) is indispensable for achieving accurate postoperative refractive outcomes. Thus, we evaluated decentration and tilt of single- and three-piece IOLs, as well as anterior chamber depth (ACD), at 3 hours, 24 hours, 2 weeks, and 4 weeks after cataract surgery, using swept-so...
journal_title：Scientific reports
pub_type： 杂志文章,随机对照试验
doi：10.1038/s41598-018-28609-1
更新日期：2018-07-06 00:00:00
abstract：:Anti-EGFR antibodies are effective in therapies for late-stage colorectal cancer (CRC); however, many tumours are unresponsive or develop resistance. We performed genomic analysis of intrinsic and acquired resistance to anti-EGFR therapy in prospectively collected tumour samples from 25 CRC patients receiving cetuxima...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51981-5
更新日期：2019-10-25 00:00:00
abstract：:Spontaneous activity found in neural networks usually results in a reduction of computational performance. As a consequence, artificial neural networks are often operated at the edge of chaos, where the network is stable yet highly susceptible to input information. Surprisingly, regular spontaneous dynamics in Neural ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21624-2
更新日期：2018-02-20 00:00:00
abstract：:Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the cardiovascular homostasis. We recently defined 3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3H)-one (3BDO) as a ne...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05519
更新日期：2014-07-01 00:00:00
abstract：:Heparan sulfate (HS) is a polysaccharide known to modulate many important biological processes, including Wnt signaling. However, the biochemical interaction between HS and Wnt molecules is not well characterized largely due to the lack of suitable methods. To determine the Wnt binding domain in HS, we used a Wnt sign...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26245
更新日期：2016-05-17 00:00:00
abstract：:Spinal cord injury (SCI) is frequently accompanied by a degree of spontaneous functional recovery. The underlying mechanisms through which such recovery is generated remain elusive. In this study, we observed a significant spontaneous motor function recovery 14 to 28 days after spinal cord transection (SCT) in rats. U...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep16911
更新日期：2015-11-23 00:00:00
abstract：:Barrett's esophagus (BE) is the only known precursor to esophageal adenocarcinoma (EAC). Methods of identifying BE patients at high risk for progression to high-grade dysplasia (HGD) or EAC are needed to improve outcomes and identify who will benefit most from intensive surveillance or ablative therapy. Clinical predi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-61874-7
更新日期：2020-03-17 00:00:00
