The short isoform of extended synaptotagmin-2 controls Ca2+ dynamics in T cells via interaction with STIM1.

abstract：:For augmentation or reconstruction of urinary bladder after cystectomy, bladder urothelium derived from human induced pluripotent stem cells (hiPSCs) has recently received focus. However, previous studies have only shown the emergence of cells expressing some urothelial markers among derivatives of hiPSCs, and no repo...

journal_title：Scientific reports

authors： Suzuki K,Koyanagi-Aoi M,Uehara K,Hinata N,Fujisawa M,Aoi T

更新日期：2019-07-19 00:00:00

abstract：:The Gram-negative bacterium Pseudomonas aeruginosa represents a prototype of multi-drug resistant opportunistic pathogens for which novel therapeutic options are urgently required. In order to identify new candidates as potential drug targets, we combined large-scale transposon mutagenesis data analysis and bioinforma...

journal_title：Scientific reports

authors： Fernández-Piñar R,Lo Sciuto A,Rossi A,Ranucci S,Bragonzi A,Imperi F

更新日期：2015-12-01 00:00:00

abstract：:This work reports a facile method for preparing the new photoactive In(2)O(3) films as well as their implementation in photoelectrochemical (PEC) application. We firstly investigated the relationship between oxygen vacancies (V(O)) and PEC performance and revealed a rule between them. We found that the optimized In(2)...

journal_title：Scientific reports

authors： Gan J,Lu X,Wu J,Xie S,Zhai T,Yu M,Zhang Z,Mao Y,Wang SC,Shen Y,Tong Y

更新日期：2013-01-01 00:00:00

abstract：:Toxin-antitoxin (TA) systems were initially discovered as plasmid addiction systems on low-copy-number plasmids. Thousands of TA loci have since been identified on chromosomes, plasmids and mobile elements in bacteria and archaea with diverse roles in bacterial physiology and in maintenance of genetic elements. Here, ...

journal_title：Scientific reports

authors： Kamruzzaman M,Iredell J

更新日期：2019-07-08 00:00:00

abstract：:Enterovirus A89 (EV-A89) is a novel member of the EV-A species. To date, only one full-length genome sequence (the prototype strain) has been published. Here, we report the molecular identification and genomic characterization of a Chinese EV-A89 strain, KSYPH-TRMH22F/XJ/CHN/2011, isolated in 2011 from a contact of an...

journal_title：Scientific reports

authors： Fan Q,Zhang Y,Hu L,Sun Q,Cui H,Yan D,Sikandaner H,Tang H,Wang D,Zhu Z,Zhu S,Xu W

更新日期：2015-12-21 00:00:00

abstract：:Short QT syndrome (SQTS) is a rare condition characterized by abnormally 'short' QT intervals on the ECG and increased susceptibility to cardiac arrhythmias and sudden death. This simulation study investigated arrhythmia dynamics in multi-scale human ventricle models associated with the SQT2-related V307L KCNQ1 'gain-...

journal_title：Scientific reports

authors： Adeniran I,Whittaker DG,El Harchi A,Hancox JC,Zhang H

更新日期：2017-08-16 00:00:00

abstract：:Multidrug-resistant organisms are increasing in healthcare settings, and there are few antimicrobials available to treat infections from these bacteria. Pseudomonas aeruginosa is an opportunistic pathogen in burn patients and individuals with cystic fibrosis (CF), and a leading cause of nosocomial infections. P. aerug...

journal_title：Scientific reports

authors： Lloyd MG,Vossler JL,Nomura CT,Moffat JF

更新日期：2019-04-30 00:00:00

abstract：:Flooding is one of the major constraints for rice production in rainfed lowlands, especially in years and areas of high rainfall. Incorporating the Sub1 (Submergence1) gene into high yielding popular varieties has proven to be the most feasible approach to sustain rice production in submergence-prone areas. Introgress...

journal_title：Scientific reports

authors： Dar MH,Zaidi NW,Waza SA,Verulkar SB,Ahmed T,Singh PK,Roy SKB,Chaudhary B,Yadav R,Islam MM,Iftekharuddaula KM,Roy JK,Kathiresan RM,Singh BN,Singh US,Ismail AM

更新日期：2018-06-18 00:00:00

abstract：:Cardiac contractility is enhanced by phosphorylation of myosin light chain 2 (MLC2) by cardiac-specific MLC kinase (cMLCK), located at the neck region of myosin heavy chain. In normal mouse and human hearts, the level of phosphorylation is maintained relatively constant, at around 30-40% of total MLC2, likely by well-...

journal_title：Scientific reports

authors： X Cai L,Tanada Y,D Bello G,C Fleming J,F Alkassis F,Ladd T,Golde T,Koh J,Chen S,Kasahara H

更新日期：2019-08-29 00:00:00

abstract：:We report an effective and rare-earth free light conversion material synthesized via a facile fabrication route, in which organic fluorescent dyes, i.e. Rhodamine B (RhB) and fluorescein isothiocyanate (FITC) are embedded into activated boron nitride (αBN) to form a composite phosphor. The composite phosphor shows hig...

journal_title：Scientific reports

authors： Li J,Lin J,Huang Y,Xu X,Liu Z,Xue Y,Ding X,Luo H,Jin P,Zhang J,Zou J,Tang C

更新日期：2015-02-16 00:00:00

abstract：:Effective application of whole-cell devices in synthetic biology and biocatalysis will always require consideration of the uptake of molecules of interest into the cell. Here we demonstrate that the AlkL protein from Pseudomonas putida GPo1 is an alkane import protein capable of industrially relevant rates of uptake o...

journal_title：Scientific reports

authors： Grant C,Deszcz D,Wei YC,Martínez-Torres RJ,Morris P,Folliard T,Sreenivasan R,Ward J,Dalby P,Woodley JM,Baganz F

更新日期：2014-07-28 00:00:00

abstract：:Photonic structure designs based on optimization algorithms provide superior properties compared to those using intuition-based approaches. In the present study, we numerically and experimentally demonstrate subwavelength focusing of light using wavelength scale absorption-free dielectric scattering objects embedded i...

journal_title：Scientific reports

authors： Bor E,Turduev M,Kurt H

更新日期：2016-08-01 00:00:00

abstract：:Pavlovské vrchy Hills represent a distinctive elevation near the Czech-Austrian border where the active, dormant and relict landslides cover 12% of the area. Here we focused on the chronology of landsliding in this area using geological, archaeological and historical evidence. The earliest records of landsliding were ...

journal_title：Scientific reports

authors： Bíl M,Krejčí O,Dolák L,Krejčí V,Martínek J,Svoboda J

更新日期：2020-01-22 00:00:00

abstract：:This study aimed to determine the characteristics of CT changes in patients with severe coronavirus disease 2019 (COVID-19) based on prognosis. Serial CT scans in 47 patients with severe COVID-19 were reviewed. The patterns, distribution and CT score of lung abnormalities were assessed. Scans were classified according...

journal_title：Scientific reports

authors： Liang B,Xie L,Yang F,Makamure J,Zhang L,Pang R,Du P,Fan W,Zheng C

更新日期：2020-12-14 00:00:00

abstract：:Electron-hole exchange interaction in semiconductor quantum dots (QDs) splits the band-edge exciton manifold into optically active ("bright") and passive ("dark") states, leading to a complicated exciton fine structure. In the present work, we resolve by atomistic million-atom many-body pseudopotential calculations th...

journal_title：Scientific reports

authors： Baskoutas S,Zeng Z,Garoufalis CS,Bester G

更新日期：2017-08-24 00:00:00

abstract：:A reliable method for the diagnosis of minimal cardiac ischemia would meet a strong demand for the sensitive diagnosis of coronary artery disease in cardiac stress testing and risk stratification in patients with chest pain but unremarkable ECGs and biomarkers. We hypothesized that platelets accumulate early on in isc...

journal_title：Scientific reports

authors： Ziegler M,Alt K,Paterson BM,Kanellakis P,Bobik A,Donnelly PS,Hagemeyer CE,Peter K

更新日期：2016-12-02 00:00:00

abstract：:Patients with schizophrenia have a higher risk for cardiovascular disease (CVD) than the general population. Research has suggested that autonomic imbalance is a common pathway to increased morbidity and mortality for CVD. Heart rate variability (HRV) analysis is a non-invasive method that assesses autonomic imbalance...

journal_title：Scientific reports

authors： Wang J,Liu YS,Zhu WX,Zhang FQ,Zhou ZH

更新日期：2014-12-09 00:00:00

abstract：:Animal societies exhibit remarkable variation in their breeding strategies. Individuals can maximize their fitness by either reproducing or by helping relatives. Social hymenopterans have been key taxa for the study of Hamilton's inclusive fitness theory because the haplodiploid sex-determination system results in asy...

journal_title：Scientific reports

authors： Andrade AC,Miranda EA,Del Lama MA,Nascimento FS

更新日期：2016-05-23 00:00:00

abstract：:The significant risk of disease transmission has selected for effective immune-defense strategies in insect societies. Division of labour, with individuals specialized in immunity-related tasks, strongly contributes to prevent the spread of diseases. A trade-off, however, may exist between phenotypic specialization to...

journal_title：Scientific reports

authors： Cini A,Bordoni A,Cappa F,Petrocelli I,Pitzalis M,Iovinella I,Dani FR,Turillazzi S,Cervo R

更新日期：2020-06-02 00:00:00

abstract：:Diagnostic test accuracy of the loop-mediated isothermal amplification (LAMP) assay for culture proven tuberculosis is unclear. We searched electronic databases for both cohort and case-control studies that provided data to calculate sensitivity and specificity. The index test was any LAMP assay including both commerc...

journal_title：Scientific reports

authors： Nagai K,Horita N,Yamamoto M,Tsukahara T,Nagakura H,Tashiro K,Shibata Y,Watanabe H,Nakashima K,Ushio R,Ikeda M,Narita A,Kanai A,Sato T,Kaneko T

更新日期：2016-12-13 00:00:00

abstract：:Notarchirico (Southern Italy) has yielded the earliest evidence of Acheulean settlement in Italy and four older occupation levels have recently been unearthed, including one with bifaces, extending the roots of the Acheulean in Italy even further back in time. New 40Ar/39Ar on tephras and ESR dates on bleached quartz ...

journal_title：Scientific reports

authors： Moncel MH,Santagata C,Pereira A,Nomade S,Voinchet P,Bahain JJ,Daujeard C,Curci A,Lemorini C,Hardy B,Eramo G,Berto C,Raynal JP,Arzarello M,Mecozzi B,Iannucci A,Sardella R,Allegretta I,Delluniversità E,Terzano R,Dug

更新日期：2020-08-14 00:00:00

abstract：:A mathematical model is proposed for the autonomic control of cardiovascular system, which takes into account two separated self-exciting sympathetic control loops of heart rate and peripheral vascular tone. The control loops are represented by self-exciting time-delay systems and their tone depends on activity of the...

journal_title：Scientific reports

authors： Ishbulatov YM,Karavaev AS,Kiselev AR,Simonyan MA,Prokhorov MD,Ponomarenko VI,Mironov SA,Gridnev VI,Bezruchko BP,Shvartz VA

更新日期：2020-10-05 00:00:00

abstract：:Grapevine (Vitis vinifera L.) is one of the classical fruits of the Old World. Among the thousands of domesticated grapevine varieties and variable wild sylvestris populations, the range of variation in pip morphology is very wide. In this study we scanned representative samples of grape pip populations, in an attempt...

journal_title：Scientific reports

authors： Karasik A,Rahimi O,David M,Weiss E,Drori E

更新日期：2018-04-25 00:00:00

abstract：:The aim of the present study was to evaluate the association between statin use and the risk of age-related macular degeneration (AMD). A systematic search of the PubMed, EMBASE and ISI web of science databases was used to identify eligible published literatures without language restrictions up to April 2015. Summary ...

journal_title：Scientific reports

authors： Ma L,Wang Y,Du J,Wang M,Zhang R,Fu Y

更新日期：2015-12-14 00:00:00

abstract：:The cardiac neural crest cells (cNCCs) and the second heart field (SHF) play key roles in development of the cardiac outflow tract (OFT) for establishment of completely separated pulmonary and systemic circulations in vertebrates. A neurovascular guiding factor, Semaphorin 3c (Sema3c), is required for the development ...

journal_title：Scientific reports

authors： Kodo K,Shibata S,Miyagawa-Tomita S,Ong SG,Takahashi H,Kume T,Okano H,Matsuoka R,Yamagishi H

更新日期：2017-07-28 00:00:00

abstract：:This study is to investigate the frequencies of T-helper (Th)22, Th17 and Th1 cells and the levels of related cytokines in subchondral bone marrow in patients with rheumatoid arthritis (RA). Bone marrow and peripheral blood samples were collected from RA, osteoarthritis (OA) patients and healthy controls. The frequenc...

journal_title：Scientific reports

authors： Li S,Yin H,Zhang K,Wang T,Yang Y,Liu X,Chang X,Zhang M,Yan X,Ren Y,Pan W,Zhang L

更新日期：2017-07-06 00:00:00

abstract：:Precise mitotic spindle orientation is essential for both cell fate and tissue organization while defects in this process are associated with tumorigenesis and other diseases. In most animal cell types, the dynein motor complex is anchored at the cell cortex and exerts pulling forces on astral microtubules to position...

journal_title：Scientific reports

authors： Vodicska B,Cerikan B,Schiebel E,Hoffmann I

更新日期：2018-04-20 00:00:00

abstract：:Detailed structural analyses of the mushroom body which plays critical roles in olfactory learning and memory revealed that it is directly connected with multiple primary sensory centers in Drosophila. Connectivity patterns between the mushroom body and primary sensory centers suggest that each mushroom body lobe proc...

journal_title：Scientific reports

authors： Yagi R,Mabuchi Y,Mizunami M,Tanaka NK

更新日期：2016-07-11 00:00:00

abstract：:Birds play unique functional roles in the maintenance of ecosystems, such as pollination and seed dispersal, and thus monitoring bird species diversity is a first step towards avoiding undesirable consequences of anthropogenic impacts on bird communities. In the present study, we hypothesized that birds, regardless of...

journal_title：Scientific reports

authors： Ushio M,Murata K,Sado T,Nishiumi I,Takeshita M,Iwasaki W,Miya M

更新日期：2018-03-14 00:00:00

abstract：:Light-sheet fluorescence microscopy has emerged as a powerful platform for 3-D volumetric imaging in the life sciences. Here, we introduce an important step towards its use deep inside biological tissue. Our new technique, based on digital holography, enables delivery of the light-sheet through a multimode optical fib...

journal_title：Scientific reports

authors： Plöschner M,Kollárová V,Dostál Z,Nylk J,Barton-Owen T,Ferrier DE,Chmelík R,Dholakia K,Čižmár T

更新日期：2015-12-14 00:00:00