Abstract：
:Patients with schizophrenia have a higher risk for cardiovascular disease (CVD) than the general population. Research has suggested that autonomic imbalance is a common pathway to increased morbidity and mortality for CVD. Heart rate variability (HRV) analysis is a non-invasive method that assesses autonomic imbalance, and low HRV is correlated with high cardiovascular risk. Olanzapine, a widely used antipsychotic drug, is considered to have good cardiac safety because of not causing significant corrected QT-interval (QTc) prolongation; however, it is still unclear whether olanzapine affects HRV. We recruited 83 patients with schizophrenia who were medication-free for at least 1 month and tested their HRV at the baseline and 4 weeks after treatment with olanzapine. We found that patients who had substantial weight gain (EWG) manifested significantly lower HRV than those who had non-substantial weight gain (NWG) and that HRV decrease was positively correlated to an increase in body mass index (BMI) and weight gain. Our results indicate that olanzapine-induced weight gain may play an important role in its potential cardiovascular risk. Since olanzapine has a very high potential for weight gain compared with other antipsychotics, further research is needed to explore its cardiovascular safety profile, specifically long-term cardiac safety.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Wang J,Liu YS,Zhu WX,Zhang FQ,Zhou ZHdoi
10.1038/srep07394subject
Has Abstractpub_date
2014-12-09 00:00:00pages
7394issn
2045-2322pii
srep07394journal_volume
4pub_type
杂志文章abstract：:Glassy carbon electrode (GCE) was modified with metal oxides (MO = Fe3O4, ZnO) nanoparticles doped phthalocyanine (Pc) and functionalized MWCNTs, and the electrocatalytic properties were studied. Successful synthesis of the metal oxide nanoparticles and the MO/Pc/MWCNT composite were confirmed using FTIR, Raman and SE...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep26938
更新日期：2016-06-01 00:00:00
abstract：:Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that is associated with the destruction of immune tolerance and activation of B cells. Interleukin (IL)-35 and IL-35-producing (IL-35+) regulatory B cells (Bregs) have been demonstrated to possess immunosuppressive functions, but their roles in t...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49748-z
更新日期：2019-09-13 00:00:00
abstract：:Tumor-associated immune response plays a critical role in cancer pathogenesis. This study evaluated clinical implications of T cell cytokines and regulatory T cells (Tregs) in HCC patients treated with TACE. Whole blood was obtained for analysis of T cell cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40078-8
更新日期：2019-03-01 00:00:00
abstract：:Mid-infrared quantum cascade lasers operating under external optical feedback and external periodic bias forcing are shown to exhibit a deterministic chaotic pattern composed of frequencies which are linked to the one of the forcing. Results also show that both the amplitude and the frequency of the forcing play a key...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40861-7
更新日期：2019-03-14 00:00:00
abstract：:Rapid dilation of retinal vessels in response to flickering light (functional hyperemia) is a well-known autoregulatory response driven by increased neural activity in the inner retina. Little is known about flicker-induced changes of activity of retinal neurons themselves. We non-invasively investigated flicker-induc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54930-4
更新日期：2019-12-05 00:00:00
abstract：:Ultrafine-grained die-upset Nd-Fe-B magnets are of importance because they provide a wide researching space to redesign the textured structures. Here is presented a route to obtain a new die-upset magnet with substantially improved magnetic properties. After experiencing the optimized heat treatment, both the coercivi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep38335
更新日期：2016-12-06 00:00:00
abstract：:Anxiety and depression are commonly found in patients with diabetes, but little is known about how the anxiety and depression symptoms of diabetes patients and the health-related quality of life (HRQoL) over time influence each other. Therefore, we conducted a survey among patients with diabetes (T1) and repeated the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-57647-x
更新日期：2020-05-20 00:00:00
abstract：:Previous studies have demonstrated that gestational diabetes mellitus (GDM) and Type 2 diabetes mellitus (T2D) share common genetic polymorphisms. We conducted meta-analysis and subgroup analysis of all available variants and determined the effects of confounding and experimental components on the genetic association ...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析,评审
doi：10.1038/srep30539
更新日期：2016-07-29 00:00:00
abstract：:Potassium channel tetramerization domain containing 12 (KCTD12), the auxiliary GABAB receptor subunit, is identified as a susceptibility gene for bipolar I (BPI) disorder in the Han Chinese population. Moreover, the single-nucleotide polymorphism (SNP) rs17026688 in glutamate decarboxylase-like protein 1 (GADL1) is sh...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-46655-1
更新日期：2019-07-16 00:00:00
abstract：:Because Africa's climate hampers DNA preservation, knowledge of its genetic variability is mainly restricted to modern samples, even though population genetics dynamics and back-migrations from Eurasia may have modified haplotype frequencies, masking ancient genetic scenarios. Thanks to improved methodologies, ancient...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39802-1
更新日期：2019-03-05 00:00:00
abstract：:Understanding how a pathogen can grow on different substrates and how this growth impacts its dispersal are critical to understanding the risks and control of emerging infectious diseases. Pseudogymnoascus destructans (Pd) causes white-nose syndrome (WNS) in many bat species and can persist in, and transmit from, the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80707-1
更新日期：2021-01-12 00:00:00
abstract：:Estimating regional nutrient criteria for streams and rivers is a key step toward protecting river water quality and restoring the health of aquatic ecosystems. Using a multivariable statistical analysis technique, nutrients were identified as the main factor influencing the degradation of the benthic macroinvertebrat...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-22128-9
更新日期：2018-02-28 00:00:00
abstract：:Pleiotrophin (PTN) is a cytokine that is upregulated in different neuroinflammatory disorders. Using mice with transgenic PTN overexpression in the brain (Ptn-Tg), we have found a positive correlation between iNos and Tnfα mRNA and Ptn mRNA levels in the prefrontal cortex (PFC) of LPS-treated mice. PTN is an inhibitor...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76415-5
更新日期：2020-11-20 00:00:00
abstract：:Moderate alcohol consumption is generally associated with reduced risk of type 2 diabetes. However, this beneficial effects of alcohol intake remains controversial due to inconsistent results across studies. The analysis was performed using data from the Ansung-Ansan cohort study. We categorized the participants into ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07549-2
更新日期：2017-08-04 00:00:00
abstract：:This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-24902-1
更新日期：2018-04-23 00:00:00
abstract：:Bone homeostasis is maintained by the balance of osteoblasts (OBs) and osteoclasts (OCs). Increased activity of OCs not only contributes to pathological bone resorption, such as osteoporosis and periodontitis, but also is responsible for physiological conditions like orthodontic tooth movement (OTM). However, the deta...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08016
更新日期：2015-01-26 00:00:00
abstract：:Synchrotron radiation core-level photoemission spectroscopy, scanning tunneling microscopy (STM), and first-principles calculations have been utilized to explore the growth processes and the atomic structure of the resulting films during the two-step molecular beam epitaxy (MBE) of In and Bi on the Si(111) surface. De...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-37051-2
更新日期：2019-01-24 00:00:00
abstract：:Liquid pumping can occur along the outer surface of an electrode under a DC electric field. For biological applications, a better understanding of the ionic solution pumping mechanism is required. Here, we fabricated CNT wire electrodes (CWEs) and tungsten wire electrodes (TWEs) of various diameters to assess an ionic...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep11799
更新日期：2015-07-02 00:00:00
abstract：:Triple-negative breast cancers (TNBC) are unlikely to respond to hormonal therapies and anti-HER2-targeted therapies. TNBCs overexpress EGFR and exhibit constitutive activation of the PI3K/AKT/mTOR signalling pathway. We hypothesized that simultaneously blocking EGFR and mTOR could be a potential therapeutic strategy ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-63310-2
更新日期：2020-04-14 00:00:00
abstract：:Strongly interacting one-dimensional quantum systems often behave in a manner that is distinctly different from their higher-dimensional counterparts. When a particle attempts to move in a one-dimensional environment it will unavoidably have to interact and 'push' other particles in order to execute a pattern of motio...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep10675
更新日期：2015-06-15 00:00:00
abstract：:Telomeres, the protective, terminal parts of the chromosomes erode during cell division and as a result of oxidative damage by reactive oxygen species (ROS). Ectotherms rely on the ambient temperature for maintaining temperature-dependent metabolic rate, regulated through behavioural thermoregulation. Their temperatur...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-57084-5
更新日期：2020-01-13 00:00:00
abstract：:Randomizing the layer thickness of superlattices (SL) can lead to localization of coherent phonons and thereby reduces the lattice thermal conductivity κ l . In this work, we propose strategies that can suppress incoherent phonon transport in the above random multilayer (RML) structure to further reduce κ l . Molecula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08359-2
更新日期：2017-08-15 00:00:00
abstract：:Drying and aging paint dispersions display a wealth of complex phenomena that make their study fascinating yet challenging. To meet the growing demand for sustainable, high-quality paints, it is essential to unravel the microscopic mechanisms underlying these phenomena. Visualising the governing dynamics is, however, ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep34383
更新日期：2016-09-29 00:00:00
abstract：:PEA3 transcription factor subfamily is present in a variety of tissues with branching morphogenesis, and play a particularly significant role in neural circuit formation and specificity. Many target genes in axon guidance and cell-cell adhesion pathways have been identified for Pea3 transcription factor (but not for E...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75089-3
更新日期：2020-10-23 00:00:00
abstract：:Given that drug abuse and dependence are common reasons for hospitalization, we aimed to derive and validate a model allowing early identification of life-threatening hospital admissions for drug dependence or abuse. Using the French National Hospital Discharge Data Base, we extracted 66,101 acute inpatient stays for ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep44428
更新日期：2017-03-14 00:00:00
abstract：:Because of the unique climate characteristics, the runoff law in mid-temperate zone is very different from other regions in spring. Accurate runoff simulation and forecasting is of great importance to spring flood control and efficient use of water resources. Baishan reservoir is located in the upper Second Songhua Ri...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-35282-x
更新日期：2018-11-16 00:00:00
abstract：:Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-51294-7
更新日期：2019-10-14 00:00:00
abstract：:We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is the key factor that determines production of the branching cellular structures, as optimization of this component removes the need for heteroty...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep08054
更新日期：2015-01-27 00:00:00
abstract：:The conservation of plant and animal genetic heritage is not a purpose in itself, but it represents the sine qua non condition for practicing a sustainable agriculture and to ensure nutrition and food security on long-term. Our research focused on identifying the areas with the richest genetic diversity of vegetables ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75413-x
更新日期：2020-10-28 00:00:00
abstract：:The potential of Massively Parallel Sequencing (MPS) technology to vastly expand the capabilities of human identification led to the emergence of different MPS platforms that use forensically relevant genetic markers. Two of the MPS platforms that are currently available are the MiSeq® FGx™ Forensic Genomics System (I...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00510-3
更新日期：2017-03-24 00:00:00
