Abstract：
:We study the spreading of cell aggregates deposited on adhesive substrates decorated with microparticles (MPs). A cell monolayer expands around the aggregate. The cells on the periphery of the monolayer take up the MPs, clearing the substrate as they progress and forming an aureole of cells filled with MPs. We study the dynamics of spreading and determine the width of the aureole and the level of MP internalization in cells as a function of MP size, composition, and density. From the radius and width of the aureole, we quantify the volume fraction of MPs within the cell, which leads to an easy, fast, and inexpensive measurement of the cell - particle internalization.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Beaune G,Lam AYW,Dufour S,Winnik FM,Brochard-Wyart Fdoi
10.1038/s41598-017-15665-2subject
Has Abstractpub_date
2017-11-16 00:00:00pages
15729issue
1issn
2045-2322pii
10.1038/s41598-017-15665-2journal_volume
7pub_type
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