Abstract：
:A number of Bruton's tyrosine kinase (BTK) inhibitors are currently in development, yet it has been difficult to visualize BTK expression and pharmacological inhibition in vivo in real time. We synthesized a fluorescent, irreversible BTK binder based on the drug Ibrutinib and characterized its behavior in cells and in vivo. We show a 200 nM affinity of the imaging agent, high selectivity, and irreversible binding to its target following initial washout, resulting in surprisingly high target-to-background ratios. In vivo, the imaging agent rapidly distributed to BTK expressing tumor cells, but also to BTK-positive tumor-associated host cells.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Turetsky A,Kim E,Kohler RH,Miller MA,Weissleder Rdoi
10.1038/srep04782subject
Has Abstractpub_date
2014-04-24 00:00:00pages
4782issn
2045-2322pii
srep04782journal_volume
4pub_type
杂志文章abstract：:Tissue adhesion is a common complication after surgery. In this work, a dexamethasone loaded polymeric micelles in thermosensitive hydrogel composite (Dex hydrogel) was prepared, which combined the anti-adhesion barrier with controlled release of anti-adhesion drug. Dexamethasone (Dex) was encapsulated in polymeric mi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep13553
更新日期：2015-09-01 00:00:00
abstract：:Experimental models that recapitulate mutational landscapes of human cancers are needed to decipher the rapidly expanding data on human somatic mutations. We demonstrate that mutation patterns in immortalised cell lines derived from primary murine embryonic fibroblasts (MEFs) exposed in vitro to carcinogens recapitula...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep04482
更新日期：2014-03-27 00:00:00
abstract：:A novel type of transparent monitor with high-resolution images based on Si-SiO2 core-shell nanoparticles is presented in this contribution. In this monitor, a quasi-array of nanoparticles was used to obtain a very sharp scattering profile. For this purpose, the Si-SiO2 nanoparticles were synthesized and with controll...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-38771-9
更新日期：2019-02-19 00:00:00
abstract：:Increasing influence of Atlantic water in the Arctic Ocean has the potential to significantly impact regional water temperature and salinity. Here we use a rDNA barcoding approach to reveal how microbial communities are partitioned into distinct assemblages across a gradient of Atlantic-Polar Water influence in the No...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-76293-x
更新日期：2020-11-06 00:00:00
abstract：:Meromictic lakes are useful biogeochemical models because of their stratified chemical gradients and separation of redox reactions down the water column. Perennially ice-covered meromictic lakes are particularly stable, with long term constancy in their density profiles. Here we sampled Lake A, a deep meromictic lake ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00604
更新日期：2012-01-01 00:00:00
abstract：:The quantification of hepatitis C virus (HCV) is essential for the management of chronic hepatitis C therapy. We have developed a fully automated microfluidic RT-qPCR system for rapid quantitative detection of HCV RNA in human EDTA-plasma and serum, and the performance of the method was assessed. The platform for the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-64169-z
更新日期：2020-04-30 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by interstitial remodeling and pulmonary dysfunction. The etiology of IPF is not completely understood but involves pathologic inflammation and subsequent failure to resolve fibrosis in response to epithelial injury. Treatments for IPF are limi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-68336-0
更新日期：2020-07-15 00:00:00
abstract：:α-MnO2 nanotubes were fabricated using a hydrothermal technique. Li, Na and K ions were introduced into MnO2 nanotubes to tailor their magnetic properties. It was found that with a doping concentration lower than 12 at%, the nanotubes showed ferromagnetic-like ordering at low temperature (<50 K), while antiferromagnet...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09094
更新日期：2015-03-13 00:00:00
abstract：:A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent 'click chemistry' coupling. This novel glycopeptidomimetic was determined to effectively antagonize the interaction between a transmembrane hepatic le...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep05513
更新日期：2014-07-01 00:00:00
abstract：:Uncertainties over future climatic conditions pose significant challenges when selecting appropriate conservation strategies for heritage sites. Choosing effective strategies is especially important for earthen heritage sites located in dryland regions, as many are experiencing rapid environmentally-driven deteriorati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73456-8
更新日期：2020-10-02 00:00:00
abstract：:This retrospective study was undertaken to identify predictors for the development of hypocalcaemia even with prophylactic administration of calcium and vitamin D, and to help guide future strategies to improve the safety, efficacy, and QOL of patients receiving denosumab. Between January 2016 and February 2020, a tot...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-80243-y
更新日期：2021-01-13 00:00:00
abstract：:The purpose of the study was to assess both anatomic and functional outcomes between short-pulse continuous wavelength and infrared micropulse lasers in the treatment of DME. This was a prospective interventional study from tertiary care eye hospital-King Khaled Eye Specialist Hospital (Riyadh, Saudi Arabia). Patients...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79699-9
更新日期：2021-01-08 00:00:00
abstract：:The transient silencing effects currently demonstrated by nonviral siRNA delivery systems limit the therapeutic utility of RNAi, but it remains a technical challenge to prolong duration of gene silencing. We have developed a T7 autogene-based hybrid mRNA/DNA system to enable long-term expression of shRNA in cytoplasm ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-39407-8
更新日期：2019-02-28 00:00:00
abstract：:Transition metal dichalcogenides (TMDCs) are promising materials for sensing applications, due to their exceptional high performance in nano-electronics. Inherentely, the chemical and thermal responses of TMDCs are highly stable, hence, they pave way for real time sensor applications. This article proposes inceptively...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-62397-x
更新日期：2020-03-26 00:00:00
abstract：:Reciprocity is frequently assumed to require complex cognitive abilities. Therefore, it has been argued that reciprocity may be restricted to animals that can meet these demands. Here, we provide evidence for the potential presence of direct reciprocity in teleost fishes. We demonstrate that in pairs of coral reef rab...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep14556
更新日期：2015-09-25 00:00:00
abstract：:Ovarian tissue cryopreservation is considered as a useful option to preserve fertility for cancer patients. This study purposed to evaluate the change of telomere length and senescence markers during human ovarian tissue cryopreservation. Ovarian tissues were obtained from women who underwent benign ovarian surgery in...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81973-3
更新日期：2021-01-26 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death worldwide. The use of alpha fetoprotein (AFP) alone was not an accurate biomarker for HCC despite its high specificity. Therefore, we assessed the possible role of serum biomarkers that have been mentioned briefly in previous studie...
journal_title：Scientific reports
pub_type： 杂志文章,评审
doi：10.1038/s41598-020-62051-6
更新日期：2020-03-20 00:00:00
abstract：:During symbiosis, organisms use a range of metabolic and protein-based signals to communicate. Of these protein signals, one class is defined as 'effectors', i.e., small secreted proteins (SSPs) that cause phenotypical and physiological changes in another organism. To date, protein-based effectors have been described ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00400-8
更新日期：2017-03-23 00:00:00
abstract：:Moisture in materials can be a source of future outgassing and exacerbate unwanted changes in physical and chemical properties. Here, we investigate the effect of sample size and shape on the moisture transport phenomena through a combined experimental and modeling approach. Several different materials varying in size...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-74898-w
更新日期：2020-10-20 00:00:00
abstract：UNLABELLED:Understanding the mechanism of the strain-dependent conductivity change in polymers in stretched conditions is important. We observed a strain-induced growth of the conductive regions of PEDOT:PSS films, induced by a coalescence of conductive PEDOT-rich cores. This growth due to coalescence leads to a gradu...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25332
更新日期：2016-04-29 00:00:00
abstract：:We developed a novel integrated technology for diver-operated surveying of shallow marine ecosystems. The HyperDiver system captures rich multifaceted data in each transect: hyperspectral and color imagery, topographic profiles, incident irradiance and water chemistry at a rate of 15-30 m2 per minute. From surveys in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07337-y
更新日期：2017-08-02 00:00:00
abstract：:Rhizomorphic lycopsids are the land plant group that includes the first giant trees to grow on Earth and extant species in the genus Isoetes. Two mutually exclusive hypotheses account for the evolution of terminal rooting axes called rootlets among the rhizomorphic lycopsids. One hypothesis states that rootlets are tr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78171-y
更新日期：2020-12-09 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-79133-0
更新日期：2020-12-15 00:00:00
abstract：:Laser-Stimulated Fluorescence (LSF) is used to identify fully fledged feathering in the hatchling enantiornithine bird specimen MPCM-LH-26189, supporting precocial nesting behavior in this extinct group. The LSF results include the detection of a long pennaceous wing feather as well as cover feathers around the body. ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-41423-7
更新日期：2019-03-21 00:00:00
abstract：:The roles of CD4 + T cells and CD8 + T cells in hepatitis B virus (HBV) infection have been well documented. However, the role of innate immunity in HBV infection remains obscure. Here we examined the effect of activation of innate immunity by polyinosinic: polycytidylic acid (PolyI:C) on HBV infection. A chronic HBV ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-00387-2
更新日期：2017-03-22 00:00:00
abstract：:Trastuzumab combined with chemotherapy is standard of care for HER2 positive advanced gastro-esophageal cancers. The reported prevalence of HER2 discordance between primary tumors and corresponding metastases varies, hampering uniform patient selection for HER2 targeted therapy. This meta-analysis explores the influen...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-017-03304-9
更新日期：2017-06-09 00:00:00
abstract：:In this study, a novel resorufin thionocarbonate-based Hg2+-selective signaling probe (RT) for microfluidic paper-based analytical device (μPAD) applications is reported. The designed probe, RT, was readily synthesized by the one-step reaction of resorufin with phenyl thionochloroformate. The RT probe displayed a prom...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-40169-6
更新日期：2019-03-04 00:00:00
abstract：:The aim of this study was to investigate the correlation between elastography and histologic characteristics including fibrosis and calcification. We also wanted to investigate whether other clinicopathologic indexes influence the strain ratio (SR) of papillary thyroid carcinomas (PTCs). We retrospectively reviewed 12...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45042
更新日期：2017-03-22 00:00:00
abstract：:Plant defensins (PDFs) are cysteine-rich peptides that have a range of biological functions, including defence against fungal pathogens. However, little is known about their role in defence against bacteria. In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-08497-7
更新日期：2017-08-23 00:00:00
abstract：:Change in body composition with skeletal muscle wasting, a major component of pulmonary cachexia, is associated with mortality in chronic obstructive pulmonary disease and cancer. However, its relevance in interstitial lung diseases (ILDs) remains unclear. We hypothesized changes in body composition would be associate...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-32478-z
更新日期：2018-09-19 00:00:00
