Modelling mutational landscapes of human cancers in vitro.

abstract：:Nano-suspensions (NS) exhibit unusual thermophysical behaviors once interparticle aggregations and the shear flows are imposed, which occur ubiquitously in applications but remain poorly understood, because existing theories have not paid these attentions but focused mainly on stationary NS. Here we report the critica...

journal_title：Scientific reports

authors： Sui J,Zhao P,Bin-Mohsin B,Zheng L,Zhang X,Cheng Z,Chen Y,Chen G

更新日期：2016-12-20 00:00:00

abstract：:Voltage-gated potassium (Kv) channels comprise pore-forming α subunits and a multiplicity of regulatory proteins, including the cardiac-expressed and cardiac arrhythmia-linked transmembrane KCNE subunits. After recently uncovering novel, N-terminally extended (L) KCNE3 and KCNE4 isoforms and detecting their transcript...

journal_title：Scientific reports

authors： Abbott GW

更新日期：2016-12-06 00:00:00

abstract：:Oligomers populated during the early amyloid aggregation process are more toxic than mature fibrils, but pinpointing the exact toxic species among highly dynamic and heterogeneous aggregation intermediates remains a major challenge. β-barrel oligomers, structurally-determined recently for a slow-aggregating peptide de...

journal_title：Scientific reports

authors： Sun Y,Ge X,Xing Y,Wang B,Ding F

更新日期：2018-07-09 00:00:00

abstract：:Membrane proteins are key elements in cell-mediated processes. In particular, G protein-coupled receptors (GPCRs) have attracted increasing interest since they affect cellular signaling. Furthermore, mutations in GPCRs can cause acquired and inheritable diseases. Up to date, there still exist a number of GPCRs that ha...

journal_title：Scientific reports

authors： Zemella A,Grossmann S,Sachse R,Sonnabend A,Schaefer M,Kubick S

更新日期：2017-06-16 00:00:00

abstract：:Translational motion of neurotransmitter receptors is key for determining receptor number at the synapse and hence, synaptic efficacy. We combine live-cell STORM superresolution microscopy of nicotinic acetylcholine receptor (nAChR) with single-particle tracking, mean-squared displacement (MSD), turning angle, ergodic...

journal_title：Scientific reports

authors： Mosqueira A,Camino PA,Barrantes FJ

更新日期：2018-08-10 00:00:00

abstract：:Transparent Er3+-doped germanotellurite glass ceramics (GCs) with variable Te/Ge ratio were prepared by controllable heat-treated process. X-ray diffraction (XRD) and transmission electron microscope (TEM) confirmed the formation of nanocrystals in glass matrix. Raman spectra were used to investigate the evolution of ...

journal_title：Scientific reports

authors： Kang S,Xiao X,Pan Q,Chen D,Qiu J,Dong G

更新日期：2017-03-07 00:00:00

abstract：:Poly(N-isopropylacrylamide) (PNIPAm) is widely used to fabricate cell sheet surfaces for cell culturing, however copolymer and interpenetrated polymer networks based on PNIPAm have been rarely explored in the context of tissue engineering. Many complex and expensive techniques have been employed to produce PNIPAm-base...

journal_title：Scientific reports

authors： Sanzari I,Buratti E,Huang R,Tusan CG,Dinelli F,Evans ND,Prodromakis T,Bertoldo M

更新日期：2020-04-09 00:00:00

abstract：:Fine particulate matter 2.5 (PM2.5) induces free radicals and oxidative stress in animals, leading to a range of illnesses. In this study, Ganoderma Microsporum immunomodulatory (GMI) proteins were administered to alleviate PM2.5-induced inflammatory responses in mother rats, and PM2.5-induced inflammatory responses a...

journal_title：Scientific reports

authors： Tseng CY,Yu JY,Chuang YC,Lin CY,Wu CH,Liao CW,Yang FH,Chao MW

更新日期：2019-05-02 00:00:00

abstract：:Biological N2 fixation (BNF) in the rhizosphere of Podocarpaceae is currently attributed to unspecific diazotrophs with negligible impact on N acquisition. Here, we report specific and high associative BNF in dead cells of root nodules of Lepidothamnus fonkii distributed in ombrotrophic peatlands of Patagonia. BNF of ...

journal_title：Scientific reports

authors： Borken W,Horn MA,Geimer S,Aguilar NA,Knorr KH

更新日期：2016-12-15 00:00:00

abstract：:Novel predictive biomarkers are needed to improve patient selection and optimize the use of bevacizumab (B) in metastatic colorectal cancer. We analyzed the potential of five circulating biomarkers to predict B efficacy and monitor response. Peripheral blood samples collected at baseline, at the first clinical evaluat...

journal_title：Scientific reports

authors： Marisi G,Scarpi E,Passardi A,Nanni O,Ragazzini A,Valgiusti M,Casadei Gardini A,Neri LM,Frassineti GL,Amadori D,Ulivi P

更新日期：2017-05-02 00:00:00

abstract：:It remains unclear how infantile febrile seizures (FS) enhance adult seizure susceptibility. Here we showed that the transient increase of interleukin-1β (IL-1β) after prolonged FS promoted adult seizure susceptibility, which was blocked by interleukin-1 receptor antagonist (IL-1Ra) within a critical time window. Post...

journal_title：Scientific reports

authors： Feng B,Tang Y,Chen B,Xu C,Wang Y,Dai Y,Wu D,Zhu J,Wang S,Zhou Y,Shi L,Hu W,Zhang X,Chen Z

更新日期：2016-02-23 00:00:00

abstract：:We assessed the relationship between the heterogeneity of HCC on preoperative non-contrast-enhanced CT and patient prognosis. The heterogeneity of CT images from 122 patients was assessed and texture feature parameters such as mean, standard deviation (SD), entropy, mean of the positive pixels (MPP), skewness, and kur...

journal_title：Scientific reports

authors： Kiryu S,Akai H,Nojima M,Hasegawa K,Shinkawa H,Kokudo N,Yasaka K,Ohtomo K

更新日期：2017-10-04 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Robertson KE,Truong CD,Craciunescu FM,Yang JH,Chiu PL,Fromme P,Hansen DT

更新日期：2020-03-02 00:00:00

abstract：:Changes associated with cognitive function in the high-fat high-carbohydrate diet-induced prediabetes animal model and effect of exercise remain unclear. Rats were randomly assigned to the following groups (n = 6): non-diabetic (ND), prediabetic (PD), intermittent exercising PD (PD + IE) and regular exercising PD (PD ...

journal_title：Scientific reports

authors： Luvuno M,Khathi A,Mabandla MV

更新日期：2020-09-14 00:00:00

abstract：:The Holocene drying trend in the northern Altai Mountains and the wetting trend in the southern Altai Mountains inferred from the paleoclimatic studies indicated it is needed to understand the modern climatic characters in this region. However, a detailed analysis of modern climate variations in the northern and south...

journal_title：Scientific reports

authors： Zhang D,Yang Y,Lan B

更新日期：2018-02-19 00:00:00

abstract：:Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leadi...

journal_title：Scientific reports

authors： Ruiz-Cruz S,Moreno-Blanco A,Espinosa M,Bravo A

更新日期：2019-04-16 00:00:00

abstract：:While the glass transition at non-zero temperature seems to be hard to access for experimental, theoretical, or simulation studies, jamming at zero temperature has been studied in great detail. Motivated by the exploration of the energy landscape that has been successfully used to investigate athermal jamming, we intr...

journal_title：Scientific reports

authors： Maiti M,Schmiedeberg M

更新日期：2018-01-30 00:00:00

abstract：:We propose a simple quantum voting scenario with a set of pairs of particles in a multi-particle entangled state. This scenario is suitable for large scale general votings. We also provide a proof of security of our scheme against the most general type of attack by generalizing Shor and Preskill's proof of security of...

journal_title：Scientific reports

authors： Xue P,Zhang X

更新日期：2017-08-08 00:00:00

abstract：:Omniphobic surfaces with reentrant microstructures have been investigated for a range of applications, but the evaporation of high- and low-surface-tension liquid droplets placed on such surfaces has not been rigorously studied. In this work, we develop a technique to fabricate omniphobic surfaces on copper substrates...

journal_title：Scientific reports

authors： Chen X,Weibel JA,Garimella SV

更新日期：2015-11-25 00:00:00

abstract：:Induction of premature senescence represents a novel functional strategy to curb the uncontrolled proliferation of malignant cancer cells. This study unveils the regiospecific synthesis of novel isoxazoline derivatives condensed to ring A of medicinal plant product Withaferin-A. Intriguingly, the cis fused products wi...

journal_title：Scientific reports

authors： Rasool F,Nayak D,Katoch A,Faheem MM,Yousuf SK,Hussain N,Belawal C,Satti NK,Goswami A,Mukherjee D

更新日期：2017-10-23 00:00:00

abstract：:The prevalence of type 2 diabetes (T2D) has increased dramatically in Middle Eastern populations that represent the largest non-European immigrant group in Sweden today. As proneurotensin predicts T2D, the aim of this study was to investigate differences in proneurotensin levels across populations of Middle Eastern an...

journal_title：Scientific reports

authors： Fawad A,Nilsson PM,Struck J,Bergmann A,Melander O,Bennet L

更新日期：2019-09-20 00:00:00

abstract：:We evaluated bioactive glass graft (S53P4) in patients undergoing Le Fort I osteotomy, with non-grafted patients as controls. Computed tomography facial scans of the 25 patients submitted for Le Fort I were divided into two groups: Group 1-S53P4 group and Group 2-without grafting. CT scans were analyzed in the immedia...

journal_title：Scientific reports

authors： de Souza Cruz EL,de Souza FJ Jr,de Menezes LM,Tuji FM,Carneiro JT Jr

更新日期：2020-07-29 00:00:00

abstract：:This study was aimed to explore the bidirectional association between depression and peptic ulcers. The ≥20-year-old participants of the Korean National Health Insurance Service-National Sample Cohort from 2002 to 2013 were included in the study. In study I, 30,306 depression patients were 1:4 matched with 121,224 con...

journal_title：Scientific reports

authors： Kim SY,Min C,Oh DJ,Choi HG

更新日期：2020-02-04 00:00:00

abstract：:A major goal of biology is to develop a quantitative ligand-binding assay that does not involve the use of radioactivity. Existing fluorescence-based assays have a serious drawback due to fluorescence quenching that accompanies the binding of fluorescently-labeled ligands to their receptors. This limitation of existin...

journal_title：Scientific reports

authors： Breen CJ,Raverdeau M,Voorheis HP

更新日期：2016-05-10 00:00:00

abstract：:The recombination is one of the most frequently identified drivers of double-stranded DNA viruses evolution. However, the recombination events in African swine fever virus (ASFV) genomes have been poorly annotated. We hypothesize that the genetic determinants of ASFV variability are potential hot-spots for recombinati...

journal_title：Scientific reports

authors： Nefedeva M,Titov I,Tsybanov S,Malogolovkin A

更新日期：2020-10-28 00:00:00

abstract：:Advanced structural characterisation techniques which are rapid to use, non-destructive and structurally definitive on the nanoscale are in demand, especially for a detailed understanding of extended-defects and their influence on the properties of materials. We have applied the electron backscatter diffraction (EBSD)...

journal_title：Scientific reports

authors： Naresh-Kumar G,Vilalta-Clemente A,Jussila H,Winkelmann A,Nolze G,Vespucci S,Nagarajan S,Wilkinson AJ,Trager-Cowan C

更新日期：2017-09-07 00:00:00

abstract：:WRINKLED1 (WRI1), an APETALA2 (AP2)-type transcription factor, has been shown to be required for the regulation of carbon partitioning into fatty acid (FA) synthesis in plant seeds. To our knowledge, the regulatory network of WRI1 remains unknown in Prunus sibirica kernel (PSK), a novel woody biodiesel feedstock in Ch...

journal_title：Scientific reports

authors： Deng S,Mai Y,Shui L,Niu J

更新日期：2019-02-25 00:00:00

abstract：:Urbanization is associated with dramatic increases in noise and light pollution, which affect animal behaviour, physiology and fitness. However, few studies have examined these stressors simultaneously. Moreover, effects of urbanization during early-life may be detrimental but are largely unknown. In developing great ...

journal_title：Scientific reports

authors： Raap T,Pinxten R,Casasole G,Dehnhard N,Eens M

更新日期：2017-06-05 00:00:00

abstract：:Reduced near-infrared reflectance observed in September 1973 in Skylab images of the western flank of Mt. Etna has been interpreted as an eruption precursor of the January 1974 eruption. Until now, it has been unclear when this signal started, whether it was sustained and which process(es) could have caused it. By ana...

journal_title：Scientific reports

authors： Seiler R,Houlié N,Cherubini P

更新日期：2017-03-07 00:00:00

abstract：:The transparency of animals is an important biological feature. Ascidian eggs have various degrees of transparency, but this characteristic has not yet been measured quantitatively and comprehensively. In this study, we established a method for evaluating the transparency of eggs to first characterize the transparency...

journal_title：Scientific reports

authors： Shito TT,Hasegawa N,Oka K,Hotta K

更新日期：2020-11-30 00:00:00