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Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin.

Abstract：

:Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker formed during the hemoglobin metabolism of Plasmodium species. By quantifying hemozoin production over the intraerythrocytic cycle, we reveal that hemozoin formation is already initiated by ~ 6-12 h old ring-stage parasites. We demonstrate that the new assay is capable of drug efficacy testing with incubation times as short as 6-10 h, using synchronized P. falciparum 3D7 cultures incubated with chloroquine, piperaquine and dihydroartemisinin. The determined 50% inhibitory concentrations agree well with values established by standard assays requiring significantly longer testing time. Accordingly, we conclude that magneto-optical hemozoin detection provides a practical approach for the quick assessment of drug effect with short incubation times, which may also facilitate stage-specific assessment of drug inhibitory effects.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Molnár P,Orbán Á,Izrael R,Babai R,Marton L,Butykai Á,Karl S,Vértessy BG,Kézsmárki I

doi

10.1038/s41598-020-70860-y

subject

Has Abstract

pub_date

2020-08-20 00:00:00

pages

14025

issue

1

issn

2045-2322

pii

10.1038/s41598-020-70860-y

journal_volume

10

pub_type

杂志文章

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