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Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model.

Abstract：

:The effects of tumorigenesis and tumor growth on the non-involved organs remain poorly understood although many research efforts have already been made for understanding the metabolic phenotypes of various tumors. To better the situation, we systematically analyzed the metabolic phenotypes of multiple non-involved mouse organ tissues (heart, liver, spleen, lung and kidney) in an A549 lung cancer xenograft model at two different tumor-growth stages using the NMR-based metabonomics approaches. We found that tumor growth caused significant metabonomic changes in multiple non-involved organ tissues involving numerous metabolic pathways, including glycolysis, TCA cycle and metabolisms of amino acids, fatty acids, choline and nucleic acids. Amongst these, the common effects are enhanced glycolysis and nucleoside/nucleotide metabolisms. These findings provided essential biochemistry information about the effects of tumor growth on the non-involved organs.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Xu S,Tian Y,Hu Y,Zhang N,Hu S,Song D,Wu Z,Wang Y,Cui Y,Tang H

doi

10.1038/srep28057

subject

Has Abstract

pub_date

2016-06-22 00:00:00

pages

28057

issn

2045-2322

pii

srep28057

journal_volume

6

pub_type

杂志文章

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