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Camouflaged Nanosilver with Excitation Wavelength Dependent High Quantum Yield for Targeted Theranostic.

Abstract：

:The present study shows the thorough investigations on optical properties and hydrodynamic diameters of glutathione (GSH) stabilized nanosilver clusters (AgNC) at different stages of synthesis and engineering for the optimized absolute quantum yield to generate fluorescent images of Dalton Lymphoma Ascites (DLA) tumour bearing mice. The initial increment of quantum yield was wavelength dependent and finally it became 0.509 which was due to the camouflaging or entrapment of AgNC in macrophages membranes. The potentiality of macrophages membrane camouflaged silver nanoclusters (AgM) was reflected in the cell viability assay and confocal based live dead cell assay where the AgM has better cell killing effect compared to AgNC with reduced dosage and in vivo mice imaging generated the clear visualization at the tumour sites. Therefore, from the present study, it can be considered that the camouflaged nanosilver can be used for targeted theranostic applications.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Girigoswami A,Yassine W,Sharmiladevi P,Haribabu V,Girigoswami K

doi

10.1038/s41598-018-34843-4

subject

Has Abstract

pub_date

2018-11-07 00:00:00

pages

16459

issue

1

issn

2045-2322

pii

10.1038/s41598-018-34843-4

journal_volume

8

pub_type

杂志文章

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