Abstract：
:While neurofilament light chain (NfL) measurement in serum is a well-established marker of neuroaxonal damage in multiple sclerosis (MS), data on astroglial markers in serum are missing. In our study, glial fibrillary acid protein (GFAP) and NfL were measured in cerebrospinal fluid (CSF) and serum of MS patients and patients with other non-inflammatory neurological diseases (OND) using the Simoa technology. Clinical data like age, gender, expanded disability status scale (EDSS) and MRI findings were correlated to neurochemical markers. We included 80 MS patients: 42 relapsing-remitting MS (RRMS), 38 progressive MS (PMS), as well as 20 OND. Serum GFAP levels were higher in PMS compared to RRMS and OND (p < 0.001, p = 0.02 respectively). Serum GFAP levels correlated with disease severity in the whole MS group and PMS (Spearman-rho = 0.5, p < 0.001 in both groups). Serum GFAP correlated with serum NfL in PMS patients (Spearman-rho = 0.4, p = 0.01). Levels of serum GFAP were higher with increasing MRI-lesion count (p = 0.01). in summary, we report elevated levels of GFAP in the serum of MS patients. Since serum levels of GFAP correlate with the clinical severity scores and MRI lesion count, especially in PMS patients, it might be a suitable disease progression marker.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Abdelhak A,Huss A,Kassubek J,Tumani H,Otto Mdoi
10.1038/s41598-018-33158-8subject
Has Abstractpub_date
2018-10-04 00:00:00pages
14798issue
1issn
2045-2322pii
10.1038/s41598-018-33158-8journal_volume
8pub_type
杂志文章abstract：:Starch is the main storage carbohydrate in higher plants. Although several enzymes and regulators for starch biosynthesis have been characterized, a complete regulatory network for starch synthesis in cereal seeds remains elusive. Here, we report the identification and characterization of the rice Brittle1 (OsBT1) gen...
journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-05 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
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abstract：:Recently a new diluted magnetic semiconductor, (Ba,K)(Zn,Mn)2As2 (BZA), with high Curie temperature was discovered, showing an independent spin and charge-doping mechanism. This makes BZA a promising material for spintronics devices. We report the successful growth of a BZA single crystal for the first time in this st...
journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2015-11-23 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2017-01-05 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2019-05-17 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-05-31 00:00:00
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更新日期：2020-05-21 00:00:00
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更新日期：2018-09-21 00:00:00
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2018-01-18 00:00:00
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
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journal_title：Scientific reports
pub_type： 杂志文章
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journal_title：Scientific reports
pub_type： 杂志文章
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更新日期：2013-10-30 00:00:00
